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Last Updated: April 25, 2024

Claims for Patent: 8,791,071

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Summary for Patent: 8,791,071

Title:	Cartilage material
Abstract:	Cartilage materials such as cartilage fluff and a cartilage composition comprising a particulate material are disclosed. These are suitable for stimulating chondrogenesis and/or producing cartilage regeneration. Also disclosed are processes for their preparation. Methods for regenerating articular cartilage are also disclosed, which involve, for example, placing the cartilage fluff or cartilage composition into a cartilage defect.
Inventor(s):	Malinin; Theodore I. (Key Biscayne, FL)
Assignee:	Vivex Biomedical, Inc. (Marietta, GA)
Application Number:	14/246,588
Patent Claims:	1. A treatment method of regenerating articular cartilage comprising: administering a therapeutically effective amount of a cartilage fluff composition at the site of a cartilage defect, the fluff having a size 1,100 .mu.m to 6,000 .mu.m made of a plurality of intertwined branched strands in the form of a continuous network of cartilage fluff for packing; and packing the cartilage fluff into the site, wherein the fluff is directly packed with or without the use of a vehicle. 2. The treatment method of claim 1 wherein the fluff is directly packed without the use of a vehicle. 3. The treatment method of claim 1 further comprises the step of: using an overlying cover. 4. The treatment method of claim 1 further comprises the step of: administering one or more additional growth promoting factors or additives applied to the cartilage fluff to increase chondrocyte migration and proliferation. 5. The treatment method of claim 4 wherein the growth factors include one or more of: FGF-2, FGF-5, IGF-1, TGF-13, BMP-2, BMP-7, PDGF, VEGF, human allogenic or autologous chondrocytes, human allogenic or autologous bone marrow cells, stem cells, demineralized bone matrix, insulin, insulin-like growth factor-I, transforming growth factor-B, interleukin-1 receptor antagonist, hepatocyte growth factor, platelet-derived growth factor, Indian hedgehog or parathyroid hormone-related peptide. 6. The treatment method of claim 1 wherein the cartilage fluff releases cartilage growth factors that induce or enhance regeneration of articular cartilage.

Details for Patent 8,791,071

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Nps Pharmaceuticals, Inc.	NATPARA	parathyroid hormone	For Injection	125511	01/23/2015	⤷ Try a Trial	2027-05-10
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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