Claims for Patent: 8,809,330
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Summary for Patent: 8,809,330
Title: | Pyrazolo[1,5-A]pyrimidines for antiviral treatment |
Abstract: | The invention provides compounds of Formula I or Formula II: ##STR00001## or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections. |
Inventor(s): | Babaoglu; Kerim (Pacifica, CA), Boojamra; Constantine G. (San Francisco, CA), Eisenberg; Eugene J. (San Carlos, CA), Hui; Hon Chung (San Mateo, CA), Mackman; Richard L. (Milbrae, CA), Parrish; Jay P. (Redwood City, CA), Sangi; Michael (Oakland, CA), Saunders; Oliver L. (San Mateo, CA), Siegel; Dustin (Foster City, CA), Sperandio; David (Palo Alto, CA), Yang; Hai (San Mateo, CA) |
Assignee: | Gilead Sciences, Inc. (Foster City, CA) |
Application Number: | 14/069,685 |
Patent Claims: | 1. A method of treating a Pneumovirinae virus infection in a human in need thereof comprising administering to the human a therapeutically effective amount of a compound of
formula: ##STR00774## or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 wherein the Pneumovirinae virus infection is caused by human respiratory syncytial virus. 3. The method of claim 1 further comprising administering a therapeutically effective amount of at least one other therapeutic agent selected from ribavirin, palivizumab, motavizumab, RSV-IGIV, MEDI-557, A-60444, MDT-637, BMS-433771, ALN-RSV0 and ALX-0171, or mixtures thereof. 4. The method of claim 1 wherein the therapeutically effective amount is a daily dose of from 1 mg to 1,000 mg administered in a single dose or multiple doses. 5. The method of claim 4 wherein the therapeutically effective amount is administered orally. 6. The method of claim 5 wherein the therapeutically effective amount is administered in an aqueous solution or suspension. 7. The method of claim 1 wherein the therapeutically effective amount is a daily dose of from 5 mg to 500 mg administered in a single dose or multiple doses. 8. The method of claim 7 wherein the therapeutically effective amount is administered orally. 9. The method of claim 7 wherein the therapeutically effective amount is administered in an aqueous solution or suspension. 10. The method of claim 1 wherein the pharmaceutically acceptable salt is a trifluoroacetic acid salt. |
Details for Patent 8,809,330
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Swedish Orphan Biovitrum Ab (publ) | SYNAGIS | palivizumab | For Injection | 103770 | 06/19/1998 | ⤷ Try a Trial | 2030-06-24 |
Swedish Orphan Biovitrum Ab (publ) | SYNAGIS | palivizumab | Injection | 103770 | 07/23/2004 | ⤷ Try a Trial | 2030-06-24 |
Hoffmann-la Roche Inc. | PEGASYS COPEGUS COMBINATION PACK | peginterferon alfa-2a and ribavirin | 125083 | 06/04/2004 | ⤷ Try a Trial | 2030-06-24 | |
Schering Corporation A Subsidiary Of Merck & Co., Inc. | PEGINTRON/ REBETOL COMBO PACK | peginterferon alfa-2b and ribavirin | 125196 | 06/13/2008 | ⤷ Try a Trial | 2030-06-24 | |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
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