Upgrade for Complete Access See Plans and Pricing

Serving leading biopharmaceutical companies globally:

McKesson
Johnson and Johnson
Express Scripts
Dow
Colorcon
Baxter

Last Updated: December 6, 2021

DrugPatentWatch Database Preview

Claims for Patent: 9,248,164

➤ Subscribe for complete access

« Back to Dashboard

Summary for Patent: 9,248,164
Title:Growth factor anchoring type bone graft material, method for producing growth factor anchoring type bone graft material, kit for producing growth factor anchoring type bone graft material, and method for forming bone
Abstract: Provided is a growth factor anchoring type bone graft material, wherein a bone graft substrate exposing at least a collagen fiber is bound to a collagen-binding-site-containing growth factor which contains a growth factor receptor agonist peptide and a collagen-binding peptide. The same can be produced by mixing a bone graft substrate and a collagen-binding-site-containing growth factor which contains a growth factor receptor agonist peptide and a collagen-binding peptide, and is also superior in osteogenic ability.
Inventor(s): Uchida; Kentaro (Sagamihara, JP), Naruse; Koji (Sagamihara, JP), Takaso; Masashi (Sagamihara, JP), Mima; Takehiko (Sagamihara, JP), Matsushita; Osamu (Sagamihara, JP), Haraguchi; Takashi (Sagamihara, JP), Nishi; Nozomu (Kagawa, JP)
Assignee: SCHOOL JURIDICAL PERSON KITASATO INSTITUTE (Tokyo, JP) NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY (Takamatsu-Shi, Kagawa, JP)
Application Number:14/117,599
Patent Claims:1. A growth factor anchoring type bone graft material, wherein a bone graft substrate exposing at least a collagen fiber is bound to a collagen-binding-site-containing growth factor which comprises a growth factor receptor agonist peptide and a collagen-binding peptide, wherein the bone graft substrate is a high-density collagen material in a sheet form with a collagen fiber density of 100 to 800 mg/cm.sup.3, and the collagen-binding-site-containing growth factor is formed by ligating a basic fibroblast growth factor and the collagen-binding peptide through a polycystic kidney disease I domain of a collagenase.

2. A kit for production of a growth factor anchoring type bone graft material wherein a bone graft substrate exposing at least a collagen fiber is bound to a collagen-binding-site-containing growth factor which comprises a growth factor receptor agonist peptide and a collagen-binding peptide, wherein the bone graft substrate is a high-density collagen material in a sheet form with a collagen fiber density of 100 to 800 mg/cm.sup.3, and the collagen-binding-site-containing growth factor is formed by ligating a basic fibroblast growth factor and the collagen-binding peptide through a polycystic kidney disease I domain of a collagenase, which kit comprises: a solution comprising a collagen-binding-site-containing growth factor formed by ligating a basic fibroblast growth factor and the collagen-binding peptide through a polycystic kidney disease I domain of a collagenase; and a bone graft substrate which is said high-density collagen material in a sheet form with the collagen fiber density of 100 to 800 mg/cm.sup.3.

Make Better Decisions: Try a trial or see plans & pricing

Serving leading biopharmaceutical companies globally:

Express Scripts
Harvard Business School
McKesson
Medtronic
Boehringer Ingelheim
Johnson and Johnson

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.