You’re using a public version of DrugPatentWatch with 5 free searches available | Register to unlock more free searches. CREATE FREE ACCOUNT

Last Updated: March 29, 2024

Claims for Patent: 9,132,003


✉ Email this page to a colleague

« Back to Dashboard


Summary for Patent: 9,132,003
Title:Optimized drug-eluting stent assembly
Abstract: A stent assembly including a stent configured to be positioned in a body lumen, and a knitted stent jacket including an expansible mesh structure having a coverage area of less than 25%, having approximate aperture diameters greater than 20 micrometers, and surrounding an external surface of the stent and coaxially associated therewith, wherein the stent assembly elutes an amount of an active pharmaceutical agent.
Inventor(s): Bar; Eli (Moshav, IL), Holzer; Asher (Raanana, IL), Paz; Ofir (Rishon Lezion, IL)
Assignee: INSPIREMD, LTD. (Tel Aviv, IL)
Application Number:14/314,777
Patent Claims:1. A stent assembly, comprising: a stent configured to be positioned in a body lumen; and a knitted stent jacket comprising an expansible mesh structure disposed over a circumference of the stent and along an entire thereof, the mesh structure being formed from a single fiber and having a coverage area of about 9% to less than 25% relative to the coverage area of a plurality of apertures therein, the apertures having approximate aperture diameters greater than 20 micrometers up to a minimum center dimension of 234 micrometers and the knitted stent jacket being coaxially associated with the stent, wherein the stent assembly elutes an amount of an active pharmaceutical agent that is present therein, and wherein the fiber has a diameter of approximately 7 micrometers to 40 micrometers.

2. The stent assembly of claim 1, wherein the active pharmaceutical agent is eluted from the stent.

3. The stent assembly of claim 1, wherein the active pharmaceutical agent is eluted from a coating disposed over a portion of the stent.

4. The stent assembly of claim 1, wherein the active pharmaceutical agent is time-released according to a predetermined treatment schedule.

5. The stent assembly of claim 4, wherein the treatment schedule covers a period of 8 hours to a plurality of months.

6. The stent assembly of claim 1, wherein the active pharmaceutical agent is eluted from the knitted stent jacket.

7. The stent assembly of claim 1, wherein the active pharmaceutical agent is eluted from a coating on the expansible mesh structure.

8. The stent assembly of claim 1, wherein the coaxial association comprises the knitted stent jacket being sewed, adhered, glued, folded, or sutured to the stent.

9. The stent assembly of claim 7, wherein the coaxial association is that the knitted stent jacket is sutured to the stent.

10. The stent assembly of claim 1, wherein a proximal portion of the knitted stent jacket is attached to a proximal portion of the stent.

11. The stent assembly of claim 10, wherein a distal portion of the stent jacket is attached to a distal portion of the stent.

12. The stent assembly of claim 7, wherein the amount of active pharmaceutical agent eluted comprises a therapeutically effective amount to treat a disorder in a carotid or coronary artery.

13. The stent assembly of claim 1, wherein the active pharmaceutical agent is eluted from the stent, a coating on the stent, the knitted stent jacket, a coating on the knitted stent jacket, or any combination thereof.

14. The stent assembly of claim 1, wherein the mesh structure is formed from a polymer component comprising one or more poly lactic-co-polyglycolic ("PLGA"), polycaprolactone ("PCL"), polygluconate, polylactic acid-polyethylene oxide, poly(hydroxybutyrate), polyanhydride, poly-phosphoester, poly(amino acids), poly-L-lactide, poly-D-lactide, polyglycolide, or poly(alpha-hydroxy acid) co-polymer(s), polyethylene terephthalate, or any combination thereof.

15. The stent assembly of claim 13, wherein the mesh structure comprises a single polymer fiber.

16. The stent assembly of claim 15, wherein the polymer is elastic, biocompatible, and hemocompatible.

17. The stent assembly of claim 1, wherein the expansible mesh structure comprises a retracted state and a deployed state, and further wherein the expansible mesh structure defines apertures having a minimum center dimension of 150 micrometers to 200 micrometers in the deployed state.

18. The stent assembly of claim 1, wherein the expansible mesh structure comprises a retracted state and a deployed state, and further wherein the expansible mesh structure defines apertures having a minimum center dimension of 150 micrometers to 180 micrometers in the deployed state.

19. The stent assembly of claim 1, wherein the active pharmaceutical agent comprises zolimus, zotarolimus, sirolimus, taxol/paclitaxel, or a combination thereof.

20. The stent assembly of claim 1, wherein the active pharmaceutical agent comprises an anti-proliferative agent, an antithrombotic agent, an anticoagulant, an antioxidant, a growth factor inhibitor, a collagen inhibitor, a liposome, a steroid or corticosteroid, a statin, endothelial cell seeds, a hydrogel containing endothelial cells, or a combination thereof.

21. The stent assembly of claim 20, wherein the anti-proliferative agent is present and comprises sirolimus, zolimus or zotarolimus, a taxane, tacrolimus, everolimus, vincritine, viblastine, a HMG-CoA reductase inhibitor, doxorubicin, colchicine, actinomycin D, mitomycin C, cycloporine, mycophenolic acid, triazolopyrimidine, or a combination thereof; wherein the antithrombotic agent is present and comprises heparin, a heparin-like dextran derivative, acid citrate dextrose, coumadin, warfarin, streptokinase, anistreplase, tissue plasminogen activator (tPA), urokinase, abciximab, or a combination thereof; wherein the growth factor inhibitor is present and comprises tranilast, angiopeptin, or a combination thereof; wherein the steroid or corticosteroid is present and comprises cortisone, prednisolone, or both; wherein the statin is present and comprises simvastatin, lovastatin, or a combination thereof; or any combination of the foregoing.

22. The stent assembly of claim 1, wherein the stent assembly comprises 1 microgram to 200 micrograms of each pharmaceutical agent.

23. The stent assembly of claim 1, wherein the mesh of the knitted stent jacket comprises 1 microgram to 200 micrograms of each pharmaceutical agent.

24. The stent assembly of claim 1, wherein the active pharmaceutical agent comprises a 'limus drug at a concentration of 10 .mu.g/mm.sup.2 to 80 .mu.g/mm.sup.2.

25. The stent assembly of claim 1, wherein the active pharmaceutical agent comprises a 'limus drug at a concentration of 80 .mu.g/mm.sup.2 to 140 .mu.g/mm.sup.2.

26. The stent assembly of claim 2, wherein the stent comprises a metal alloy coated with a biodegradable polymer, biostable polymer, bioresorbable polymer, or a combination thereof.

27. The stent assembly of claim 1, wherein the stent comprises a biodegradable material.

28. The stent assembly of claim 27, wherein the biodegradable material comprises a polymer.

29. The stent assembly of claim 27, wherein the biodegradable material comprises a metal alloy.

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.