Claims for Patent: 9,289,460

Summary for Patent: 9,289,460

Title:	Use of natural active substances in cosmetic or therapeutic compositions
Abstract:	The invention relates to cosmetic or therapeutic compositions that contain hydrolyzed yeast proteins as an active ingredient, to the use of said cosmetic or therapeutic compositions, and to a method for cosmetic treatment.
Inventor(s):	Justen; Peter (Rueil-Malmaison, FR), Borreill; Dominique Marie Noelle (Chennevieres sur Marne, FR), Marques; William (Rueil-Malmaison, FR)
Assignee:	Lesaffre et Compagnie (Paris, FR)
Application Number:	13/926,707
Patent Claims:	1. A method for treating a skin or skin appendage condition in a subject, the method comprising a step of administering to the subject a composition comprising hydrolysed yeast proteins, wherein the hydrolysed yeast proteins comprise at least 40% of yeast proteins with a molecular weight ranging from 1 to 5 kDa and are obtained by: submitting Saccharomyces cerevisiae yeast cells to a thermal treatment carried out for 1 to 3 hours at between 70.degree. C. and 90.degree. C., separating yeast hulls after thermal treatment of yeast, and submitting the yeast hulls to exogenous enzymatic hydrolysis with at least one peptidase for at least 18 hours at a temperature of between 45.degree. C. and 65.degree. C. to produce a reaction mixture comprising hydrolyzed yeast proteins, and separating the hydrolyzed yeast proteins from the reaction mixture, wherein treating a skin or skin appendage condition is selected from the group consisting of: treating dry skin, reducing sebum secretion, treating skin aging, promoting skin firmness, treating dandruff, promoting hair brightness and softness, and any combination thereof. 2. The method according to claim 1, wherein administering the composition to the subject comprises contacting the skin or skin appendage of the subject with the composition. 3. The method according to claim 1, wherein dry skin is associated to ichthyosis, eczema or psoriasis. 4. The method according to claim 1, wherein the yeast hulls are separated by centrifugation. 5. The method according to claim 1, wherein the at least one peptidase is selected from the group consisting of papain, trypsin, chymotrypsin, subtilisin, pepsin, thermolysin, pronase, flavastacine, enterokinase, factor Xa protease, furin, bromelain, proteinase K, generase I, thermitase, carboxypeptidase A, carboxypeptidase B, collagenase, and mixtures thereof. 6. The method according to claim 5, wherein the at least one peptidase is papain. 7. The method according to claim 6, wherein the papain is used at a concentration of 0.01% to 0.3% w/w. 8. The method according to claim 1, wherein the hydrolysed yeast proteins comprise at least 60% of yeast proteins with a molecular weight ranging from 1 to 5 kDa. 9. The method according to claim 1, wherein the hydrolysed yeast proteins comprise at most 55% of yeast proteins with a molecular weight lower than 1 kDa. 10. The method according to claim 1, wherein the hydrolysed yeast proteins comprise at most 35% of hydrolysed yeast proteins with a molecular weight lower than 1 kDa. 11. The method according to claim 1, wherein the composition comprises from 0.001% to 20% of hydrolysed yeast proteins. 12. The method according to claim 11, wherein the composition comprises from 0.01% to 2% of hydrolysed yeast proteins. 13. The method according to claim 1, wherein the hydrolysed yeast proteins have an AN/TN ratio lower than or equal to 35%. 14. The method according to claim 1, wherein the hydrolysed yeast proteins have an AN/TN ratio lower than or equal to 20%. 15. The method according to claim 1, wherein the composition further comprises at least one additive selected from the group consisting of preservatives, chelating agents, colouring agents, UV filters, pH regulators, texturizing agents, perfumes, and antioxidants. 16. The method according to claim 1, wherein the composition further comprises at least one excipient selected from the group consisting of hydrophilic excipients, hydrophobic excipients and surfactants. 17. The method according to claim 1, wherein the Saccharomyces cerevisiae yeast cells have a dry matter content of between 12% and 30% by mass. 18. The method according to claim 1, wherein the yeast hulls have a dry matter content of between 12% and 25 by mass.

Details for Patent 9,289,460

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965		2028-02-12