Claims for Patent: 9,115,133

Summary for Patent: 9,115,133

Title:	Substituted fused tricyclic compounds, compositions and medicinal applications thereof
Abstract:	The present invention relates to substituted fused tricyclic compounds of formula (I) or (Ia), their tautomers, polymorphs, stereoisomers, prodrugs, solvates, co-crystals, pharmaceutically acceptable salts, pharmaceutical compositions containing them and methods of treating conditions and diseases that are mediated by JAK activity. The compounds of the present invention are useful in the treatment, prevention or suppression of diseases and disorders mediated by JAK activity. Such conditions include, but not limited to, arthritis, Alzheimer\'s disease, autoimmune thyroid disorders, cancer, diabetes, leukemia, T-cell prolymphocytic leukemia, lymphoma, myleoproliferation disorders, lupus, multiple myeloma, multiple sclerosis, osteoarthritis, sepsis, psoriatic arthritis, prostate cancer, T-cell autoimmune disease, inflammatory diseases, chronic and acute allograft transplant rejection, bone marrow transplant, stroke, asthma, chronic obstructive pulmonary disease, allergy, bronchitis, viral diseases, or Type I diabetes, complications from diabetes, rheumatoid arthritis, asthma, Crohn\'s disease, dry eye, uveitis, inflammatory bowel disease, organ transplant rejection, psoriasis and ulcerative colitis. The present disclosure also relates to process for the preparation of such compounds, and to pharmaceutical compositions containing them. ##STR00001##
Inventor(s):	Barawkar; Dinesh (Hinjewadi, IN), Bende; Tanushree (Pune, IN), Zahler; Robert (Pennington, NJ), Bandyopadhyay; Anish (Pune, IN), Sarangthem; Robindro Singh (Pune, IN), Doshi; Jignesh (Pune, IN), Waman; Yogesh (Pune, IN), Jadhav; Rushikesh (Pune, IN), Singh; Umesh Prasad (Pune, IN)
Assignee:	Advinus Therapeutics Limited (Bangalore, IN)
Application Number:	14/006,630
Patent Claims:	1. A compound of formula (Ia): ##STR00230## wherein, Y.sup.1 represents CR' wherein R' is H or alkyl; A is selected from ##STR00231## R.sup.1 is selected from hydrogen or alkyl; R.sup.2 is selected from hydrogen or alkyl; R.sup.3 is selected from hydrogen or alkyl; R.sup.4 is selected from hydrogen, alkyl, alkoxy, cyano, halogen, hydroxy, hydroxyalkyl, haloalkyl, perhaloalkyl, carboxy, alkylcarboxy, carboxyalkyl, carboxyalkyloxy, alkylcarboxyalkyloxy or nitro; Z is a bond or is a group selected from cycloalkylene, arylene, heterocyclylene, heterocyclylenealkyl, heteroarylene, spirocyclyl, (C.sub.1-6)alkylene, (C.sub.1-6)alkenylene or (C.sub.1-6)alkynylene wherein one or more than one methylene groups from alkylene, alkenylene or alkynylene are optionally replaced by hetero atoms or groups selected from --O--, --S(O)p-, --N(R.sup.5)--, or --C(O); B is a bond or is a group selected from cycloalkylene, cycloalkenylene, arylene, heterocyclylene, heteroarylene, (C.sub.1-6)alkylene, (C.sub.1-6)alkenylene or (C.sub.1-6)alkynylene wherein one or more than one methylene groups from alkylene, alkenylene or alkynylene are optionally replaced by hetero atoms or groups selected from --O--, --S(O)p-, --N(R.sup.5)--, --C(O) or --C(.dbd.NR'')-- wherein R'' is H, alkyl, cyano, hydroxy, hydroxyalkyl, haloalkyl or perhaloalkyl; D is selected from hydroxy, alkoxy, alkoxyalkyl, cyano, halogen, haloalkyl, perhaloalkyl, alkyl, alkenyl, alkynyl, carboxy, carboxyalkyl, cyanoalkyl, acyl, cyanoalkylarbonyl, cyanoalkenylcarbonyl, --(CR.sup.aR.sup.b).sub.nOR.sup.5, --SR.sup.5, --(CR.sup.aR.sup.b).sub.nCOOR.sup.5, --(CR.sup.aR.sup.b).sub.nNR.sup.6R.sup.7, --(CR.sup.aR.sup.b).sub.nC(O)NR.sup.6R.sup.7, --(CR.sup.aR.sup.b).sub.nNR.sup.5C(O)NR.sup.6R.sup.7, thiocarbonyl, S(O).sub.2NR.sup.6R.sup.7, --NR.sup.5S(O).sub.2R.sup.5, --S(O).sub.pR.sup.5, --SO.sub.3H, cycloalkyl, cycloalkenyl, cycloalkylalkyl, cycloalkyloxy, cycloalkylamino, aryl, arylalkyl, aryloxy, arylamino, heterocyclyl, heterocyclylalkyl, heterocyclyloxy, heterocycloalkylamino, heteroaryl, heteroarylalkyl, heteroaryloxy, or heteroarylamino; R.sup.5 is selected from the group consisting of hydrogen, halogen, haloalkyl, alkyl, alkenyl, alkynyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl and heterocyclylalkyl; wherein alkyl, alkenyl, alkynyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl or heterocyclylalkyl are optionally substituted with one or more substituents selected from hydroxy, alkyl, alkoxy, alkoxyalkyl, halogen, haloalkyl, perhaloalkyl, cyano, cyanoalkyl, amino, carboxy, or carboxyalkyl; R.sup.6 and R.sup.7 are independently selected from the group consisting of hydrogen, --(CR.sup.aR.sup.b).sub.nOR.sup.5, haloalkyl, --(CR.sup.aR.sup.b).sub.nC(O)R.sup.5, alkyl, alkenyl, alkynyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl or heterocyclylalkyl, or R.sup.6 and R.sup.7 taken together form a monocyclic or a bicyclic ring system which is saturated or partially unsaturated and optionally have additional heteroatoms selected from O, N or S, the said ring system is further optionally substituted with 1 to 4 substituents independently selected from halo, alkyl, alkenyl, alkynyl, nitro, cyano, --(CR.sup.aR.sup.b).sub.nOR.sup.5, --SR.sup.5, oxo, alkylsulfonyl, --(CR.sup.aR.sup.b).sub.nCOOR.sup.5, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, and heteroarylalkyl; Z, B and D may be optionally substituted with one or more substituents independently selected from cyano, nitro, keto, oxo, halogen, haloalkyl, perhaloalkyl, hydroxyamino, --(CR.sup.aR.sup.b).sub.nOR.sup.5, --(CR.sup.aR.sup.b).sub.nC(O)R.sup.5OC(O)R.sup.5, --SR.sup.5, --(CR.sup.aR.sup.b).sub.nCOOR.sup.5, --(CR.sup.aR.sup.b).sub.nNR.sup.6R.sup.7, --(CR.sup.aR.sup.b).sub.nC(O)NR.sup.6R.sup.7, --(CR.sup.aR.sup.b).sub.nNR.sup.5C(O)NR.sup.6R.sup.7, --NR.sup.5C(O)R.sup.5, thiocarbonyl, S(O).sub.2NR.sup.6R.sup.7, --NR.sup.5, --S(O).sub.2R.sup.5, --S(O).sub.pR.sup.5, --SO.sub.3H, --OP(O)(R.sup.8).sub.q, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, aryl, heterocyclyl or heteroaryl; wherein alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, aryl, heterocyclyl or heteroaryl are optionally substituted with one or more substituents selected from hydroxy, alkyl, alkoxy, alkoxyalkyl, halogen, haloalkyl, perhaloalkyl, cyano, cyanoalkyl, amino, carboxy, carboxyalkyl, --OC(O)R.sup.5, --(CR.sup.aR.sup.b).sub.nC(O)NR.sup.6R.sup.7, --NR.sup.5C(O)R.sup.5, --SR.sup.5, --S(O).sub.pR.sup.5, --S(O).sub.2NR.sup.6R.sup.7 or --NR.sup.5S(O).sub.2R.sup.5; R.sup.8 is selected from the group consisting of hydroxy and alkoxy; R.sup.a and R.sup.b are independently selected from the group consisting of hydrogen, --OR.sup.5, halogen, haloalkyl, perhaloalkyl and alkyl; n is 0-6; m is 0, 1 or 2; p is 0, 1 or 2; q is 1 or 2. 2. The compound of formula (Ia) as claimed in claim 1, wherein, Y.sup.1 represents CR' wherein R' is H or alkyl; A is selected from ##STR00232## R.sup.1 is selected from hydrogen or alkyl; R.sup.2 is selected from hydrogen or alkyl; R.sup.3 is selected from hydrogen or alkyl; R.sup.4 is selected from hydrogen, alkyl, alkoxy, cyano, halogen, hydroxy, hydroxyalkyl, haloalkyl, perhaloalkyl, carboxy, alkylcarboxy, carboxyalkyl, carboxyalkyloxy, alkylcarboxyalkyloxy or nitro; Z is selected from ##STR00233## B is a bond or (C.sub.1-6)alkylene wherein one or more than one methylene groups are optionally replaced by hetero atoms or groups --O--, --S(O)p-, --N(R.sup.5)--, --C(O) or --C(.dbd.NR'')-- wherein R'' is H, alkyl, cyano, hydroxy, hydroxyalkyl, haloalkyl or perhaloalkyl; D is selected from alkoxy, alkoxyalkyl, cyano, halogen, haloalkyl, perhaloalkyl, alkyl, alkenyl, alkynyl, carboxy, carboxyalkyl, cyanoalkyl, acyl, cyanoalkylarbonyl, cyanoalkenylcarbonyl, --(CR.sup.aR.sup.b).sub.nOR.sup.5, --SR.sup.5, --(CR.sup.aR.sup.b).sub.nCOOR.sup.5, --(CR.sup.aR.sup.b).sub.nNR.sup.6R.sup.7, --(CR.sup.aR.sup.b).sub.nC(O)NR.sup.6R.sup.7, --(CR.sup.aR.sup.b).sub.nNR.sup.5C(O)NR.sup.6R.sup.7, thiocarbonyl, S(O).sub.2NR.sup.6R.sup.7, --NR.sup.5S(O).sub.2R.sup.5, --S(O).sub.pR.sup.5, --SO.sub.3H, cycloalkyl, cycloalkenyl, cycloalkylalkyl, cycloalkyloxy, cycloalkylamino, aryl, arylalkyl, aryloxy, arylamino, heterocyclyl, heterocyclylalkyl, heterocyclyloxy, heterocycloalkylamino, heteroaryl, heteroarylalkyl, heteroaryloxy, or heteroarylamino; R.sup.5 is selected from the group consisting of hydrogen, halogen, haloalkyl, alkyl, alkenyl, alkynyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl and heterocyclylalkyl; wherein alkyl, alkenyl, alkynyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl or heterocyclylalkyl are optionally substituted with one or more substituents selected from hydroxy, alkyl, alkoxy, alkoxyalkyl, halogen, haloalkyl, perhaloalkyl, cyano, cyanoalkyl, amino, carboxy, or carboxyalkyl; R.sup.6 and R.sup.7 are independently selected from the group consisting of hydrogen, --(CR.sup.aR.sup.b).sub.nOR.sup.5, haloalkyl, --(CR.sup.aR.sup.b).sub.nC(O)R.sup.5, alkyl, alkenyl, alkynyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl or heterocyclylalkyl, or R.sup.6 and R.sup.7 taken together form a monocyclic or a bicyclic ring system which is saturated or partially unsaturated and optionally have additional heteroatoms selected from O, N or S, the said ring system is further optionally substituted with 1 to 4 substituents independently selected from halo, alkyl, alkenyl, alkynyl, nitro, cyano, --(CR.sup.aR.sup.b).sub.nOR.sup.5, --SR.sup.5, oxo, alkylsulfonyl, --(CR.sup.aR.sup.b).sub.nCOOR.sup.5, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl; Z, B and D may be optionally substituted with one or more substituents independently selected from cyano, nitro, keto, oxo, halogen, haloalkyl, perhaloalkyl, hydroxyamino, --(CR.sup.aR.sup.b).sub.nOR.sup.5, --(CR.sup.aR.sup.b).sub.nC(O)R.sup.5OC(O)R.sup.5, --SR.sup.5, --(CR.sup.aR.sup.b).sub.nCOOR.sup.5, --(CR.sup.aR.sup.b).sub.nNR.sup.6R.sup.7, --(CR.sup.aR.sup.b).sub.nC(O)NR.sup.6R.sup.7, --(CR.sup.aR.sup.b).sub.nNR.sup.5C(O)NR.sup.6R.sup.7, --NR.sup.5C(O)R.sup.5, thiocarbonyl, S(O).sub.2NR.sup.6R.sup.7, --NR.sup.5S(O).sub.2R.sup.5, --S(O).sub.pR.sup.5, --SO.sub.3H, --OP(O)(R.sup.8).sub.q, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, aryl, heterocyclyl or heteroaryl; wherein alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, aryl, heterocyclyl or heteroaryl are optionally substituted with one or more substituents selected from hydroxy, alkyl, alkoxy, alkoxyalkyl, halogen, haloalkyl, perhaloalkyl, cyano, cyanoalkyl, amino, carboxy, carboxyalkyl, --OC(O)R.sup.5, --(CR.sup.aR.sup.b).sub.nC(O)NR.sup.6R.sup.7, --NR.sup.5C(O)R.sup.5, --SR.sup.5, --S(O).sub.pR.sup.5, --S(O).sub.2NR.sup.6R.sup.7 or --NR.sup.5S(O).sub.2R.sup.5; R.sup.8 is selected from the group consisting of hydroxy and alkoxy; R.sup.a and R.sup.b are independently selected from the group consisting of hydrogen, --OR.sup.5, halogen, haloalkyl, perhaloalkyl and alkyl; n is 0-6; m is 0, 1 or 2; p is 0, 1 or 2; and q is 1 or 2. 3. A compound of formula (Ia) as claimed in claim 1 which is selected from a group consisting of: 1 tert-butyl 3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperidine-1-carboxylate; 1 tert-butyl 3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)pyrrolidine-1-carboxylate; 3-(3H-3,4,6,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-1-carboxy- lic acid tert-butyl ester; 3-oxo-3-[3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-piperidyl]propanen- itrile; (R)3-oxo-3-[3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-piperidy- l]propanenitrile; (S)3-oxo-3-[3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-piperidyl]propa- nenitrile; cyclopropyl-[3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-pipe- ridyl]methanone; 2-methyl-1-[3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-piperidyl]propa- n-1-one; 3,3,3-trifluoro-1-[3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-- piperidyl]propan-1-one; (R)3,3,3-trifluoro-1-[3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-piper- idyl]propan-1-one; (S)3,3,3-trifluoro-1-[3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-piper- idyl]propan-1-one; 3-methyl-1-[3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-piperidyl]butan- -1-one; 9-(1-cyclopropylsulfonyl-3-piperidyl)-3H-pyrrolo[3,2-f][1,7]naphth- yridine; 2-[[3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-piperidyl]sulfo- nyl]acetonitrile; 9-(1-isobutylsulfonyl-3-piperidyl)-3H-pyrrolo[3,2-f][1,7]naphthyridine; 9-(1-ethylsulfonyl-3-piperidyl)-3H-pyrrolo[3,2-f][1,7]naphthyridine; 9-(1-methylsulfonyl-3-piperidyl)-3H-pyrrolo[3,2-f][1,7]naphthyridine; 9-(1-methylsulfonyl-3-piperidyl)-3H-pyrrolo[3,2-f][1,7]naphthyridine; (R)9-(1-methylsulfonyl-3-piperidyl)-3H-pyrrolo[3,2-f][1,7]naphthyridine; (S)9-(1-isopropylsulfonyl-3-piperidyl)-3H-pyrrolo[3,2-][1,7]naphthyridine- ; 2-methylsulfonyl-1-[3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-piperi- dyl]ethanone; N-isopropyl-3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperidine-1-carbo- xamide; 3-oxo-3-[3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)pyrrolidin-1-y- l]propanenitrile; (R)3-oxo-3-[3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)pyrrolidin-1-yl]pr- opanenitrile; (S)3-oxo-3-[3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)pyrrolidin-1-yl]pr- opanenitrile; 3,3,3-trifluoro-1-[3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)pyrrolidin-- 1-yl]propan-1-one; (R)3,3,3-trifluoro-1-[3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)pyrrolid- in-1-yl]propan-1-one; (S)3,3,3-trifluoro-1-[3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)pyrrolid- in-1-yl]propan-1-one; 2-[3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)pyrrolidin-1-yl]sulfonylace- tonitrile; (R)2-[3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)pyrrolidin-1-y- l]sulfonylacetonitrile; (S)2-[3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)pyrrolidin-1-yl]sulfonyl- acetonitrile; 9-[1-(trifluoromethylsulfonyl)pyrrolidin-3-yl]-3H-pyrrolo[3,2-f][1,7]naph- thyridine; 9-(1-isobutylsulfonylpyrrolidin-3-yl)-3H-pyrrolo[3,2-f][1,7]nap- hthyridine; 9-(1-ethylsulfonylpyrrolidin-3-yl)-3H-pyrrolo[3,2-f][1,7]naphthyridine; 9-(1-methylsulfonylpyrrolidin-3-yl)-3H-pyrrolo[3,2-f][1,7]naphthyridine; 3-Methyl-1-[3-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidi- n-1-yl]-butan-1-one; 2-Methyl-1-[3-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidi- n-1-yl]-propan-1-one; 3-Oxo-3-[3-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidin-1- -yl]-propionitrile; (R)3-Oxo-3-[3-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidi- n-1-yl]-propionitrile; (S)3-Oxo-3-[3-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidi- n-1-yl]-propionitrile; 3,3,3-Trifluoro-1-[3-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-p- iperidin-1-yl]-propan-1-one; (R)3,3,3-Trifluoro-1-[3-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl- )-piperidin-1-yl]-propan-1-one; (S)3,3,3-Trifluoro-1-[3-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl- )-piperidin-1-yl]-propan-1-one; 2-Cyclopropyl-1-[3-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-pip- eridin-1-yl]-ethanone; [3-(3H-3,4,6,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidin-1-yl]-(te- trahydro-furan-3-yl)-methanone; 1-[3-(3H-3,4,6,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidin-1-yl]-p- ropan-1-one; 2,2-Dimethyl-1-[3-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-pipe- ridin-1-yl]-propan-1-one; Cyclopropyl-[3-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperid- in-1-yl]-methanone; 9-[1-(2-Methyl-propane-1-sulfonyl)-piperidin-3-yl]-3H-3,4,6,8-tetraaza-cy- clopenta[a]naphthalene; 9-(1-Cyclopropanesulfonyl-piperidin-3-yl)-3H-3,4,6,8-tetraaza-cyclopenta[- a]naphthalene; 3-(3H-3,4,6,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-1-carboxy- lic acid isopropylamide; 3,3,3-Trifluoro-1-[3-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-p- yrrolidin-1-yl]-propan-1-one; 3-Oxo-3-[3-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidin-- 1-yl]-propionitrile; Cyclopropyl-[3-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrroli- din-1-yl]-methanone; 2-Methyl-1-[3-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolid- in-1-yl]-propan-1-one; 4,4,4-Trifluoro-1-[3-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-p- yrrolidin-1-yl]-butan-1-one; 2,2-Dimethyl-1-[3-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrr- olidin-1-yl]-propan-1-one; [3-(3H-3,4,6,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidin-1-yl]-(1- -trifluoromethyl-cyclopropyl)-methanone; 9-[1-(2-Methyl-propane-1-sulfonyl)-pyrrolidin-3-yl]-3H-3,4,6,8-tetraaza-c- yclopenta[a]naphthalene; 3-oxo-3-[3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-2,5-dihydropyrrol-1-- yl]propanenitrile; 3,3,3-trifluoro-1-[3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-2,5-dihydr- opyrrol-1-yl]propan-1-one; (E)-[2-methyl-1-[3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-piperidyl]- propylidene]cyanamide; (R)(E)-[2-methyl-1-[3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-piperid- yl]propylidene]cyanamide; (S)(E)-[2-methyl-1-[3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-piperid- yl]propylidene]cyanamide; (R)(E)-[3,3,3-trifluoro-1-[3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-- piperidyl]propylidene]cyanamide; (S)(E)-[3,3,3-trifluoro-1-[3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)pyr- rolidin-1-yl]propylidene]cyanamide; N-cyclopropyl-3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperidine-1-car- boxamide; N,N-dimethyl-3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperidi- ne-1-carboxamide; N-ethyl-3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperidine-1-carboxami- de; N-isobutyl-3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperidine-1-car- boxamide; N-methyl-3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperidine-1- -carboxamide; 2,2,2-trifluoroethyl 3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperidine-1-carboxylate; Isopropyl 3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperidine-1-carboxy- late; 3,3,3-trifluoro-1-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-pip- eridyl]propan-1-one; 1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl) piperidin-3-ol; (3R)-1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)pyrrolidin-3-ol; 9-[3-(cyclopropylmethoxy)-1-piperidyl]-3H pyrrolo[3,2f][1,7]naphthyridine; 9-[3-(2-methoxyethoxy)-1-piperidyl]-3H-pyrrolo[3,2-f][1,7]naphthyridine; 9-(1-piperidyl)-3H-pyrrolo[3,2-f][1,7]naphthyridine; 9-[3-(cyclopropylmethoxy)pyrrolidin-1-yl]-3H-pyrrolo[3,2-f][1,7]naphthyri- dine; 9-[4-(cyclopropylmethoxy)-1-piperidyl]-3H-pyrrolo[3,2-f][1,7]naphthy- ridine; N-cyclopropyl-1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperidin- e-3-carboxamide; (3S)--N-cyclopropyl-1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperidine- -3-carboxamide; (3R)--N-cyclopropyl-1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperidine- -3-carboxamide; N-(cyclopropylmethyl)-N-methyl-1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl- )pyrrolidin-3-amine; 2-cyclopropyl-N-methyl-N-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-3-p- iperidyl]acetamide; 4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)morpholine; 3,3,3-trifluoro-N-methyl-N-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-3- -piperidyl]propanamide; N-methyl-N-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-3-piperidyl]cyclo- pentane carboxamide; N-isobutyl-1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperidine-3-carbox- amide; N-isopropyl-1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperidine-3- -carboxamide; N-(2-methoxyethyl)-1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperidine-- 3-carboxamide; 4-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-3-piperidiyl]morpholine; N-methyl-1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperidine-3-carboxam- ide; N-ethyl-1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperidine-3-carbo- xamide; N-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-3-piperidyl]methane- sulfonamide; N-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-3-piperidyl]cyclopropaneca- rboxamide; N-isopropyl-1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperidi- ne-4-carboxamide; N-cyclopropyl-1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperidine-4-car- boxamide; N-(2-methoxyethyl)-1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)pi- peridine-4-carboxamide; 1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-N-(2,2,2-trifluoroethyl)piper- idine-4-carboxamide; N-cyclopropyl-N-methyl-1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperid- ine-3-carboxamide; N-methyl-1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-N-(2,2,2-trifluoroet- hyl)piperidine-3-carboxamide; 1,1,1-trifluoro-N-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-3-piperidy- l]methane sulfonamide; N-methyl-1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-N-(2,2,2-trifluoroet- hyl) piperidine-4-carboxamide; 1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-N-(2,2,2-trifluoroethyl)piper- idine-3-carboxamide; N-isopropyl-1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)pyrrolidine-3-carb- oxamide; N-cyclopropyl-1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)pyrrolid- ine-3-carboxamide; 2,2,2-trifluoro-N-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-3-piperidy- l]ethanesulfonamide; 3,3,3-trifluoro-N-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-3-piperidy- l]propanamide; cis-N-cyclopropyl-6-methyl-1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)pip- eridine-3-carboxamide; trans-N-cyclopropyl-6-methyl-1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)p- iperidine-3-carboxamide; (3S,6S)--N-cyclopropyl-6-methyl-1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-y- l)piperidine-3-carboxamide; 3,3-Difluoro-N-[1-(3H-3,4,6,7-tetraaza-cyclopenta[a]naphthalen-9-yl)-pipe- ridin-3-yl]-butyramide; tert-Butyl N-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)pyrrolidin-3-yl]carbamate; 1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)pyrrolidin-3-amine; 2,2,2-trifluoro-N-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)pyrrolidin-- 3-yl]ethanesulfonamide; N-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)pyrrolidin-3-yl]cyclopropan- esulfonamide; N-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)pyrrolidin-3-yl]propane-2-s- ulfonamide; 2-methyl-N-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)pyrrolidin-3-yl]pr- opane-1-sulfonamide; 1-cyano-N-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)pyrrolidin-3-yl]met- hane sulfonamide; 1-isopropyl-3-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)pyrrolidin-3-yl- ]urea N-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)pyrrolidin-3-yl]cyclop- ropanecarboxamide; 2-methyl-N-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)pyrrolidin-3-yl]pr- opanamide; 2-cyclopropyl-N-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)pyr- rolidin-3-yl]acetamide; 2-cyano-N-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)pyrrolidin-3-yl]ace- tamide; 3,3,3-trifluoro-N-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)pyrr- olidin-3-yl]propanamide; N-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)pyrrolidin-3-yl]methanesulf- onamide; tert-butyl 4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperazine-1-carboxylate; 3-oxo-3-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperazin-1-yl]propan- enitrile; 3,3,3-trifluoro-1-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)pi- perazin-1-yl]propan-1-one; 9-[4-(2,2,2-trifluoroethylsulfonyl)piperazin-1-yl]-3H-pyrrolo[3,2-f][1,7]- naphthyridine; 2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperazin-1-yl]sulfonylacet- onitrile; 2-Cyano-N-[1-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-- piperidin-3-yl]-acetamide; 3,3,3-trifluoro-N-[1-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-p- iperidin-3-yl]-propionamide; 9-[4-[[3-[(4-fluorophenoxy)methyl]-1-piperidyl]sulfonylmethyl]-1-piperidy- l]-3H-pyrrolo[3,2-f][1,7]naphthyridine; 1-[3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperidine-1-carbonyl]cyclo- propanecarbonitrile; [3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-piperidyl]-[1-(trifluorome- thyl)cyclopropyl]methanone; 4-oxo-4-[3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-piperidyl]butaneni- trile; 4,4,4-trifluoro-1-[3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-pi- peridyl]butan-1-one; 1-[3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)pyrrolidine-1-carbonyl]cycl- opropanecarbonitrile; [3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)pyrrolidin-1-yl]-[1-(trifluor- omethyl)cyclopropyl]methanone; 4-oxo-4-[3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)pyrrolidin-1-yl]butan- enitrile; 4,4,4-trifluoro-1-[3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)py- rrolidin-1-yl]butan-1-one; [3-(3H-3,4,6,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-1-sulfon- yl]-acetonitrile; 9-[1-(2,2,2-Trifluoro-ethanesulfonyl)-piperidin-3-yl]-3H-3,4,6,8-tetraaza- -cyclopenta[a]naphthalene; 9-(1-Methanesulfonyl-piperidin-3-yl)-3H-3,4,6,8-tetraaza-cyclopenta[a]nap- hthalene; 9-(1-Ethanesulfonyl-piperidin-3-yl)-3H-3,4,6,8-tetraaza-cyclopen- ta[a]naphthalene; 9-[1-(Propane-2-sulfonyl)-piperidin-3-yl]-3H-3,4,6,8-tetraaza-cyclopenta[- a]naphthalene; [3-(3H-3,4,6,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidine-1-sulfo- nyl]-acetonitrile; 9-[1-(2,2,2-Trifluoro-ethanesulfonyl)-pyrrolidin-3-yl]-3H-3,4,6,8-tetraaz- a-cyclopenta[a]naphthalene; 9-(1-Methanesulfonyl-pyrrolidin-3-yl)-3H-3,4,6,8-tetraaza-cyclopenta[a]na- phthalene; 9-(1-Ethanesulfonyl-pyrrolidin-3-yl)-3H-3,4,6,8-tetraaza-cyclop- enta[a]naphthalene; 9-[1-(Propane-2-sulfonyl)-pyrrolidin-3-yl]-3H-3,4,6,8-tetraaza-cyclopenta- [a]naphthalene; 9-(1-Cyclopropanesulfonyl-pyrrolidin-3-yl)-3H-3,4,6,8-tetraaza-cyclopenta- [a]naphthalene; 3-Oxo-3-[3-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidin-1- -yl]-propionitrile; 3,3,3-Trifluoro-1-[3-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-p- iperidin-1-yl]-propan-1-one; 2-Methyl-1-[3-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidi- n-1-yl]-propan-1-one; Cyclopropyl-[3-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperid- in-1-yl]-methanone; [3-(3H-3,4,7,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-1-sulfon- yl]-acetonitrile; 9-[1-(2,2,2-Trifluoro-ethanesulfonyl)-piperidin-3-yl]-3H-3,4,7,8-tetraaza- -cyclopenta[a]naphthalene; 9-(1-Methanesulfonyl-piperidin-3-yl)-3H-3,4,7,8-tetraaza-cyclopenta[a]nap- hthalene; 9-(1-Ethanesulfonyl-piperidin-3-yl)-3H-3,4,7,8-tetraaza-cyclopen- ta[a]naphthalene; 9-[1-(Propane-2-sulfonyl)-piperidin-3-yl]-3H-3,4,7,8-tetraaza-cyclopenta[- a]naphthalene; 9-(1-Cyclopropanesulfonyl-piperidin-3-yl)-3H-3,4,7,8-tetraaza-cyclopenta[- a]naphthalene; 3-(3H-3,4,7,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-1-carboxy- lic acid methylamide; 3-(3H-3,4,7,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-1-carboxy- lic acid ethylamide; 3-(3H-3,4,7,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-1-carboxy- lic acid isopropylamide; 3-Oxo-3-[3-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidin-- 1-yl]-propionitrile; 3,3,3-Trifluoro-1-[3-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-p- yrrolidin-1-yl]-propan-1-one; 2-Methyl-1-[3-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolid- in-1-yl]-propan-1-one; Cyclopropyl-[3-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrroli- din-1-yl]-methanone; [3-(3H-3,4,7,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidine-1-sulfo- nyl]-acetonitrile; 9-[1-(2,2,2-Trifluoro-ethanesulfonyl)-pyrrolidin-3-yl]-3H-3,4,7,8-tetraaz- a-cyclopenta[a]naphthalene; 9-(1-Methanesulfonyl-pyrrolidin-3-yl)-3H-3,4,7,8-tetraaza-cyclopenta[a]na- phthalene; 9-(1-Ethanesulfonyl-pyrrolidin-3-yl)-3H-3,4,7,8-tetraaza-cyclop- enta[a]naphthalene; 9-[1-(Propane-2-sulfonyl)-pyrrolidin-3-yl]-3H-3,4,7,8-tetraaza-cyclopenta- [a]naphthalene; 9-(1-Cyclopropanesulfonyl-pyrrolidin-3-yl)-3H-3,4,7,8-tetraaza-cyclopenta- [a]naphthalene; 3-(3H-3,4,7,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidine-1-carbox- ylic acid methylamide; 3-(3H-3,4,7,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidine-1-carbox- ylic acid ethylamide; 3-(3H-3,4,7,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidine-1-carbox- ylic acid isopropylamide; 3-oxo-3-[3-(7H-pyrrolo[2,3-h][2,6]naphthyridin-1-yl)-1-piperidyl]propanen- itrile; 3,3,3-trifluoro-1-[3-(7H-pyrrolo[2,3-h][2,6]naphthyridin-1-yl)-1-p- iperidyl]propan-1-one; 2-methyl-1-[3-(7H-pyrrolo[2,3-h][2,6]naphthyridin-1-yl)-1-piperidyl]propa- n-1-one; cyclopropyl-[3-(7H-pyrrolo[2,3-h][2,6]naphthyridin-1-yl)-1-piperi- dyl]methanone; 2-[[3-(7H-pyrrolo[2,3-h][2,6]naphthyridin-1-yl)-1-piperidyl]sulfonyl]acet- onitrile; 1-[1-(2,2,2-trifluoroethylsulfonyl)-3-piperidyl]-7H-pyrrolo[2,3-- c][2,6]naphthyridine; 1-(1-methylsulfonyl-3-piperidyl)-7H-pyrrolo[2,3-c][2,6]naphthyridine; 1-(1-ethylsulfonyl-3-piperidyl)-7H-pyrrolo[2,3-c][2,6]naphthyridine; 1-(1-isopropylsulfonyl-3-piperidyl)-7H-pyrrolo[2,3-c][2,6]naphthyridine; 1-(1-cyclopropylsulfonyl-3-piperidyl)-7H-pyrrolo[2,3-c][2,6]naphthyridine- ; N-methyl-3-(7H-pyrrolo[2,3-h][2,6]naphthyridin-1-yl)piperidine-1-carboxa- mide; N-ethyl-3-(7H-pyrrolo[2,3-h][2,6]naphthyridin-1-yl)piperidine-1-carb- oxamide; N-isopropyl-3-(7H-pyrrolo[2,3-h][2,6]naphthyridin-1-yl)piperidine- -1-carboxamide; 3-oxo-3-[3-(7H-pyrrolo[2,3-h][2,6]naphthyridin-1-yl)pyrrolidin-1-yl]propa- nenitrile; 3,3,3-trifluoro-1-[3-(7H-pyrrolo[2,3-h][2,6]naphthyridin-1-yl)p- yrrolidin-1-yl]propan-1-one; 2-methyl-1-[3-(7H-pyrrolo[2,3-h][2,6]naphthyridin-1-yl)pyrrolidin-1-yl]pr- opan-1-one; cyclopropyl-[3-(7H-pyrrolo[2,3-h][2,6]naphthyridin-1-yl)pyrrolidin-1-yl]m- ethanone; 2-[3-(7H-pyrrolo[2,3-h][2,6]naphthyridin-1-yl)pyrrolidin-1-yl]su- lfonylacetonitrile; 1-[1-(2,2,2-trifluoroethylsulfonyl)pyrrolidin-3-yl]-7H-pyrrolo[2,3-c][2,6- ]naphthyridine; 1-(1-methylsulfonylpyrrolidin-3-yl)-7H-pyrrolo[2,3-c][2,6]naphthyridine; 1-(1-ethylsulfonylpyrrolidin-3-yl)-7H-pyrrolo[2,3-c][2,6]naphthyridine; 1-(1-isopropylsulfonylpyrrolidin-3-yl)-7H-pyrrolo[2,3-c][2,6]naphthyridin- e; 1-(1-cyclopropylsulfonylpyrrolidin-3-yl)-7H-pyrrolo[2,3-c][2,6]naphthyr- idine; N-methyl-3-(7H-pyrrolo[2,3-h][2,6]naphthyridin-1-yl)pyrrolidine-1-c- arboxamide; N-ethyl-3-(7H-pyrrolo[2,3-h][2,6]naphthyridin-1-yl)pyrrolidine-1-carboxam- ide; N-isopropyl-3-(7H-pyrrolo[2,3-h][2,6]naphthyridin-1-yl)pyrrolidine-1-- carboxamide; 3-oxo-3-[3-(3H-pyrrolo[2,3-c][2,7]naphthyridin-9-yl)-1-piperidyl]propanen- itrile; 3,3,3-trifluoro-1-[3-(3H-pyrrolo[2,3-c][2,7]naphthyridin-9-yl)-1-p- iperidyl]propan-1-one; 2-methyl-1-[3-(3H-pyrrolo[2,3-c][2,7]naphthyridin-9-yl)-1-piperidyl]propa- n-1-one; cyclopropyl-[3-(3H-pyrrolo[2,3-c][2,7]naphthyridin-9-yl)-1-piperi- dyl]methanone; 2-[[3-(3H-pyrrolo[2,3-c][2,7]naphthyridin-9-yl)-1-piperidyl]sulfonyl]acet- onitrile; 9-[1-(2,2,2-trifluoro ethylsulfonyl)-3-piperidyl]-3H-pyrrolo[2,3-c][2,7]naphthyridine; 9-(1-methylsulfonyl-3-piperidyl)-3H-pyrrolo[2,3-c][2,7]naphthyridine; 9-(1-ethylsulfonyl-3-piperidyl)-3H-pyrrolo[2,3-c][2,7]naphthyridine; 9-(1-isopropylsulfonyl-3-piperidyl)-3H-pyrrolo[2,3-c][2,7]naphthyridine; 9-(1-cyclopropylsulfonyl-3-piperidyl)-3H-pyrrolo[2,3-c][2,7]naphthyridine- ; N-methyl-3-(3H-pyrrolo[2,3-c][2,7]naphthyridin-9-yl)piperidine-1-carboxa- mide; N-ethyl-3-(3H-pyrrolo[2,3-c][2,7]naphthyridin-9-yl)piperidine-1-carb- oxamide; N-isopropyl-3-(3H-pyrrolo[2,3-c][2,7]naphthyridin-9-yl)piperidine- -1-carboxamide; 3-oxo-3-[3-(3H-pyrrolo[2,3-c][2,7]naphthyridin-9-yl)pyrrolidin-1-yl]propa- nenitrile; 3,3,3-trifluoro-1-[3-(3H-pyrrolo[2,3-c][2,7]naphthyridin-9-yl)p- yrrolidin-1-yl]propan-1-one; 2-methyl-1-[3-(3H-pyrrolo[2,3-c][2,7]naphthyridin-9-yl)pyrrolidin-1-yl]pr- opan-1-one; cyclopropyl-[3-(3H-pyrrolo[2,3-c][2,7]naphthyridin-9-yl)pyrrolidin-1-yl]m- ethanone; 2-[3-(3H-pyrrolo[2,3-c][2,7]naphthyridin-9-yl)pyrrolidin-1-yl]su- lfonylacetonitrile; 9-[1-(2,2,2-trifluoroethylsulfonyl)pyrrolidin-3-yl]-3H-pyrrolo[2,3-c][2,7- ]naphthyridine; 9-(1-methylsulfonylpyrrolidin-3-yl)-3H-pyrrolo[2,3-c][2,7]naphthyridine; 9-(1-ethylsulfonylpyrrolidin-3-yl)-3H-pyrrolo[2,3-c][2,7]naphthyridine; 9-(1-isopropylsulfonylpyrrolidin-3-yl)-3H-pyrrolo[2,3-c][2,7]naphthyridin- e; 9-(1-cyclopropylsulfonylpyrrolidin-3-yl)-3H-pyrrolo[2,3-c][2,7]naphthyr- idine; N-methyl-3-(3H-pyrrolo[2,3-c][2,7]naphthyridin-9-yl)pyrrolidine-1-c- arboxamide; N-ethyl-3-(3H-pyrrolo[2,3-c][2,7]naphthyridin-9-yl)pyrrolidine-1-carboxam- ide; N-isopropyl-3-(3H-pyrrolo[2,3-c][2,7]naphthyridin-9-yl)pyrrolidine-1-- carboxamide; 3-[3-(7-Methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidi- n-1-yl]-3-oxo-propionitrile; 3,3,3-Trifluoro-1-[3-(7-methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthale- n-9-yl)-piperidin-1-yl]-propan-1-one; 2-Methyl-1-[3-(7-methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)- -piperidin-1-yl]-propan-1-one; Cyclopropyl-[3-(7-methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl- )-piperidin-1-yl]-methanone; [3-(7-Methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine- -1-sulfonyl]-acetonitrile; 7-Methyl-9-[1-(2,2,2-trifluoro-ethanesulfonyl)-piperidin-3-yl]-3H-3,4,6,8- -tetraaza-cyclopenta[a]naphthalene; 9-(1-Methanesulfonyl-piperidin-3-yl)-7-methyl-3H-3,4,6,8-tetraaza-cyclope- nta[a]naphthalene; 9-(1-Ethanesulfonyl-piperidin-3-yl)-7-methyl-3H-3,4,6,8-tetraaza-cyclopen- ta[a]naphthalene; 7-Methyl-9-[1-(propane-2-sulfonyl)-piperidin-3-yl]-3H-3,4,6,8-tetraaza-cy- clopenta[a]naphthalene; 9-(1-Cyclopropanesulfonyl-piperidin-3-yl)-7-methyl-3H-3,4,6,8-tetraaza-cy- clopenta[a]naphthalene; 3-(7-Methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-- 1-carboxylic acid methylamide; 3-(7-Methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-- 1-carboxylic acid ethylamide; 3-(7-Methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-- 1-carboxylic acid isopropylamide; 3-[3-(7-Methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolid- in-1-yl]-3-oxo-propionitrile; 3,3,3-Trifluoro-1-[3-(7-methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthale- n-9-yl)-pyrrolidin-1-yl]-propan-1-one; 2-Methyl-1-[3-(7-methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)- -pyrrolidin-1-yl]-propan-1-one; Cyclopropyl-[3-(7-methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl- )-pyrrolidin-1-yl]-methanone; [3-(7-Methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidin- e-1-sulfonyl]-acetonitrile; 7-Methyl-9-[1-(2,2,2-trifluoro-ethanesulfonyl)-pyrrolidin-3-yl]-3H-3,4,6,- 8-tetraaza-cyclopenta[a]naphthalene; 9-(1-Methanesulfonyl-pyrrolidin-3-yl)-7-methyl-3H-3,4,6,8-tetraaza-cyclop- enta[a]naphthalene; 9-(1-Ethanesulfonyl-pyrrolidin-3-yl)-7-methyl-3H-3,4,6,8-tetraaza-cyclope- nta[a]naphthalene; 7-Methyl-9-[1-(propane-2-sulfonyl)-pyrrolidin-3-yl]-3H-3,4,6,8-tetraaza-c- yclopenta[a]naphthalene; 9-(1-Cyclopropanesulfonyl-pyrrolidin-3-yl)-7-methyl-3H-3,4,6,8-tetraaza-c- yclopenta[a]naphthalene; 3-(7-Methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidine- -1-carboxylic acid methylamide; 3-(7-Methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidine- -1-carboxylic acid ethylamide; 3-(7-Methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidine- -1-carboxylic acid isopropylamide; 3-oxo-3-[5-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-3,6-dihydro-2H-pyrid- in-1-yl]propanenitrile; 3,3,3-trifluoro-1-[5-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-3,6-dihydr- o-2H-pyridin-1-yl]propan-1-one; 2-[[5-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-3,6-dihydro-2H-pyridin-1-- yl]sulfonyl]acetonitrile; 9-[1-(2,2,2-trifluoroethylsulfonyl)-3,6-dihydro-2H-pyridin-5-yl]-3H-pyrro- lo[3,2-f][1,7]naphthyridine; 9-(1-methylsulfonyl-3,6-dihydro-2H-pyridin-5-yl)-3H-pyrrolo[3,2-f][1,7]na- phthyridine; 3-oxo-3-[5-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-3,4-dihydro-2H-pyrid- in-1-yl]propanenitrile; 3,3,3-trifluoro-1-[5-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-3,4-dihydr- o-2H-pyridin-1-yl]propan-1-one; 2-[[5-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-3,4-dihydro-2H-pyridin-1-- yl]sulfonyl]acetonitrile; 9-[1-(2,2,2-trifluoroethylsulfonyl)-3,4-dihydro-2H-pyridin-5-yl]-3H-pyrro- lo[3,2-f][1,7]naphthyridine; 9-(1-methylsulfonyl-3,4-dihydro-2H-pyridin-5-yl)-3H-pyrrolo[3,2-f][1,7]na- phthyridine; 2-[[3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-2,5-dihydropyrrol-1-yl]su- lfonyl]acetonitrile; 9-[1-(2,2,2-trifluoroethylsulfonyl)-2,5-dihydropyrrol-3-yl]-3H-pyrrolo[3,- 2-f][1,7]naphthyridine; 9-(1-methylsulfonyl-2,5-dihydropyrrol-3-yl)-3H-pyrrolo[3,2-f][1,7]naphthy- ridine; 3-[4-methyl-3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-piperidy- l]-3-oxo-propanenitrile; 3,3,3-trifluoro-1-[4-methyl-3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1- -piperidyl]propan-1-one; 2-[[4-methyl-3-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-piperidyl]sulf- onyl]acetonitrile; 9-[4-methyl-1-(2,2,2-trifluoroethylsulfonyl)-3-piperidyl]-3H-pyrrolo[3,2-- f][1,7]naphthyridine; 9-(4-methyl-1-methylsulfonyl-3-piperidyl)-3H-pyrrolo[3,2-f][1,7]naphthyri- dine; 3-[3-methyl-4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)pyrrolidin-1-- yl]-3-oxo-propanenitrile; 3,3,3-trifluoro-1-[3-methyl-4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)py- rrolidin-1-yl]propan-1-one; 2-[3-methyl-4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)pyrrolidin-1-yl]su- lfonylacetonitrile; 9-[4-methyl-1-(2,2,2-trifluoroethylsulfonyl)pyrrolidin-3-yl]-3H-pyrrolo[3- ,2-f][1,7]naphthyridine; 9-(4-methyl-1-methylsulfonyl-pyrrolidin-3-yl)-3H-pyrrolo[3,2-f][1,7]napht- hyridine; 3-[3-(2-methyl-3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-piperi- dyl]-3-oxo-propanenitrile; 3,3,3-trifluoro-1-[3-(2-methyl-3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1- -piperidyl]propan-1-one; 2-[[3-(2-methyl-3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-piperidyl]sulf- onyl]acetonitrile; 2-methyl-9-[1-(2,2,2-trifluoroethylsulfonyl)-3-piperidyl]-3H-pyrrolo[3,2-- f][1,7]naphthyridine; 2-methyl-9-(1-methylsulfonyl-3-piperidyl)-3H-pyrrolo[3,2-f][1,7]naphthyri- dine; 3-[3-(2-methyl-3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)pyrrolidin-1-- yl]-3-oxo-propanenitrile; 3,3,3-trifluoro-1-[3-(2-methyl-3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)py- rrolidin-1-yl]propan-1-one; 2-[3-(2-methyl-3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)pyrrolidin-1-yl]su- lfonylacetonitrile; 2-methyl-9-[1-(2,2,2-trifluoroethylsulfonyl)pyrrolidin-3-yl]-3H-pyrrolo[3- ,2-f][1,7]naphthyridine; 2-methyl-9-(1-methylsulfonylpyrrolidin-3-yl)-3H-pyrrolo[3,2-f][1,7]naphth- yridine; 3-oxo-3-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-piperidyl]- propanenitrile; 4-oxo-4-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-piperidyl]butaneni- trile; 4,4,4-trifluoro-1-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-pi- peridyl]butan-1-one; 2-[[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-piperidyl]sulfonyl]acet- onitrile; 9-[1-(2,2,2-trifluoroethylsulfonyl)-4-piperidyl]-3H-pyrrolo[3,2-- f][1,7]naphthyridine; 9-(3-Morpholin-4-yl-piperidin-1-yl)-3H-3,4,6,7-tetraaza-cyclopenta[a]naph- thalene; 9-(3-Cyclopropylmethoxy-piperidin-1-yl)-3H-3,4,6,7-tetraaza-cyclo- penta[a]naphthalene; 2-Cyano-N-[1-(3H-3,4,6,7-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidin- -3-yl]-acetamide; 1-(3H-3,4,6,7-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-carboxy- lic acid cyanomethyl-amide; 2-Nitrilo-ethanesulfonic acid [1-(3H-3,4,6,7-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidin-3-yl]-ami- de; 1-(3H-3,4,6,7-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-carb- oxylic acid cyanomethyl-methyl-amide; 2-Cyano-N-methyl-N-[1-(3H-3,4,6,7-tetraaza-cyclopenta[a]naphthalen-9-yl)-- piperidin-3-yl]-acetamide; 1-(3H-3,4,6,7-Tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidine-3-carbox- ylic acid cyanomethyl-methyl-amide; 1-(3H-3,4,6,7-Tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidine-3-carbox- ylic acid methyl-(2,2,2-trifluoro-ethyl)-amide; 2-Cyano-N-methyl-N-[1-(3H-3,4,6,7-tetraaza-cyclopenta[a]naphthalen-9-yl)-- pyrrolidin-3-yl]-acetamide; 3,3,3-Trifluoro-N-methyl-N-[1-(3H-3,4,6,7-tetraaza-cyclopenta[a]naphthale- n-9-yl)-pyrrolidin-3-yl]-propionamide; 1-(3H-3,4,6,7-Tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidine-3-carbox- ylic acid cyanomethyl-amide; 1-(3H-3,4,6,7-Tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidine-3-carbox- ylic acid (2,2,2-trifluoro-ethyl)-amide; 2,2,2-Trifluoro-ethanesulfonic acid [1-(3H-3,4,6,7-tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidin-3-y- l]-amide; 2-Cyano-N-[1-(3H-3,4,6,7-tetraaza-cyclopenta[a]naphthalen-9-yl)-- pyrrolidin-3-yl]-acetamide; 2-Nitrilo-ethanesulfonic acid [1-(3H-3,4,6,7-tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidin-3-yl]-am- ide; 3,3,3-Trifluoro-N-[1-(3H-3,4,6,7-tetraaza-cyclopenta[a]naphthalen-9-y- l)-pyrrolidin-3-yl]-propionamide; 3,3,3-Trifluoro-N-[1-(3H-3,4,6,7-tetraaza-cyclopenta[a]naphthalen-9-yl)-p- iperidin-3-yl]-propionamide; 2,2,2-Trifluoro-ethanesulfonic acid [1-(3H-3,4,6,7-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidin-3-yl]-ami- de; 1-(3H-3,4,6,7-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-4-carb- oxylic acid (2,2,2-trifluoro-ethyl)-amide; 1-(3H-3,4,6,7-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-4-carboxy- lic acid methyl-(2,2,2-trifluoro-ethyl)-amide; 1-(3H-3,4,6,7-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-4-carboxy- lic acid cyanomethyl-methyl-amide; 1-(3H-3,4,6,7-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-4-carboxy- lic acid cyanomethyl-amide; 2-Cyano-N-[1-(3H-3,4,6,7-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidin- -4-yl]-acetamide; 2-Cyano-N-methyl-N-[1-(3H-3,4,6,7-tetraaza-cyclopenta[a]naphthalen-9-yl)-- piperidin-4-yl]-acetamide; 3,3,3-Trifluoro-N-methyl-N-[1-(3H-3,4,6,7-tetraaza-cyclopenta[a]naphthale- n-9-yl)-piperidin-3-yl]-propionamide; 1-(3H-3,4,6,7-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-carboxy- lic acid cyclopropylamide; 1-(3H-3,4,6,7-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-carboxy- lic acid cyclopropyl-methyl-amide; 1-(3H-3,4,6,7-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-carboxy- lic acid methyl-(2,2,2-trifluoro-ethyl)-amide; 6-Methyl-1-(3H-3,4,6,7-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-- 3-carboxylic acid cyclopropylamide; 1-(3H-3,4,6,7-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-sulfoni- c acid (2,2,2-trifluoro-ethyl)-amide; 1-(3H-3,4,6,7-Tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidine-3-sulfon- ic acid (2,2,2-trifluoro-ethyl)-amide; 1-(3H-3,4,6,7-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-carboxy- lic acid (2,2,2-trifluoro-ethyl)-amide; 2-Cyano-N-[1-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidin- -3-yl]-acetamide; 2-Nitrilo-ethanesulfonic acid [1-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidin-3-yl]-ami- de; 1-(3H-3,4,6,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-carb- oxylic acid cyanomethyl-methyl-amide; 2-Cyano-N-methyl-N-[1-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-- piperidin-3-yl]-acetamide; 1-(3H-3,4,6,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidine-3-carbox- ylic acid cyanomethyl-methyl-amide; 1-(3H-3,4,6,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidine-3-carbox- ylic acid methyl-(2,2,2-trifluoro-ethyl)-amide; 2-Cyano-N-methyl-N-[1-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-- pyrrolidin-3-yl]-acetamide; 3,3,3-Trifluoro-N-methyl-N-[1-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthale- n-9-yl)-pyrrolidin-3-yl]-propionamide; 1-(3H-3,4,6,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidine-3-carbox- ylic acid cyanomethyl-amide; 1-(3H-3,4,6,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidine-3-carbox- ylic acid (2,2,2-trifluoro-ethyl)-amide; 1-(3H-3,4,6,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-carboxy- lic acid cyanomethyl-amide; 2,2,2-Trifluoro-ethanesulfonic acid [1-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidin-3-yl]-am- ide; Cyclopropanesulfonic acid [1-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidin-3-yl]-am- ide; Propane-2-sulfonic acid [1-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidin-3-yl]-am- ide; 2-Cyano-N-[1-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrro- lidin-3-yl]-acetamide; 2-Nitrilo-ethanesulfonic acid [1-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidin-3-yl]-am- ide; 1-Isopropyl-3-[1-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-p- yrrolidin-3-yl]-urea; N-[1-(3H-3,4,6,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidin-3-yl]-- isobutyramide; 3,3,3-Trifluoro-N-[1-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-p- yrrolidin-3-yl]-propionamide; 1-(3H-3,4,6,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidine-3-carbox- ylic acid cyclopropylamide; N-[1-(3H-3,4,6,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidin-3-yl]-m- ethanesulfonamide; C,C,C-Trifluoro-N-[1-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-p- iperidin-3-yl]-methanesulfonamide; 2,2,2-Trifluoro-ethanesulfonic acid [1-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidin-3-yl]-ami- de; 1-(3H-3,4,6,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-4-carb- oxylic acid (2,2,2-trifluoro-ethyl)-amide; 1-(3H-3,4,6,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-4-carboxy- lic acid methyl-(2,2,2-trifluoro-ethyl)-amide; 1-(3H-3,4,6,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-4-carboxy- lic acid cyanomethyl-methyl-amide; 1-(3H-3,4,6,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-4-carboxy- lic acid cyanomethyl-amide; 2-Cyano-N-[1-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidin- -4-yl]-acetamide; 2-Cyano-N-methyl-N-[1-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-- piperidin-4-yl]-acetamide; 2-Cyclopropyl-N-methyl-N-[1-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-- 9-yl)-piperidin-3-yl]-acetamide; 3,3,3-Trifluoro-N-methyl-N-[1-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthale- n-9-yl)-piperidin-3-yl]-propionamide; Cyclopentanecarboxylic acid methyl-[1-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidin-3-- yl]-amide; Cyclopropanecarboxylic acid [1-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidin-3-yl]-ami- de; 3,3,3-Trifluoro-N-[1-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl- )-piperidin-3-yl]-propionamide; 1-(3H-3,4,6,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-4-carboxy- lic acid isopropylamide; 1-(3H-3,4,6,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-4-carboxy- lic acid cyclopropylamide; 1-(3H-3,4,6,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-4-carboxy- lic acid (2-methoxy-ethyl)-amide; 1-(3H-3,4,6,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-carboxy- lic acid cyclopropylamide; 1-(3H-3,4,6,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-carboxy- lic acid methyl-(2,2,2-trifluoro-ethyl)-amide; 1-(3H-3,4,6,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-carboxy- lic acid (2,2,2-trifluoro-ethyl)-amide; 1-(3H-3,4,6,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-carboxy- lic acid isopropylamide; 1-(3H-3,4,6,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-carboxy- lic acid cyclopropyl-methyl-amide 6-Methyl-1-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-- 3-carboxylic acid cyclopropylamide; 1-(3H-3,4,6,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-sulfoni- c acid (2,2,2-trifluoro-ethyl)-amide; 1-(3H-3,4,6,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidine-3-sulfon- ic acid (2,2,2-trifluoro-ethyl)-amide; 2-Cyano-N-[1-(7-methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-- piperidin-3-yl]-acetamide; 2-Nitrilo-ethanesulfonic acid [1-(7-methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidin-- 3-yl]-amide; 1-(7-Methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidine- -3-carboxylic acid cyanomethyl-amide; 1-(7-Methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidine- -3-carboxylic acid (2,2,2-trifluoro-ethyl)-amide; 1-(7-Methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-- 3-carboxylic acid cyanomethyl-amide; 1-(7-Methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-- 3-carboxylic acid cyanomethyl-methyl-amide; 2-Cyano-N-methyl-N-[1-(7-methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthal- en-9-yl)-piperidin-3-yl]-acetamide; 1-(7-Methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidine- -3-carboxylic acid cyanomethyl-methyl-amide; 1-(7-Methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidine- -3-carboxylic acid methyl-(2,2,2-trifluoro-ethyl)-amide; 2-Cyano-N-methyl-N-[1-(7-methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthal- en-9-yl)-pyrrolidin-3-yl]-acetamide; 3,3,3-Trifluoro-N-methyl-N-[1-(7-methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]- naphthalen-9-yl)-pyrrolidin-3-yl]-propionamide; 2,2,2-Trifluoro-ethanesulfonic acid [1-(7-methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidin- -3-yl]-amide; 2-Nitrilo-ethanesulfonic acid [1-(7-methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidin- -3-yl]-amide; 3,3,3-Trifluoro-N-[1-(7-methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthale- n-9-yl)-pyrrolidin-3-yl]-propionamide; N-[1-(7-Methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolid- in-3-yl]-methanesulfonamide; 2-Cyano-N-[1-(7-methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-- pyrrolidin-3-yl]-acetamide; N-[1-(7-Methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidi- n-3-yl]-methanesulfonamide; 1-(7-Methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-- 4-carboxylic acid methyl-(2,2,2-trifluoro-ethyl)-amide; 1-(7-Methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-- 4-carboxylic acid cyanomethyl-methyl-amide; 1-(7-Methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-- 4-carboxylic acid cyanomethyl-amide; 2-Cyano-N-[1-(7-methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-- piperidin-4-yl]-acetamide; 2-Cyano-N-methyl-N-[1-(7-methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthal- en-9-yl)-piperidin-4-yl]-acetamide; 2,2,2-Trifluoro-ethanesulfonic acid [1-(7-methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidin-- 3-yl]-amide; 1-(7-Methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-- 4-carboxylic acid (2,2,2-trifluoro-ethyl)-amide; 3,3,3-Trifluoro-N-[1-(7-methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthale- n-9-yl)-piperidin-3-yl]-propionamide; 3,3,3-Trifluoro-N-methyl-N-[1-(7-methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]- naphthalen-9-yl)-piperidin-3-yl]-propionamide; 1-(7-Methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-- 3-carboxylic acid cyclopropylamide; 1-(7-Methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-- 3-carboxylic acid isopropylamide; 1-(7-Methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-- 3-carboxylic acid cyclopropyl-methyl-amide; 1-(7-Methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-- 3-carboxylic acid methyl-(2,2,2-trifluoro-ethyl)-amide; 6-Methyl-1-(7-methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-pi- peridine-3-carboxylic acid cycloPropylamide; 1-(7-Methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-- 3-sulfonic acid (2,2,2-trifluoro-ethyl)-amide; 1-(7-Methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidine- -3-sulfonic acid (2,2,2-trifluoro-ethyl)-amide; 1-(7-Methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-- 3-carboxylic acid (2,2,2-trifluoro-ethyl)-amide; 9-(3-Cyclopropylmethoxy-pyrrolidin-1-yl)-3H-3,4,7,8-tetraaza-cyclopenta[a- ]naphthalene; 9-(3-Morpholin-4-yl-piperidin-1-yl)-3H-3,4,7,8-tetraaza-cyclopenta[a]naph- thalene; Cyclopropylmethyl-methyl-[1-(3H-3,4,7,8-tetraaza-cyclopenta[a]nap- hthalen-9-yl)-pyrrolidin-3-yl]-amine; 2-Cyano-N-[1-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidin- -3-yl]-acetamide; 9-Morpholin-4-yl-3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalene; 1-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidine-3-carbox- ylic acid (2,2,2-trifluoro-ethyl)-amide; 2-Nitrilo-ethanesulfonic acid [1-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidin-3-yl]-ami- de; 1-(3H-3,4,7,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidine-3-car- boxylic acid cyanomethyl-amide; 1-(3H-3,4,7,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-carboxy- lic acid cyanomethyl-amide; 1-(3H-3,4,7,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-carboxy- lic acid cyanomethyl-methyl-amide; 2-Cyano-N-methyl-N-[1-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-- piperidin-3-yl]-acetamide; 1-(3H-3,4,7,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidine-3-carbox- ylic acid cyanomethyl-methyl-amide; 1-(3H-3,4,7,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidine-3-carbox- ylic acid methyl-(2,2,2-trifluoro-ethyl)-amide; 2-Cyano-N-methyl-N-[1-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-- pyrrolidin-3-yl]-acetamide; 3,3,3-Trifluoro-N-methyl-N-[1-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthale- n-9-yl)-pyrrolidin-3-yl]-propionamide; 2,2,2-Trifluoro-ethanesulfonic acid [1-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidin-3-yl]-am- ide; Cyclopropanesulfonic acid [1-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidin-3-yl]-am- ide; 1-Isopropyl-3-[1-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-p- yrrolidin-3-yl]-urea; N-[1-(3H-3,4,7,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidin-3-yl]-- methanesulfonamide; 2-Nitrilo-ethanesulfonic acid [1-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidin-3-yl]-am- ide; 2-Cyano-N-[1-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrro- lidin-3-yl]-acetamide; 3,3,3-Trifluoro-N-[1-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-p- yrrolidin-3-yl]-propionamide; 3,3,3-Trifluoro-N-[1-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-p- iperidin-3-yl]-methanesulfonamide; 2,2,2-Trifluoro-ethanesulfonic acid [1-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidin-3-yl]-ami- de; 1-(3H-3,4,7,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-4-carb- oxylic acid (2,2,2-trifluoro-ethyl)-amide; 1-(3H-3,4,7,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-4-carboxy- lic acid methyl-(2,2,2-trifluoro-ethyl)-amide; 1-(3H-3,4,7,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-4-carboxy- lic acid cyanomethyl-methyl-amide; 1-(3H-3,4,7,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-4-carboxy- lic acid cyanomethyl-amide; 2-Cyano-N-[1-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidin- -4-yl]-acetamide; 2-Cyano-N-methyl-N-[1-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-- piperidin-4-yl]-acetamide; 3,3,3-Trifluoro-N-methyl-N-[1-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthale- n-9-yl)-piperidin-3-yl]-propionamide; 3,3,3-Trifluoro-N-[1-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-p- iperidin-3-yl]-propionamide; 1-(3H-3,4,7,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-carboxy- lic acid cyclopropylamide; 1-(3H-3,4,7,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-carboxy- lic acid isopropylamide; 1-(3H-3,4,7,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-carboxy- lic acid cyclopropyl-methyl-amide; 1-(3H-3,4,7,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-carboxy- lic acid methyl-(2,2,2-trifluoro-ethyl)-amide; 6-Methyl-1-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-- 3-carboxylic acid cyclopropylamide; 1-(3H-3,4,7,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidine-3-sulfon- ic acid (2,2,2-trifluoro-ethyl)-amide; 1-(3H-3,4,7,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-sulfoni- c acid (2,2,2-trifluoro-ethyl)-amide; 1-(3H-3,4,7,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-carboxy- lic acid (2,2,2-trifluoro-ethyl)-amide; 9-(3-Cyclopropylmethoxy-pyrrolidin-1-yl)-3H-3,4,7-triaza-cyclopenta[a]nap- hthalene; 9-(3-Morpholin-4-yl-piperidin-1-yl)-3H-3,4,7-triaza-cyclopenta[a- ]naphthalene; Cyclopropylmethyl-methyl-[1-(3H-3,4,7-triaza-cyclopenta[a]naphthalen-9-yl- )-pyrrolidin-3-yl]-amine; 1-(3H-3,4,7-Triaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidine-3-carboxylic acid (2,2,2-trifluoro-ethyl)-amide; 2-Cyano-N-[1-(3H-3,4,7-triaza-cyclopenta[a]naphthalen-9-yl)-piperidin-3-y- l]-acetamide; 2-Nitrilo-ethanesulfonic acid [1-(3H-3,4,7-triaza-cyclopenta[a]naphthalen-9-yl)-piperidin-3-yl]-amide; 9-Morpholin-4-yl-3H-3,4,7-triaza-cyclopenta[a]naphthalene; 1-(3H-3,4,7-Triaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-carboxylic acid cyanomethyl-amide; 1-(3H-3,4,7-Triaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-carboxylic acid cyanomethyl-methyl-amide; 2-Cyano-N-methyl-N-[1-(3H-3,4,7-triaza-cyclopenta[a]naphthalen-9-yl)-pipe- ridin-3-yl]-acetamide; 1-(3H-3,4,7-Triaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidine-3-carboxylic acid cyanomethyl-methyl-amide; 1-(3H-3,4,7-Triaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidine-3-carboxylic acid methyl-(2,2,2-trifluoro-ethyl)-amide; 2-Cyano-N-methyl-N-[1-(3H-3,4,7-triaza-cyclopenta[a]naphthalen-9-yl)-pyrr- olidin-3-yl]-acetamide; 3,3,3-Trifluoro-N-methyl-N-[1-(3H-3,4,7-triaza-cyclopenta[a]naphthalen-9-- yl)-pyrrolidin-3-yl]-propionamide; 1-(3H-3,4,7-Triaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidine-3-carboxylic acid cyanomethyl-amide; 2,2,2-Trifluoro-ethanesulfonic acid [1-(3H-3,4,7-triaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidin-3-yl]-amide; Cyclopropanesulfonic acid [1-(3H-3,4,7-triaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidin-3-yl]-amide; N-[1-(3H-3,4,7-Triaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidin-3-yl]-meth- anesulfonamide; 2-Nitrilo-ethanesulfonic acid [1-(3H-3,4,7-triaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidin-3-yl]-amide; 3,3,3-Trifluoro-N-[1-(3H-3,4,7-triaza-cyclopenta[a]naphthalen-9-yl)-pyrro- lidin-3-yl]-propionamide; 2-Cyano-N-[1-(3H-3,4,7-triaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidin-3-- yl]-acetamide; 1-Isopropyl-3-[1-(3H-3,4,7-triaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidi- n-3-yl]-urea; N-[1-(3H-3,4,7-Triaza-cyclopenta[a]naphthalen-9-yl)-piperidin-3-yl]-metha- nesulfonamide; 2,2,2-Trifluoro-ethanesulfonic acid [1-(3H-3,4,7-triaza-cyclopenta[a]naphthalen-9-yl)-piperidin-3-yl]-amide; 1-(3H-3,4,7-Triaza-cyclopenta[a]naphthalen-9-yl)-piperidine-4-carboxylic acid (2,2,2-trifluoro-ethyl)-amide; 1-(3H-3,4,7-Triaza-cyclopenta[a]naphthalen-9-yl)-piperidine-4-carboxylic acid cyanomethyl-methyl-amide; 1-(3H-3,4,7-Triaza-cyclopenta[a]naphthalen-9-yl)-piperidine-4-carboxylic acid cyanomethyl-amide; 2-Cyano-N-[1-(3H-3,4,7-triaza-cyclopenta[a]naphthalen-9-yl)-piperidin-4-y- l]-acetamide; 2-Cyano-N-methyl-N-[1-(3H-3,4,7-triaza-cyclopenta[a]naphthalen-9-yl)-pipe- ridin-4-yl]-acetamide; 3,3,3-Trifluoro-N-methyl-N-[1-(3H-3,4,7-triaza-cyclopenta[a]naphthalen-9-- yl)-piperidin-3-yl]-propionamide; 3,3,3-Trifluoro-N-[1-(3H-3,4,7-triaza-cyclopenta[a]naphthalen-9-yl)-piper- idin-3-yl]-propionamide; 1-(3H-3,4,7-Triaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-carboxylic acid cyclopropylamide; 1-(3H-3,4,7-Triaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-carboxylic acid isobutyl-amide; 1-(3H-3,4,7-Triaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-carboxylic acid (2,2,2-trifluoro-ethyl)-amide; 1-(3H-3,4,7-Triaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-carboxylic acid cyclopropyl-methyl-amide; 1-(3H-3,4,7-Triaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidine-3-sulfonic acid (2,2,2-trifluoro-ethyl)-amide; 1-(3H-3,4,7-Triaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-sulfonic acid (2,2,2-trifluoro-ethyl)-amide; 1-(3H-3,4,7-Triaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-carboxylic acid methyl-(2,2,2-trifluoro-ethyl)-amide; 6-Methyl-1-(3H-3,4,7-triaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-ca- rboxylic acid cyclopropylamide; 1-(3H-3,4,8-Triaza-cyclopenta[a]naphthalen-9-yl)-piperidin-3-ol; 9-(3-Morpholin-4-yl-piperidin-1-yl)-3H-3,4,8-triaza-cyclopenta[a]naphthal- ene; Cyclopropylmethyl-methyl-[1-(3H-3,4,8-triaza-cyclopenta[a]naphthalen-- 9-yl)-pyrrolidin-3-yl]-amine; 9-Morpholin-4-yl-3H-3,4,8-triaza-cyclopenta[a]naphthalene; 2-Cyano-N-[1-(3H-3,4,8-triaza-cyclopenta[a]naphthalen-9-yl)-piperidin-3-y- l]-acetamide; 2-Nitrilo-ethanesulfonic acid [1-(3H-3,4,8-triaza-cyclopenta[a]naphthalen-9-yl)-piperidin-3-yl]-amide; 1-(3H-3,4,8-Triaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidine-3-carboxylic acid (2,2,2-trifluoro-ethyl)-amide; 1-(3H-3,4,8-Triaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-carboxylic acid cyanomethyl-amide; 1-(3H-3,4,8-Triaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-carboxylic acid cyanomethyl-methyl-amide; 2-Cyano-N-methyl-N-[1-(3H-3,4,8-triaza-cyclopenta[a]naphthalen-9-yl)-pipe- ridin-3-yl]-acetamide; 1-(3H-3,4,8-Triaza-cyclopenta[a]naphthalene-9-yl)-pyrrolidine-3-carboxyli- c acid cyanomethyl-methyl-amide; 1-(3H-3,4,8-Triaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidine-3-carboxylic acid methyl-(2,2,2-trifluoro-ethyl)-amide; 2-Cyano-N-methyl-N-[1-(3H-3,4,8-triaza-cyclopenta[a]naphthalen-9-yl)-pyrr- olidin-3-yl]-acetamide; 3,3,3-Trifluoro-N-methyl-N-[1-(3H-3,4,8-triaza-cyclopenta[a]naphthalen-9-- yl)-pyrrolidin-3-yl]-propionamide; 1-(3H-3,4,8-Triaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidine-3-carboxylic acid cyanomethyl-amide; 2,2,2-Trifluoro-ethanesulfonic acid [1-(3H-3,4,8-triaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidin-3-yl]-amide; N-[1-(3H-3,4,8-Triaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidin-3-yl]-meth- anesulfonamide; 2-Methyl-propane-1-sulfonic acid [1-(3H-3,4,8-triaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidin-3-yl]-amide; 2-Nitrilo-ethanesulfonic acid [1-(3H-3,4,8-triaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidin-3-yl]-amide; 1-Isopropyl-3-[1-(3H-3,4,8-triaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidi- n-3-yl]-urea; 2-Cyano-N-[1-(3H-3,4,8-triaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidin-3-- yl]-acetamide; Cyclopropanecarboxylic acid [1-(3H-3,4,8-triaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidin-3-yl]-amide; 1-(3H-3,4,8-Triaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidine-3-carboxylic acid cyclopropylamide; 3,3,3-Trifluoro-N-[1-(3H-3,4,8-triaza-cyclopenta[a]naphthalen-9-yl)-pyrro- lidin-3-yl]-propionamide; N-[1-(3H-3,4,8-Triaza-cyclopenta[a]naphthalen-9-yl)-piperidin-3-yl]-metha- nesulfonamide; 2,2,2-Trifluoro-ethanesulfonic acid [1-(3H-3,4,8-triaza-cyclopenta[a]naphthalen-9-yl)-piperidin-3-yl]-amide; 1-(3H-3,4,8-Triaza-cyclopenta[a]naphthalen-9-yl)-piperidine-4-carboxylic acid (2,2,2-trifluoro-ethyl)-amide; 1-(3H-3,4,8-Triaza-cyclopenta[a]naphthalen-9-yl)-piperidine-4-carboxylic acid methyl-(2,2,2-trifluoro-ethyl)-amide; 1-(3H-3,4,8-Triaza-cyclopenta[a]naphthalen-9-yl)-piperidine-4-carboxylic acid cyanomethyl-methyl-amide; 1-(3H-3,4,8-Triaza-cyclopenta[a]naphthalen-9-yl)-piperidine-4-carboxylic acid cyanomethyl-amide; 2-Cyano-N-[1-(3H-3,4,8-triaza-cyclopenta[a]naphthalen-9-yl)-piperidin-4-y- l]-acetamide; 2-Cyano-N-methyl-N-[1-(3H-3,4,8-triaza-cyclopenta[a]naphthalen-9-yl)-pipe- ridin-4-yl]-acetamide; 3,3,3-Trifluoro-N-methyl-N-[1-(3H-3,4,8-triaza-cyclopenta[a]naphthalen-9-- yl)-piperidin-3-yl]-propionamide; 3,3,3-Trifluoro-N-[1-(3H-3,4,8-triaza-cyclopenta[a]naphthalen-9-yl)-piper- idin-3-yl]-propionamide; 1-(3H-3,4,8-Triaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-carboxylic acid cyclopropylamide; 1-(3H-3,4,8-Triaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-carboxylic acid cyclopropyl-methyl-amide; 1-(3H-3,4,8-Triaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-carboxylic acid methyl-(2,2,2-trifluoro-ethyl)-amide; 6-Methyl-1-(3H-3,4,8-triaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-ca- rboxylic acid cyclopropylamide; 1-(3H-3,4,8-Triaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidine-3-sulfonic acid (2,2,2-trifluoro-ethyl)-amide; 1-(3H-3,4,8-Triaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-sulfonic acid (2,2,2-trifluoro-ethyl)-amide; 1-(3H-3,4,8-Triaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-carboxylic acid (2,2,2-trifluoro-ethyl)-amide; 2-Cyano-N-[1-(3H-3,4,6-triaza-cyclopenta[a]naphthalen-9-yl)-piperidin-3-y- l]-acetamide; 2-Nitrilo-ethanesulfonic acid [1-(3H-3,4,6-triaza-cyclopenta[a]naphthalen-9-yl)-piperidin-3-yl]-amide; 1-(3H-3,4,6-Triaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidine-3-carboxylic acid (2,2,2-trifluoro-ethyl)-amide; 1-(3H-3,4,6-Triaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-carboxylic acid cyanomethyl-amide; 1-(3H-3,4,6-Triaza-cyclopenta[a]naphthalen-9-yl)-pyrrolidine-3-carboxylic acid cyanomethyl-amide; 6-Methyl-1-(3H-3,4,6,7-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-- 3-carboxylic acid cyanomethyl-amide; 6-Methyl-1-(7-methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-pi- peridine-3-carboxylic acid cyanomethyl-amide; 6-Methyl-1-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-- 3-carboxylic acid cyanomethyl-amide; 6-Methyl-1-(3H-3,4,7-triaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-ca- rboxylic acid cyanomethyl-amide; 6-Methyl-1-(3H-3,4,8-triaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-ca- rboxylic acid cyanomethyl-amide; 6-Methyl-1-(3H-3,4,6,7-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-- 3-carboxylic acid (2,2,2-trifluoro-ethyl)-amide; 6-Methyl-1-(7-methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-pi- peridine-3-carboxylic acid (2,2,2-trifluoro-ethyl)-amide; 6-Methyl-1-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-- 3-carboxylic acid (2,2,2-trifluoro-ethyl)-amide; 6-Methyl-1-(3H-3,4,7-triaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-ca- rboxylic acid (2,2,2-trifluoro-ethyl)-amide; 6-Methyl-1-(3H-3,4,8-triaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-ca- rboxylic acid (2,2,2-trifluoro-ethyl)-amide; 2-Cyano-N-[6-methyl-1-(3H-3,4,6,7-tetraaza-cyclopenta[a]naphthalen-9-yl)-- piperidin-3-yl]-acetamide; 2-Cyano-N-[6-methyl-1-(7-methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthal- en-9-yl)-piperidin-3-yl]-acetamide; 2-Cyano-N-[6-methyl-1-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-- piperidin-3-yl]-acetamide; 2-Cyano-N-[6-methyl-1-(3H-3,4,7-triaza-cyclopenta[a]naphthalen-9-yl)-pipe- ridin-3-yl]-acetamide; 2-Cyano-N-[6-methyl-1-(3H-3,4,8-triaza-cyclopenta[a]naphthalen-9-yl)-pipe- ridin-3-yl]-acetamide; 3,3,3-Trifluoro-N-[6-methyl-1-(3H-3,4,6,7-tetraaza-cyclopenta[a]naphthale- n-9-yl)-piperidin-3-yl]-propionamide; 3,3,3-Trifluoro-N-[6-methyl-1-(7-methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]- naphthalen-9-yl)-piperidin-3-yl]-propionamide; 3,3,3-Trifluoro-N-[6-methyl-1-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthale- n-9-yl)-piperidin-3-yl]-propionamide; 3,3,3-Trifluoro-N-[6-methyl-1-(3H-3,4,7-triaza-cyclopenta[a]naphthalen-9-- yl)-piperidin-3-yl]-propionamide; 3,3,3-Trifluoro-N-[6-methyl-1-(3H-3,4,8-triaza-cyclopenta[a]naphthalen-9-- yl)-piperidin-3-yl]-propionamide; 2-Nitrilo-ethanesulfonic acid [6-methyl-1-(3H-3,4,6,7-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidin-- 3-yl]-amide; 2-Nitrilo-ethanesulfonic acid [6-methyl-1-(7-methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-p- iperidin-3-yl]-amide; 2-Nitrilo-ethanesulfonic acid [6-methyl-1-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidin-- 3-yl]-amide; 2-Nitrilo-ethanesulfonic acid [6-methyl-1-(3H-3,4,7-triaza-cyclopenta[a]naphthalen-9-yl)-piperidin-3-yl- ]-amide; 2-Nitrilo-ethanesulfonic acid [6-methyl-1-(3H-3,4,8-triaza-cyclopenta[a]naphthalen-9-yl)-piperidin-3-yl- ]-amide; 2,2,2-Trifluoro-ethanesulfonic acid [6-methyl-1-(3H-3,4,6,7-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidin-- 3-yl]-amide; 2,2,2-Trifluoro-ethanesulfonic acid [6-methyl-1-(7-methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-p- iperidin-3-yl]-amide; 2,2,2-Trifluoro-ethanesulfonic acid [6-methyl-1-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidin-- 3-yl]-amide; 2,2,2-Trifluoro-ethanesulfonic acid [6-methyl-1-(3H-3,4,7-triaza-cyclopenta[a]naphthalen-9-yl)-piperidin-3-yl- ]-amide; 2,2,2-Trifluoro-ethanesulfonic acid [6-methyl-1-(3H-3,4,8-triaza-cyclopenta[a]naphthalen-9-yl)-piperidin-3-yl- ]-amide; 6-Methyl-1-(3H-3,4,6,7-tetraaza-cyclopenta[a]naphthalen-9-yl)-pip- eridine-3-sulfonic acid cyanomethyl-amide; 6-Methyl-1-(7-methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-pi- peridine-3-sulfonic acid cyanomethyl-amide; 6-Methyl-1-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-piperidine-- 3-sulfonic acid cyanomethyl-amide; 6-Methyl-1-(3H-3,4,7-triaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-su- lfonic acid cyanomethyl-amide; 6-Methyl-1-(3H-3,4,8-triaza-cyclopenta[a]naphthalen-9-yl)-piperidine-3-su- lfonic acid cyanomethyl-amide; 9-[4-[[3-(pyrrolidin-1-ylmethyl)-1-piperidyl]sulfonylmethyl]-1-piperidyl]- -3H-pyrrolo[3,2-f][1,7]naphthyridine; 9-[4-[[3-(methoxymethyl) pyrrolidin-1-yl]sulfonylmethyl]-1-piperidyl]-3H-pyrrolo[3,2-f][1,7]naphth- yridine; 3-methyl-1-[[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-4-piperi- dyl]methylsulfonyl]pyrrolidin-3-ol; 9-[4-[(3-methoxy-1-piperidyl)sulfonylmethyl]-1-piperidyl]-3H-pyrrolo[3,2-- f][1,7]naphthyridine; [1-[[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-4-piperidyl]methylsulfon- yl]-3-piperidyl]methanesulfonamide; 9-[4-[(3-isobutoxy-1-piperidyl)sulfonylmethyl]-1-piperidyl]-3H-pyrrolo[3,- 2-f][1,7]naphthyridine; 9-[4-[[3-(2-methoxyethoxy)-1-piperidyl]sulfonylmethyl]-1-piperidyl]-3H-py- rrolo[3,2-f][1,7]naphthyridine; N-(cyclopropylmethyl)-1-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-4-pi- peridyl]methanesulfonamide; N-cyclobutyl-1-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-4-piperidyl]m- ethanesulfonamide; 9-[4-[[3-[(4-fluorophenoxy)methyl]-1-piperidyl]sulfonylmethyl]-1-piperidy- l]-3H-pyrrolo[3,2-f][1,7]naphthyridine; 9-[4-[[3-[(4-chlorophenoxy)methyl]-1-piperidyl]sulfonyl methyl]-1-piperidyl]-3H-pyrrolo[3,2-f][1,7]naphthyridine; 4-[[1-[[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-4-piperidyl]methylsul- fonyl]-3-piperidyl]methoxy]benzonitrile; 4-[[1-[[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-piperidyl]methylsul- fonyl]-3-piperidyl]methoxy]benzoic acid; 4-[[1-[[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-piperidyl]methylsul- fonyl]-3-piperidyl]methoxy]benzamide; 9-[4-[[3-[(2,4-difluorophenoxy)methyl]-1-piperidyl]sulfonyl methyl]-1-piperidyl]-3H-pyrrolo[3,2-f][1,7]naphthyridine; 9-[4-[[3-[(4-methoxyphenoxy)methyl]-1-piperidyl]sulfonyl methyl]-1-piperidyl]-3H-pyrrolo[3,2-f][1,7]naphthyridine; 9-[4-[[3-[[4-(trifluoromethoxy)phenoxy]methyl]-1-piperidyl]sulfonylmethyl- ]-1-piperidyl]-3H-pyrrolo[3,2-f][1,7]naphthyridine; 9-[4-[[3-[[4-(trifluoromethyl)phenoxy]methyl]-1-piperidyl]sulfonylmethyl]- -1-piperidyl]-3H-pyrrolo[3,2-f][1,7]naphthyridine; 9-[4-[(3-methyl-1-piperidyl)sulfonylmethyl]-1-piperidyl]-3H-pyrrolo[3,2-f- ][1,7]naphthyridine; 9-[4-[[3-(trifluoromethyl)-1-piperidyl]sulfonylmethyl]-1-piperidyl]-3H-py- rrolo[3,2-f][1,7]naphthyridine; 9-[4-[[3-(pyrrolidin-1-ylmethyl)-1-piperidyl]sulfonylmethyl]piperazin-1-y- l]-3H-pyrrolo[3,2-f][1,7]naphthyridine; 9-[4-[[3-(methoxymethyl) pyrrolidin-1-yl]sulfonylmethyl]piperazin-1-yl]-3H-pyrrolo[3,2-f][1,7]naph- thyridine; 3-methyl-1-[[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperaz- in-1-yl]methylsulfonyl]pyrrolidin-3-ol; 9-[4-[(3-methoxy-1-piperidyl)sulfonylmethyl]piperazin-1-yl]-3H-pyrrolo[3,- 2-f][1,7]naphthyridine; [1-[[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperazin-1-yl]methylsulf- onyl]-3-piperidyl]methanesulfonamide; 9-[4-[(3-isobutoxy-1-piperidyl)sulfonylmethyl]piperazin-1-yl]-3H-pyrrolo[- 3,2-f][1,7]naphthyridine; 9-[4-[[3-(2-methoxyethoxy)-1-piperidyl]sulfonylmethyl]piperazin-1-yl]-3H-- pyrrolo[3,2-f][1,7]naphthyridine; N-(cyclopropylmethyl)-1-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piper- azin-1-yl]methane sulfonamide; N-cyclobutyl-1-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperazin-1-yl- ]methanesulfonamide; 9-[4-[[3-[(4-fluorophenoxy)methyl]-1-piperidyl]sulfonylmethyl]piperazin-1- -yl]-3H-pyrrolo[3,2-f][1,7]naphthyridine; 9-[4-[[3-[(4-chlorophenoxy)methyl]-1-piperidyl]sulfonyl methyl]piperazin-1-yl]-3H-pyrrolo[3,2-f][1,7]naphthyridine; 4-[[1-[[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperazin-1-yl]methyls- ulfonyl]-3-piperidyl]methoxy]benzonitrile; 4-[[1-[[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperazin-1-yl]methyls- ulfonyl]-3-piperidyl]methoxy]benzoic acid; 4-[[1-[[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperazin-1-yl]methyls- ulfonyl]-3-piperidyl]methoxy]benzamide; 9-[4-[[3-[(2,4-difluorophenoxy)methyl]-1-piperidyl]sulfonylmethyl]piperaz- in-1-yl]-3H-pyrrolo[3,2-f][1,7]naphthyridine; 9-[4-[[3-[(4-methoxyphenoxy)methyl]-1-piperidyl]sulfonylmethyl]piperazin-- 1-yl]-3H-pyrrolo[3,2-f][1,7]naphthyridine; 9-[4-[[3-[[4-(trifluoromethoxy)phenoxy]methyl]-1-piperidyl]sulfonylmethyl- ]piperazin-1-yl]-3H-pyrrolo[3,2-f][1,7]naphthyridine; 9-[4-[[3-[[4-(trifluoromethyl)phenoxy]methyl]-1-piperidyl]sulfonylmethyl]- piperazin-1-yl]-3H-pyrrolo[3,2-f][1,7]naphthyridine; 9-[4-[(3-methyl-1-piperidyl)sulfonylmethyl]piperazin-1-yl]-3H-pyrrolo[3,2- -f][1,7]naphthyridine; 9-[4-[[3-(trifluoromethyl)-1-piperidyl]sulfonylmethyl]piperazin-1-yl]-3H-- pyrrolo[3,2-f][1,7]naphthyridine; 9-[1-[[3-(pyrrolidin-1-ylmethyl)-1-piperidyl]sulfonylmethyl]-4-piperidyl]- -3H-pyrrolo[3,2-f][1,7]naphthyridine; 9-[1-[ [3-(methoxymethyl) pyrrolidin-1-yl]sulfonylmethyl]-4-piperidyl]-3H-pyrrolo[3,2-f][1,7]naphth- yridine; 3-methyl-1-[[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-piperi- dyl]methylsulfonyl]pyrrolidin-3-ol; 9-[1-[(3-methoxy-1-piperidyl)sulfonylmethyl]-4-piperidyl]-3H-pyrrolo[3,2-- f][1,7]naphthyridine; [1-[[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-piperidyl]methylsulfon- yl]-3-piperidyl]methanesulfonamide; 9-[1-[(3-isobutoxy-1-piperidyl)sulfonylmethyl]-4-piperidyl]-3H-pyrrolo[3,- 2-f][1,7]naphthyridine; 9-[1-[[3-(2-methoxyethoxy)-1-piperidyl]sulfonylmethyl]-4-piperidyl]-3H-py- rrolo[3,2-f][1,7]naphthyridine; N-(cyclopropylmethyl)-1-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-pi- peridyl]methanesulfonamide; N-cyclobutyl-1-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-piperidyl]m- ethanesulfonamide; 9-[1-[[3-[(4-fluorophenoxy)methyl]-1-piperidyl]sulfonylmethyl]-4-piperidy- l]-3H-pyrrolo[3,2-f][1,7]naphthyridine; 9-[1-[[3-[(4-chlorophenoxy)methyl]-1-piperidyl]sulfonylmethyl]-4-piperidy- l]-3H-pyrrolo[3,2-f][1,7]naphthyridine; 4-[[1-[[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-piperidyl]methylsul- fonyl]-3-piperidyl]methoxy]benzonitrile; 4-[[1-[[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-piperidyl]methylsul- fonyl]-3-piperidyl]methoxy]benzoic acid; 4-[[1-[[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-piperidyl]methylsul- fonyl]-3-piperidyl]methoxy]benzamide; 9-[1-[[3-[(2,4-difluorophenoxy)methyl]-1-piperidyl]sulfonyl methyl]-4-piperidyl]-3H-pyrrolo[3,2-f][1,7]naphthyridine; 9-[1-[[3-[(4-methoxyphenoxy)methyl]-1-piperidyl]sulfonylmethyl]-4-piperid- yl]-3H-pyrrolo[3,2-f][1,7]naphthyridine; 9-[1-[[3-[[4-(trifluoromethoxy)phenoxy]methyl]-1-piperidyl]sulfonylmethyl- ]-4-piperidyl]-3H-pyrrolo[3,2-f][1,7]naphthyridine; 9-[1-[[3-[[4-(trifluoromethyl)phenoxy]methyl]-1-piperidyl]sulfonylmethyl]- -4-piperidyl]-3H-pyrrolo[3,2-f][1,7]naphthyridine; 9-[1-[(3-methyl-1-piperidyl)sulfonylmethyl]-4-piperidyl]-3H-pyrrolo[3,2-f- ][1,7]naphthyridine; 9-[1-[[3-(trifluoromethyl)-1-piperidyl]sulfonylmethyl]-4-piperidyl]-3H-py- rrolo[3,2-f][1,7]naphthyridine; 9-[4-[[3-(pyrrolidin-1-ylmethyl)-1-piperidyl]sulfonylmethyl]cyclohexyl]-3- H-pyrrolo[3,2-f][1,7]naphthyridine; 9-[4-[[3-(methoxymethyl)pyrrolidin-1-yl]sulfonylmethyl]cyclohexyl]-3H-pyr- rolo[3,2-f][1,7]naphthyridine; 3-methyl-1-[[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cyclohexyl]methyl- sulfonyl]pyrrolidin-3-ol; 9-[4-[(3-methoxy-1-piperidyl) sulfonyl methyl]cyclohexyl]-3H-pyrrolo[3,2-f][1,7]naphthyridine; [1-[[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cyclohexyl]methylsulfonyl- ]-3-piperidyl]methanesulfonamide 9-[4-[(3-isobutoxy-1-piperidyl)sulfonylmethyl]cyclohexyl]-3H-pyrrolo[3,2-- f][1,7]naphthyridine; 9-[4-[[3-(2-methoxyethoxy)-1-piperidyl]sulfonylmethyl]cyclohexyl]-3H-pyrr- olo[3,2-f][1,7]naphthyridine; N-(cyclopropylmethyl)-1-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cyclo- hexyl]methanesulfonamide; N-cyclobutyl-1-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cyclohexyl]met- hanesulfonamide; 9-[4-[[3-[(4-fluorophenoxy)methyl]-1-piperidyl]sulfonylmethyl]cyclohexyl]- -3H-pyrrolo[3,2-f][1,7]naphthyridine; 9-[4-[[3-[(4-chlorophenoxy)methyl]-1-piperidyl]sulfonylmethyl]cyclohexyl]- -3H-pyrrolo[3,2-f][1,7]naphthyridine; 4-[[1-[[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cyclohexyl]methylsulfo- nyl]-3-piperidyl]methoxy]benzonitrile; 4-[[1-[[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cyclohexyl]methylsulfo- nyl]-3-piperidyl]methoxy]benzoic acid; 4-[[1-[[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cyclohexyl]methylsulfo- nyl]-3-piperidyl]methoxy]benzamide; 9-[4-[[3-[(2,4-difluorophenoxy)methyl]-1-piperidyl]sulfonylmethyl]cyclohe- xyl]-3H-pyrrolo[3,2-f][1,7]naphthyridine; 9-[4-[[3-[(4-methoxyphenoxy)methyl]-1-piperidyl]sulfonylmethyl]cyclohexyl- ]-3H-pyrrolo[3,2-f][1,7]naphthyridine; 9-[4-[[3-[[4-(trifluoromethoxy)phenoxy]methyl]-1-piperidyl]sulfonylmethyl- ]cyclohexyl]-3H-pyrrolo[3,2-f][1,7]naphthyridine; 9-[4-[[3-[[4-(trifluoromethyl)phenoxy]methyl]-1-piperidyl]sulfonylmethyl]- cyclohexyl]-3H-pyrrolo[3,2-f][1,7]naphthyridine; 9-[4-[(3-methyl-1-piperidyl)sulfonyl methyl]cyclohexyl]-3H-pyrrolo[3,2-f][1,7]naphthyridine; 9-[4-[[3-(trifluoromethyl)-1-piperidyl]sulfonylmethyl]cyclohexyl]-3H-pyrr- olo[3,2-f][1,7]naphthyridine; 1-[3-(pyrrolidin-1-ylmethyl)-1-piperidyl]-2-[1-(3H-pyrrolo[3,2-f][1,7]nap- hthyridin-9-yl)-4-piperidyl]ethanone; 1-[3-(methoxymethyl)pyrrolidin-1-yl]-2-[1-(3H-pyrrolo[3,2-f][1,7]naphthyr- idin-9-yl)-4-piperidyl]ethanone; 1-(3-hydroxy-3-methyl-pyrrolidin-1-yl)-2-[ 1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-4-piperidyl]ethanone; 1-(3-methoxy-1-piperidyl)-2-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-- 4-piperidyl]ethanone; [1-[2-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-4-piperidyl]acetyl]-3-- piperidyl]methane sulfonamide; 1-(3-isobutoxy-1-piperidyl)-2-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl- )-4-piperidyl]ethanone; 1-[3-(2-methoxyethoxy)-1-piperidyl]-2-[1-(3H-pyrrolo[3,2-f][1,7]naphthyri- din-9-yl)-4-piperidyl]ethanone; N-(cyclopropylmethyl)-2-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-4-pi- peridyl]acetamide; N-cyclobutyl-2-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-4-piperidyl]a- cetamide; 1-[3-[(4-fluorophenoxy)methyl]-1-piperidyl]-2-[1-(3H-pyrrolo[3,2- -f][1,7]naphthyridin-9-yl)-4-piperidyl]ethanone; 1-[3-[(4-chlorophenoxy)methyl]-1-piperidyl]-2-[1-(3H-pyrrolo[3,2-f][1,7]n- aphthyridin-9-yl)-4-piperidyl]ethanone; 4-[[1-[2-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-4-piperidyl]acetyl]- -3-piperidyl]methoxy]benzonitrile; 4-[[1-[2-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-4-piperidyl]acetyl]- -3-piperidyl]methoxy]benzoic acid; 4-[[1-[2-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-4-piperidyl]acetyl]- -3-piperidyl]methoxy]benzamide; 1-[3-[(2,4-difluorophenoxy)methyl]-1-piperidyl]-2-[1-(3H-pyrrolo[3,2-f][1- ,7]naphthyridin-9-yl)-4-piperidyl]ethanone; 1-[3-[(4-methoxyphenoxy)methyl]-1-piperidyl]-2-[1-(3H-pyrrolo[3,2-f][1,7]- naphthyridin-9-yl)-4-piperidyl]ethanone; 2-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-4-piperidyl]-1-[3-[[4-(tri- fluoromethoxy)phenoxy]methyl]-1-piperidyl]ethanone; 2-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-4-piperidyl]-1-[3-[[4-(tri- fluoromethyl)phenoxy]methyl]-1-piperidyl]ethanone; 1-(3-methyl-1-piperidyl)-2-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-4- -piperidyl]ethanone; 2-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-4-piperidyl]-1-[3-(trifluo- romethyl)-1-piperidyl]ethanone; 1-[3-(pyrrolidin-1-ylmethyl)-1-piperidyl]-2-[4-(3H-pyrrolo[3,2-f][1,7]nap- hthyridin-9-yl)piperazin-1-yl]ethanone; 1-[3-(methoxymethyl)pyrrolidin-1-yl]-2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyr- idin-9-yl)piperazin-1-yl]ethanone; 1-(3-hydroxy-3-methyl-pyrrolidin-1-yl)-2-[4-(3H-pyrrolo[3,2-f][1,7]naphth- yridin-9-yl)piperazin-1-yl]ethanone; 1-(3-methoxy-1-piperidyl)-2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)p- iperazin-1-yl]ethanone; [1-[2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperazin-1-yl]acetyl]-- 3-piperidyl]methane sulfonamide; 1-(3-isobutoxy-1-piperidyl)-2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl- )piperazin-1-yl]ethanone; 1-[3-(2-methoxyethoxy)-1-piperidyl]-2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyri- din-9-yl)piperazin-1-yl]ethanone; N-(cyclopropylmethyl)-2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piper- azin-1-yl]acetamide; N-cyclobutyl-2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperazin-1-yl- ]acetamide; 1-[3-[(4-fluorophenoxy)methyl]-1-piperidyl]-2-[4-(3H-pyrrolo[3,2-f][1,7]n- aphthyridin-9-yl)piperazin-1-yl]ethanone; 1-[3-[(4-chlorophenoxy)methyl]-1-piperidyl]-2-[4-(3H-pyrrolo[3,2-f][1,7]n- aphthyridin-9-yl)piperazin-1-yl]ethanone; 4-[[1-[2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperazin-1-yl]acety- l]-3-piperidyl]methoxy]benzonitrile; 4-[[1-[2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperazin-1-yl]acety- l]-3-piperidyl]methoxy]benzoic acid; 4-[[1-[2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperazin-1-yl]acety- l]-3-piperidyl]methoxy]benzamide; 1-[3-[(2,4-difluorophenoxy)methyl]-1-piperidyl]-2-[4-(3H-pyrrolo[3,2-f][1- ,7]naphthyridin-9-yl)piperazin-1-yl]ethanone; 1-[3-[(4-methoxyphenoxy)methyl]-1-piperidyl]-2-[4-(3H-pyrrolo[3,2-f][1,7]- naphthyridin-9-yl)piperazin-1-yl]ethanone; 2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperazin-1-yl]-1-[3-[[4-(t- rifluoromethoxy)phenoxy]methyl]-1-piperidyl]ethanone; 2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperazin-1-yl]-1-[3-[[4-(t- rifluoromethyl)phenoxy]methyl]-1-piperidyl]ethanone; 1-(3-methyl-1-piperidyl)-2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)pi- perazin-1-yl]ethanone; 2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperazin-1-yl]-1-[3-(trifl- uoromethyl)-1-piperidyl]ethanone; 1-[3-(pyrrolidin-1-ylmethyl)-1-piperidyl]-2-[4-(3H-pyrrolo[3,2-f][1,7]nap- hthyridin-9-yl)-1-piperidyl]ethanone; 1-[3-(methoxymethyl)pyrrolidin-1-yl]-2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyr- idin-9-yl)-1-piperidyl]ethanone; 1-(3-hydroxy-3-methyl-pyrrolidin-1-yl)-2-[4-(3H-pyrrolo[3,2-f][1,7]naphth- yridin-9-yl)-1-piperidyl]ethanone; 1-(3-methoxy-1-piperidyl)-2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-- 1-piperidyl]ethanone; [1-[2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-piperidyl]acetyl]-3-- piperidyl]methane sulfonamide; 1-(3-isobutoxy-1-piperidyl)-2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl- )-1-piperidyl]ethanone; 1-[3-(2-methoxyethoxy)-1-piperidyl]-2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyri- din-9-yl)-1-piperidyl]ethanone; N-(cyclopropylmethyl)-2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-pi- peridyl]acetamide N-cyclobutyl-2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-piperidyl]a- cetamide; 1-[3-[(4-fluorophenoxy)methyl]-1-piperidyl]-2-[4-(3H-pyrrolo[3,2- -f][1,7]naphthyridin-9-yl)-1-piperidyl]ethanone; 1-[3-[(4-chlorophenoxy)methyl]-1-piperidyl]-2-[4-(3H-pyrrolo[3,2-f][1,7]n- aphthyridin-9-yl)-1-piperidyl]ethanone; 4-[[1-[2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-piperidyl]acetyl]- -3-piperidyl]methoxy]benzonitrile; 4-[[1-[2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-piperidyl]acetyl]- -3-piperidyl]methoxy]benzoic acid; 4-[[1-[2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-piperidyl]acetyl]- -3-piperidyl]methoxy]benzamide; 1-[3-[(2,4-difluorophenoxy)methyl]-1-piperidyl]-2-[4-(3H-pyrrolo[3,2-f][1- ,7]naphthyridin-9-yl)-1-piperidyl]ethanone; 1-[3-[(4-methoxyphenoxy)methyl]-1-piperidyl]-2-[4-(3H-pyrrolo[3,2-f][1,7]- naphthyridin-9-yl)-1-piperidyl]ethanone; 2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-piperidyl]-1-[3-[[4-(tri- fluoromethoxy)phenoxy]methyl]-1-piperidyl]ethanone; 2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-piperidyl]-1-[3-[[4-(tri- fluoromethyl)phenoxy]methyl]-1-piperidyl]ethanone; 1-(3-methyl-1-piperidyl)-2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1- -piperidyl]ethanone; 2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-piperidyl]-1-[3-(trifluo- romethyl)-1-piperidyl]ethanone; 1-[3-(pyrrolidin-1-ylmethyl)-1-piperidyl]-2-[4-(3H-pyrrolo[3,2-f][1,7]nap- hthyridin-9-yl)cyclohexyl]ethanone; 1-[3-(methoxymethyl)pyrrolidin-1-yl]-2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyr- idin-9-yl)cyclohexyl]ethanone; 1-(3-hydroxy-3-methyl-pyrrolidin-1-yl)-2-[4-(3H-pyrrolo[3,2-f][1,7]naphth- yridin-9-yl)cyclohexyl]ethanone; 1-(3-methoxy-1-piperidyl)-2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)c- yclohexyl]ethanone; [1-[2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cyclohexyl]acetyl]-3-pi- peridyl]methane sulfonamide; 1-(3-isobutoxy-1-piperidyl)-2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl- )cyclohexyl]ethanone; 1-[3-(2-methoxyethoxy)-1-piperidyl]-2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyri- din-9-yl)cyclohexyl]ethanone; N-(cyclopropylmethyl)-2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cyclo- hexyl]acetamide; N-cyclobutyl-2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cyclohexyl]ace- tamide; 1-[3-[(4-fluorophenoxy)methyl]-1-piperidyl]-2-[4-(3H-pyrrolo[3,2-f- ][1,7]naphthyridin-9-yl)cyclohexyl]ethanone; 1-[3-[(4-chlorophenoxy)methyl]-1-piperidyl]-2-[4-(3H-pyrrolo[3,2-f][1,7]n- aphthyridin-9-yl)cyclohexyl]ethanone; 4-[[1-[2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cyclohexyl]acetyl]-3- -piperidyl]methoxy]benzonitrile 4-[[1-[2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cyclohexyl]acetyl]-3- -piperidyl]methoxy]benzoic acid; 4-[[1-[2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cyclohexyl]acetyl]-3- -piperidyl]methoxy]benzamide; 1-[3-[(2,4-difluorophenoxy)methyl]-1-piperidyl]-2-[4-(3H-pyrrolo[3,2-f][1- ,7]naphthyridin-9-yl)cyclohexyl]ethanone; 1-[3-[(4-methoxyphenoxy)methyl]-1-piperidyl]-2-[4-(3H-pyrrolo[3,2-f][1,7]- naphthyridin-9-yl)cyclohexyl]ethanone; 2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cyclohexyl]-1-[3-[[4-(trifl- uoromethoxy)phenoxy]methyl]-1-piperidyl]ethanone; 2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cyclohexyl]-1-[3-[[4-(trifl- uoromethyl)phenoxy]methyl]-1-piperidyl]ethanone; 1-(3-methyl-1-piperidyl)-2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cy- clohexyl]ethanone; 2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cyclohexyl]-1-[3-(trifluoro- methyl)-1-piperidyl]ethanone; 3-(pyrrolidin-1-ylmethyl)-N-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-- 4-piperidyl]piperidine-1-carboxamide; 3-(methoxymethyl)-N-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-4-piperi- dyl]pyrrolidine-1-carboxamide; 3-hydroxy-3-methyl-N-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-4-piper- idyl]pyrrolidine-1-carboxamide; 3-methoxy-N-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-4-piperidyl]pipe- ridine-1-carboxamide; N-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-4-piperidyl]-3-(sulfamoylm- ethyl)piperidine-1-carboxamide; 3-isobutoxy-N-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-4-piperidyl]pi- peridine-1-carboxamide; 3-(2-methoxyethoxy)-N-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-4-pipe- ridyl]piperidine-1-carboxamide; 1-(cyclopropylmethyl)-3-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-4-pi- peridyl]urea; 1-cyclobutyl-3-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-4-piperidyl]u- rea; 3-[(4-fluorophenoxy)methyl]-N-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-- 9-yl)-4-piperidyl]piperidine-1-carboxamide; 3-[(4-chlorophenoxy)methyl]-N-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl- )-4-piperidyl]piperidine-1-carboxamide; 3-[(4-cyanophenoxy)methyl]-N-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)- -4-piperidyl]piperidine-1-carboxamide; 4-[[1-[[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-4-piperidyl]carbamoyl- ]-3-piperidyl]methoxy]benzoic acid; 3-[(4-carbamoylphenoxy)methyl]-N-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9- -yl)-4-piperidyl]piperidine-1-carboxamide; 3-[(2,4-difluorophenoxy)methyl]-N-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-- 9-yl)-4-piperidyl]piperidine-1-carboxamide; 3-[(4-methoxyphenoxy)methyl]-N-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-y- l)-4-piperidyl]piperidine-1-carboxamide; N-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-4-piperidyl]-3-[[4-(triflu- oromethoxy)phenoxy]methyl]piperidine-1-carboxamide; N-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-4-piperidyl]-3-[[4-(triflu- oromethyl)phenoxy]methyl]piperidine-1-carboxamide; 3-methyl-N-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-4-piperidyl]piper- idine-1-carboxamide; N-[1-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-4-piperidyl]-3-(trifluorom- ethyl)piperidine-1-carboxamide; [3-(pyrrolidin-1-ylmethyl)-1-piperidyl]-[4-(3H-pyrrolo[3,2-f][1,7]naphthy- ridin-9-yl)piperazin-1-yl]methanone; [3-(methoxymethyl)pyrrolidin-1-yl]-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin- -9-yl)piperazin-1-yl]methanone; (3-hydroxy-3-methyl-pyrrolidin-1-yl)-[4-(3H-pyrrolo[3,2-f][1,7]naphthyrid- in-9-yl)piperazin-1-yl]methanone; (3-methoxy-1-piperidyl)-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piper- azin-1-yl]methanone; [1-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperazine-1-carbonyl]-3-p- iperidyl]methane sulfonamide; (3-isobutoxy-1-piperidyl)-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)pip- erazin-1-yl]methanone; [3-(2-methoxyethoxy)-1-piperidyl]-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-- 9-yl)piperazin-1-yl]methanone; N-(cyclopropylmethyl)-4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperazi- ne-1-carboxamide; N-cyclobutyl-4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperazine-1-carb- oxamide; [3-[(4-fluorophenoxy)methyl]-1-piperidyl]-[4-(3H-pyrrolo[3,2-f][1- ,7]naphthyridin-9-yl)piperazin-1-yl]methanone; [3-[(4-chlorophenoxy)methyl]-1-piperidyl]-[4-(3H-pyrrolo[3,2-f][1,7]napht- hyridin-9-yl)piperazin-1-yl]methanone; 4-[[1-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperazine-1-carbonyl]-- 3-piperidyl]methoxy]benzonitrile; 4-[[1-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperazine-1-carbonyl]-- 3-piperidyl]methoxy]benzoic acid; 4-[[1-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperazine-1-carbonyl]-- 3-piperidyl]methoxy]benzamide; [3-[(2,4-difluorophenoxy)methyl]-1-piperidyl]-[4-(3H-pyrrolo[3,2-f][1,7]n- aphthyridin-9-yl)piperazin-1-yl]methanone; [3-[(4-methoxyphenoxy)methyl]-1-piperidyl]-[4-(3H-pyrrolo[3,2-f][1,7]naph- thyridin-9-yl)piperazin-1-yl]methanone; [4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-piperidyl]-[3-[[4-(trifluo- romethoxy)phenoxy]methyl]-1-piperidyl]methanone; [4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperazin-1-yl]-[3-[[4-(trifl- uoromethyl) phenoxy]methyl]-1-piperidyl]methanone; (3-methyl-1-piperidyl)-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)pipera- zin-1-yl]methanone; [4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperazin-1-yl]-[3-(trifluoro- methyl)-1-piperidyl]methanone; [3-(pyrrolidin-1-ylmethyl)-1-piperidyl]-[4-(3H-pyrrolo[3,2-f][1,7]naphthy- ridin-9-yl)-1-piperidyl]methanone; [3-(methoxymethyl)pyrrolidin-1-yl]-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin- -9-yl)-1-piperidyl]methanone; (3-hydroxy-3-methyl-pyrrolidin-1-yl)-[4-(3H-pyrrolo[3,2-f][1,7]naphthyrid- in-9-yl)-1-piperidyl]methanone (3-methoxy-1-piperidyl)-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-pi- peridyl]methanone; [1-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperidine-1-carbonyl]-3-p- iperidyl]methane sulfonamide; (3-isobutoxy-1-piperidyl)-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-- piperidyl]methanone; [3-(2-methoxyethoxy)-1-piperidyl]-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-- 9-yl)-1-piperidyl]methanone; N-(cyclopropylmethyl)-4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperidi- ne-1-carboxamide; N-cyclobutyl-4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperidine-1-carb- oxamide; [3-[(4-fluorophenoxy)methyl]-1-piperidyl]-[4-(3H-pyrrolo[3,2-f][1- ,7]naphthyridin-9-yl)-1-piperidyl]methanone; [3-[(4-chlorophenoxy)methyl]-1-piperidyl]-[4-(3H-pyrrolo[3,2-f][1,7]napht- hyridin-9-yl)-1-piperidyl]methanone; 4-[[1-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperidine-1-carbonyl]-- 3-piperidyl]methoxy]benzonitrile; 4-[[1-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperidine-1-carbonyl]-- 3-piperidyl]methoxy]benzoic acid; 4-[[1-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)piperidine-1-carbonyl]-- 3-piperidyl]methoxy]benzamide; [3-[(2,4-difluorophenoxy)methyl]-1-piperidyl]-[4-(3H-pyrrolo[3,2-f][1,7]n- aphthyridin-9-yl)-1-piperidyl]methanone; [3-[(4-methoxyphenoxy)methyl]-1-piperidyl]-[4-(3H-pyrrolo[3,2-f][1,7]naph- thyridin-9-yl)-1-piperidyl]methanone; [4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-piperidyl]-[3-[[4-(trifluo- romethoxy)phenoxy]methyl]-1-piperidyl]methanone; [4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-piperidyl]-[[3-[4-(trifluo- romethyl)phenoxy]methyl]-1-piperidyl]methanone; (3-methyl-1-piperidyl)-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-pip- eridyl]methanone; [4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)-1-piperidyl]-[3-(trifluorome- thyl)-1-piperidyl]methanone; 3-(pyrrolidin-1-ylmethyl)-N-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)c- yclohexyl]piperidine-1-carboxamide; 3-(methoxymethyl)-N-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cyclohexy- l]pyrrolidine-1-carboxamide; 3-hydroxy-3-methyl-N-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cyclohex- yl]pyrrolidine-1-carboxamide; 3-methoxy-N-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cyclohexyl]piperi- dine-1-carboxamide; N-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cyclohexyl]-3-(sulfamoylmet- hyl)piperidine-1-carboxamide; 3-isobutoxy-N-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cyclohexyl]pipe- ridine-1-carboxamide; 3-(2-methoxyethoxy)-N-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cyclohe- xyl]piperidine-1-carboxamide; 1-(cyclopropylmethyl)-3-[4(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cycloh- exyl]urea; 1-cyclobutyl-3-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cycl- ohexyl]urea; 3-[(4-fluorophenoxy)methyl]-N-[4(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)- cyclohexyl]piperidine-1-carboxamide; 3-[(4-chlorophenoxy)methyl]-N-[4(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)- cyclohexyl]piperidine-1-carboxamide; 3-[(4-cyanophenoxy)methyl]-N-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)- cyclohexyl]piperidine-1-carboxamide; 4-[[1-[[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cyclohexyl]carbamoyl]-- 3-piperidyl]methoxy]benzoic acid; 3-[(4-carbamoylphenoxy)methyl]-N-[4(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-- yl)cyclohexyl]piperidine-1-carboxamide; 3-[(2,4-difluorophenoxy)methyl]-N-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-- 9-yl)cyclohexyl]piperidine-1-carboxamide; 3-[(4-methoxyphenoxy)methyl]-N-[4(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl- )cyclohexyl]piperidine-1-carboxamide; N-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cyclohexyl]-3-[[4-(trifluor- omethoxy)phenoxy]methyl]piperidine-1-carboxamide; N-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cyclohexyl]-3-[[4-(trifluor- omethyl)phenoxy]methyl]piperidine-1-carboxamide; 3-methyl-N-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cyclohexyl]piperid- ine-1-carboxamide; N-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cyclohexyl]-3-(trifluoromet- hyl)piperidine-1-carboxamide; 9-[4-[[3-(pyrrolidin-1-ylmethyl)-1-piperidyl]methylsulfonyl]cyclohexyl]-3- H-pyrrolo[3,2-f][1,7]naphthyridine; 9-[4-[[3-(methoxymethyl) pyrrolidin-1-yl]methylsulfonyl]cyclohexyl]-3H-pyrrolo[3,2-f][1,7]naphthyr- idine; 3-methyl-1-[[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cyclohexyl]- sulfonylmethyl]pyrrolidin-3-ol; 9-[4-[(3-methoxy-1-piperidyl)methylsulfonyl]cyclohexyl]-3H-pyrrolo[3,2-f]- [1,7]naphthyridine; [1-[[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cyclohexyl]sulfonylmethyl- ]-3-piperidyl]methanesulfonamide; 9-[4-[(3-isobutoxy-1-piperidyl)methylsulfonyl]cyclohexyl]-3H-pyrrolo[3,2-- f][1,7]naphthyridine; 9-[4-[[3-(2-methoxyethoxy)-1-piperidyl]methylsulfonyl]cyclohexyl]-3H-pyrr- olo[3,2-f][1,7]naphthyridine; 1-cyclopropyl-N-[[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cyclohexyl]s- ulfonylmethyl]methanamine; N-[[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cyclohexyl]sulfonylmethyl]- cyclobutanamine; 9-[4-[[3-[(4-fluorophenoxy)methyl]-1-piperidyl]methylsulfonyl]cyclohexyl]- -3H-pyrrolo[3,2-f][1,7]naphthyridine; 9-[4-[[3-[(4-chlorophenoxy)methyl]-1-piperidyl]methylsulfonyl]cyclohexyl]- -3H-pyrrolo[3,2-f][1,7]naphthyridine; 4-[[3-[[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cyclohexyl]sulfonylmet- hyl]cyclohexyl]methoxy]benzonitrile; 4-[[3-[[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cyclohexyl]sulfonylmet- hyl]cyclohexyl]methoxy]benzoic acid; 4-[[3-[[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cyclohexyl]sulfonylmet- hyl]cyclohexyl]methoxy]benzamide; 9-[4-[[3-[(2,4-difluorophenoxy)methyl]-1-piperidyl]methylsulfonyl]cyclohe- xyl]-3H-pyrrolo[3,2-f][1,7]naphthyridine; 9-[4-[[3-[(4-methoxyphenoxy)methyl]-1-piperidyl]methylsulfonyl]cyclohexyl- ]-3H-pyrrolo[3,2-f][1,7]naphthyridine; 9-[4-[[3-[[4-(trifluoromethoxy)phenoxy]methyl]-1-piperidyl]methylsulfonyl- ]cyclohexyl]-3H-pyrrolo[3,2-f][1,7]naphthyridine; 9-[4-[[3-[[4-(trifluoromethyl)phenoxy]methyl]-1-piperidyl]methylsulfonyl]- cyclohexyl]-3H-pyrrolo[3,2-f][1,7]naphthyridine; 9-[4-[(3-methyl-1-piperidyl)methylsulfonyl]cyclohexyl]-3H-pyrrolo[3,2-f][- 1,7]naphthyridine; 9-[4-[[3-(trifluoromethyl)-1-piperidyl]methylsulfonyl]cyclohexyl]-3H-pyrr- olo[3,2-f][1,7]naphthyridine; 2-[3-(pyrrolidin-1-ylmethyl)-1-piperidyl]-1-[4-(3H-pyrrolo[3,2-f][1,7]nap- hthyridin-9-yl)cyclohexyl]ethanone; 2-[3-(methoxymethyl)pyrrolidin-1-yl]-1-[4-(3H-pyrrolo[3,2-f][1,7]naphthyr- idin-9-yl)cyclohexyl]ethanone; 2-(3-hydroxy-3-methyl-pyrrolidin-1-yl)-1-[4-(3H-pyrrolo[3,2-f][1,7]naphth- yridin-9-yl)cyclohexyl]ethanone; 2-(3-methoxy-1-piperidyl)-1-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)c- yclohexyl]ethanone; [1-[2-oxo-2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cyclohexyl]ethyl]- -3-piperidyl]methane sulfonamide; 2-(3-isobutoxy-1-piperidyl)-1-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl- )cyclohexyl]ethanone; 2-[3-(2-methoxyethoxy)-1-piperidyl]-1-[4-(3H-pyrrolo[3,2-f][1,7]naphthyri- din-9-yl)cyclohexyl]ethanone; 2-(cyclopropylmethylamino)-1-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)- cyclohexyl]ethanone; 2-(cyclobutylamino)-1-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cyclohe- xyl]ethanone; 2-[3-[(4-fluorophenoxy)methyl]-1-piperidyl]-1-[4-(3H-pyrrolo[3,2-f][1,7]n- aphthyridin-9-yl)cyclohexyl]ethanone; 2-[3-[(4-chlorophenoxy)methyl]-1-piperidyl]-1-[4-(3H-pyrrolo[3,2-f][1,7]n- aphthyridin-9-yl)cyclohexyl]ethanone; 4-[[3-[2-oxo-2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cyclohexyl]eth- yl]cyclohexyl]methoxy]benzonitrile; 4-[[3-[2-oxo-2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cyclohexyl]eth- yl]cyclohexyl]methoxy]benzoic acid; 4-[[3-[2-oxo-2-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cyclohexyl]eth- yl]cyclohexyl]methoxy]benzamide; 2-[3-[(2,4-difluorophenoxy)methyl]-1-piperidyl]-1-[4-(3H-pyrrolo[3,2-f][1- ,7]naphthyridin-9-yl)cyclohexyl]ethanone; 2-[3-[(4-methoxyphenoxy)methyl]-1-piperidyl]-1-[4-(3H-pyrrolo[3,2-f][1,7]- naphthyridin-9-yl)cyclohexyl]ethanone; 1-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cyclohexyl]-2-[3-[[4-(trifl- uoromethoxy)phenoxy]methyl]-1-piperidyl]ethanone; 1-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cyclohexyl]-2-[3-[[4-(trifl- uoromethyl)phenoxy]methyl]-1-piperidyl]ethanone; 2-(3-methyl-1-piperidyl)-1-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cy- clohexyl]ethanone; 1-[4-(3H-pyrrolo[3,2-f][1,7]naphthyridin-9-yl)cyclohexyl]-2-[3-(trifluoro- methyl)-1-piperidyl]ethanone; 9-{4-[3-(4-Fluoro-phenoxymethyl)-piperidine-1-sulfonylmethyl]-cyclohexyl}- -3H-3,4,6,7-tetraaza-cyclopenta[a]naphthalene; 9-{4-[3-(4-Chloro-phenoxymethyl)-piperidine-1-sulfonylmethyl]-cyclohexyl}- -3H-3,4,6,7-tetraaza-cyclopenta[a]naphthalene; 4-{1-[4-(3H-3,4,6,7-Tetraaza-cyclopenta[a]naphthalen-9-yl)-cyclohexylmeth- anesulfonyl]-piperidin-3-ylmethoxy}-benzonitrile; 4-{1-[4-(3H-3,4,6,7-Tetraaza-cyclopenta[a]naphthalen-9-yl)-cyclohexylmeth- anesulfonyl]-piperidin-3-ylmethoxy}-benzoic acid; 4-{1-[4-(3H-3,4,6,7-Tetraaza-cyclopenta[a]naphthalen-9-yl)-cyclohexylmeth- anesulfonyl]-piperidin-3-ylmethoxy}-benzamide; 9-[4-(3-Pyrrolidin-1-ylmethyl-piperidine-1-sulfonylmethyl)-cyclohexyl]-3H- -3,4,6,7-tetraaza-cyclopenta[a]naphthalene; 9-[4-(3-Methoxymethyl-pyrrolidine-1-sulfonylmethyl)-cyclohexyl]-3H-3,4,6,- 7-tetraaza-cyclopenta[a]naphthalene; 3-Methyl-1-[4-(3H-3,4,6,7-tetraaza-cyclopenta[a]naphthalen-9-yl)-cyclohex- ylmethanesulfonyl]-pyrrolidin-3-ol; 9-[4-(3-Methoxy-piperidine-1-sulfonylmethyl)-cyclohexyl]-3H-3,4,6,7-tetra- aza-cyclopenta[a]naphthalene; {1-[4-(3H-3,4,6,7-Tetraaza-cyclopenta[a]naphthalen-9-yl)-cyclohexylmethan- esulfonyl]-piperidin-3-yl}-methanesulfonamide; 9-[4-(3-Isobutoxy-piperidine-1-sulfonylmethyl)-cyclohexyl]-3H-3,4,6,7-tet- raaza-cyclopenta[a]naphthalene; 9-{4-[3-(2-Methoxy-ethoxy)-piperidine-1-sulfonylmethyl]-cyclohexyl}-3H-3,- 4,6,7-tetraaza-cyclopenta[a]naphthalene; N-Cyclopropylmethyl-C-[4-(3H-3,4,6,7-tetraaza-cyclopenta[a]naphthalen-9-y- l)-cyclohexyl]-methanesulfonamide; N-Cyclobutyl-C-[4-(3H-3,4,6,7-tetraaza-cyclopenta[a]naphthalen-9-yl)-cycl- ohexyl]-methanesulfonamide 9-{4-[3-(2,4-Difluoro-phenoxymethyl)-piperidine-1-sulfonylmethyl]-cyclohe- xyl}-3H-3,4,6,7-tetraaza-cyclopenta[a]naphthalene; 9-{4-[3-(4-Methoxy-phenoxymethyl)-piperidine-1-sulfonylmethyl]-cyclohexyl- }-3H-3,4,6,7-tetraaza-cyclopenta[a]naphthalene; 9-{4-[3-(4-Trifluoromethoxy-phenoxymethyl)-piperidine-1-sulfonylmethyl]-c- yclohexyl}-3H-3,4,6,7-tetraaza-cyclopenta[a]naphthalene; 9-{4-[3-(4-Trifluoromethyl-phenoxymethyl)-piperidine-1-sulfonylmethyl]-cy- clohexyl}-3H-3,4,6,7-tetraaza-cyclopenta[a]naphthalene; 9-[4-(3-Methyl-piperidine-1-sulfonylmethyl)-cyclohexyl]-3H-3,4,6,7-tetraa- za-cyclopenta[a]naphthalene; 9-[4-(3-Trifluoromethyl-piperidine-1-sulfonylmethyl)-cyclohexyl]-3H-3,4,6- ,7-tetraaza-cyclopenta[a]naphthalene; 9-{4-[3-(4-Fluoro-phenoxymethyl)-piperidine-1-sulfonylmethyl]-cyclohexyl}- -3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalene; 9-{4-[3-(4-Chloro-phenoxymethyl)-piperidine-1-sulfonylmethyl]-cyclohexyl}- -3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalene; 4-{1-[4-(3H-3,4,6,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-cyclohexylmeth- anesulfonyl]-piperidin-3-ylmethoxy}-benzonitrile; 4-{1-[4-(3H-3,4,6,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-cyclohexylmeth- anesulfonyl]-piperidin-3-ylmethoxy}-benzoic acid; 4-{1-[4-(3H-3,4,6,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-cyclohexylmeth- anesulfonyl]-piperidin-3-ylmethoxy}-benzamide; 9-[4-(3-Pyrrolidin-1-ylmethyl-piperidine-1-sulfonylmethyl)-cyclohexyl]-3H- -3,4,6,8-tetraaza-cyclopenta[a]naphthalene; 9-[4-(3-Methoxymethyl-pyrrolidine-1-sulfonylmethyl)-cyclohexyl]-3H-3,4,6,- 8-tetraaza-cyclopenta[a]naphthalene; 3-Methyl-1-[4-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-cyclohex- ylmethanesulfonyl]-pyrrolidin-3-ol; 9-[4-(3-Methoxy-piperidine-1-sulfonylmethyl)-cyclohexyl]-3H-3,4,6,8-tetra- aza-cyclopenta[a]naphthalene; {1-[4-(3H-3,4,6,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-cyclohexylmethan- esulfonyl]-piperidin-3-yl}-methanesulfonamide; 9-[4-(3-Isobutoxy-piperidine-1-sulfonylmethyl)-cyclohexyl]-3H-3,4,6,8-tet- raaza-cyclopenta[a]naphthalene; 9-{4-[3-(2-Methoxy-ethoxy)-piperidine-1-sulfonylmethyl]-cyclohexyl}-3H-3,- 4,6,8-tetraaza-cyclopenta[a]naphthalene; N-Cyclopropylmethyl-C-[4-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-y- l)-cyclohexyl]-methanesulfonamide; N-Cyclobutyl-C-[4-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-cycl- ohexyl]-methanesulfonamide; 9-{4-[3-(2,4-Difluoro-phenoxymethyl)-piperidine-1-sulfonylmethyl]-cyclohe- xyl}-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalene; 9-{4-[3-(4-Methoxy-phenoxymethyl)-piperidine-1-sulfonylmethyl]-cyclohexyl- }-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalene; 9-{4-[3-(4-Trifluoromethoxy-phenoxymethyl)-piperidine-1-sulfonylmethyl]-c- yclohexyl}-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalene; 9-{4-[3-(4-Trifluoromethyl-phenoxymethyl)-piperidine-1-sulfonylmethyl]-cy- clohexyl}-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalene; 9-[4-(3-Methyl-piperidine-1-sulfonylmethyl)-cyclohexyl]-3H-3,4,6,8-tetraa- za-cyclopenta[a]naphthalene; 9-[4-(3-Trifluoromethyl-piperidine-1-sulfonylmethyl)-cyclohexyl]-3H-3,4,6- ,8-tetraaza-cyclopenta[a]naphthalene; 9-{4-[3-(4-Fluoro-phenoxymethyl)-piperidine-1-sulfonylmethyl]-cyclohexyl}- -7-methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalene; 9-{4-[3-(4-Chloro-phenoxymethyl)-piperidine-1-sulfonylmethyl]-cyclohexyl}- -7-methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalene; 4-{1-[4-(7-Methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-cyclo- hexylmethanesulfonyl]-piperidin-3-ylmethoxy}-benzonitrile; 4-{1-[4-(7-Methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-cyclo- hexylmethanesulfonyl]-piperidin-3-ylmethoxy}-benzoic acid; 4-{1-[4-(7-Methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-cyclo- hexylmethanesulfonyl]-piperidin-3-ylmethoxy}-benzamide; 7-Methyl-9-[4-(3-pyrrolidin-1-ylmethyl-piperidine-1-sulfonylmethyl)-cyclo- hexyl]-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalene; 9-[4-(3-Methoxymethyl-pyrrolidine-1-sulfonylmethyl)-cyclohexyl]-7-methyl-- 3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalene; 3-Methyl-1-[4-(7-methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)- -cyclohexylmethanesulfonyl]-pyrrolidin-3-ol; 9-[4-(3-Methoxy-piperidine-1-sulfonylmethyl)-cyclohexyl]-7-methyl-3H-3,4,- 6,8-tetraaza-cyclopenta[a]naphthalene; {1-[4-(7-Methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-cyclohe- xylmethanesulfonyl]-piperidin-3-yl}-methanesulfonamide; 9-[4-(3-Isobutoxy-piperidine-1-sulfonylmethyl)-cyclohexyl]-7-methyl-3H-3,- 4,6,8-tetraaza-cyclopenta[a]naphthalene; 9-{4-[3-(2-Methoxy-ethoxy)-piperidine-1-sulfonylmethyl]-cyclohexyl}-7-met- hyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalene; N-Cyclopropylmethyl-C-[4-(7-methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]napht- halen-9-yl)-cyclohexyl]-methanesulfonamide; N-Cyclobutyl-C-[4-(7-methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9- -yl)-cyclohexyl]-methanesulfonamide; 9-{4-[3-(2,4-Difluoro-phenoxymethyl)-piperidine-1-sulfonylmethyl]-cyclohe- xyl}-7-methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalene; 9-{4-[3-(4-Methoxy-phenoxymethyl)-piperidine-1-sulfonylmethyl]-cyclohexyl- }-7-methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalene; 7-Methyl-9-{4-[3-(4-trifluoromethoxy-phenoxymethyl)-piperidine-1-sulfonyl- methyl]-cyclohexyl}-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalene; 7-Methyl-9-{4-[3-(4-trifluoromethyl-phenoxymethyl)-piperidine-1-sulfonylm- ethyl]-cyclohexyl}-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalene; 7-Methyl-9-[4-(3-methyl-piperidine-1-sulfonylmethyl)-cyclohexyl]-3H-3,4,6- ,8-tetraaza-cyclopenta[a]naphthalene; 7-Methyl-9-[4-(3-trifluoromethyl-piperidine-1-sulfonylmethyl)-cyclohexyl]- -3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalene; 9-{4-[3-(4-Fluoro-phenoxymethyl)-piperidine-1-sulfonylmethyl]-cyclohexyl}- -3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalene; 9-{4-[3-(4-Chloro-phenoxymethyl)-piperidine-1-sulfonylmethyl]-cyclohexyl}- -3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalene; 4-{1-[4-(3H-3,4,7,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-cyclohexylmeth- anesulfonyl]-piperidin-3-ylmethoxy}-benzonitrile; 4-{1-[4-(3H-3,4,7,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-cyclohexylmeth- anesulfonyl]-piperidin-3-ylmethoxy}-benzoic acid; 4-{1-[4-(3H-3,4,7,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-cyclohexylmeth- anesulfonyl]-piperidin-3-ylmethoxy}-benzamide; 9-[4-(3-Pyrrolidin-1-ylmethyl-piperidine-1-sulfonylmethyl)-cyclohexyl]-3H- -3,4,7,8-tetraaza-cyclopenta[a]naphthalene; 9-[4-(3-Methoxymethyl-pyrrolidine-1-sulfonylmethyl)-cyclohexyl]-3H-3,4,7,- 8-tetraaza-cyclopenta[a]naphthalene; 3-Methyl-1-[4-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-cyclohex- ylmethanesulfonyl]-pyrrolidin-3-ol; 9-[4-(3-Methoxy-piperidine-1-sulfonylmethyl)-cyclohexyl]-3H-3,4,7,8-tetra- aza-cyclopenta[a]naphthalene; {1-[4-(3H-3,4,7,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-cyclohexylmethan- esulfonyl]-piperidin-3-yl}-methanesulfonamide; 9-[4-(3-Isobutoxy-piperidine-1-sulfonylmethyl)-cyclohexyl]-3H-3,4,7,8-tet- raaza-cyclopenta[a]naphthalene; 9-{4-[3-(2-Methoxy-ethoxy)-piperidine-1-sulfonylmethyl]-cyclohexyl}-3H-3,- 4,7,8-tetraaza-cyclopenta[a]naphthalene; N-Cyclopropylmethyl-C-[4-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalen-9-y- l)-cyclohexyl]-methanesulfonamide; N-Cyclobutyl-C-[4-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-cycl- ohexyl]-methanesulfonamide; 9-{4-[3-(2,4-Difluoro-phenoxymethyl)-piperidine-1-sulfonylmethyl]-cyclohe- xyl}-3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalene; 9-{4-[3-(4-Methoxy-phenoxymethyl)-piperidine-1-sulfonylmethyl]-cyclohexyl- }-3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalene; 9-{4-[3-(4-Trifluoromethoxy-phenoxymethyl)-piperidine-1-sulfonylmethyl]-c- yclohexyl}-3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalene; 9-{4-[3-(4-Trifluoromethyl-phenoxymethyl)-piperidine-1-sulfonylmethyl]-cy- clohexyl}-3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalene; 9-[4-(3-Methyl-piperidine-1-sulfonylmethyl)-cyclohexyl]-3H-3,4,7,8-tetraa- za-cyclopenta[a]naphthalene; 9-[4-(3-Trifluoromethyl-piperidine-1-sulfonylmethyl)-cyclohexyl]-3H-3,4,7- ,8-tetraaza-cyclopenta[a]naphthalene; 9-[4-[[3-[(4-fluorophenoxy)methyl]-1-piperidyl]sulfonylmethyl]cyclohexyl]- -3H-pyrrolo[2,3c][2,7]naphthyridine; 9-[4-[[3-[(4-chlorophenoxy)methyl]-1-piperidyl]sulfonylmethyl]cyclohexyl]- -3H-pyrrolo[2,3c][2,7]naphthyridine; 4-[[1-[[4-(3H-pyrrolo[2,3-c][2,7]naphthyridin-9-yl)cyclohexyl]methylsulfo- nyl]-3-piperidyl]methoxy]benzonitrile; 4-[[1-[[4-(3H-pyrrolo[2,3-c][2,7]naphthyridin-9-yl)cyclohexyl]methylsulfo- nyl]-3-piperidyl]methoxy]benzoic acid; 4-[[1-[[4-(3H-pyrrolo[2,3-c][2,7]naphthyridin-9-yl)cyclohexyl]methylsulfo- nyl]-3-piperidyl]methoxy]benzamide; 9-[4-[[3-(pyrrolidin-1-ylmethyl)-1-piperidyl]sulfonylmethyl]cyclohexyl]-3- H-pyrrolo[2,3-c][2,7]naphthyridine; 9-[4-[[3-(methoxymethyl)pyrrolidin-1-yl]sulfonylmethyl]cyclohexyl]-3H-pyr- rolo[2,3-c][2,7]naphthyridine; 3-methyl-1-[[4-(3H-pyrrolo[2,3-c][2,7]naphthyridin-9-yl)cyclohexyl]methyl- sulfonyl]pyrrolidin-3-ol; 9-[4-[(3-methoxy-1-piperidyl)sulfonylmethyl]cyclohexyl]-3H-pyrrolo[2,3-c]- [2,7]naphthyridine; [1-[[4-(3H-pyrrolo[2,3-c][2,7]naphthyridin-9-yl)cyclohexyl]methylsulfonyl- ]-3-piperidyl]methanesulfonamide; 9-[4-[(3-isobutoxy-1-piperidyl)sulfonylmethyl]cyclohexyl]-3H-pyrrolo[2,3-- c][2,7]naphthyridine; 9-[4-[[3-(2-methoxyethoxy)-1-piperidyl]sulfonylmethyl]cyclohexyl]-3H-pyrr- olo[2,3-c][2,7]naphthyridine; N-(cyclopropylmethyl)-1-[4-(3H-pyrrolo[2,3-c][2,7]naphthyridin-9-yl)cyclo- hexyl]methanesulfonamide; N-cyclobutyl-1-[4-(3H-pyrrolo[2,3-c][2,7]naphthyridin-9-yl)cyclohexyl]met- hanesulfonamide; 9-[4-[[3-[(2,4-difluorophenoxy)methyl]-1-piperidyl]sulfonylmethyl]cyclohe- xyl]-3H-pyrrolo[2,3-c][2,7]naphthyridine; 9-[4-[[3-[(4-methoxyphenoxy)methyl]-1-piperidyl]sulfonylmethyl]cyclohexyl- ]-3H-pyrrolo[2,3-c][2,7]naphthyridine; 9-[4-[[3-[[4-(trifluoromethoxy)phenoxy]methyl]-1-piperidyl]sulfonylmethyl- ]cyclohexyl]-3H-pyrrolo[2,3-c][2,7]naphthyridine; 9-[4-[[3-[[4-(trifluoromethyl)phenoxy]methyl]-1-piperidyl]sulfonylmethyl]- cyclohexyl]-3H-pyrrolo[2,3-c][2,7]naphthyridine; 9-[4-[(3-methyl-1-piperidyl)sulfonylmethyl]cyclohexyl]-3H-pyrrolo[2,3-c][- 2,7]naphthyridine; 9-[4-[[3-(trifluoromethyl)-1-piperidyl]sulfonylmethyl]cyclohexyl]-3H-pyrr- olo[2,3-c][2,7]naphthyridine; 1-[4-[[3-[(4-fluorophenoxy)methyl]-1-piperidyl]sulfonylmethyl]cyclohexyl]- -7H-pyrrolo[2,3-c][2,6]naphthyridine; 1-[4-[[3-[(4-chlorophenoxy)methyl]-1-piperidyl]sulfonylmethyl]cyclohexyl]- -7H-pyrrolo[2,3-c][2,6]naphthyridine; 4-[[1-[[4-(7H-pyrrolo[2,3-h][2,6]naphthyridin-1-yl)cyclohexyl]methylsulfo- nyl]-3-piperidyl]methoxy]benzonitrile; 4-[[1-[[4-(7H-pyrrolo[2,3-h][2,6]naphthyridin-1-yl)cyclohexyl]methylsulfo- nyl]-3-piperidyl]methoxy]benzoic acid; 4-[[1-[[4-(7H-pyrrolo[2,3-h][2,6]naphthyridin-1-yl)cyclohexyl]methylsulfo- nyl]-3-piperidyl]methoxy]benzamide; 1-[4-[[3-(pyrrolidin-1-ylmethyl)-1-piperidyl]sulfonylmethyl]cyclohexyl]-7- H-pyrrolo[2,3-c][2,6]naphthyridine; 1-[4-[[3-(methoxymethyl)pyrrolidin-1-yl]sulfonylmethyl]cyclohexyl]-7H-pyr- rolo[2,3-c][2,6]naphthyridine; 3-methyl-1-[[4-(7H-pyrrolo[2,3-h][2,6]naphthyridin-1-yl)cyclohexyl]methyl- sulfonyl]pyrrolidin-3-ol; 1-[4-[(3-methoxy-1-piperidyl)sulfonylmethyl]cyclohexyl]-7H-pyrrolo[2,3-c]- [2,6]naphthyridine; [1-[[4-(7H-pyrrolo[2,3-h][2,6]naphthyridin-1-yl)cyclohexyl]methylsulfonyl- ]-3-piperidyl]methanesulfonamide; 1-[4-[(3-isobutoxy-1-piperidyl)sulfonylmethyl]cyclohexyl]-7H-pyrrolo[2,3-- c][2,6]naphthyridine; 1-[4-[[3-(2-methoxyethoxy)-1-piperidyl]sulfonylmethyl]cyclohexyl]-7H-pyrr- olo[2,3-c][2,6]naphthyridine; N-(cyclopropylmethyl)-1-[4-(7H-pyrrolo[2,3-h][2,6]naphthyridin-1-yl)cyclo- hexyl]methanesulfonamide; N-cyclobutyl-1-[4-(7H-pyrrolo[2,3-h][2,6]naphthyridin-1-yl)cyclohexyl]met- hanesulfonamide; 1-[4-[[3-[(2,4-difluorophenoxy)methyl]-1-piperidyl]sulfonylmethyl]cyclohe- xyl]-7H-pyrrolo[2,3-c][2,6]naphthyridine; 1-[4-[[3-[(4-methoxyphenoxy)methyl]-1-piperidyl]sulfonylmethyl]cyclohexyl- ]-7H-pyrrolo[2,3-c][2,6]naphthyridine; 1-[4-[[3-[[4-(trifluoromethoxy)phenoxy]methyl]-1-piperidyl]sulfonylmethyl- ]cyclohexyl]-7H-pyrrolo[2,3-c][2,6]naphthyridine; 1-[4-[[3-[[4-(trifluoromethyl)phenoxy]methyl]-1-piperidyl]sulfonylmethyl]- cyclohexyl]-7H-pyrrolo[2,3-c][2,6]naphthyridine; 1-[4-[(3-methyl-1-piperidyl)sulfonylmethyl]cyclohexyl]-7H-pyrrolo[2,3-c][- 2,6]naphthyridine; 1-[4-[[3-(trifluoromethyl)-1-piperidyl]sulfonylmethyl]cyclohexyl]-7H-pyrr- olo[2,3-c][2,6]naphthyridine; 4,4,4-Trifluoro-1-[3-(3H-3,4,6-triaza-cyclopenta[a]naphthalen-9-yl)-2,5-d- ihydro-pyrrol-1-yl]-butan-1-one; Cyclopropyl-[3-(3H-3,4,6-triaza-cyclopenta[a]naphthalen-9-yl)-2,5-dihydro- -pyrrol-1-yl]-methanone; 3-Oxo-3-[3-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-2,5-dihydro- -pyrrol-1-yl]-propionitrile; 3,3,3-Trifluoro-1-[3-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-2- ,5-dihydro-pyrrol-1-yl]-propan-1-one; 4,4,4-Trifluoro-1-[3-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-2- ,5-dihydro-pyrrol-1-yl]-butan-1-one; Cyclopropyl-[3-(3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-2,5-dih- ydro-pyrrol-1-yl]-methanone; [3-(3H-3,4,6,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-2,5-dihydro-pyrrole- -1-sulfonyl]-acetonitrile; 9-[1-(2,2,2-Trifluoro-ethanesulfonyl)-2,5-dihydro-1H-pyrrol-3-yl]-3H-3,4,- 6,8-tetraaza-cyclopenta[a]naphthalene; 9-(1-Methanesulfonyl-2,5-dihydro-1H-pyrrol-3-yl)-3H-3,4,6,8-tetraaza-cycl- openta[a]naphthalene; 3-[3-(7-Methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-2,5-dihy- dro-pyrrol-1-yl]-3-oxo-propionitrile; 3,3,3-Trifluoro-1-[3-(7-methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthale- n-9-yl)-2,5-dihydro-pyrrol-1-yl]-propan-1-one; 4,4,4-Trifluoro-1-[3-(7-methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthale- n-9-yl)-2,5-dihydro-pyrrol-1-yl]-butan-1-one; Cyclopropyl-[3-(7-methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl- )-2,5-dihydro-pyrrol-1-yl]-methanone; [3-(7-Methyl-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-2,5-dihydr- o-pyrrole-1-sulfonyl]-acetonitrile; 7-Methyl-9-[1-(2,2,2-trifluoro-ethanesulfonyl)-2,5-dihydro-1H-pyrrol-3-yl- ]-3H-3,4,6,8-tetraaza-cyclopenta[a]naphthalene; 9-(1-Methanesulfonyl-2,5-dihydro-1H-pyrrol-3-yl)-7-methyl-3H-3,4,6,8-tetr- aaza-cyclopenta[a]naphthalene; 3-Oxo-3-[3-(3H-3,4,6,7-tetraaza-cyclopenta[a]naphthalen-9-yl)-2,5-dihydro- -pyrrol-1-yl]-propionitrile; 3,3,3-Trifluoro-1-[3-(3H-3,4,6,7-tetraaza-cyclopenta[a]naphthalen-9-yl)-2- ,5-dihydro-pyrrol-1-yl]-propan-1-one 4,4,4-Trifluoro-1-[3-(3H-3,4,6,7-tetraaza-cyclopenta[a]naphthalen-9-yl)-2- ,5-dihydro-pyrrol-1-yl]-butan-1-one; Cyclopropyl-[3-(3H-3,4,6,7-tetraaza-cyclopenta[a]naphthalen-9-yl)-2,5-dih- ydro-pyrrol-1-yl]-methanone; [3-(3H-3,4,6,7-Tetraaza-cyclopenta[a]naphthalen-9-yl)-2,5-dihydro-pyrrole- -1-sulfonyl]-acetonitrile; 9-[1-(2,2,2-Trifluoro-ethanesulfonyl)-2,5-dihydro-1H-pyrrol-3-yl]-3H-3,4,- 6,7-tetraaza-cyclopenta[a]naphthalene; 9-(1-Methanesulfonyl-2,5-dihydro-1H-pyrrol-3-yl)-3H-3,4,6,7-tetraaza-cycl- openta[a]naphthalene; 3-Oxo-3-[3-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-2,5-dihydro- -pyrrol-1-yl]-propionitrile; 3,3,3-Trifluoro-1-[3-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-2- ,5-dihydro-pyrrol-1-yl]-propan-1-one; 4,4,4-Trifluoro-1-[3-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-2- ,5-dihydro-pyrrol-1-yl]-butan-1-one; Cyclopropyl-[3-(3H-3,4,7,8-tetraaza-cyclopenta[a]naphthalen-9-yl)-2,5-dih- ydro-pyrrol-1-yl]-methanone; [3-(3H-3,4,7,8-Tetraaza-cyclopenta[a]naphthalen-9-yl)-2,5-dihydro-pyrrole- -1-sulfonyl]-acetonitrile; 9-[1-(2,2,2-Trifluoro-ethanesulfonyl)-2,5-dihydro-1H-pyrrol-3-yl]-3H-3,4,- 7,8-tetraaza-cyclopenta[a]naphthalene; 9-(1-Methanesulfonyl-2,5-dihydro-1H-pyrrol-3-yl)-3H-3,4,7,8-tetraaza-cycl- openta[a]naphthalene; 3-Oxo-3-[3-(3H-3,4,8-triaza-cyclopenta[a]naphthalen-9-yl)-2,5-dihydro-pyr- rol-1-yl]-propionitrile; 3,3,3-Trifluoro-1-[3-(3H-3,4,8-triaza-cyclopenta[a]naphthalen-9-yl)-2,5-d- ihydro-pyrrol-1-yl]-propan-1-one; 4,4,4-Trifluoro-1-[3-(3H-3,4,8-triaza-cyclopenta[a]naphthalen-9-yl)-2,5-d- ihydro-pyrrol-1-yl]-butan-1-one; Cyclopropyl-[3-(3H-3,4,8-triaza-cyclopenta[a]naphthalen-9-yl)-2,5-dihydro- -pyrrol-1-yl]-methanone; [3-(3H-3,4,8-Triaza-cyclopenta[a]naphthalen-9-yl)-2,5-dihydro-pyrrole-1-s- ulfonyl]-acetonitrile; 9-[1-(2,2,2-Trifluoro-ethanesulfonyl)-2,5-dihydro-1H-pyrrol-3-yl]-3H-3,4,- 8-triaza-cyclopenta[a]naphthalene; 9-(1-Methanesulfonyl-2,5-dihydro-1H-pyrrol-3-yl)-3H-3,4,8-triaza-cyclopen- ta[a]naphthalene; 3-Oxo-3-[3-(3H-3,4,7-triaza-cyclopenta[a]naphthalen-9-yl)-2,5-dihydro-pyr- rol-1-yl]-propionitrile 3,3,3-Trifluoro-1-[3-(3H-3,4,7-triaza-cyclopenta[a]naphthalen-9-yl)-2,5-d- ihydro-pyrrol-1-yl]-propan-1-one; 4,4,4-Trifluoro-1-[3-(3H-3,4,7-triaza-cyclopenta[a]naphthalen-9-yl)-2,5-d- ihydro-pyrrol-1-yl]-butan-1-one; Cyclopropyl-[3-(3H-3,4,7-triaza-cyclopenta[a]naphthalen-9-yl)-2,5-dihydro- -pyrrol-1-yl]-methanone; [3-(3H-3,4,7-Triaza-cyclopenta[a]naphthalen-9-yl)-2,5-dihydro-pyrrole-1-s- ulfonyl]-acetonitrile; 9-[1-(2,2,2-Trifluoro-ethanesulfonyl)-2,5-dihydro-1H-pyrrol-3-yl]-3H-3,4,- 7-triaza-cyclopenta[a]naphthalene; and 9-(1-Methanesulfonyl-2,5-dihydro-1H-pyrrol-3-yl)-3H-3,4,7-triaza-cyclopen- ta[a]naphthalene. 4. A pharmaceutical composition comprising a compound of formula (Ia) as claimed in claim 1 together with a pharmaceutically acceptable carrier, optionally in combination with one or more other pharmaceutical compositions. 5. A pharmaceutical composition comprising a compound of formula (Ia) as claimed in claim 1 together with a pharmaceutically acceptable carrier, optionally in combination with one or more additional therapeutic agent selected from the group consisting of cytokine suppressive anti-inflammatory drugs, antibodies to or antagonists of other human cytokines or growth factors, IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-12, IL-15, IL-16, IL-21, IL-23, interferons, EMAP-II, GM-CSF, FGF, PDGF, CTLA or their ligands including CD 154, AdalimumaB, Infliximab, golimumab, Certolizumab Pegol, Tocilizumab, CDP 571, soluble p55 or p75 TNF receptors, Etanercept, Lenercept, TNFa converting enzyme inhibitors, IL-1 inhibitors, Interleukin 11, IL-18 antagonists, IL-12 antagonists, IL-12 antibodies, soluble IL-12 receptors, IL-12 binding proteins, non-depleting anti-CD4 inhibitors FK506, rapamycin, mycophenolate mofetil, leflunomide, NSAIDs, ibuprofen, corticosteroids, phosphodiesterase inhibitors, adensosine agonists, antithrombotic agents, complement inhibitors, adrenergic agents, IL-I.beta. converting enzyme inhibitors, T-cell signalling kinase inhibitors, metalloproteinase inhibitors, sulfasalazine, 6-mercaptopurines, derivatives p75TNFRIgG, sIL-1RI, sIL-1RII, sIL-6R, celecoxib, hydroxychloroquine sulfate, rofecoxib, infliximab, naproxen, valdecoxib, sulfasalazine, meloxicam, acetate, gold sodium thiomalate, aspirin, triamcinolone acetonide, propoxyphene napsylate/apap, folate, nabumetone, diclofenac, piroxicam, etodolac, diclofenac sodium, oxaprozin, oxycodone HCl, hydrocodone bitartrate/apap, diclofenac sodium/misoprostol, fentanyl, anakinra, tramadol HCl, salsalate, sulindac, cyanocobalamin/fa/pyridoxine, acetaminophen, alendronate sodium, morphine sulfate, lidocaine hydrochloride, indomethacin, glucosamine sulf/chondroitin, amitriptyline HCl, sulfadiazine, oxycodone HCl/acetaminophen, olopatadine HCl misoprostol, naproxen sodium, omeprazole, cyclophosphamide, rituximab, IL-1 TRAP, MRA, CTLA4-IG, IL-18 BP, anti-IL-12, anti-ILLS, VX-740, Roflumilast, IC-485, CDC-801, S1P1 agonists, FTY720, PKC family inhibitors, Ruboxistaurin, AEB-071, Mesopram, methotrexate, leflunomide, corticosteroids, budenoside, dexamethasone, sulfasalazine, 5-aminosalicylic acid, olsalazine, IL-1.beta. converting enzyme inhibitors, IL-1ra, T cell signaling inhibitors, tyrosine kinase inhibitors, 6-mercaptopurines, IL-11, mesalamine, prednisone, azathioprine, mercaptopurine, infliximab, methylprednisolone sodium succinate, diphenoxylate/atrop sulfate, loperamide hydrochloride, omeprazole, folate, ciprofloxacin/dextrose-water, hydrocodone, bitartrate/apap, tetracycline hydrochloride, fluocinonide, metronidazole, thimerosal/boric acid, cholestyramine/sucrose, ciprofloxacin hydrochloride, hyoscyamine sulfate, meperidine hydrochloride, midazolam hydrochloride, oxycodone HCl/acetaminophen, promethazine hydrochloride, sodium phosphate, sulfamethoxazole/trimethoprim, polycarbophil, propoxyphene napsylate, hydrocortisone, multivitamins, balsalazide disodium, codeine phosphate/apap, colesevelam HCl, cyanocobalamin, folic acid, levofloxacin, natalizumab, interferon-gamma, methylprednisolone, azathioprine, cyclophosphamide, cyclosporine, methotrexate, 4-aminopyridine, tizanidine, interferon-ia, Interferon Beta-1A, interferon-ib, Interferon Beta-1B, interferon a-n3, interferon-a, interferon .beta.IA-IF, Peginterferon a 2b, Copolymer 1, Glatiramer Acetate, hyperbaric oxygen, intravenous immunoglobulin, cladribine, cyclosporine, FK506, mycophenolate mofetil, leflunomide, NSAIDs, corticosteroids, prednisolone, phosphodiesterase inhibitors, adensosine agonists, antithrombotic agents, complement inhibitors, adrenergic agents, antiinflammatory cytokines, interferon-.beta., IFN ia, IFN ib, Copaxone, corticosteroids, caspase inhibitors, inhibitors of caspase-1, antibodies to CD40 ligand and CD80, alemtuzumab, dronabinol, daclizumab, mitoxantrone, xaliproden hydrochloride, fampridine, glatiramer acetate, natalizumab, sinnabidol, a-immunokine NNS03, ABR-215062, AnergiX.MS, chemokine receptor antagonists, BBR-2778, calagualine, CPI-1189, liposome encapsulated mitoxantrone, THC.CBD, cannabinoid agonists, MBP-8298, mesopram, MNA-715, anti-IL-6 receptor antibody, neurovax, pirfenidone allotrap 1258 (RDP-1258), sTNF-R1, talampanel, teriflunomide, TGF-beta2, tiplimotide, VLA-4 antagonists, interferon gamma antagonist, IL-4 agonists, Diclofenac, Misoprostol, naproxen, Meloxicam, indomethacin, Diclofenac, Methotrexate, Azathioprine, Minocycline, prednisone, etanercept, Rofecoxib, Sulfasalazine, naproxen, leflunomide, methylprednisolone acetate, indomethacin, hydroxychloroquine sulfate, prednisone, sulindac, betamethasone diprop augmented, infliximab, Methotrexate, folate, Triamcinolone acetonide, Diclofenac, dimethylsulfoxide, Piroxicam, Diclofenac Sodium, ketoprofen, Meloxicam, methylprednisolone, nabumetone, tolmetin Sodium, calcipotriene, cyclosporine, Diclofenac Sodium/Misoprostol, fluocinonide, glucosamine sulfate, Sodium gold thiomalate, hydrocodone bitartrate/Apap, Sodium risedronate, sulfadiazine, thioguanine, valdecoxib, alefacept, and efalizumab, Diclofenac, naproxen, ibuprofen, Piroxicam, indomethacin, COX2 Inhibitors, Rofecoxib, valdecoxib, hydroxychloroquine, Steroids, Prednisolone, budenoside, Dexamethasone, cytotoxics, Azathioprine, cyclophosphamide, mycophenolate mofetil, Inhibitors of PDE4, purine synthesis Inhibitor, Sulfasalazine, 5-aminosalicylic acid, olsalazine, Azathioprine, CTLA-4-IgG, anti-B7 family antibodies, anti-PD-1 family antibodies, anti-cytokine antibodies, fonotolizumab, Antibody anti-IFNg, anti-receptor receptor antibodies, anti-IL-6 receptor Antibody, antibodies to B-cell Surface molecules, LJP 394, rituximab, anti-CD20 Antibody and B-lymphostat.

Details for Patent 9,115,133

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Bayer Healthcare Pharmaceuticals Inc.	BETASERON	interferon beta-1b	For Injection	103471	07/23/1993		2031-03-22
Biogen Inc.	AVONEX	interferon beta-1a	For Injection	103628	05/17/1996		2031-03-22
Biogen Inc.	AVONEX	interferon beta-1a	Injection	103628	05/28/2003		2031-03-22
Biogen Inc.	AVONEX	interferon beta-1a	Injection	103628	02/27/2012		2031-03-22
Genentech, Inc.	RITUXAN	rituximab	Injection	103705	11/26/1997		2031-03-22
Idec Pharmaceuticals Corp.	RITUXAN	rituximab	Injection	103737	02/19/2002		2031-03-22