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Last Updated: April 16, 2024

Claims for Patent: 9,220,771

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Summary for Patent: 9,220,771

Title:	Peptide for use in the treatment of breast cancer and/or bone metastases
Abstract:	The invention relates to the use of the Peptide of the formula Cyclo-(Arg-Gly-Asp-DPhe-NMe-Val) and/or the pharmaceutically acceptable derivatives, solvates and/or salts thereof, for the manufacture of a medicament for the treatment of breast cancer and/or bone metastases in humans, wherein the medicament is optionally to be used in combination with one or more cancer cotherapeutic agents, preferably selected from a) hormone modulating agents, b) osteoclast activity modulating agents, c) cancer chemotherapeutic agents, and/or d) radiotherapy, alone, concurrently or not in the dosage regime of the present invention.
Inventor(s):	Kerber; Anne (Langen, DE), Baeuerle; Tobias (Heidelberg, DE)
Assignee:	MERCK PATENT GMBH (Darmstadt, DE)
Application Number:	13/810,593
Patent Claims:	1. A method of treating bone metastasis in a subject, comprising administering to said subject a Peptide of the formula Cyclo-(Arg-Gly-Asp-DPhe-NMe-Val) and/or the pharmaceutically acceptable, solvates and/or salts thereof, and one or more cancer therapeutic agents, selected from the group consisting of: osteoclast activity modulating agents. 2. The method according to claim 1, wherein the osteoclast activity modulating agents are selected from the group consisting of bisphosphonates and RANK/RANKL/OPG modulators. 3. The method of claim 2, wherein the bisphosphonates are selected from the group consisting of: Etidronate, Clodronate, Tiludronate, Pamidronate, Neridronate, Olpadronate, Alendronate, Ibandronate, Risedronate, Zoledronate and/or the pharmaceutically acceptable solvates or salts thereof and/or the RANK/RANKL/OPG modulators are selected from the group consisting of: Denosumab and/or the pharmaceutically acceptable solvates and/or salts thereof. 4. The method according to claim 3, additionally comprising administering to the subject radiotherapy. 5. The method according to claim 1, wherein the Peptide of the formula Cyclo-(Arg-Gly-Asp-DPhe-NMe-Val) and/or the pharmaceutically acceptable solvates and/or salts thereof is administered to a subject in an amount of 250 mg to 12500 mg per week. 6. The method according to claim 1, wherein the Peptide of the formula Cyclo-(Arg-Gly-Asp-DPhe-NMe-Val) and/or the pharmaceutically acceptable derivatives, solvates and/or salts thereof is administered to a subject in an amount of 800 mg to 8000 mg per week. 7. The method according to claim 1, wherein the Peptide of the formula Cyclo-(Arg-Gly-Asp-DPhe-NMe-Val) and/or the pharmaceutically acceptable solvates and/or salts thereof is administered to a subject in an amount of 1500 mg to 7000 mg per week. 8. The method according to claim 1, wherein the Peptide of the formula Cyclo-(Arg-Gly-Asp-DPhe-NMe-Val) and/or the pharmaceutically acceptable solvates and/or salts thereof is administered to a subject in a twice weekly to four times weekly administration scheme consisting of about 500 mg or about 2000 mg per administration. 9. The method according to claim 1, wherein the Peptide of the formula Cyclo-(Arg-Gly-Asp-DPhe-NMe-Val) and/or the pharmaceutically acceptable solvates and/or salts thereof is administered to a subject in a once weekly to three times weekly administration scheme consisting of about 500 mg or about 2000 mg per administration. 10. The method according to claim 1, wherein the Peptide of the formula Cyclo-(Arg-Gly-Asp-DPhe-NMe-Val) and/or the pharmaceutically acceptable solvates and/or salts thereof is administered to a subject in a once weekly to five times weekly administration scheme consisting of about 500 mg or in a once weekly to three times weekly administration scheme consisting of about 2000 mg per administration. 11. The method according to claim 1, wherein the Peptide of the formula Cyclo-(Arg-Gly-Asp-DPhe-NMe-Val) and/or the pharmaceutically acceptable solvates and/or salts thereof is administered to a subject 1 to 20 hours prior to the application of the one or more cancer chemotherapeutic agents. 12. The method according to claim 1, said method further comprising administering to the subject radiotherapy. 13. The method according to claim 1, wherein said subject is a human subject.

Details for Patent 9,220,771

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Amgen, Inc.	PROLIA	denosumab	Injection	125320	06/01/2010	⤷ Try a Trial	2030-07-16
Amgen, Inc.	XGEVA	denosumab	Injection	125320	11/18/2010	⤷ Try a Trial	2030-07-16
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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