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Last Updated: March 19, 2024

Claims for Patent: 9,186,274


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Summary for Patent: 9,186,274
Title:Method and apparatus for reducing intraocular pressure
Abstract: A drainage apparatus is disclosed to reduce intraocular pressure in an eyeball that includes an anterior chamber having aqueous humor disposed therein, a cornea and a surrounding marginal limbus by which the cornea is continuous with a scleral layer and a conjunctival layer disposed on an exposed surface of the eyeball and under eyelids, the apparatus comprising an inlet assembly configured to be disposed at the anterior chamber of the eyeball, an outlet assembly configured to be disposed at the external surface of the eyeball, the assembly having a central chamber, a tube extending between the inlet and outlet assemblies and configured to promote fluid communication between the inlet and outlet assemblies, and control means disposed within the outlet assembly for controlling a flow of aqueous humor through the tube from the anterior chamber of the eyeball to the external surface of the eyeball, the control means further comprising a replaceable filter disposed within the central chamber of the outer member to prevent intraocular infection, the filter having a medicinal agent applied thereto for preventing occlusion of the filter or bacterial contamination by inhibiting at least one of the formation of fibrotic membranes, inflammatory membrane, or bacterial adhesions or biofilms, thereby preventing increased of intraocular pressure or infection.
Inventor(s): Camras; Carl B. (Omaha, NE), Camras; Lucinda J. (Omaha, NE)
Assignee: CAMRAS VISION INC. (Research Triangle Park, NC)
Application Number:12/546,864
Patent Claims:1. A drainage apparatus to reduce intraocular pressure in an eyeball that includes an anterior chamber having aqueous humor disposed therein, a cornea and a surrounding marginal limbus by which the cornea is continuous with a scleral layer and a conjunctival layer disposed on an exposed surface of the eyeball and under eyelids, said apparatus comprising: an inlet assembly configured to be disposed at the anterior chamber of the eyeball; an outlet assembly configured to be disposed at the external surface of the eyeball, said outlet assembly comprising inner and outer convex members; said inner and outer convex members being separated, thereby providing openings to allow aqueous humor to exit around an outer periphery thereof onto the external ocular surface, said inner and outer convex members being configured to generally correspond to the external surface of the eyeball, said inner member having a central cavity disposed therein and said outer member having a central chamber and at least one aperture disposed therein, where said central cavity and said central chamber are configured to matingly engage one another; a tube extending between said inlet and outlet assemblies and configured to promote fluid communication between said inlet and outlet assemblies; and control structure disposed within said outlet assembly for controlling a flow of aqueous humor through said tube from said anterior chamber of the eyeball to said external surface of the eyeball; said control structure further comprising a replaceable filter disposed within said central chamber of said outer convex member, said replaceable filter having a medicinal agent applied thereto for preventing occlusion or bacterial contamination of the replaceable filter by inhibiting at least one of the formation of fibrotic membranes or other extracellular matrix formations which can occlude the replaceable filter and lead to increased intraocular pressure or infection, said outer convex member being configured to be removable to facilitate removal and replacement of said replaceable filter without removing said inner convex member.

2. The apparatus as defined in claim 1 wherein said medicinal agent is for preventing the formation of fibrosis.

3. The apparatus as defined in claim 2 wherein 5-fluorouracil (5-FU) is applied to the filter.

4. The apparatus as defined in claim 2 wherein mitomycin C (MMC) is applied to the filter.

5. The apparatus as defined in claim 1 wherein said medicinal agent is for preventing inflammatory membrane on the filter, and further comprises high efficacy steroids.

6. The apparatus as defined in claim 5 wherein said steroids are selected from the group consisting of triamcinolone.

7. The apparatus as defined in claim 1 wherein said medicinal agent is for preventing bacterial and membranous adhesions, and further comprises heparin.

8. The apparatus as defined in claim 7 wherein said medicinal agent for preventing bacterial adhesions is coated on the outlet assembly.

9. The apparatus as defined in claim 1 wherein said medicinal agent is a tissue plasminogen activator.

10. The apparatus as defined in claim 1 wherein said medicinal agent is a collagenase.

11. The apparatus as defined in claim 1 wherein said medicinal agent is for preventing inflammatory membrane on the filter, and further comprises inhibitor to vascular endothelia growth factor (anti-VEGF).

12. The apparatus as defined in claim 11 wherein said vascular endothelia growth factor inhibitor (anti-VEGF) is selected from the group consisting of bevacizumab or ranibizumab.

13. The apparatus as defined in claim 1 wherein the inlet assembly and the tube are formed as one continuous unit.

14. The apparatus as defined in claim 1 wherein said replaceable filter is comprised of polycarbonate.

15. The apparatus as defined in claim 1 wherein a porosity of said replaceable filter is configured to selectively optimize a flow of aqueous humor.

16. The apparatus as defined in claim 1 wherein said control structure comprises a pressure-sensitive valve for providing a predetermined amount of resistance to control a flow of aqueous humor through said outlet assembly.

17. The apparatus as defined in claim 1 further comprising a replaceable valve disposed between said replaceable filter and said at least one aperture of said central chamber.

18. The apparatus as defined in claim 1 further comprising a plurality of spacers located between said inner and outer convex members to enable aqueous humor to flow from said central chamber to the outer periphery, the openings of said outlet assembly being distributed around the outer periphery thereof through which aqueous humor can exit to the external surface of the eyeball.

19. The apparatus as defined in claim 18 wherein said spacers are formed with said inner convex member and are pie shaped with adjacent spacers being spaced apart from one another to define said flow paths.

20. The apparatus as defined in claim 18 wherein one of said inner and outer convex members has said openings.

21. The apparatus as defined in claim 18 wherein said openings comprise a plurality of elongated slots.

22. A drainage apparatus to reduce intraocular pressure within an eyeball, the eyeball having aqueous humor, a curved external surface having multiple points of ingress disposed thereon, and an anterior chamber, a conjunctival layer and a limbus, said apparatus comprising: an inlet assembly disposed within the anterior chamber for ingress of aqueous humor from the anterior chamber; an outlet assembly disposed externally to the eyeball for draining aqueous humor exterior to the eyeball, said outlet assembly comprising inner and outer convex members with a central chamber located in one of said inner and outer convex members, said inner and outer convex members having a space between them, thereby providing openings to allow aqueous humor to exit around the outer periphery thereof onto the external ocular surface, said members being configured to matingly engage one another, said outer convex member being removable from said inner convex member, and said inner convex member abutting the external surface of the eyeball; a conduit for conducting a flow of aqueous humor between said inlet assembly and outlet assembly; control structure for controlling the flow of aqueous humor between said inlet assembly and outlet assembly, said control structure disposed within said central chamber and comprising a replaceable filter and a replaceable valve, said replaceable filter having a medicinal agent applied thereto for preventing occlusion or bacterial contamination of the replaceable filter by inhibiting at least one of the formation of fibrotic membranes or other extracellular matrix formations which can occlude the replaceable filter and lead to increased intraocular pressure or infection; and an anchor structure for preventing extrusion of said apparatus.

Details for Patent 9,186,274

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Smith & Nephew, Inc. SANTYL collagenase Ointment 101995 06/04/1965 ⤷  Try a Trial 2025-02-23
Genentech, Inc. AVASTIN bevacizumab Injection 125085 02/26/2004 ⤷  Try a Trial 2025-02-23
Genentech, Inc. LUCENTIS ranibizumab Injection 125156 06/30/2006 ⤷  Try a Trial 2025-02-23
Genentech, Inc. LUCENTIS ranibizumab Injection 125156 08/10/2012 ⤷  Try a Trial 2025-02-23
Genentech, Inc. LUCENTIS ranibizumab Injection 125156 10/13/2016 ⤷  Try a Trial 2025-02-23
Genentech, Inc. LUCENTIS ranibizumab Injection 125156 03/20/2018 ⤷  Try a Trial 2025-02-23
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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