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Last Updated: March 28, 2024

Claims for Patent: 9,138,458


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Summary for Patent: 9,138,458
Title:Treatment for dupuytren\'s disease
Abstract: Musculoskeletal fibroproliferative disorders, such as Dupuytren\'s disease may be treated by administering locally a TNF-.alpha. antagonist. TNF-.alpha. antagonists find particular utility in inhibiting the progression of early disease state Dupuytren\'s disease and other musculoskeletal fibroproliferative disorders and, in combination with extracellular matrix degradation agents (such ascollagenase or matrix metalloproteinase I), treating advanced disease state Dupuytren\'s disease and, in particular inhibiting recurrence.
Inventor(s): Nanchahal; Jagdeep (Richmond, GB), Midwood; Kim Suzanne (London, GB)
Assignee: Isis Innovation Limited (Oxford, GB)
Application Number:13/882,262
Patent Claims:1. A method for treating a patient with early disease state Dupuytren's disease comprising injecting an amount of a TNF-.alpha. antagonist effective to treat the patient directly into one or more clinical or histological nodules of the patient.

2. A method according to claim 1, wherein the TNF-.alpha. antagonist is selected from one or more of Infliximab, Adalimumab, Certolizumab pegol, Golimumab or Etanercept.

3. A method according to claim 1, wherein the TNF-.alpha. antagonist is an anti-TNF-.alpha. antibody.

4. A method according to claim 1, wherein the TNF-.alpha. antagonist is injected into clinical nodules.

5. A method according to claim 1, wherein the TNF-.alpha. antagonist is Infliximab.

6. A method according to claim 1, wherein the TNF-.alpha. antagonist is Adalimumab.

7. A method according to claim 1, wherein the TNF-.alpha. antagonist is Certolizumab pegol.

8. A method according to claim 1, wherein the TNF-.alpha. antagonist is Golimumab.

9. A method according to claim 1, wherein the TNF-.alpha. antagonist is Etanercept.

Details for Patent 9,138,458

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Janssen Biotech, Inc. REMICADE infliximab For Injection 103772 08/24/1998 ⤷  Try a Trial 2030-10-30
Immunex Corporation ENBREL etanercept For Injection 103795 11/02/1998 ⤷  Try a Trial 2030-10-30
Immunex Corporation ENBREL etanercept For Injection 103795 05/27/1999 ⤷  Try a Trial 2030-10-30
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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