Claims for Patent: 8,940,308

Summary for Patent: 8,940,308

Title:	Methods for treating depression
Abstract:	Disclosed is a method for decreasing depression in a patient by local administration of a botulinum neurotoxin to the frontalis, corrugator, procereus, occipitalis, temporalis, trapezius and cervical paraspinal muscles.
Inventor(s):	Turkel; Catherine C. (Newport Coast, CA), Brin; Mitchell F. (Newport Beach, CA)
Assignee:	Allergan, Inc. (Irvine, CA)
Application Number:	13/757,312
Patent Claims:	1. A method for treating or reducing the occurrence of depression in a patient, the method comprising: local administration of a botulinum neurotoxin to 31 fixed injection sites across seven head and neck muscles, and optionally up to 8 additional injection sites into three specific muscles, wherein these three muscles are subset of the seven head and neck muscles, to thereby treat or reduce the occurrence of depression in the patient. 2. The method of claim 1, wherein the botulinum neurotoxin is serotype A. 3. The method of claim 1, wherein the botulinum neurotoxin is serotype B. 4. The method of claim 1 wherein the total amount of onabotulinumtoxinA administered to the 31 injection sites is about 77.5 units. 5. The method of claim 1 wherein the total amount of onabotulinumtoxinA administered is from about 155 units to about 195 units. 6. The method of claim 1, wherein the depression is measured according to the Beck Depression Inventory. 7. The method of claim 1, wherein the depression is decreased for at least 12 weeks. 8. The method of claim 1, wherein the administration is by injection. 9. The method of claim 1, wherein the administration is by subcutaneous injection. 10. The method of claim 1, wherein the administration is by intramuscular injection. 11. The method of claim 1, wherein the 31 fixed injection sites across the seven head and neck muscles comprise four injection sites in the frontalis; two injection sites in the corrugator; one injection site in the procerus; six injection sites in the occipitalis; eight injection sites in the temporalis; six sites in the trapezius and four injection sites in the paraspinal muscles. 12. The method of claim 1, wherein the 8 additional injection sites into three specific muscles comprise two injection sites in the occipitalis; two injection sites in the temporalis; and four injection sites in the trapezius. 13. A method for treating or reducing the occurrence of depression in a patient, the method comprising: local administration of a botulinum neurotoxin to the frontalis, corrugator, procerus, occipitalis, temporalis, trapezius and cervical paraspinal muscles of the patient that suffers from depression; wherein the botulinum neurotoxin is administered to the frontalis at about twenty units divided among four sites of injection; to the corrugator at about ten units divided among two sites of injection; to the procerus at about five units to one site of injection; to the occipitalis at about thirty units divided among six sites of injection to about forty units divided among eight sites of injection; to the temporalis at about forty units divided among eight sites of injection up to fifty units divided among ten sites of injection; to the trapezius at about thirty units divided among six sites of injection up to about fifty units divided among ten sites of injection and to the cervical paraspinal muscles at about twenty units divided among four sites of injection; wherein the botulinum neurotoxin is injected at 31 to 39 injection sites; thereby to treat or reduce the occurrence of depression in the patient. 14. The method of claim 13, wherein the total amount of botulinum neurotoxin administered is from about 155 units to about 195 units of onabotulinumtoxinA. 15. The method of claim 13, wherein the administration is by injection. 16. The method of claim 13, wherein the administration is by subcutaneous injection. 17. The method of claim 13, wherein the administration is by intramuscular injection.

Details for Patent 8,940,308

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Allergan, Inc.	BOTOX COSMETIC	onabotulinumtoxina	For Injection	103000	12/09/1991		2030-03-30
Allergan, Inc.	BOTOX	onabotulinumtoxina	For Injection	103000	12/09/1991		2030-03-30