Claims for Patent: 8,802,622

Summary for Patent: 8,802,622

Title:	Composition for nasal administration and method for preparing same
Abstract:	The invention provides a powdered composition for nasal administration, comprising a physiologically active peptide and cellulose acetate as the base, and having excellent nasal absorption for physiologically active peptides.
Inventor(s):	Matsumoto; Masaru (Kobe, JP), Takeda; Shuji (Kobe, JP), Nobori; Kyohei (Kobe, JP)
Assignee:	Daiichi Sankyo Company, Limited (Chuo-ku, Tokyo, JP)
Application Number:	13/635,580
Patent Claims:	1. A powdered composition for nasal administration comprising a physiologically active peptide and cellulose acetate as a base, wherein the composition is obtained by 1) mixing the physiologically active peptide, cellulose acetate and at least 20 wt % of water with respect to the cellulose acetate, and 2) drying the mixture, wherein the physiologically active peptide is human glucagon-like peptide-1, human parathyroid hormone (hPTH), hPTH (1-34), human motilin, a human motilin derivative consisting of the amino acid sequence of SEQ ID NO: 1, human ghrelin, human atrial natriuretic peptide, brain natriuretic peptide (BNP) or C-type natriurectic peptide (CNP). 2. The composition according to claim 1, wherein the amount of water used in the mixture of the physiologically active peptide, cellulose acetate and water is at least 20 wt % and no greater than 250 wt % with respect to the cellulose acetate. 3. The composition according to claim 2, wherein the amount of water used in the mixture of the physiologically active peptide, cellulose acetate and water is at least 100 wt % and no greater than 250 wt % with respect to the cellulose acetate. 4. The composition according to claim 1, wherein an acetylation degree of the cellulose acetate is 32-40%. 5. A method for preparing a powdered composition for nasal administration, which comprises a physiologically active peptide and cellulose acetate as a base, wherein the method comprises 1) mixing a physiologically active peptide, cellulose acetate and at least 20 wt % of water with respect to the cellulose acetate, and 2) drying the mixture, wherein the physiologically active peptide is human glucagon-like peptide-1, human parathyroid hormone (hPTH), hPTH (1-34), human motilin, a human motilin derivative consisting of the amino acid sequence of SEQ ID NO: 1, human gherlin, human atrail natriurectic peptide, brain natriurectic, peptide (BNP) or C-type natriuretic peptide (CNP). 6. The method according to claim 5, wherein the amount of water used in the mixture of the physiologically active peptide, cellulose acetate and water is at least 20wt % and no greater than 250 wt % with respect to the cellulose acetate. 7. The method according to claim 6, wherein the amount of water used in the mixture of the physiologically active peptide, cellulose acetate and water is at least 100 wt % and no greater than 250 wt % with respect to the cellulose acetate. 8. The method according to claim 5, wherein an acetylation degree of the cellulose acetate is 32-40%.

Details for Patent 8,802,622

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Nps Pharmaceuticals, Inc.	NATPARA	parathyroid hormone	For Injection	125511	01/23/2015		2030-03-19