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Last Updated: September 24, 2020

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Claims for Patent: 8,986,724

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Summary for Patent: 8,986,724
Title:Nitric oxide generating medical devices
Abstract: Medical devices having a catalyst capable of catalyzing the generation of nitric oxide in vivo and methods of treating a vascular condition using the devices are provided.
Inventor(s): Glauser; Thierry (Redwood City, CA), Pacetti; Stephen D. (San Jose, CA), Consigny; Paul M. (San Jose, CA)
Assignee: Advanced Cardiovascular Systems, Inc. (Santa Clara, CA)
Application Number:13/923,559
Patent Claims:1. A medical device comprising a metal complex comprising a metal and at least one ligand, at least one of the ligands being a bipyridine ligand; wherein the metal complex attaches to a surface of the medical device or a coating on the medical device via a spacer, wherein the spacer is a short chain alkyl group, phenyl group, aryl group, or poly(ethylene glycol), and wherein the metal complex catalyzes the in-vivo generation of nitric oxide.

2. The medical device of claim 1, wherein the in vivo generation of nitric oxide is nitric oxide generation in a blood stream or a tissue adjacent to the medical device.

3. The medical device of claim 1, wherein the coating on the medical device is present; and wherein the coating comprises a polymer to which the metal complex is attached.

4. The medical device of claim 1, wherein the medical device is a bioabsorbable stent comprising a polymer to which the metal complex is attached.

5. The medical device of claim 1, wherein the metal of the metal complex comprises copper.

6. The medical device of claim 1, wherein the metal complex attaches to the surface of the medical device.

7. The medical device of claim 1, wherein the metal of the metal complex comprises a member of the group consisting of Cu, Co, Ni, Zn, Mn, Al, and Fe.

8. The medical device of claim 1, wherein the metal complex comprises an ion selected from the group consisting of Cu.sup.2+, Co.sup.2+, Ni.sup.2+, Zn.sup.+2+, Mn.sup.2+, Al.sup.3+, and Fe.sup.3+.

9. The medical device of claim 1, further comprising a drug adapted to be released from the device.

10. The medical device of claim 9, wherein the coating on the medical device is present and the coating comprises the drug.

11. The medical device of claim 10, wherein the coating comprises a polymer to which the metal complex is attached.

12. The medical device of claim 10, wherein the drug is selected from the group consisting of paclitaxel, docetaxel, estradiol, super oxide dismutases, tacrolimus, dexamethasone, rapamycin, everolimus, 40-O-(3-hydroxy)propyl-rapamycin, 40-O-[2-(2-hydroxy)ethoxy]ethyl-rapamycin, 40-O-tetrazole-rapamycin, 40-epi-(N1-tetrazolyl)-rapamycin (ABT-578), pimecrolimus, imatinib mesylate, midostaurin, clobetasol, bioactive RGD, CD-34 antibody, abciximab (REOPRO), and combinations thereof.

13. A method of treating a disorder in a patient comprising implanting in the patient the medical device of claim 12, wherein the disorder is selected from the group consisting of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, diabetic vascular disease, and combinations thereof.

14. The medical device of claim 1, which is a stent.

15. The medical device of claim 1, which is a bioabsorbable stent.

16. The medical device of claim 1, wherein the nitric oxide is released from a nitrosylated biomolecule present in a blood stream or a tissue adjacent to the medical device.

17. The medical device of claim 1, wherein the nitric oxide is released from a nitrosylated protein or S-nitrosothiols present in a blood stream or a tissue adjacent to the medical device.

18. A method of treating a disorder in a patient comprising implanting in the patient the medical device of claim 1, wherein the disorder is selected from the group consisting of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, diabetic vascular disease, and combinations thereof.

Details for Patent 8,986,724

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Centocor Inc REOPRO abciximab INJECTABLE; INJECTION 103575 001 1994-12-22   Start Trial Advanced Cardiovascular Systems, Inc. (Santa Clara, CA) 2039-03-29 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

International Patent Family for US Patent 8,986,724

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