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Last Updated: April 16, 2024

Claims for Patent: 9,157,916

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Summary for Patent: 9,157,916

Title:	Measuring circulating therapeutic antibody, antigen and antigen/antibody complexes using ELISA assays
Abstract:	The present invention relates to the field of immunology and hyperproliferative diseases. More specifically, the present invention relates to a method of detecting and monitoring therapeutic antibody:antigen complex, soluble antigen and soluble therapeutic antibody, wherein a patient has undergone at least one course of immunotherapy. Yet further, levels of therapeutic antibody:antigen complexes, soluble antigens or soluble therapeutic antibodies may be measured and used to stage or monitor a hyperproliferative disease.
Inventor(s):	Albitar; Maher (Sugar Land, TX), Keating; Michael J. (Houston, TX), Manshouri; Taghi (Houston, TX)
Assignee:	Board of Regents, The University of Texas Systems (Austin, TX)
Application Number:	14/305,430
Patent Claims:	1. A method of monitoring the progress of therapy in patient being treated with a therapeutic anti-CD33 antibody, the method comprising testing a sample from the patient to measure the level of circulating cell-free CD33, circulating cell-free anti-CD33 or circulating cell-free CD33/anti-CD33 complexes. 2. The method of claim 1, wherein the sample is selected from the group consisting of serum, cell lysate and plasma. 3. The method of claim 1, wherein the patient is being treated with Mylotarg. 4. The method of claim 1, wherein the sample is tested to measure the level of circulating cell-free CD33. 5. The method of claim 1, wherein the sample is tested to measure the level of circulating cell-free anti-CD33. 6. The method of claim 1, wherein the sample is tested to measure the level of circulating cell-free CD33/anti-CD33 complexes.

Details for Patent 9,157,916

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Wyeth Pharmaceuticals Llc	MYLOTARG	gemtuzumab ozogamicin	For Injection	761060	09/01/2017	⤷ Try a Trial	2021-09-20
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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