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Last Updated: March 28, 2024

Claims for Patent: 8,741,873


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Summary for Patent: 8,741,873
Title:Controls and kit for thrombocyte activity tests
Abstract: The present invention is in the field of coagulation diagnostics and relates to a kit and method for preparing controls for use in test methods for determining thrombocyte function.
Inventor(s): Rechner; Andreas (Marburg, DE), Zander; Norbert (Marburg, DE)
Assignee: Siemens Healthcare Diagnostics Products GmbH (Marburg, DE)
Application Number:13/433,377
Patent Claims:1. A kit for preparing controls for a method for determining thrombocyte function, wherein the kit contains the following components: a. a first lyophilisate suitable for preparing a first control having normal thrombocyte function, wherein the lyophilisate consists of the following components: a buffer substance capable of maintaining a physiological pH, and an auxiliary substance capable of providing a cryoprotective or lyoprotective effect during lyophilization; and b. a second lyophilisate suitable for preparing a second control having abnormally reduced thrombocyte function, wherein the lyophilisate contains at least the following components: a buffer substance capable of maintaining a physiological pH, an auxiliary substance capable of providing a cryoprotective or lyoprotective effect during lyophilization, and a direct inhibitor of thrombocyte aggregation.

2. The kit as claimed in claim 1, wherein each lyophilisate additionally contains normal human plasma.

3. The kit as claimed in claim 1, wherein the buffer substance for maintaining a physiological pH is selected from the group consisting of HEPES, PBS, OVB, MES, PIPES, TAPS, CHES, CAPS, Tris and MOPS.

4. The kit as claimed in claim 1, wherein the second lyophilisate contains a direct inhibitor of thrombocyte aggregation from the group consisting of tirofiban, abciximab, eptifibatide, acetylsalicylic acid, MRS 2395, AR-C66096, cangrelor, ticagrelor, cilostazol, dipyridamole, prostaglandin E1, prostacyclin, iloprost, cicaprost, forskolin, 2-MeSAMP, C1330-7, MRS 2179, MRS 2279, MRS 2500, A2P5P, A3P5P and A3P5PS.

5. The kit as claimed in claim 1, wherein the second lyophilisate contains a direct inhibitor of thrombocyte aggregation in such an amount that a control is obtainable which exhibits thrombocyte function of between about 50% and about 80% of normal thrombocyte function.

6. The kit as claimed in claim 1, wherein the second lyophilisate contains a direct inhibitor of thrombocyte aggregation in such an amount that a control is obtainable which exhibits thrombocyte function of about 70% of normal thrombocyte function.

7. A kit for preparing controls for a method for determining thrombocyte function, wherein the kit includes: a first lyophilisate that is dissolvable in whole blood to produce a first control having normal thrombocyte function, wherein the lyophilisate consists of: a buffer substance capable of maintaining a physiological pH, and an auxiliary substance capable of providing a cryoprotective or lyoprotective effect during lyophilization; and a second lyophilisate that is dissolvable in whole blood to produce a second control having abnormally reduced thrombocyte function, wherein the lyophilisate includes: a buffer substance capable of maintaining a physiological pH, an auxiliary substance capable of providing a cryoprotective or lyoprotective effect during lyophilization, and a direct inhibitor of thrombocyte aggregation.

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