Claims for Patent: 9,192,662

Summary for Patent: 9,192,662

Title:	Methods using immunomodulatory compounds for modulating level of CD59
Abstract:	Provided herein are methods of treating, preventing or managing disorders associated with low CD59 levels. The methods encompass the administration of an immunomodulatory compound provided herein, such as 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione or 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline. Further described are methods of treatment using the immunomodulatory compounds in combination with other therapeutic agents or therapies. Pharmaceutical compositions and single unit dosage forms suitable for use in the methods provided herein are also disclosed.
Inventor(s):	Brady; Helen A. (San Diego, CA), Chan; Kyle (San Diego, CA)
Assignee:	Celgene Corporation (Summit, NJ)
Application Number:	12/362,411
Patent Claims:	1. A method of treating or managing a disease associated with CD59 deficiency comprising administering to a patient a therapeutically effective amount of an immunomodulatory compound, wherein the immunomodulatory compound is 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione or 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione, and wherein the disease or disorder is paroxysmal nocturnal hemoglobinuria. 2. The method of claim 1, further comprising administration of an anti-C5 antibody, wherein the anti-C5 antibody is eculizumab, h5G1.1-mAb, h5G1.1-scFv, or a functional fragment of h5G 1.1. 3. The method of claim 2, wherein the anti-C5 antibody is eculizumab.

Details for Patent 9,192,662

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Alexion Pharmaceuticals, Inc.	SOLIRIS	eculizumab	Injection	125166	03/16/2007		2028-01-29