Claims for Patent: 8,758,301

Summary for Patent: 8,758,301

Title:	Firing button for automatic injection device
Abstract:	Exemplary embodiments provide firing mechanism assemblies that minimize or eliminate a misfire of an automatic injection device that causes a delay in the delivery of an injection. Exemplary embodiments provide automatic injection devices including firing mechanism assemblies that minimize or eliminate a misfire that causes a delay in the delivery of an injection. Exemplary embodiments provide methods for minimizing or eliminating misfire that causes a delay in delivery of an injection in automatic injection devices. Exemplary embodiments provide methods for using automatic injection devices that are free of a misfire that causes delay in delivery of a therapeutic substance into a patient\'s body.
Inventor(s):	Shang; Sherwin S. (Vernon Hills, IL), Ozdaryal; Esra (Deerfield, IL), Post; David A. (Kenosha, WI), Tsvirko; Eduard N. (Arlington Heights, IL)
Assignee:	AbbVie Biotechnology Ltd (Hamilton, BM)
Application Number:	12/968,744
Patent Claims:	1. An automatic injection device having a proximal end configured to deliver a dose of a therapeutic agent and a distal end configured to be controllable by a user, the automatic injection device comprising: a firing body provided at the distal end of the automatic injection device, the firing body comprising: a hollow tubular member having a bore, and a radial surface extending inwardly from a distal portion of the hollow tubular member; a plunger having a first and second longitudinally extending plunger arm, each plunger arm terminating in a respective, first radially extending plunger foot and a second radially extending plunger foot, the plunger arms extending through the bore of the hollow tubular member of the firing body, and the first and second plunger foot seated on the radial surface of the firing body, the first plunger foot of the first plunger arm has a first conical surface and a second conical surface, and the second plunger foot of the second plunger arm has a first conical surface and a second conical surface, wherein a first contact surface of the plunger is defined by the first conical surface of the first plunger foot and the first conical surface of the second plunger foot, and wherein a second contact surface of the plunger is defined by the second conical surface of the first plunger foot and the second conical surface of the second plunger foot; and a firing button provided at the distal end of the automatic injection device, the firing button comprising: an inner ring having an inner diameter of between 6.0 mm and 6.7 mm provided in proximity to the plunger foot, the inner ring configured to contact the plunger foot and to disengage the plunger foot from the radial surface of the firing body to allow the plunger to move through the bore of the hollow tubular member of the firing body, when the firing button is activated by the user. 2. The automatic injection device of claim 1, further comprising: a housing; a syringe slideably mounted within the housing; and a bung slideably mounted in the syringe and moveable to expel a dose through a needle provided at the proximal end of the syringe; wherein the plunger is configured to contact the bung and to transmit an expulsion force thereto. 3. The automatic injection device of claim 1, further comprising: an actuating bias member operable to move the plunger when released. 4. The automatic injection device of claim 1, further comprising: a return bias member acting between the housing and a distal end of the syringe to hold the syringe retracted within the housing until the actuating bias member is released. 5. The automatic injection device of claim 1, wherein the inner diameter of the inner ring is 6.4 mm. 6. The automatic injection device of claim 1, wherein the inner diameter of the inner ring is 6.5 mm. 7. The automatic injection device of claim 1, wherein the inner diameter of the inner ring is 6.6 mm. 8. The automatic injection device of claim 1, wherein the inner diameter of the inner ring is 6.7 mm. 9. The automatic injection device of claim 1, wherein a length of the inner ring is 6.73 mm. 10. The automatic injection device of claim 1, wherein a length of the inner ring is greater than 6.73 mm. 11. The automatic injection device of claim 1, wherein a length of the 5 inner ring is 6.75 mm. 12. The automatic injection device of claim 1, wherein a length of the inner ring is between 6.73 mm and 6.83 mm. 13. The automatic injection device of claim 1, wherein a length of the inner ring is 6.80 mm. 14. The automatic injection device of claim 1, wherein a length of the inner ring ranges 15 from 6.73 mm to 6.83 mm. 15. The automatic injection device of claim 1, wherein the inner ring is formed of a thermoplastic material or a thermosetting material. 16. The automatic injection device of claim 1, wherein the firing button further comprises: an outer portion configured for contact by the user of the automatic injection device to allow the user to depress the outer portion toward the proximal end of the automatic injection device. 17. The automatic injection device of claim 16, wherein the outer portion protrudes from the distal end of the automatic injection device. 18. The automatic injection device of claim 16, wherein the outer portion covers all or part of the distal end of the automatic injection device. 19. The automatic injection device of claim 16, wherein the outer portion of the firing button further comprises: an outer tubular wall; and an end wall coupled to a terminal end of the outer tubular wall, the end wall configured for contact by the user. 20. The automatic injection device of claim 1, wherein the inner ring comprises: a tubular wall with a circular cross-section. 21. The automatic injection device of claim 1, wherein the inner ring has a minimum wall thickness configured to minimize deformation of the inner ring during engagement of the inner ring with the first and the second plunger foot. 22. The automatic injection device of claim 21, wherein the minimum wall thickness of the inner ring ranges between 0.6 mm and 2.0 mm. 23. The automatic injection device of claim 21, wherein the minimum wall thickness of the inner ring ranges between 0.8 and 2.0 mm. 24. The automatic injection device of claim 21, wherein the minimum wall thickness of the inner ring is 0.9 mm. 25. The automatic injection device of claim 1, wherein the firing button avoids a misfiring of the automatic injection device, the misfiring causing a delayed 5 delivery of an injection. 26. The automatic injection device of claim 25, wherein a measure of the delay in the delivery of the injection caused by the misfiring is greater than three seconds. 27. The automatic injection device of claim 1, further comprising a dose of a TNF.alpha. inhibitor. 28. The automatic injection device of claim 27, wherein the TNF.alpha. inhibitor is a human TNF.alpha. antibody, or antigen-binding portion thereof. 29. The automatic injection device of claim 28, wherein the human TNF.alpha. antibody, or antigen-binding portion thereof, is adalimumab or golimumab. 30. The automatic injection device of claim 1, wherein the first plunger foot of the first plunger arm further includes a third conical surface, the second plunger foot of the second plunger arm further includes a third conical surface, and the plunger further includes a third contact surface defined by the third conical surface of the first plunger foot of the first plunger arm and the third conical surface of the second plunger foot of the second plunger arm. 31. The automatic injection device of claim 1, wherein the inner ring of the firing button is configured so that, when the firing button is activated by the user, the initial contact of the inner ring with the plunger is at a distal portion of the first conical surface. 32. The automatic injection device of claim 1, wherein the firing button is displaced toward the plunger when activated by the user. 33. The automatic injection device of claim 1, wherein the radial surface of the firing body is an inclined surface. 34. The automatic injection device of claim 1, wherein the inner ring of the firing button is configured to initially contact a distal portion of the plunger foot during an injection. 35. The automatic injection device of claim 1, wherein the inner ring of the firing button initially contacts the plunger foot after the firing button is depressed over a first distance relative to the firing body.

Details for Patent 8,758,301

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Abbvie Inc.	HUMIRA	adalimumab	Injection	125057	12/31/2002		2029-12-15
Abbvie Inc.	HUMIRA	adalimumab	Injection	125057	02/21/2008		2029-12-15
Abbvie Inc.	HUMIRA	adalimumab	Injection	125057	04/24/2013		2029-12-15