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Last Updated: March 28, 2024

Claims for Patent: 9,315,826


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Summary for Patent: 9,315,826
Title:Nucleic acids containing a synthetic codon-optimized Sin Nombre virus full-length M gene
Abstract: The invention contemplates a new synthetic, codon-optimized Sin Nombre virus (SNV) full-length M gene open reading frame (ORF) that encodes a unique consensus amino acid sequence. The SNV ORF was cloned into a plasmid to form the first stable recombinant SNV full-length M gene that elicits neutralizing antibodies. The gene can be engineered into a vaccine system, and is useful to protect mammals against infection with Sin Nombre virus.
Inventor(s): Hooper; Jay (New Market, MD)
Assignee: The United States of America as rep. by the Sec\'y of the Army, for U.S. Army Medical Research Institute of Infectious Diseases (Washington, DC)
Application Number:13/982,606
Patent Claims:1. An isolated nucleic acid sequence set forth in SEQ ID NO:1.

2. The isolated nucleic acid sequence of claim 1, wherein the sequence is SEQ ID NO:2.

3. The isolated nucleic acid sequence of claim 2, wherein the sequence is SEQ ID NO:3

4. A recombinant DNA construct comprising: (i) a vector, and (ii) the DNA fragment comprising the nucleic acid sequence set forth in SEQ ID NO:1, SEQ ID NO:2 or SEQ ID NO:3, operably linked to a promoter sequence.

5. The recombinant DNA construct of claim 4 wherein the promoter is the cytomegalovirus promoter operably linked to Intron A, or wherein the promoter is the beta-actin promoter or the SV40 promoter.

6. The recombinant DNA construct of claim 4 wherein said construct is pWRG/SN-M(opt).

7. The recombinant DNA construct of claim 4, wherein the vector is a recombinant adenovirus or recombinant vesicular stomatitis virus, or alphavirus replicon.

8. A DNA cassette comprising either SEQ ID NO:2 or SEQ ID NO:3, linked to a promoter operable in a eukaryotic expression system.

Details for Patent 9,315,826

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 06/04/1986 ⤷  Try a Trial 2039-02-26
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 ⤷  Try a Trial 2039-02-26
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b Injection 103132 ⤷  Try a Trial 2039-02-26
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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