You’re using a public version of DrugPatentWatch with 5 free searches available | Register to unlock more free searches. CREATE FREE ACCOUNT

Last Updated: April 25, 2024

Claims for Patent: 8,933,051

✉ Email this page to a colleague

« Back to Dashboard

Summary for Patent: 8,933,051

Title:	Treatment of B-cell lymphoma with microRNA
Abstract:	The invention relates to microRNA-34a and related microRNAs for use in the treatment of B-cell lymphoma. Likewise it relates to microRNA-34a for use in the preparation of a medicament for the treatment of B-cell lymphoma, and for a method of treatment of B-cell lymphoma comprising administering microRNA-34a. These claims are based on the observation that microRNA-34a shows strong anti-proliferative effects when overexpressed in diffuse large B-cell lymphoma (gDLBCL) cell lines, or when delivered intratumorally or systemically in xenograft models of DLBCL.
Inventor(s):	Craig; Vanessa (Zurich, CH), Mueller; Anne (Dubendorf, CH)
Assignee:	University of Zurich (Zurich, CH)
Application Number:	13/876,725
Patent Claims:	1. A method of treating a B-cell lymphoma, the method comprising administering to a patient a therapeutically effective amount of a microRNA, wherein the B cell lymphoma is diffuse large B-cell lymphoma and wherein the microRNA is a member of the miR-34 family. 2. The method of claim 1, wherein the gastric B-cell lymphoma is high-grade gastric diffuse large B-cell lymphoma. 3. The method of claim 1, wherein the microRNA is miR-34a, miR-34b, miR-34c-5p or miR-34c-3p. 4. The method of claim 1, further comprising administering another active ingredient selected from cyclophosphamide, hydroxydaunorubicin, vincristine, prednisone/prednisolone, rituximab, or combinations thereof. 5. A method of treating gastric B-cell lymphoma or diffuse large B-cell lymphoma, the method comprising administering a therapeutically effective amount of a microRNA which is a member of the miR-34 family. 6. The method of claim 5, wherein the microRNA is miR-34a. 7. A method of treating a diffuse large B-cell lymphoma, comprising administering a therapeutically effective amount of a microRNA, wherein the diffuse large B-cell lymphoma is characterized by an over-expression of FoxP1, and wherein the microRNA is a member of the miR-34 family. 8. The method of claim 7, wherein the B-cell lymphoma is diffuse large B-cell lymphoma. 9. The method of claim 7, wherein the B-cell lymphoma is gastric B-cell lymphoma. 10. The method of claim 7, wherein the microRNA is miR-34a, miR-34b, miR-34c-5p or miR-34c-3p. 11. The method of claim 7, further comprising administering another active ingredient selected from cyclophosphamide, hydroxydaunorubicin, vincristine, prednisone/prednisolone, rituximab, or combinations thereof. 12. A method of treating gastric B-cell lymphoma or diffuse large B-cell lymphoma, the method comprising administering a therapeutically effective amount of a microRNA which is a member of the miR-34 family. 13. The method of claim 12, wherein the microRNA is miR-34a. 14. The method of claim 7, wherein the microRNA is miR-34a and the B-cell lymphoma is diffuse large B-cell lymphoma. 15. The method of claim 12, wherein the microRNA is miR-34a and the B-cell lymphoma is diffuse large B-cell lymphoma. 16. The method of claim 1, wherein the microRNA is miR-34a. 17. The method of claim 7, wherein the microRNA is miR-34a. 18. The method of claim 1, wherein the diffuse large B-cell lymphoma is gastric diffuse large B-cell lymphoma. 19. The method of claim 5, wherein the diffuse large B-cell lymphoma is gastric diffuse large B-cell lymphoma.

Details for Patent 8,933,051

Subscribe to access the full database, or Try a Trial
Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Genentech, Inc.	RITUXAN	rituximab	Injection	103705	11/26/1997	⤷ Try a Trial	2030-09-30
Idec Pharmaceuticals Corp.	RITUXAN	rituximab	Injection	103737	02/19/2002	⤷ Try a Trial	2030-09-30
Genentech, Inc.	RITUXAN HYCELA	rituximab and hyaluronidase human	Injection	761064	06/22/2017	⤷ Try a Trial	2030-09-30
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.