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Summary for Patent: 9,132,118
|Title:||Taxane analogs for the treatment of brain cancer|
|Abstract:||Provided herein are compounds and methods for the treatment of brain cancer in a mammal, wherein the method comprises the administration to the mammal a compound that stabilizes tubulin dimers or microtubles at G2-M interface during mitosis but is not a substrate for MDR protein. In particular, the present application relates to the use of an orally effective abeo-taxane, alone or in combination with temozolomide or bevacizumab, for the treatment of brain cancer.|
|Inventor(s):||McChesney; James D. (Etta, MS), Tapolsky; Gilles (Louisville, KY), Emerson; David L. (Longmont, CO), Marshall; John (Washington, DC), Kurman; Michael (Upper Saddle River, NJ), Modiano; Manuel (Tucson, AZ)|
|Assignee:||Tapestry Pharmaceuticals, Inc. (Atlanta, GA)|
|Patent Claims:||1. A compound of the structure of formula (1): ##STR00026##
2. The compound of claim 1, wherein the compound of formula (1) is an isomer having the structure of formula R-(1): ##STR00027##
3. The compound of claim 1, wherein the compound of formula (1) is an isomer having the structure of formula S-(1): ##STR00028##
4. A pharmaceutical composition comprising the compound of claim 1 and a pharmaceutically acceptable carrier.
5. The pharmaceutical composition of claim 4 further comprising one or more chemotherapeutic agents effective in the treatment of brain cancer.
6. The composition of claim 4 which further comprises temozolomide or bevacizumab.
7. The composition of claim 4 formulated for oral administration.
8. The pharmaceutical composition of claim 4, wherein the compound has the structure of formula S-(1): ##STR00029##
|Applicant||Tradename||Biologic Ingredient||Dosage Form||BLA||Number||Approval Date||Patent No.||Assignee||Estimated Patent Expiration||Status||Orphan||Source|
|Genentech||AVASTIN||bevacizumab||VIAL; INTRAVENOUS||125085||001||2004-02-26||Start Trial||Tapestry Pharmaceuticals, Inc. (Atlanta, GA)||2027-02-28||RX||Orphan||search|
|Genentech||AVASTIN||bevacizumab||VIAL; INTRAVENOUS||125085||002||2004-02-26||Start Trial||Tapestry Pharmaceuticals, Inc. (Atlanta, GA)||2027-02-28||RX||Orphan||search|
|>Applicant||>Tradename||>Biologic Ingredient||>Dosage Form||>BLA||>Number||>Approval Date||>Patent No.||>Assignee||>Estimated Patent Expiration||>Status||>Orphan||>Source|
|Country||Patent Number||Publication Date|
|China||101490575||Jul 22, 2009|
|China||101490575||May 22, 2013|
|European Patent Office||2067049||Aug 29, 2012|
|European Patent Office||2067049||Jun 10, 2009|
|European Patent Office||2067049||May 04, 2011|
|>Country||>Patent Number||>Publication Date|
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