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Last Updated: April 23, 2024

Claims for Patent: 9,050,248

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Summary for Patent: 9,050,248

Title:	Methods of delivering stable topical drug compositions
Abstract:	A method of delivering a drug composition comprises providing a carrier having a phosphatidylcholine component and a drug entrapped therein, and applying the composition to the skin for transdermal delivery of the drug, wherein the composition is stable at room temperature.
Inventor(s):	Perricone; Nicholas V. (Madison, CT), Potini; Chim (Bloomington, IL)
Assignee:	Transdermal Biotechnology, Inc. (Meriden, CT)
Application Number:	13/947,353
Patent Claims:	1. A carrier composition for transdermal delivery of a polypeptide, comprising a silicone fluid comprising polydimethylsiloxane, at least one polyglycol, a siloxylated polyether comprising dimethyl, methyl(propylpolyethylene oxide propylene oxide, acetate) siloxane, and polyenylphosphatidylcholine, the carrier composition comprising the polypeptide for transdermal delivery to dermal vasculature, wherein the polyenylphosphatidylcholine stabilizes the polypeptide such that the polypeptide is stable when stored at room temperature for at least 65 days. 2. The composition of claim 1, wherein the polypeptide is insulin. 3. The composition of claim 1, wherein the polypeptide is selected from the group consisting of oxytocin, vasopressin, somatotropin, calcitonin, chorionic gonadotropin, menotropins, follitropins, somatostatins, progestins, and combinations of any of these. 4. The composition of claim 1, wherein the at least one polyglycol comprises polyglycol having a molecular weight of 200 and polyglycol having a molecular weight of 400. 5. The composition of claim 1, wherein the carrier composition further comprises methyl paraben. 6. A stable topical composition, comprising: a carrier comprising polyenylphosphatidylcholine, a polyglycol having a molecular weight of 200 and a polyglycol having a molecular weight of 400 , a silicone fluid, a siloxylated polyether; and a polypeptide comprised within the carrier for transdermal delivery of the polypeptide to the dermal vasculature, wherein the polyenylphosphatidylcholine stabilizes the polypeptide such that the polypeptide is stable when stored at room temperature for at least 65 days. 7. The composition of claim 6, wherein the polypeptide is selected from the group consisting of oxytocin, vasopressin, somatotropin, calcitonin, chorionic gonadotropin, menotropins, follitropins, somatostatins, progestins, and combinations of any of these. 8. The composition of claim 6, wherein the polypeptide is insulin.

Details for Patent 9,050,248

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Ferring Pharmaceuticals Inc.	NOVAREL	chorionic gonadotropin	For Injection	017016	01/15/1974	⤷ Try a Trial	2022-05-31
Ferring Pharmaceuticals Inc.	NOVAREL	chorionic gonadotropin	For Injection	017016	12/27/1984	⤷ Try a Trial	2022-05-31
Ferring Pharmaceuticals Inc.	NOVAREL	chorionic gonadotropin	For Injection	017016	02/15/1985	⤷ Try a Trial	2022-05-31
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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