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Last Updated: March 29, 2024

Claims for Patent: 8,802,683


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Summary for Patent: 8,802,683
Title:Compounds for use in treatment of mucositis
Abstract: The present invention provides methods for treating and/or preventing mucostitis with one or more compounds, or pharmaceutically acceptable salts thereof, disclosed herein, or compositions comprising the same.
Inventor(s): Scott; Richard W. (Radnor, PA), Korczak; Bozena (Radnor, PA)
Assignee: Cellceutix Corporation (Beverly, MA)
Application Number:13/471,689
Patent Claims:1. A method of treating mucositis in a mammal comprising administering to the mammal in need thereof a therapeutically effective amount of a compound of Formula III: ##STR00549## or a pharmaceutically acceptable salt thereof, wherein: each A is, independently, --C.dbd.O, --C.dbd.S, or CH.sub.2; each D is, independently, O or S; each R.sup.1 is, independently, hydrogen, C.sub.1-3alkyl, C.sub.1-3alkoxy, halo, or haloC.sub.1-3alkyl; each R.sup.2 is, independently, hydrogen, C.sub.1-3alkyl, C.sub.1-3alkoxy, halo, or haloC.sub.1-3alkyl; each R.sup.3 is, independently, hydrogen, C.sub.1-4alkyl, C.sub.1-4alkoxy, halo, or haloC.sub.1-4alkyl; and each R.sup.4 is, independently, hydrogen, C.sub.1-3alkyl, C.sub.1-3alkoxy, halo, or haloC.sub.1-3alkyl.

2. The method of claim 1 wherein at least one A is --C.dbd.O.

3. The method of claim 1 wherein at least one D is O.

4. The method of claim 1 wherein each R.sup.1 is, independently, hydrogen, methyl, methoxy, halo, or haloC.sub.1-3alkyl.

5. The method of claim 1 wherein at least one R.sup.1 is hydrogen.

6. The method of claim 1 wherein each R.sup.2 is, independently, hydrogen, methyl, methoxy, or halo.

7. The method of claim 1 wherein at least one R.sup.2 is hydrogen.

8. The method of claim 1 wherein each R.sup.3 is, independently, methyl, methoxy, halo, or haloC.sub.1-3alkyl.

9. The method of claim 1 wherein each R.sup.3 is, independently, haloC.sub.1-3alkyl.

10. The method of claim 1 wherein at least one R.sup.3 is trifluoromethyl.

11. The method of claim 1 wherein each R.sup.4 is, independently, hydrogen, methyl, methoxy, halo, or haloC.sub.1-3alkyl.

12. The method of claim 1 wherein each R.sup.4 is, independently, hydrogen, methyl, methoxy, or halo.

13. The method of claim 1 wherein at least one R.sup.4 is hydrogen.

14. The method of claim 1 wherein: each A is, independently, --C.dbd.O or --C.dbd.S; each D is, independently, O or S; each R.sup.1 is, independently, hydrogen, methyl, methoxy, halo, or halomethyl; each R.sup.2 is, independently, hydrogen, halo, or halomethyl; each R.sup.3 is, independently, methyl, ethyl, methoxy, ethoxy, halo, halomethyl, or haloethyl; and each R.sup.4 is, independently, hydrogen, methyl, ethyl, methoxy, ethoxy, halo, halomethyl, or haloethyl.

15. The method of claim 1 wherein: each A is --C.dbd.O; each D is O; each R.sup.1 is, independently, hydrogen, halo, or halomethyl; each R.sup.2 is, independently, hydrogen or halo; each R.sup.3 is, independently, methyl, methoxy, halo, or halomethyl; and each R.sup.4 is, independently, hydrogen, methyl, methoxy, halo, or halomethyl.

16. The method of claim 1 wherein: each A is --C.dbd.O; each D is O; each R.sup.1 is, independently, hydrogen or halo; each R.sup.2 is, independently, hydrogen or halo; each R.sup.3 is, independently, methyl, halo, or halomethyl; and each R.sup.4 is, independently, hydrogen, methyl, halo, or halomethyl.

17. The method of claim 1 wherein: each A is --C.dbd.O; each D is O; each R.sup.1 is, independently, hydrogen or halo; each R.sup.2 is, independently, hydrogen or halo; each R.sup.3 is, independently, methyl, halo, or halomethyl; and each R.sup.4 is, independently, hydrogen, methyl, halo, or halomethyl.

18. The method of claim 1 wherein: each A is --C.dbd.O; each D is O; each R.sup.1 is, independently, hydrogen or halo; each R.sup.2 is, independently, hydrogen or halo; each R.sup.3 is, independently, halo or halomethyl; and each R.sup.4 is, independently, hydrogen, halo, or halomethyl.

19. The method according to claim 1 wherein the compound of Formula III is, ##STR00550## or a pharmaceutically acceptable salt thereof.

20. The method of claim 1 wherein the mammal is a human.

21. The method of claim 1 wherein the compound of Formula III is present in a composition further comprising palifermin.

22. A composition comprising ##STR00551## or a pharmaceutically acceptable salt thereof, and palifermin.

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