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Summary for Patent: 9,192,662
|Title:||Methods using immunomodulatory compounds for modulating level of CD59|
|Abstract:||Provided herein are methods of treating, preventing or managing disorders associated with low CD59 levels. The methods encompass the administration of an immunomodulatory compound provided herein, such as 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione or 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline. Further described are methods of treatment using the immunomodulatory compounds in combination with other therapeutic agents or therapies. Pharmaceutical compositions and single unit dosage forms suitable for use in the methods provided herein are also disclosed.|
|Inventor(s):||Brady; Helen A. (San Diego, CA), Chan; Kyle (San Diego, CA)|
|Assignee:||Celgene Corporation (Summit, NJ)|
|Patent Claims:||1. A method of treating or managing a disease associated with CD59 deficiency comprising administering to a patient a therapeutically effective amount of an immunomodulatory
compound, wherein the immunomodulatory compound is 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione or 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione, and wherein the disease or disorder is paroxysmal nocturnal hemoglobinuria.
2. The method of claim 1, further comprising administration of an anti-C5 antibody, wherein the anti-C5 antibody is eculizumab, h5G1.1-mAb, h5G1.1-scFv, or a functional fragment of h5G 1.1.
3. The method of claim 2, wherein the anti-C5 antibody is eculizumab.
|Applicant||Tradename||Biologic Ingredient||Dosage Form||BLA||Number||Approval Date||Patent No.||Assignee||Estimated Patent Expiration||Status||Orphan||Source|
|Alexion Pharm||SOLIRIS||eculizumab||INJECTABLE; IV (INFUSION)||125166||001||2007-03-16||Start Trial||Celgene Corporation (Summit, NJ)||2028-01-29||RX||Orphan||search|
|>Applicant||>Tradename||>Biologic Ingredient||>Dosage Form||>BLA||>Number||>Approval Date||>Patent No.||>Assignee||>Estimated Patent Expiration||>Status||>Orphan||>Source|
|Country||Patent Number||Publication Date|
|World Intellectual Property Organization (WIPO)||2009097120||Aug 06, 2009|
|United States of America||2009317385||Dec 24, 2009|
|Mexico||2010008220||Aug 23, 2010|
|Japan||2011510983||Apr 07, 2011|
|European Patent Office||2249835||Nov 17, 2010|
|China||101977603||Feb 16, 2011|
|>Country||>Patent Number||>Publication Date|
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