Claims for Patent: 8,785,616

Summary for Patent: 8,785,616

Title:	Constitutive photomorphogenesis 1 (COP1) nucleic acid sequence from Zea mays and its use thereof
Abstract:	The present invention relates to an isolated COP1 nucleic acid sequence from a maize plant and the isolated COP1 nucleic acid sequence is named as ZmCOP1. The present invention also relates to a method of using the ZmCOP1 nucleic acid sequence to control the shade avoidance response of a crop plant for high density farming and yield enhancement.
Inventor(s):	Cheikh; Nordine (Davis, CA), Deng; Molian (Grover, MO), Miller; Philip W. (Ballwin, MO), Xu; Nanfei (Wildwood, MO)
Assignee:	Monsanto Technology LLC (St. Louis, MO)
Application Number:	11/683,281
Patent Claims:	1. A recombinant DNA construct comprising: a nucleic acid molecule complementary to a nucleotide sequence encoding all or part of a polypeptide having at least 93% sequence identity to SEQ ID NO: 13; and a heterologous promoter operably linked to said nucleic acid molecule; wherein, upon transformation into a plant, the presence of said nucleic acid molecule causes reduction of endogenous COP1 mRNA level. 2. The recombinant DNA construct of claim 1, wherein said promoter comprises a light-inducible promoter. 3. The recombinant DNA construct of claim 2, wherein said promoter is selected from the group consisting of a cab promoter, an ATHB-2 promoter, and a far red light inducible promoter. 4. The recombinant DNA construct of claim 2, wherein said promoter comprises a cab promoter. 5. The recombinant DNA construct of claim 1, wherein said recombinant DNA construct comprises an intron. 6. The recombinant DNA construct of claim 5, wherein said intron comprises a hsp70 intron. 7. The recombinant DNA construct of claim 1, wherein said nucleotide sequence is isolated from a monocot plant. 8. The recombinant DNA construct of claim 7, wherein said nucleotide sequence is isolated from a maize plant. 9. The recombinant DNA construct of claim 1, wherein the nucleic acid molecule is complementary to a nucleotide sequence encoding all or a part of a polypeptide having at least 95% sequence identity to SEQ ID NO: 13. 10. The recombinant DNA construct of claim 1, wherein the nucleic acid molecule is complementary to a nucleotide sequence encoding (i) amino acid position 1 through 411 of SEQ ID NO: 13; (ii) amino acid position 1 through 301 of SEQ ID NO: 13 or (iii) SEQ ID NO:13. 11. The recombinant DNA construct of claim 1, wherein said nucleic acid molecule is complementary to a nucleotide sequence having at least 90% sequence identity to SEQ ID NO: 12; at least 90% sequence identity to nucleotide residue position 1 through 1233 of SEQ ID NO: 12; or at least 90% sequence identity to nucleotide residue position 1 through 906 of SEQ ID NO: 12. 12. A method for increasing yield of a crop, comprising the steps of: transforming a cell of a crop plant with the recombinant DNA construct of claim 1, wherein the nucleic acid molecule of the recombinant DNA construct is overexpressed in said cell; regenerating from said transformed plant cell a transformed crop plant, wherein expression of the nucleic acid molecule of the recombinant DNA construct in cells of the transformed crop plant causes reduction of endogenous COP1 mRNA levels; obtaining seeds from said transformed crop plant and progeny of said transformed crop plant; and planting said seeds at a population density at least 10% higher than normal. 13. The recombinant DNA construct of claim 11, wherein said nucleic acid molecule is complementary to SEQ ID NO:12.

Details for Patent 8,785,616

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132	06/04/1986		2021-08-29
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132			2021-08-29
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	Injection	103132			2021-08-29