Claims for Patent: 9,296,815
✉ Email this page to a colleague
Summary for Patent: 9,296,815
Title: | Antibodies with enhanced or suppressed effector function |
Abstract: | Rationally designed antibodies and polypeptides that comprise multiple Fc region amino acid substitutions that synergistically provide enhanced selectivity and binding affinity to a target Fc receptor are provided. The polypeptides are mutated at multiple positions to make them more effective when incorporated in antibody therapeutics than those having wild-type Fc components. |
Inventor(s): | D\'Angelo; Igor (Port Moody, CA), Bleile; Dustin (Vancouver, CA), Tom-Yew; Stacey A. L. (New Westminster, CA), Escobar-Cabrera; Eric (Burnaby, CA), Lario; Paula I. (Vancouver, CA), Ohrn; Anders (Vancouver, CA), Poon; David K. Y. (Richmond, CA), Dixit; Surjit B. (Richmond, CA) |
Assignee: | Zymeworks Inc. (Vancouver, British Columbia, CA) |
Application Number: | 13/638,362 |
Patent Claims: | 1. A polypeptide comprising a variant Fc region, wherein said variant Fc region comprises amino acid modifications relative to a wild-type Fc region, said amino acid
modifications comprising a mutation at position 239 and further comprises the mutation D265S, wherein the numbering of amino acid residues is according to the EU index as set forth in Kabat, and wherein the mutation at position 239 is S239D or S239E.
2. The polypeptide of claim 1, wherein said modification at position 239 is S239E wherein the polypeptide has higher selectivity in binding to the Fc.gamma.RIIIa receptor compared to a polypeptide comprising the wild-type Fc region. 3. The polypeptide of claim 1, wherein said modifications further comprise the mutation S298A. 4. The polypeptide of claim 1 wherein the polypeptide comprises the amino acid modifications S239D/D265S/S298A/I332E S239E/D265S/H268D/I332E, or S239E/D265S/I332E. 5. The polypeptide of claim 1, wherein the variant Fc region is based on a human IgG Fc region. 6. The polypeptide of claim 5, wherein the human IgG Fc region is a human IgG1, IgG2, IgG3, or IgG4 Fc region. 7. The polypeptide of claim 1 wherein said polypeptide is an antibody. 8. The polypeptide of claim 7, wherein said antibody is a monoclonal antibody, a humanized antibody, or a human antibody. 9. A therapeutic antibody comprising the polypeptide of claim 1. 10. The therapeutic antibody of claim 9, wherein said therapeutic antibody is based on a parent antibody selected from the group consisting of abagovomab, adalimumab, alemtuzumab, aurograb, bapineuzumab, basiliximab, belimumab, bevacizumab, briakinumab, canakinumab, catumaxomab, certolizumab pegol, cetuximab, daclizumab, denosumab, efalizumab, galiximab, gemtuzumab ozogamicin, golimumab, ibritumomab tiuxetan, infliximab, ipilimumab, lumiliximab, mepolizumab, motavizumab, muromonab, mycograb, natalizumab, nimotuzumab, ocrelizumab, ofatumumab, omalizumab, palivizumab, panitumumab, pertuzumab, ranibizumab, reslizumab, rituximab, teplizumab, tocilizumab/atlizumab, tositumomab, trastuzumab, VB4-847, girentuximab, ustekinumab, zalutumumab, and any other antibodies. 11. The therapeutic antibody of claim 9, wherein said therapeutic antibody binds to a target antigen selected from the group consisting of a-chain (CD25) of IL-2R, Amyloid beta, BLyS (or BAFF), CD11a, CD20, CD22, CD23, CD3, CD4, CD52, CD80, CTLA-4, EGFR, EpCAM, F protein of RSV, G250, glycoprotein IIb/IIIa R, HER2, Hsp90, IgE antibody, IL-12/IL-23, IL-1b, IL-5, IL-6 receptor, Integrin alpha-4/beta-1, Mucin 16/CA-125, RANKL, TNF alpha, and VEGF-A. 12. A pharmaceutical composition comprising a therapeutically effective amount of the polypeptide of claim 1, and a pharmaceutically acceptable carrier. 13. The polypeptide of claim 1 wherein the variant Fc region further comprises one or more mutations selected from the group consisting of: L234Q, L234N, L235A, G236E, E236L, E236D, G237F, G237N, S267E, S267D, S267G, H268D, H268E, E269L, E269L, D270N, D270I, D270E, S298A, K326A, K326D, A327H, A327V, A327L, A327T, A330V, A330L, A330W, A330I, A330S, I332L, I332D, and I332E. 14. The polypeptide of claim 1 wherein the variant Fc region further comprises one or more mutations selected from the group consisting of: S298A, K326A, K326D, A327H, A327V, A327L, A327T, I332L, I332D, and I332E. |
Details for Patent 9,296,815
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Genentech, Inc. | RITUXAN | rituximab | Injection | 103705 | 11/26/1997 | ⤷ Try a Trial | 2030-03-29 |
Idec Pharmaceuticals Corp. | RITUXAN | rituximab | Injection | 103737 | 02/19/2002 | ⤷ Try a Trial | 2030-03-29 |
Hoffmann-la Roche Inc. | ZENAPAX | daclizumab | Injection | 103749 | 12/10/1997 | ⤷ Try a Trial | 2030-03-29 |
Novartis Pharmaceuticals Corporation | SIMULECT | basiliximab | For Injection | 103764 | 05/12/1998 | ⤷ Try a Trial | 2030-03-29 |
Novartis Pharmaceuticals Corporation | SIMULECT | basiliximab | For Injection | 103764 | 01/02/2003 | ⤷ Try a Trial | 2030-03-29 |
Swedish Orphan Biovitrum Ab (publ) | SYNAGIS | palivizumab | For Injection | 103770 | 06/19/1998 | ⤷ Try a Trial | 2030-03-29 |
Swedish Orphan Biovitrum Ab (publ) | SYNAGIS | palivizumab | Injection | 103770 | 07/23/2004 | ⤷ Try a Trial | 2030-03-29 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
Make Better Decisions: Try a trial or see plans & pricing
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.