Claims for Patent: 8,735,599
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Summary for Patent: 8,735,599
Title: | Substituted imidazole derivates |
Abstract: | The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula: ##STR00001## |
Inventor(s): | Wang; Weibo (Moraga, CA), Barsanti; Paul A. (Pleasant Hill, CA), Yia; Xia (Palo Alto, CA), Boyce; Rustum S. (New York, NY), Pecchi; Sabina (Oakland, CA), Brammeier; Nathan (Walnut Creek, CA), Phillips; Megan C. (Lake Orion, MI), Mendenhall; Kris (Concord, CA), Wayman; Kelly (San Rafael, CA), Lagnition; Liana Marie (Oakland, CA), Constantine; Ryan N. (Salt Lake City, UT), Yang; Hong (Fremont, CA), Mieuli; Elizabeth (Redwood City, CA), Ramurthy; Savithri (Walnut Creek, CA), Jazan; Elisa (Siena, IT), Sharma; Anu (El Cerrito, CA), Jain; Rama (Fremont, CA), Subramanian; Sharadha (San Ramon, CA), Renhowe; Paul A. (Danville, CA), Bair; Kenneth W. (Oakland, CA), Duhl; David (Oakland, CA), Walter; Annette (Mill Valley, CA), Abrams; Tinya (Richmond, CA), Huh; Kay (San Mateo, CA), Martin; Eric (El Cerrrito, CA), Knapp; Mark (Oakland, CA), Le; Vincent P. (San Francisco, CA) |
Assignee: | Novartis Vaccines and Diagnostics, Inc. (Emeryville, CA) |
Application Number: | 13/613,977 |
Patent Claims: | 1. A compound of formula I: ##STR00546## wherein: R.sup.1 is 1 to 6 carbon alkyl optionally substituted with hydroxy or halo; R.sup.2 is selected from the group consisting
of hydrogen, methyl, and ethyl; R.sup.3 is --X-A, wherein X is --C(O)--; and A is a substituted aryl or heteroaryl group selected from 5-methyl-2H-imidazol-4yl, 2-aminothiazol-4-yl, 4-t-butylphenyl, 2-chlorophenyl, 2-chloro-6-methylpyrid-4-yl,
3-chlorophenyl, 4-chlorophenyl, 6-chloropyridin-3-yl, 3,4-dichlorophenyl, 2,4-difluorophenyl, 1,5-dimethyl-1H-pyrazol-3-yl, 2,4-dimethylthiazol-5-yl, 1-ethyl-3-methyl-1H-pyrazol-5-yl, 2-methoxyphenyl, 4-methoxyphenyl, 4-methylisoxazol-3-yl,
5-methylisoxazol-4-yl, 4-methylphenyl, 1-methyl-3-trifluoromethyl-1H-pyrazol-4-yl, 1-methyl-5-chloro-1H-pyrazol-4-yl, 5-methyl-1H-pyrazol-3-yl, 6-methylpyridin-3-yl, 2-pyrrolidin-3-ylphenyl, 4-(trifluoromethyl)phenyl, 6-(trifluoromethyl)pyridin-3-yl,
2,5-dimethyloxazol-4-yl, 2-aminothiazol-4-yl, 4-methylpyrazol-5-yl, 3-trifluoromethylpyrazol-4-yl, 2-methyl-3-trifluoromethylpyrazol-5-yl, 4-chloro-1,3-dimethylpyrazolo[3,4]pyridine, and 1-methylbenzimidazol-2-yl; R.sup.4 is
-[alkylene].sub.p-nitrogen-containing heterocyclic, -[alkylene].sub.p-nitrogen-containing substituted heterocyclic, -[alkylene].sub.p-nitrogen-containing heteroaryl, -[alkylene].sub.p-nitrogen-containing substituted heteroaryl, or
-[alkylene].sub.p--NR.sup.10R.sup.11 wherein p is 1, selected from the group consisting of --(CH.sub.2).sub.2--NH.sub.2, --CH.sub.2-azetidin-3-yl, --CH.sub.2-(2,5-dihydropyrrol-3-yl), --(CH.sub.2).sub.3-imidazol-1-yl, --CH.sub.2-(1H-imidazol-4-yl),
--CH.sub.2-pyridin-3-yl, --CH.sub.2-(2-hydroxypyridin-4-yl), --CH.sub.2-(6-hydroxypyridin-3-yl), --CH.sub.2-morpholin-2-yl, --CH.sub.2-pyrrolidin-3-yl, --CH.sub.2-(3-fluoropyrrolidin-3-yl), --CH.sub.2-(3-hydroxypyrrolidin-3-yl),
--CH.sub.2-(4-fluoropyrrolidin-3-yl), --CH.sub.2-(4-hydroxypyrrolidin-3-yl), --CH.sub.2-(2-hydroxymethylpyrrolidin-3-yl), --CH.sub.2-piperidin-3-yl, --CH.sub.2-[1H-(1,2,3-triazol-4-yl)], --CH.sub.2CH(NH.sub.2)CH.sub.2OH, --(CH.sub.2).sub.3--NH.sub.2,
--(CH.sub.2).sub.3--NHCH.sub.3, --(CH.sub.2).sub.3--N(CH.sub.3).sub.2, --(CH.sub.2).sub.3NH-(5-cyanopyridin-2-yl), --(CH.sub.2).sub.3NH-cyclopropyl, --(CH.sub.2).sub.3NH-cyclobutyl, --(CH.sub.2).sub.3-(1H-imidazol-2-yl),
--(CH.sub.2).sub.3-(2-hydroxyethylpiperidin-1-yl), --(CH.sub.2).sub.3NHCH.sub.2-cyclopropyl, --CH.sub.2CHOHCH.sub.2NH.sub.2, --CH.sub.2CH(CH.sub.2OH)CH.sub.2NH.sub.2, --CH.sub.2C(CH.sub.3).sub.2CH.sub.2--N(CH.sub.3).sub.2,
--CH.sub.2C(CH.sub.3).sub.2CH.sub.2-(4-methylpiperazin-1-yl), --(CH.sub.2).sub.2C(O)NH.sub.2, --(CH.sub.2).sub.2CH(NH.sub.2)C(O)NH.sub.2, --(CH.sub.2).sub.2CH(NH.sub.2)CH.sub.2OH, --(CH.sub.2).sub.2CH(NH.sub.2)CH.sub.3, --CH.sub.2CHFCH.sub.2NH.sub.2,
--(CH.sub.2).sub.3--NHCH.sub.2CH.sub.2OH, --(CH.sub.2).sub.3--N(CH.sub.2CH.sub.2OH).sub.2, --(CH.sub.2).sub.3--NHCH(CH.sub.2OH).sub.2, --(CH.sub.2).sub.3CH.sub.3, --(CH.sub.2).sub.2CH(NH.sub.2)CH.sub.2OH, --(CH.sub.2).sub.2C(CH.sub.3).sub.2NH.sub.2,
--(CH.sub.2).sub.2CH(NH.sub.2)CH.sub.2OCH.sub.3, --(CH.sub.2).sub.2CH(NH.sub.2)CH.sub.2F, and --CH.sub.2CHFCH(NH.sub.2)CH.sub.2OH; R.sup.5 is L-A.sup.1, wherein L is methylene and A.sup.1 is selected from the group consisting of phenyl,
6-aminopyridin-2-yl, 3-chlorophenyl, 3-cyanophenyl, 2,4-difluorophenyl, 2,5-difluorophenyl, 3,5-difluorophenyl, 2-fluorophenyl, 3-fluorophenyl, 4-fluorophenyl, 3-hydroxyphenyl, 3-methoxyphenyl, 1-(5-methyl)-isoxazol-3-yl, 2-methylphenyl, 3-methylphenyl,
4-methylphenyl, pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, tetrahydropyran-4-yl, thiazol-4-yl, and 5-trifluoromethylfuran-2-yl; and R.sup.6 is selected from the group consisting of phenyl, 3-bromophenyl, 3-chlorophenyl, 4-cyanophenyl, 2,5-difluorophenyl,
3-fluorophenyl, 2-methoxyphenyl, 3-methoxyphenyl, 4-methoxyphenyl, 4-methylphenyl, pyrazin-2-yl, pyridin-2-yl, thiazol-2-yl, 2-trifluoromethylphenyl, and 3-trifluoromethylphenylR.sup.7 is hydrogen, halo, or methyl; or a pharmaceutically acceptable salt
thereof.
2. The compound of claim 1, wherein R.sup.1 is selected from the group consisting of methyl, iso-propyl, t-butyl, 1-methyl-n-prop-1-yl, and 2-hydroxy-iso-propyl. 3. The compound of claim 1, wherein R.sup.2 is hydrogen. 4. The compound of claim 1, wherein R.sup.7 is hydrogen. 5. The compound of claim 4, wherein R.sup.6 is selected from the group consisting of phenyl, 3-bromophenyl, 3-chlorophenyl, 4-cyanophenyl, 2,5-difluorophenyl, 3-fluorophenyl, and 3-trifluoromethylphenyl. 6. A compound selected from the group consisting of: N-(3-aminopropyl)-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2-methyl- propyl]-4-methylbenzamide; N-(3-aminopropyl)-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2-methyl- propyl]benzamide; N-(3-aminopropyl)-N--[(R)-(1-benzyl-4-phenyl-1H-imidazol-2-yl)(phenyl)met- hyl]-4-methylbenzamide; N-(3-aminopropyl)-N--[(R)-(1-benzyl-4-phenyl-1H-imidazol-2-yl)(phenyl)met- hyl]benzamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-bromophenyl)-1H-imidazol-2-yl]- -2-methylpropyl}benzamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-bromophenyl)-1H-imidazol-2-yl]- -2-methylpropyl}-4-methylbenzamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-bromophenyl)-1H-imidazol-2-yl]- -2-methylpropyl}-4-(trifluoromethyl)benzamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-bromophenyl)-1H-imidazol-2-yl]- -2-methylpropyl}-2,4-difluorobenzamide; N-(3-aminopropyl)-4-methyl-N-{2-methyl-1-[1-(3-methylbenzyl)-4-phenyl-1H-- imidazol-2-yl]propyl}benzamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-methoxyphenyl)-1H-imidazol-2-y- l]-2-methylpropyl}benzamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-methoxyphenyl)-1H-imidazol-2-y- l]-2-methylpropyl}-4-methylbenzamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-methoxyphenyl)-1H-imidazol-2-y- l]-2-methylpropyl}-4-(trifluoromethyl)benzamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-methoxyphenyl)-1H-imidazol-2-y- l]-2-methylpropyl}-2,4-difluorobenzamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}benzamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}-4-methylbenzamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}-4-(trifluoromethyl)benzamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}-2,4-difluorobenzamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(4-methylphenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}benzamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(4-methylphenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}-4-methylbenzamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(4-methylphenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}-4-(trifluoromethyl)benzamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(4-methylphenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}-2,4-difluorobenzamide; N-(3-aminopropyl)-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dime- thylpropyl]-4-methylbenzamide; N-(3-aminopropyl)-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dime- thylpropyl]benzamide; N-(3-aminopropyl)-N-{(1R)-1-[1-(3,5-difluorobenzyl)-4-phenyl-1H-imidazol-- 2-yl]-2-methylpropyl}-4-methylbenzamide; N-(3-aminopropyl)-N-{(1R)-1-[1-(3,5-difluorobenzyl)-4-phenyl-1H-imidazol-- 2-yl]-2-methylpropyl}benzamide; N-{(1R)-1-[1-benzyl-4-(3-bromophenyl)-1H-imidazol-2-yl]-2-methylpropyl}-4- -methyl-N-{3-[(methylsulfonyl)amino]propyl}benzamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2-methylpropyl]-N-[(3R)-pi- peridin-3-ylmethyl]benzamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2-methylpropyl]-N-[(3S)-pi- peridin-3-ylmethyl]benzamide; N-(3-aminopropyl)-4-methyl-N-{(1R)-2-methyl-1-[1-(4-methylbenzyl)-4-pheny- l-1H-imidazol-2-yl]propyl}benzamide; N-(3-aminopropyl)-N-{(1R)-2-methyl-1-[1-(4-methylbenzyl)-4-phenyl-1H-imid- azol-2-yl]propyl}benzamide; N-(3-aminopropyl)-4-methyl-N-{(1R)-2-methyl-1-[1-(2-methylbenzyl)-4-pheny- l-1H-imidazol-2-yl]propyl}benzamide; N-(3-aminopropyl)-N-{(1R)-2-methyl-1-[1-(2-methylbenzyl)-4-phenyl-1H-imid- azol-2-yl]propyl}benzamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2-methylpropyl]-N-[2,2-dim- ethyl-3-(4-methylpiperazin-1-yl)propyl]benzamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2-methylpropyl]-N-[2,2-dim- ethyl-3-(4-methylpiperazin-1-yl)propyl]-4-methylbenzamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2-methylpropyl]-4-methyl-N- -[(3R)-piperidin-3-ylmethyl]benzamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2-methylpropyl]-4-methyl-N- -[(3S)-piperidin-3-ylmethyl]benzamide; N-(3-aminopropyl)-N-((1R)-1-{1-benzyl-4-[2-(trifluoromethyl)phenyl]-1H-im- idazol-2-yl}-2-methylpropyl)benzamide; N-(3-aminopropyl)-N-((1R)-1-{1-benzyl-4-[2-(trifluoromethyl)phenyl]-1H-im- idazol-2-yl}-2-methylpropyl)-4-methylbenzamide; N-(3-aminopropyl)-N-((1R)-1-{1-benzyl-4-[2-(trifluoromethyl)phenyl]-1H-im- idazol-2-yl}-2-methylpropyl)-2,4-difluorobenzamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}-4-methoxybenzamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}-3-chlorobenzamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}-4-chlorobenzamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}-4-tert-butylbenzamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}-3,4-dichlorobenzamide; N-{(1R)-1-[1-benzyl-4-(3-bromophenyl)-1H-imidazol-2-yl]-2-methylpropyl}-N- -{3-[(5-cyanopyridin-2-yl)amino]propyl}benzamide; N-{(1R)-1-[1-benzyl-4-(3-bromophenyl)-1H-imidazol-2-yl]-2-methylpropyl}-N- -(3-{[5-(trifluoromethyl)pyridin-2-yl]amino}propyl)benzamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2-methylpropyl]-N-piperidi- n-4-ylbenzamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2-methylpropyl]-4-methyl-N- -piperidin-4-ylbenzamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2-methylpropyl]-2,4-difluo- ro-N-piperidin-4-ylbenzamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}cyclohexanecarboxamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}-6-chloronicotinamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2,2-dimethylpropyl}benzamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2,2-dimethylpropyl}-4-methylbenzamide; N-(3-aminopropyl)-N-{(1R)-1-[4-(3-chlorophenyl)-1-(2,4-difluorobenzyl)-1H- -imidazol-2-yl]-2,2-dimethylpropyl}benzamide; N-(3-aminopropyl)-N-{(1R)-1-[4-(3-chlorophenyl)-1-(2,4-difluorobenzyl)-1H- -imidazol-2-yl]-2,2-dimethylpropyl}-4-methylbenzamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2-methylpropyl]-N-[3-(dime- thylamino)-2,2-dimethylpropyl]benzamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2-methylpropyl]-N-[3-(dime- thylamino)-2,2-dimethylpropyl]-4-methylbenzamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2,2-dimethylpropyl}-6-chloronicotinamide; N-(3-aminopropyl)-6-chloro-N-{(1R)-1-[4-(3-chlorophenyl)-1-(3,5-difluorob- enzyl)-1H-imidazol-2-yl]-2,2-dimethylpropyl}nicotinamide; N-(3-aminopropyl)-N-[(1R)-1-(1-benzyl-5-methyl-4-phenyl-1H-imidazol-2-yl)- -2-methylpropyl]benzamide; N-(3-aminopropyl)-N-[(1R)-1-(1-benzyl-5-methyl-4-phenyl-1H-imidazol-2-yl)- -2-methylpropyl]-4-methylbenzamide; N-(3-aminopropyl)-N-[(1R)-1-(1-benzyl-5-methyl-4-phenyl-1H-imidazol-2-yl)- -2-methylpropyl]-2,4-difluorobenzamide; N-(3-aminopropyl)-N-[(1R)-1-(1-benzyl-5-methyl-4-phenyl-1H-imidazol-2-yl)- -2-methylpropyl]-6-chloronicotinamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}-2-chlorobenzamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}-2-chloro-6-methylisonicotinamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}-3-furamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}-5-methyl-2H-imidazole-4-carboxamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}-2-methoxybenzamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}pyridine-2-carboxamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}-1,5-dimethyl-1H-pyrazole-3-carboxamide; N-(3-aminopropyl)-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-1,2-dime- thylpropyl]benzamide; N-(3-aminopropyl)-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-1,2-dime- thylpropyl]-4-methylbenzamide; N-(2-aminoethyl)-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2-methylp- ropyl]-4-methylbenzamide; N-(2-aminoethyl)-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2-methylp- ropyl]benzamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}-1,3-thiazole-4-carboxamide; N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl]-2,2-dimethylprop- yl}-N-(pyrrolidin-3-ylmethyl)benzamide; N-{(1R)-1-[4-(3-chlorophenyl)-1-(3,5-difluorobenzyl)-1H-imidazol-2-yl]-2,- 2-dimethylpropyl}-N-(pyrrolidin-3-ylmethyl)benzamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}benzenesulfonamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}-4-methylisoxazole-3-carboxamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}isoxazole-3-carboxamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}-5-methyl-1H-pyrazole-3-carboxamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}-2,4-dimethyl-1,3-thiazole-5-carboxamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}tetrahydrofuran-3-carboxamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}piperidine-4-carboxamide; 2-amino-N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imida- zol-2-yl]-2-methylpropyl}-1,3-thiazole-4-carboxamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-(1H-- imidazol-4-ylmethyl)benzamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-[(2-- hydroxypyridin-4-yl)methyl]benzamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-[(6-- hydroxypyridin-3-yl)methyl]benzamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-(pyr- idin-3-ylmethyl)benzamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-[3-(- cyclobutylamino)propyl]benzamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-(pyr- rolidin-3-ylmethyl)benzamide; N-(3-aminopropyl)-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dime- thylpropyl]-6-methylnicotinamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-{3-[- (cyclopropylmethyl)amino]propyl}benzamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-[3-(- {[5-(pyridin-3-yloxy)-1H-indazol-3-yl]methyl}amino)propyl]benzamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-[(5-- methoxy-1H-indazol-3-yl)methyl]benzamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-(3-{- [(6-fluoro-1H-indazol-3-yl)methyl]amino}propyl)benzamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[5-- (pyridin-3-yloxy)-1H-indazol-3-yl]methyl}benzamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-(3-h- ydroxypropyl)benzamide; N-(3-aminopropyl)-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dime- thylpropyl]-1,5-dimethyl-1H-pyrazole-3-carboxamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-[(3R- )-3,5-diamino-5-oxopentyl]benzamide; N-{3-[(aminoacetyl)amino]propyl}-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol- -2-yl)-2,2-dimethylpropyl]benzamide; N-{2-[(aminoacetyl)amino]ethyl}-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-- 2-yl)-2,2-dimethylpropyl]benzamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2-methylpropyl]-1,5-dimeth- yl-N-(piperidin-3-ylmethyl)-1H-pyrazole-3-carboxamide; (2R)--N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazo- l-2-yl]-2-methylpropyl}tetrahydrofuran-2-carboxamide; (2S)--N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazo- l-2-yl]-2-methylpropyl}tetrahydrofuran-2-carboxamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}pyrazine-2-carboxamide; 3-{benzoyl[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl- ]amino}propyl benzoate; N-{(1R)-1-[4-(3-chlorophenyl)-1-(3,5-difluorobenzyl)-1H-imidazol-2-yl]-2,- 2-dimethylpropyl}-1,5-dimethyl-N-[(3R)-pyrrolidin-3-ylmethyl]-1H-pyrazole-- 3-carboxamide; N-{(1R)-1-[4-(3-chlorophenyl)-1-(3,5-difluorobenzyl)-1H-imidazol-2-yl]-2,- 2-dimethylpropyl}-1,5-dimethyl-N-[(3S)-pyrrolidin-3-ylmethyl]-1H-pyrazole-- 3-carboxamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}-5-chloro-1-methyl-1H-pyrazole-4-carboxamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}-2-(dimethylamino)acetamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-[3-(- 1H-imidazol-2-yl)propyl]benzamide; 1-benzyl-6-(1-benzyl-4-phenyl-1H-imidazol-2-yl)piperidin-2-one; 1-benzyl-6-[1-(3-chlorobenzyl)-4-phenyl-1H-imidazol-2-yl]piperidin-2-one; N-(3-aminopropyl)-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2-methyl- propyl]-1,5-dimethyl-1H-pyrazole-3-carboxamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-{3-[- (2-hydroxyethyl)amino]propyl}benzamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-[3-(- cyclopropylamino)propyl]benzamide; N-(3-aminopropyl)-N-{(1R)-2-methyl-1-[4-phenyl-1-(1,3-thiazol-4-ylmethyl)- -1H-imidazol-2-yl]propyl}benzamide; N-(3-aminopropyl)-4-methyl-N-{(1R)-2-methyl-1-[4-phenyl-1-(1,3-thiazol-4-- ylmethyl)-1H-imidazol-2-yl]propyl}benzamide; N-(3-aminopropyl)-2,4-difluoro-N-{(1R)-2-methyl-1-[4-phenyl-1-(1,3-thiazo- l-4-ylmethyl)-1H-imidazol-2-yl]propyl}benzamide; N-(3-aminopropyl)-6-chloro-N-{(1R)-2-methyl-1-[4-phenyl-1-(1,3-thiazol-4-- ylmethyl)-1H-imidazol-2-yl]propyl}nicotinamide; N-(3-aminopropyl)-N-[(1R)-1-(1-benzyl-4-pyridin-2-yl-1H-imidazol-2-yl)-2,- 2-dimethylpropyl]benzamide; N-(3-aminopropyl)-N-[(1R)-1-(1-benzyl-4-pyridin-2-yl-1H-imidazol-2-yl)-2,- 2-dimethylpropyl]-4-methylbenzamide; N-(3-aminopropyl)-N-[(1R)-1-(1-benzyl-4-pyridin-2-yl-1H-imidazol-2-yl)-2,- 2-dimethylpropyl]-2,4-difluorobenzamide; N-(3-aminopropyl)-N-[(1R)-1-(1-benzyl-4-pyridin-2-yl-1H-imidazol-2-yl)-2,- 2-dimethylpropyl]-6-chloronicotinamide; N-(2-amino-3-hydroxypropyl)-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl- )-2-methylpropyl]benzamide; N-(3-aminopropyl)-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-3-methyl- butyl]benzamide; N-(3-aminopropyl)-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-3-methyl- butyl]-4-methylbenzamide; N-(3-aminopropyl)-N-[(1R,2R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2-met- hylbutyl]benzamide; N-(3-aminopropyl)-N-[(1R,2R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2-met- hylbutyl]-4-methylbenzamide; N-(3-aminopropyl)-N-[(1R,2S)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2-met- hylbutyl]benzamide; N-(3-aminopropyl)-N-[(1R,2S)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2-met- hylbutyl]-4-methylbenzamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}-5-methylisoxazole-4-carboxamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}acetamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}-2-(4-fluorophenoxy)acetamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}-2-(1H-imidazol-1-yl)acetamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}-2-morpholin-4-ylacetamide; [(3-{benzoyl[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylprop- yl]amino}propyl)amino]acetic acid; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}-2-hydroxyacetamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}-2-methoxyacetamide; N-(3-aminopropyl)-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dime- thylpropyl]-2-hydroxyacetamide; N-(3-aminopropyl)-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dime- thylpropyl]-2-methoxyacetamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}-1-ethyl-3-methyl-1H-pyrazole-5-carboxamide; ethyl [(3-{benzoyl[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylprop- yl]amino}propyl)amino]acetate; N-{3-[(2-amino-3-methylbutanoyl)amino]propyl}-N-[(1R)-1-(1-benzyl-4-pheny- l-1H-imidazol-2-yl)-2,2-dimethylpropyl]benzamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}tetrahydro-2H-pyran-4-carboxamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}-2-(methylamino)acetamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-prop- ylbenzamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-buty- lbenzamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-buty- l-1,5-dimethyl-1H-pyrazole-3-carboxamide; [[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl](butyl)a- mino](oxo)acetic acid; [[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl](propyl)- amino](oxo)acetic acid; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-{3-[- 2-(hydroxymethyl)piperidin-1-yl]propyl}benzamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-{3-[- bis(2-hydroxyethyl)amino]propyl}benzamide; 1-(2-amino-1-phenylethyl)-6-(1-benzyl-4-phenyl-1H-imidazol-2-yl)piperidin- -2-one; 6-(1-benzyl-4-phenyl-1H-imidazol-2-yl)piperidin-2-one; N-[(2S)-3-amino-2-fluoropropyl]-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-- 2-yl)-2,2-dimethylpropyl]benzamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-(3-{- [2-hydroxy-1-(hydroxymethyl)ethyl]amino}propyl)benzamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-(3-{- [2-(hydroxymethyl)phenyl]amino}propyl)benzamide; N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl]-2-methylpropyl}-- N-piperidin-4-ylbenzamide; N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl]-2-methylpropyl}-- N-(piperidin-3-ylmethyl)benzamide; 2-(3-amino-2-oxopyridin-1(2H)-yl)-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazo- l-2-yl)-2,2-dimethylpropyl]acetamide; N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl]-2-methylpropyl}-- 2-pyrrolidin-3-ylbenzamide; (1R,3S)-3-{[(2-aminoethyl)sulfonyl]amino}-N-[(1R)-1-(1-benzyl-4-phenyl-1H- -imidazol-2-yl)-2,2-dimethylpropyl]cyclohexanecarboxamide; (1R,3S)-3-[(aminoacetyl)amino]-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2- -yl)-2,2-dimethylpropyl]cyclohexanecarboxamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}-6-(trifluoromethyl)nicotinamide; N-[(2R)-3-amino-2-fluoropropyl]-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-- 2-yl)-2,2-dimethylpropyl]benzamide; (3R)--N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazo- l-2-yl]-2-methylpropyl}piperidine-3-carboxamide; (3S)--N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazo- l-2-yl]-2-methylpropyl}piperidine-3-carboxamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}-2-(1H-1,2,4-triazol-1-yl)acetamide; [(5R)-1-benzoyl-5-(1-benzyl-4-phenyl-1H-imidazol-2-yl)pyrrolidin-2-yl]met- hylamine; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imid- azol-2-yl]-2-methylpropyl}-2-(4H-1,2,4-triazol-4-yl)acetamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}-2,1,3-benzothiadiazole-4-carboxamide; N-[(2S)-3-amino-2-hydroxypropyl]-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol- -2-yl)-2,2-dimethylpropyl]benzamide; N-[(2S)-3-amino-2-fluoropropyl]-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-- 2-yl)-2,2-dimethylpropyl]-1,5-dimethyl-1H-pyrazole-3-carboxamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-1,5-di- methyl-N-[(2S)-morpholin-2-ylmethyl]-1H-pyrazole-3-carboxamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-1,5-di- methyl-N-[(2R)-morpholin-2-ylmethyl]-1H-pyrazole-3-carboxamide; N-[(2S)-3-amino-2-hydroxypropyl]-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol- -2-yl)-2,2-dimethylpropyl]-1,5-dimethyl-1H-pyrazole-3-carboxamide; N-[(2S)-3-amino-2-hydroxypropyl]-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol- -2-yl)-2,2-dimethylpropyl]-2-methoxyacetamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-2-pyrr- olidin-3-ylbenzamide; N-(3-aminopropyl)-N-{(1R)-1-[1-benzyl-4-(3-chlorophenyl)-1H-imidazol-2-yl- ]-2-methylpropyl}-2-(1H-pyrazol-1-yl)acetamide; N-[(2R)-3-amino-2-fluoropropyl]-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-- 2-yl)-2,2-dimethylpropyl]-1,5-dimethyl-1H-pyrazole-3-carboxamide; methyl 3-aminopropyl[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpro- pyl]carbamate; N-(3-aminopropyl)-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dime- thylpropyl]-2-(1H-tetrazol-1-yl)acetamide; N-(3-aminopropyl)-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dime- thylpropyl]-2-(2H-tetrazol-2-yl)acetamide; N-(3-aminopropyl)-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dime- thylpropyl]-2-(1H-1,2,4-triazol-1-yl)acetamide; N-(3-aminopropyl)-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dime- thylpropyl]-2-(4H-1,2,4-triazol-4-yl)acetamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-2-meth- oxy-N-[(2S)-morpholin-2-ylmethyl]acetamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-2-meth- oxy-N-[(2R)-morpholin-2-ylmethyl]acetamide; N-(3-aminopropyl)-N-[(1S)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2-hydrox- y-2-methylpropyl]benzamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-2-hydr- oxy-N-[(2S)-morpholin-2-ylmethyl]acetamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-2-hydr- oxy-N-[(2R)-morpholin-2-ylmethyl]acetamide; (2S)--N-(3-aminopropyl)-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,- 2-dimethylpropyl]tetrahydrofuran-2-carboxamide; N-(3-aminopropyl)-N-{(1R)-1-[4-(3-chlorophenyl)-1-(3-cyanobenzyl)-1H-imid- azol-2-yl]-2-methylpropyl}benzamide; N-(3-aminopropyl)-N-{(1R)-1-[4-(3-chlorophenyl)-1-(3-cyanobenzyl)-1H-imid- azol-2-yl]-2-methylpropyl}-4-methylbenzamide; N-(3-aminopropyl)-N-{(1R)-1-[4-(3-chlorophenyl)-1-(3-methylbenzyl)-1H-imi- dazol-2-yl]-2-methylpropyl}-4-methylbenzamide; N-(3-aminopropyl)-N-{(1R)-1-[4-(3-chlorophenyl)-1-(3-methylbenzyl)-1H-imi- dazol-2-yl]-2-methylpropyl}benzamide; ethyl 3-aminopropyl[1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylprop- yl]carbamate; neopentyl 3-aminopropyl[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpro- pyl]carbamate; isobutyl 3-aminopropyl[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpro- pyl]carbamate; propyl 3-aminopropyl[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpro- pyl]carbamate; N-(3-aminopropyl)-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dime- thylpropyl]-2-cyanoacetamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-2-meth- oxy-N-[(3R)-pyrrolidin-3-ylmethyl]acetamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-2-meth- oxy-N-[(3S)-pyrrolidin-3-ylmethyl]acetamide; butyl 3-aminopropyl[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpro- pyl]carbamate; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-2-hydr- oxy-N-[(3R)-pyrrolidin-3-ylmethyl]acetamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-2-hydr- oxy-N-[(3S)-pyrrolidin-3-ylmethyl]acetamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-[(3S- )-pyrrolidin-3-ylmethyl]benzamide; N-[(2R)-3-amino-2-fluoropropyl]-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-- 2-yl)-2,2-dimethylpropyl]-2-(2H-tetrazol-2-yl)acetamide; N-[(2R)-3-amino-2-fluoropropyl]-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-- 2-yl)-2,2-dimethylpropyl]-2-(1H-tetrazol-1-yl)acetamide; N-[(2R)-3-amino-2-fluoropropyl]-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-- 2-yl)-2,2-dimethylpropyl]-2-methoxyacetamide; N-[(2S)-3-amino-2-fluoropropyl]-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-- 2-yl)-2,2-dimethylpropyl]-2-methoxyacetamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-[(3S- )-3,4-diamino-4-oxobutyl]benzamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-[(3R- )-3,4-diamino-4-oxobutyl]benzamide; N-[(3S)-3-amino-4-hydroxybutyl]-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-- 2-yl)-2,2-dimethylpropyl]benzamide; (2S)-2-amino-4-{benzoyl[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-d- imethylpropyl]amino}butanoic acid; N-[(2R)-3-amino-2-fluoropropyl]-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-- 2-yl)-2,2-dimethylpropyl]-2-hydroxyacetamide; N-(3-aminopropyl)-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dime- thylpropyl]-2-(1H-tetrazol-5-yl)acetamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-[(3S- )-pyrrolidin-3-ylmethyl]-2-(1H-tetrazol-1-yl)acetamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-[(3S- )-pyrrolidin-3-ylmethyl]-2-(2H-tetrazol-2-yl)acetamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-6-meth- yl-N-[(3S)-pyrrolidin-3-ylmethyl]nicotinamide; N-(azetidin-3-ylmethyl)-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,- 2-dimethylpropyl]-2-methoxyacetamide; N-{(1R)-1-[1-(3-cyanobenzyl)-4-phenyl-1H-imidazol-2-yl]-2,2-dimethylpropy- l}-N-(pyrrolidin-3-ylmethyl)benzamide; N-{(1R)-2,2-dimethyl-1-[1-(3-methylbenzyl)-4-phenyl-1H-imidazol-2-yl]prop- yl}-N-(pyrrolidin-3-ylmethyl)benzamide; N-[(2S)-3-amino-2-hydroxypropyl]-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol- -2-yl)-2,2-dimethylpropyl]-2-hydroxyacetamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-[3-(- methoxyamino)propyl]benzamide; N-[(2S)-3-amino-2-fluoropropyl]-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-- 2-yl)-2,2-dimethylpropyl]-2-(1H-tetrazol-1-yl)acetamide; N-[(2S)-3-amino-2-fluoropropyl]-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-- 2-yl)-2,2-dimethylpropyl]-2-(2H-tetrazol-2-yl)acetamide; N-{(1R)-1-[1-(3-cyanobenzyl)-4-phenyl-1H-imidazol-2-yl]-2,2-dimethylpropy- l}-2-methoxy-N-[(3S)-pyrrolidin-3-ylmethyl]acetamide; N-{(1R)-1-[1-(3-cyanobenzyl)-4-phenyl-1H-imidazol-2-yl]-2,2-dimethylpropy- l}-2-methoxy-N-[(3R)-pyrrolidin-3-ylmethyl]acetamide; N-(3-aminopropyl)-N-{(1R)-1-[1-(3-cyanobenzyl)-4-phenyl-1H-imidazol-2-yl]- -2,2-dimethylpropyl}benzamide; N-(3-aminopropyl)-N-{(1R)-1-[1-(3-cyanobenzyl)-4-phenyl-1H-imidazol-2-yl]- -2,2-dimethylpropyl}-2-methoxyacetamide; 2-hydroxy-N-{(1R)-1-[1-(3-hydroxybenzyl)-4-phenyl-1H-imidazol-2-yl]-2,2-d- imethylpropyl}-N-(pyrrolidin-3-ylmethyl)acetamide; N-{(1R)-2,2-dimethyl-1-[1-(3-methylbenzyl)-4-phenyl-1H-imidazol-2-yl]prop- yl}-2-methoxy-N-[(3S)-pyrrolidin-3-ylmethyl]acetamide; N-{(1R)-2,2-dimethyl-1-[1-(3-methylbenzyl)-4-phenyl-1H-imidazol-2-yl]prop- yl}-2-methoxy-N-[(3R)-pyrrolidin-3-ylmethyl]acetamide; N-(3-aminopropyl)-N-{(1R)-2,2-dimethyl-1-[1-(3-methylbenzyl)-4-phenyl-1H-- imidazol-2-yl]propyl}-2-methoxyacetamide; N-[(3S)-3-amino-4-hydroxybutyl]-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-- 2-yl)-2,2-dimethylpropyl]-1,5-dimethyl-1H-pyrazole-3-carboxamide; N-(3-amino-2-hydroxypropyl)-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl- )-2,2-dimethylpropyl]-2-(1H-tetrazol-1-yl)acetamide; N-(3-amino-2-hydroxypropyl)-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl- )-2,2-dimethylpropyl]-2-(2H-tetrazol-2-yl)acetamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-1,5-di- methyl-N-[(3S)-pyrrolidin-3-ylmethyl]-1H-pyrazole-3-carboxamide; N-(3-aminopropyl)-N-{(1R)-2,2-dimethyl-1-[1-(3-methylbenzyl)-4-phenyl-1H-- imidazol-2-yl]propyl}benzamide; N-(azetidin-3-ylmethyl)-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,- 2-dimethylpropyl]benzamide; N-(azetidin-3-ylmethyl)-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,- 2-dimethylpropyl]-2-hydroxyacetamide; N-(azetidin-3-ylmethyl)-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,- 2-dimethylpropyl]-1,5-dimethyl-1H-pyrazole-3-carboxamide; N-[(3S)-3-amino-4-hydroxybutyl]-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-- 2-yl)-2,2-dimethylpropyl]-2-methoxyacetamide; N-[(2S)-3-amino-2-fluoropropyl]-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-- 2-yl)-2,2-dimethylpropyl]-2-(1H-1,2,3-triazol-1-yl)acetamide; N-[(2S)-3-amino-2-fluoropropyl]-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-- 2-yl)-2,2-dimethylpropyl]-2-(2H-1,2,3-triazol-2-yl)acetamide; N-[(3S)-3-amino-4-hydroxybutyl]-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-- 2-yl)-2,2-dimethylpropyl]-2-(1H-tetrazol-1-yl)acetamide; N-[(3S)-3-amino-4-hydroxybutyl]-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-- 2-yl)-2,2-dimethylpropyl]-2-(2H-tetrazol-2-yl)acetamide; N-[(3S)-3-amino-4-hydroxybutyl]-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-- 2-yl)-2,2-dimethylpropyl]-2-(1H-1,2,3-triazol-1-yl)acetamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-[(3-- fluoropyrrolidin-3-yl)methyl]amine; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3- S)-3-hydroxypyrrolidin-3-yl]methyl}-2-methoxyacetamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3- R)-3-hydroxypyrrolidin-3-yl]methyl}-2-methoxyacetamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-[(3-- hydroxypyrrolidin-3-yl)methyl]-2-methoxyacetamide; N-(azetidin-3-ylmethyl)-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,- 2-dimethylpropyl]-6-methylnicotinamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3- S)-3-fluoropyrrolidin-3-yl]methyl}-1,5-dimethyl-1H-pyrazole-3-carboxamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3- R)-3-fluoropyrrolidin-3-yl]methyl}-1,5-dimethyl-1H-pyrazole-3-carboxamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-[(3-- fluoropyrrolidin-3-yl)methyl]-1,5-dimethyl-1H-pyrazole-3-carboxamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3- S)-3-fluoropyrrolidin-3-yl]methyl}benzamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3- R)-3-fluoropyrrolidin-3-yl]methyl}benzamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-[(3-- fluoropyrrolidin-3-yl)methyl]benzamide; N-(3-aminopropyl)-2-hydroxy-N-{(1R)-1-[1-(3-hydroxybenzyl)-4-phenyl-1H-im- idazol-2-yl]-2,2-dimethylpropyl}acetamide; N-{(1R)-1-[1-(3-hydroxybenzyl)-4-phenyl-1H-imidazol-2-yl]-2,2-dimethylpro- pyl}-N-(pyrrolidin-3-ylmethyl)benzamide; N-(3-aminopropyl)-N-{(1R)-2,2-dimethyl-1-[1-(3-methylbenzyl)-4-phenyl-1H-- imidazol-2-yl]propyl}-1,5-dimethyl-1H-pyrazole-3-carboxamide; N-{(1R)-2,2-dimethyl-1-[1-(3-methylbenzyl)-4-phenyl-1H-imidazol-2-yl]prop- yl}-1,5-dimethyl-N-(pyrrolidin-3-ylmethyl)-1H-pyrazole-3-carboxamide; N-(3-aminopropyl)-N-{(1R)-1-[1-(3-hydroxybenzyl)-4-phenyl-1H-imidazol-2-y- l]-2,2-dimethylpropyl}benzamide; N-(3-aminopropyl)-N-{(1R)-1-[1-(3-methoxybenzyl)-4-phenyl-1H-imidazol-2-y- l]-2,2-dimethylpropyl}benzamide; N-(3-aminopropyl)-2-methoxy-N-{(1R)-1-[1-(3-methoxybenzyl)-4-phenyl-1H-im- idazol-2-yl]-2,2-dimethylpropyl}acetamide; N-(3-aminopropyl)-N-{(1R)-1-[1-(3-cyanobenzyl)-4-phenyl-1H-imidazol-2-yl]- -2,2-dimethylpropyl}-2-hydroxyacetamide; N-(3-aminopropyl)-N-{(1R)-1-[1-(3-methoxybenzyl)-4-phenyl-1H-imidazol-2-y- l]-2,2-dimethylpropyl}-1,5-dimethyl-1H-pyrazole-3-carboxamide; N-[(3S)-3-amino-4-methoxybutyl]-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-- 2-yl)-2,2-dimethylpropyl]benzamide; N-(3-aminopropyl)-N-{(1R)-1-[1-(3-cyanobenzyl)-4-phenyl-1H-imidazol-2-yl]- -2,2-dimethylpropyl}-1,5-dimethyl-1H-pyrazole-3-carboxamide; N-{(1R)-1-[1-(3-cyanobenzyl)-4-phenyl-1H-imidazol-2-yl]-2,2-dimethylpropy- l}-1,5-dimethyl-N-(pyrrolidin-3-ylmethyl)-1H-pyrazole-3-carboxamide; N-{(1R)-1-[1-(3-cyanobenzyl)-4-phenyl-1H-imidazol-2-yl]-2,2-dimethylpropy- l}-2-hydroxy-N-[(3S)-pyrrolidin-3-ylmethyl]acetamide; N-[(2R)-3-amino-2-fluoropropyl]-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-- 2-yl)-2,2-dimethylpropyl]-2-(1H-1,2,3-triazol-1-yl)acetamide; N-[(2R)-3-amino-2-fluoropropyl]-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-- 2-yl)-2,2-dimethylpropyl]-2-(2H-1,2,3-triazol-2-yl)acetamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3- S)-3-hydroxypyrrolidin-3-yl]methyl}benzamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3- R)-3-hydroxypyrrolidin-3-yl]methyl}benzamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-[(3-- hydroxypyrrolidin-3-yl)methyl]benzamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-2-etho- xy-N-[(3S)-pyrrolidin-3-ylmethyl]acetamide; N-(3-aminopropyl)-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dime- thylpropyl]-2-ethoxyacetamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3- S)-3-hydroxypyrrolidin-3-yl]methyl}-1,5-dimethyl-1H-pyrazole-3-carboxamide- ; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(- 3R)-3-hydroxypyrrolidin-3-yl]methyl}-1,5-dimethyl-1H-pyrazole-3-carboxamid- e; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-[(- 3-hydroxypyrrolidin-3-yl)methyl]-1,5-dimethyl-1H-pyrazole-3-carboxamide; N-[(2S)-3-amino-2-fluoropropyl]-N-[(1S)-1-(1-benzyl-4-phenyl-1H-imidazol-- 2-yl)-2-hydroxy-2-methylpropyl]-2-(1H-tetrazol-1-yl)acetamide; N-[(2S)-3-amino-2-fluoropropyl]-N-[(1S)-1-(1-benzyl-4-phenyl-1H-imidazol-- 2-yl)-2-hydroxy-2-methylpropyl]-2-(2H-tetrazol-2-yl)acetamide; N-[(2S)-3-amino-2-fluoropropyl]-N-{(1R)-1-[1-benzyl-4-(3-fluorophenyl)-1H- -imidazol-2-yl]-2,2-dimethylpropyl}-2-(1H-tetrazol-1-yl)acetamide; N-[(2S)-3-amino-2-fluoropropyl]-N-{(1R)-1-[1-benzyl-4-(3-fluorophenyl)-1H- -imidazol-2-yl]-2,2-dimethylpropyl}-2-(2H-tetrazol-2-yl)acetamide; N-[(2S)-3-amino-2-(hydroxymethyl)propyl]-N-[(1R)-1-(1-benzyl-4-phenyl-1H-- imidazol-2-yl)-2,2-dimethylpropyl]-N'-methylethanediamide; N-[(2R)-3-amino-2-(hydroxymethyl)propyl]-N-[(1R)-1-(1-benzyl-4-phenyl-1H-- imidazol-2-yl)-2,2-dimethylpropyl]-N'-methylethanediamide; N-[(3R)-3-amino-4-hydroxybutyl]-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-- 2-yl)-2,2-dimethylpropyl]-2-methoxyacetamide; N-[(3R)-3-amino-4-hydroxybutyl]-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-- 2-yl)-2,2-dimethylpropyl]-2-(1H-tetrazol-1-yl)acetamide; N-[(3R)-3-amino-4-hydroxybutyl]-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-- 2-yl)-2,2-dimethylpropyl]-2-(2H-tetrazol-2-yl)acetamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3- S)-3-fluoropyrrolidin-3-yl]methyl}-2-methoxyacetamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3- R)-3-fluoropyrrolidin-3-yl]methyl}-2-methoxyacetamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3- R,4R)-4-hydroxypyrrolidin-3-yl]methyl}-2-methoxyacetamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3- S,4S)-4-hydroxypyrrolidin-3-yl]methyl}-2-methoxyacetamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3- R,4R)-4-hydroxypyrrolidin-3-yl]methyl}benzamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3- S,4S)-4-hydroxypyrrolidin-3-yl]methyl}benzamide; N-[(3S)-3-amino-4-hydroxybutyl]-N-{(1R)-1-[1-benzyl-4-(3-fluorophenyl)-1H- -imidazol-2-yl]-2,2-dimethylpropyl}-2-(1H-tetrazol-1-yl)acetamide; N-[(3S)-3-amino-4-hydroxybutyl]-N-{(1R)-1-[1-benzyl-4-(3-fluorophenyl)-1H- -imidazol-2-yl]-2,2-dimethylpropyl}-2-(2H-tetrazol-2-yl)acetamide; N-[(3S)-3-amino-4-methoxybutyl]-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-- 2-yl)-2,2-dimethylpropyl]-2-methoxyacetamide; N-[(3S)-3-amino-4-hydroxybutyl]-N-{(1R)-1-[1-benzyl-4-(3-fluorophenyl)-1H- -imidazol-2-yl]-2,2-dimethylpropyl}-2-methoxyacetamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3- S)-3-fluoropyrrolidin-3-yl]methyl}-2-(2H-tetrazol-2-yl)acetamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3- R)-3-fluoropyrrolidin-3-yl]methyl}-2-(1H-tetrazol-1-yl)acetamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3- S,4S)-4-hydroxypyrrolidin-3-yl]methyl}-2-(1H-tetrazol-1-yl)acetamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3- S,4S)-4-hydroxypyrrolidin-3-yl]methyl}-2-(2H-tetrazol-2-yl)acetamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3- R,4R)-4-hydroxypyrrolidin-3-yl]methyl}-2-(1H-tetrazol-1-yl)acetamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3- R,4R)-4-hydroxypyrrolidin-3-yl]methyl}-2-(2H-tetrazol-2-yl)acetamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(2- S,3S)-2-(hydroxymethyl)pyrrolidin-3-yl]methyl}-2-(2H-tetrazol-2-yl)acetami- de; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-{- [(2S,3S)-2-(hydroxymethyl)pyrrolidin-3-yl]methyl}-2-(1H-tetrazol-1-yl)acet- amide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-- N-{[(2S,3S)-2-(hydroxymethyl)pyrrolidin-3-yl]methyl}-2-methoxyacetamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(2- S,3S)-2-(hydroxymethyl)pyrrolidin-3-yl]methyl}benzamide; N-[(2R)-3-amino-2-fluoropropyl]-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-- 2-yl)-2,2-dimethylpropyl]-2-(5-methyl-2H-tetrazol-2-yl)acetamide; N-[(2R)-3-amino-2-fluoropropyl]-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-- 2-yl)-2,2-dimethylpropyl]-2-(5-methyl-1H-tetrazol-1-yl)acetamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3- R)-3-hydroxypyrrolidin-3-yl]methyl}-2-(1H-tetrazol-1-yl)acetamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3- S)-3-hydroxypyrrolidin-3-yl]methyl}-2-(1H-tetrazol-1-yl)acetamide; (5S)-3-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-1- -oxa-3,7-diazaspiro[4.4]nonan-2-one; (5R)-3-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-1- -oxa-3,7-diazaspiro[4.4]nonan-2-one; N-[(2S,3R)-3-amino-2-fluoro-4-hydroxybutyl]-N-[(1R)-1-(1-benzyl-4-phenyl-- 1H-imidazol-2-yl)-2,2-dimethylpropyl]-2-methoxyacetamide; N-[(3S)-3-amino-4-fluorobutyl]-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2- -yl)-2,2-dimethylpropyl]-2-methoxyacetamide; N-[(3R)-3-amino-4-fluorobutyl]-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2- -yl)-2,2-dimethylpropyl]-2-methoxyacetamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3- R,4S)-4-hydroxypyrrolidin-3-yl]methyl}-2-methoxyacetamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3- S,4R)-4-hydroxypyrrolidin-3-yl]methyl}-2-methoxyacetamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-{[(3- R,4S)-4-fluoropyrrolidin-3-yl]methyl}-2-methoxyacetamide; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dimethylpropyl]-N-(2,5- -dihydro-1H-pyrrol-3-ylmethyl)-2-methoxyacetamide; N--((R)-3-Amino-2-fluoro-propyl)-N--[(R)-1-(1-benzyl-4-pyrazin-2-yl-1H-im- idazol-2-yl)-2,2-dimethyl-propyl]-2-methoxy-acetamide; N--((R)-3-Amino-2-fluoro-propyl)-N-{(R)-1-[1-benzyl-4-(3-methoxy-phenyl)-- 1H-imidazol-2-yl]-2,2-dimethyl-propyl}-2-ethoxy-acetamide; N--((R)-3-Amino-2-fluoro-propyl)-N-{(R)-1-[1-benzyl-4-(3-methoxy-phenyl)-- 1H-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; (S)-Tetrahydro-furan-2-carboxylic acid ((R)-3-amino-2-fluoro-propyl)-[(R)-1-(1-benzyl-4-pyrazin-2-yl-1H-imidazol- -2-yl)-2,2-dimethyl-propyl]-amide; N--((R)-3-Amino-2-fluoro-propyl)-N--[(R)-1-(1-benzyl-4-pyrazin-2-yl-1H-im- idazol-2-yl)-2,2-dimethyl-propyl]-2-ethoxy-acetamide; N--((R)-3-Amino-2-fluoro-propyl)-N--[(R)-1-(1-benzyl-4-phenyl-1H-imidazol- -2-yl)-2,2-dimethyl-propyl]-2-ethoxy-acetamide; (S)-Tetrahydro-furan-2-carboxylic acid ((R)-3-amino-2-fluoro-propyl)-[(R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)- -2,2-dimethyl-propyl]-amide; N--((S)-3-Amino-4-fluoro-butyl)-N--[(R)-2,2-dimethyl-1-(4-phenyl-1-pyridi- n-3-ylmethyl-1H-imidazol-2-yl)-propyl]-2-methoxy-acetamide; N--((R)-3-Amino-4-fluoro-butyl)-N--[(R)-2,2-dimethyl-1-(4-phenyl-1-pyridi- n-3-ylmethyl-1H-imidazol-2-yl)-propyl]-2-methoxy-acetamide; N--((S)-3-Amino-4-methoxy-butyl)-N-{(R)-1-[1-benzyl-4-(3-fluoro-phenyl)-1- H-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N--((R)-3-Amino-2-fluoro-propyl)-N-{(R)-1-[1-benzyl-4-(4-cyano-phenyl)-1H- -imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N--((R)-3-Amino-2-fluoro-propyl)-N-{(R)-1-[1-benzyl-4-(4-methoxy-phenyl)-- 1H-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N--((R)-3-Amino-2-fluoro-propyl)-N-{(R)-1-[1-(2-fluoro-benzyl)-4-phenyl-1- H-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N--((R)-3-Amino-2-fluoro-propyl)-N-{(R)-1-[1-(3-fluoro-benzyl)-4-phenyl-1- H-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N--((R)-3-Amino-2-fluoro-propyl)-N-{(R)-1-[1-(3-chloro-benzyl)-4-phenyl-1- H-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N--((R)-3-Amino-2-fluoro-propyl)-N-{(R)-1-[1-(3-cyano-benzyl)-4-phenyl-1H- -imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N--((R)-3-Amino-2-fluoro-propyl)-N-{(R)-2,2-dimethyl-1-[4-phenyl-1-(tetra- hydro-pyran-4-ylmethyl)-1H-imidazol-2-yl]-propyl}-2-methoxy-acetamide; (S)-Tetrahydro-furan-2-carboxylic acid ((R)-3-amino-2-fluoro-propyl)-{(R)-1-[1-benzyl-4-(3-fluoro-phenyl)-1H-imi- dazol-2-yl]-2,2-dimethyl-propyl}-amide; (S)-Tetrahydro-furan-2-carboxylic acid ((R)-3-amino-2-fluoro-propyl)-{(R)-1-[1-benzyl-4-(2-methoxy-phenyl)-- 1H-imidazol-2-yl]-2,2-dimethyl-propyl}-amide; (S)-Tetrahydro-furan-2-carboxylic acid ((R)-3-amino-2-fluoro-propyl)-{(R)-1-[1-benzyl-4-(3-trifluoromethyl-pheny- l)-1H-imidazol-2-yl]-2,2-dimethyl-propyl}-amide; (S)-Tetrahydro-furan-2-carboxylic acid ((R)-3-amino-2-fluoro-propyl)-{(R)-1-[1-benzyl-4-(3-bromo-phenyl)-1H-imid- azol-2-yl]-2,2-dimethyl-propyl}-amide; N--((R)-3-Amino-2-fluoro-propyl)-N-{(R)-1-[1-benzyl-4-(3-fluoro-phenyl)-1- H-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N--((R)-3-Amino-2-fluoro-propyl)-N-{(R)-1-[1-benzyl-4-(2-methoxy-phenyl)-- 1H-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N--((R)-3-Amino-2-fluoro-propyl)-N-{(R)-1-[1-benzyl-4-(3-trifluoromethyl-- phenyl)-1H-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N--((R)-3-Amino-2-fluoro-propyl)-N-{(R)-1-[1-benzyl-4-(3-bromo-phenyl)-1H- -imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N--((R)-3-Amino-2-fluoro-propyl)-N--[(R)-1-(1-benzyl-4-p-tolyl-1H-imidazo- l-2-yl)-2,2-dimethyl-propyl]-2-methoxy-acetamide; N--((S)-3-Amino-4-fluoro-butyl)-N--[(R)-2,2-dimethyl-1-(4-phenyl-1-pyridi- n-4-ylmethyl-1H-imidazol-2-yl)-propyl]-2-methoxy-acetamide; N--((R)-3-Amino-4-fluoro-butyl)-N--[(R)-2,2-dimethyl-1-(4-phenyl-1-pyridi- n-4-ylmethyl-1H-imidazol-2-yl)-propyl]-2-methoxy-acetamide; N--((S)-3-Amino-4-fluoro-butyl)-N-{(R)-2,2-dimethyl-1-[1-(5-methyl-isoxaz- ol-3-ylmethyl)-4-phenyl-1H-imidazol-2-yl]-propyl}-2-methoxy-acetamide; N--((R)-3-Amino-4-fluoro-butyl)-N-{(R)-2,2-dimethyl-1-[1-(5-methyl-isoxaz- ol-3-ylmethyl)-4-phenyl-1H-imidazol-2-yl]-propyl}-2-methoxy-acetamide; N--((S)-3-Amino-4-fluoro-butyl)-N--[(R)-2,2-dimethyl-1-(4-phenyl-1-pyridi- n-2-ylmethyl-1H-imidazol-2-yl)-propyl]-2-methoxy-acetamide; N--((R)-3-Amino-4-fluoro-butyl)-N--[(R)-2,2-dimethyl-1-(4-phenyl-1-pyridi- n-2-ylmethyl-1H-imidazol-2-yl)-propyl]-2-methoxy-acetamide; N--((S)-3-Amino-4-fluoro-butyl)-N-{(R)-1-[1-benzyl-4-(3-fluoro-phenyl)-1H- -imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N--((R)-3-Amino-4-fluoro-butyl)-N-{(R)-1-[1-benzyl-4-(3-fluoro-phenyl)-1H- -imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N-(3-Amino-3-methyl-butyl)-N--[(R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)- -2,2-dimethyl-propyl]-2-methoxy-acetamide; (S)-Tetrahydro-furan-2-carboxylic acid ((R)-3-amino-2-fluoro-propyl)-[(R)-1-(1-benzyl-5-chloro-4-phenyl-1H-imida- zol-2-yl)-2,2-dimethyl-propyl]-amide; N--((R)-3-Amino-2-fluoro-propyl)-N--[(R)-1-(1-benzyl-5-chloro-4-phenyl-1H- -imidazol-2-yl)-2,2-dimethyl-propyl]-2-methoxy-acetamide; (S)-Tetrahydro-furan-2-carboxylic acid ((R)-3-amino-2-fluoro-propyl)-[(R)-1-(1-benzyl-4-thiazol-2-yl-1H-imidazol- -2-yl)-2,2-dimethyl-propyl]-amide; N--((S)-3-Amino-2-fluoro-propyl)-N-{(R)-2,2-dimethyl-1-[4-phenyl-1-(5-tri- fluoromethyl-furan-2-ylmethyl)-1H-imidazol-2-yl]-propyl}-2-methoxy-acetami- de; N--((S)-3-Amino-2-fluoro-propyl)-N-{(R)-2,2-dimethyl-1-[1-(5-methyl-is- oxazol-3-ylmethyl)-4-phenyl-1H-imidazol-2-yl]-propyl}-2-methoxy-acetamide; (S)-Tetrahydro-furan-2-carboxylic acid ((S)-3-amino-2-fluoro-propyl)-{(R)-2,2-dimethyl-1-[1-(5-methyl-isoxazol-3- -ylmethyl)-4-phenyl-1H-imidazol-2-yl]-propyl}-amide; (S)-Tetrahydro-furan-2-carboxylic acid ((S)-3-amino-2-fluoro-propyl)-{(R)-2,2-dimethyl-1-[4-phenyl-1-(5-trifluor- omethyl-furan-2-ylmethyl)-1H-imidazol-2-yl]-propyl}-amide; N--((S)-3-Amino-4-methoxy-butyl)-N-{(R)-1-[1-(3-fluoro-benzyl)-4-(3-fluor- o-phenyl)-1H-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N--((S)-3-Amino-4-hydroxy-butyl)-N-{(R)-1-[1-(3-fluoro-benzyl)-4-(3-fluor- o-phenyl)-1H-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N--((S)-3-Amino-4-fluoro-butyl)-N-{(R)-1-[1-(2,5-difluoro-benzyl)-4-pheny- l-1H-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N--((R)-3-Amino-4-fluoro-butyl)-N-{(R)-1-[1-(2,5-difluoro-benzyl)-4-pheny- l-1H-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N--((R)-3-Amino-2-fluoro-propyl)-N-{(R)-1-[1-(4-fluoro-benzyl)-4-phenyl-1- H-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N--((R)-3-Amino-2-fluoro-propyl)-2-methoxy-N-{(R)-1-[1-(3-methoxy-benzyl)- -4-phenyl-1H-imidazol-2-yl]-2,2-dimethyl-propyl}-acetamide; N--((R)-3-Amino-2-fluoro-propyl)-N-{(R)-2,2-dimethyl-1-[1-(2-methyl-benzy- l)-4-phenyl-1H-imidazol-2-yl]-propyl}-2-methoxy-acetamide; N--((R)-3-Amino-2-fluoro-propyl)-N-{(R)-2,2-dimethyl-1-[1-(3-methyl-benzy- l)-4-phenyl-1H-imidazol-2-yl]-propyl}-2-methoxy-acetamide; N--((S)-3-Amino-2-fluoro-propyl)-N-{(R)-2,2-dimethyl-1-[1-(3-methyl-benzy- l)-4-phenyl-1H-imidazol-2-yl]-propyl}-2-methoxy-acetamide; N-(3-Amino-propyl)-N--[(R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2,2-dim- ethyl-propyl]-acetamide; N--((S)-3-Amino-2-fluoro-propyl)-N--[(R)-1-(1-benzyl-1H-imidazol-2-yl)-2,- 2-dimethyl-propyl]-2-methoxy-acetamide; (S)-Tetrahydro-furan-2-carboxylic acid ((S)-3-amino-2-fluoro-propyl)-[(R)-1-(1-benzyl-1H-imidazol-2-yl)-2,2- -dimethyl-propyl]-amide; N--((S)-3-Amino-4-fluoro-butyl)-N-{(R)-1-[1-(3-fluoro-benzyl)-4-(3-fluoro- -phenyl)-1H-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N--((S)-3-Amino-2-fluoro-propyl)-N--[(R)-1-(1-benzyl-4-thiazol-2-yl-1H-im- idazol-2-yl)-2,2-dimethyl-propyl]-2-methoxy-acetamide; N--((R)-3-Amino-4-fluoro-butyl)-N-{(R)-1-[1-(3-fluoro-benzyl)-4-(3-fluoro- -phenyl)-1H-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N-[2-(1-Amino-cyclopropyl)-ethyl]-N--[(R)-1-(1-benzyl-4-phenyl-1H-imidazo- l-2-yl)-2,2-dimethyl-propyl]-2-methoxy-acetamide; (S)-Tetrahydro-furan-2-carboxylic acid [2-(1-amino-cyclopropyl)-ethyl]-[(R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-y- l)-2,2-dimethyl-propyl]-amide; [2-(1-Amino-cyclopropyl)-ethyl]-[(R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-y- l)-2,2-dimethyl-propyl]-carbamic acid methyl ester; N-[2-(1-Amino-cyclopropyl)-ethyl]-N-{(R)-1-[1-benzyl-4-(3-fluoro-phenyl)-- 1H-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; (S)-Tetrahydro-furan-2-carboxylic acid [2-(1-amino-cyclopropyl)-ethyl]-{(R)-1-[1-benzyl-4-(3-fluoro-phenyl)-1H-i- midazol-2-yl]-2,2-dimethyl-propyl}-amide; N-(3-Amino-propyl)-N-{(R)-1-[1-benzyl-4-(2,5-difluoro-phenyl)-1H-imidazol- -2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N--((S)-3-Amino-4-fluoro-butyl)-N-{(R)-1-[1-benzyl-4-(2,5-difluoro-phenyl- )-1H-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N--((R)-3-Amino-4-fluoro-butyl)-N-{(R)-1-[1-benzyl-4-(2,5-difluoro-phenyl- )-1H-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N-(3-Amino-propyl)-N-{1-[1-(3-fluoro-benzyl)-4-(3-fluoro-phenyl)-1H-imida- zol-2-yl]-1-methyl-ethyl}-2-methoxy-acetamide; N-(3-Amino-propyl)-N-{(R)-1-[1-(3-fluoro-benzyl)-4-(3-fluoro-phenyl)-1H-i- midazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; (S)-Tetrahydro-furan-2-carboxylic acid ((S)-3-amino-4-fluoro-butyl)-{(R)-1-[1-(3-fluoro-benzyl)-4-(3-fluoro-phen- yl)-1H-imidazol-2-yl]-2,2-dimethyl-propyl}-amide; N--((S)-3-Amino-4-fluoro-butyl)-N-{(R)-1-[1-benzyl-5-(3-fluoro-phenyl)-1H- -imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N--((S)-3-Amino-4-methoxy-butyl)-N-{(R)-1-[4-(3-chloro-phenyl)-1-(3-fluor- o-benzyl)-1H-imidazol-2-yl]-2-methyl-propyl}-2-methoxy-acetamide; N--((S)-3-Amino-4-fluoro-butyl)-N-{(R)-1-[1-benzyl-4-(3-chloro-phenyl)-1H- -imidazol-2-yl]-2-methyl-propyl}-2-methoxy-acetamide; N--((S)-3-Amino-4-fluoro-butyl)-N-{(R)-1-[4-(3-chloro-phenyl)-1-(3-fluoro- -benzyl)-1H-imidazol-2-yl]-2-methyl-propyl}-2-methoxy-acetamide; N-(3-Amino-4-fluoro-butyl)-N-{1-[1-(3-fluoro-benzyl)-4-(3-fluoro-phenyl)-- 1H-imidazol-2-yl]-1-methyl-ethyl}-2-methoxy-acetamide; N--((S)-3-Amino-4-fluoro-butyl)-N-{(R)-1-[1-(3-fluoro-benzyl)-4-(3-fluoro- -phenyl)-1H-imidazol-2-yl]-2,2-dimethyl-propyl}-acetamide; N--((R)-3-Amino-4-fluoro-butyl)-N-{(R)-1-[1-(3-fluoro-benzyl)-4-(3-fluoro- -phenyl)-1H-imidazol-2-yl]-2,2-dimethyl-propyl}-acetamide; (S)-Tetrahydro-furan-2-carboxylic acid ((S)-3-amino-2-fluoro-propyl)-{(R)-1-[1-(3-fluoro-benzyl)-4-(3-fluoro-phe- nyl)-1H-imidazol-2-yl]-2,2-dimethyl-propyl}-amide; (R)-9-{(R)-1-[1-(3-Fluoro-benzyl)-4-(3-fluoro-phenyl)-1H-imidazol-2-yl]-2- ,2-dimethyl-propyl}-6-oxa-2,9-diaza-spiro[4.5]decan-8-one; (3-Amino-4-fluoro-butyl)-{(R)-1-[1-(3-fluoro-benzyl)-4-(3-fluoro-phenyl)-- 1H-imidazol-2-yl]-2,2-dimethyl-propyl}-carbamic acid methyl ester; N--((S)-3-Amino-4-fluoro-butyl)-N-{(R)-1-[1-(3-fluoro-benzyl)-4-(3-fluoro- -phenyl)-1H-imidazol-2-yl]-2,2-dimethyl-propyl}-formamide; N--((R)-3-Amino-4-fluoro-butyl)-N-{(R)-1-[1-(3-fluoro-benzyl)-4-(3-fluoro- -phenyl)-1H-imidazol-2-yl]-2,2-dimethyl-propyl}-formamide; N-(3-Dimethylamino-propyl)-N-{(R)-1-[1-(3-fluoro-benzyl)-4-(3-fluoro-phen- yl)-1H-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N--((S)-3-Amino-butyl)-N-{(R)-1-[1-(3-fluoro-benzyl)-4-(3-fluoro-phenyl)-- 1H-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N--((R)-3-Amino-butyl)-N-{(R)-1-[1-(3-fluoro-benzyl)-4-(3-fluoro-phenyl)-- 1H-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N--((S)-3-Amino-4-fluoro-butyl)-N-{(R)-1-[1-(6-amino-pyridin-2-ylmethyl)-- 4-(3-fluoro-phenyl)-1H-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-aceta- mide; N--((R)-3-Amino-4-fluoro-butyl)-N-{(R)-1-[1-(6-amino-pyridin-2-ylmet- hyl)-4-(3-fluoro-phenyl)-1H-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-- acetamide; N--((S)-3-Amino-4-fluoro-butyl)-N-{(R)-1-[4-(3-fluoro-phenyl)-1- -(3-hydroxy-benzyl)-1H-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-aceta- mide; N--((R)-3-Amino-4-fluoro-butyl)-N-{(R)-1-[4-(3-fluoro-phenyl)-1-(3-h- ydroxy-benzyl)-1H-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N--((S)-3-Amino-4-fluoro-butyl)-N--[(R)-1-(1-benzyl-4-thiazol-2-yl-1H-imi- dazol-2-yl)-2,2-dimethyl-propyl]-2-methoxy-acetamide; N-{(R)-1-[1-(3-Fluoro-benzyl)-4-(3-fluoro-phenyl)-1H-imidazol-2-yl]-2,2-d- imethyl-propyl}-2-methoxy-N-(3-methylamino-propyl)-acetamide; N-(3-Amino-propyl)-N-{(R)-1-[1-benzyl-4-(2,5-difluoro-phenyl)-1H-imidazol- -2-yl]-2,2-dimethyl-propyl}-acetamide; (3-Amino-propyl)-{(R)-1-[1-benzyl-4-(2,5-difluoro-phenyl)-1H-imidazol-2-y- l]-2,2-dimethyl-propyl}-carbamic acid methyl ester; (S)-Tetrahydro-furan-2-carboxylic acid (3-amino-propyl)-{(R)-1-[1-benzyl-4-(2,5-difluoro-phenyl)-1H-imidazol-2-y- l]-2,2-dimethyl-propyl}-amide; 3-[{(R)-1-[1-(3-Fluoro-benzyl)-4-(3-fluoro-phenyl)-1H-imidazol-2-yl]-2,2-- dimethyl-propyl}-(2-methoxy-acetyl)-amino]-propionamide; N-(3-Amino-propyl)-N-{(R)-1-[1-benzyl-4-(2,5-difluoro-phenyl)-1H-imidazol- -2-yl]-2,2-dimethyl-propyl}-2-methanesulfonyl-acetamide; N--((S)-3-Amino-4-methoxy-butyl)-N-{(R)-1-[1-benzyl-4-(2,5-difluoro-pheny- l)-1H-imidazol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; (S)-Tetrahydro-furan-2-carboxylic acid ((S)-3-amino-4-fluoro-butyl)-{(R)-1-[1-benzyl-4-(2,5-difluoro-phenyl)-1H-- imidazol-2-yl]-2,2-dimethyl-propyl}-amide; (R)-1-[1-Benzyl-4-(2,5-difluoro-phenyl)-1H-imidazol-2-yl]-2,2-dimethyl-pr- opylamine; (S)-Tetrahydro-furan-2-carboxylic acid ((S)-3-amino-4-methoxy-butyl)-{(R)-1-[1-benzyl-4-(2,5-difluoro-phenyl)-1H- -imidazol-2-yl]-2,2-dimethyl-propyl}-amide; N--((R)-3-Amino-butyl)-N-{(R)-1-[1-benzyl-4-(2,5-difluoro-phenyl)-1H-imid- azol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N--((S)-3-Amino-butyl)-N-{(R)-1-[1-benzyl-4-(2,5-difluoro-phenyl)-1H-imid- azol-2-yl]-2,2-dimethyl-propyl}-2-methoxy-acetamide; N-{(R)-1-[1-Benzyl-4-(2,5-difluoro-phenyl)-1H-imidazol-2-yl]-2,2-dimethyl- -propyl}-2-methoxy-N-(1H-[1,2,3]triazol-4-ylmethyl)-acetamide; N--((S)-3-Amino-4-fluoro-butyl)-N-{(R)-1-[1-benzyl-4-(2,5-difluoro-phenyl- )-1H-imidazol-2-yl]-2,2-dimethyl-propyl}-acetamide; ((S)-3-Amino-4-fluoro-butyl)-{(R)-1-[1-benzyl-4-(2,5-difluoro-phenyl)-1H-- imidazol-2-yl]-2,2-dimethyl-propyl}-carbamic acid methyl ester; {(R)-1-[1-Benzyl-4-(2,5-difluoro-phenyl)-1H-imidazol-2-yl]-2,2-dimethyl-p- ropyl}-carbamic acid tert-butyl ester; N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-2-methylpropyl]-4-methylbe- nzamide; N-(3-aminopropyl)-N-[(1R)-1-(1-benzyl-4-phenyl-1H-imidazol-2-yl)-- 2-methylpropyl]-2-(4-fluorophenoxy)acetamide; and pharmaceutically acceptable salts thereof. 7. A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 1 and a pharmaceutically acceptable carrier. 8. The composition of claim 7 further comprising at least one additional agent for the treatment of cancer selected from the group consisting of irinotecan, topotecan, gemcitabine, imatinib, 5-fluorouracil, leucovorin, carboplatin, cisplatin, docetaxel, paclitaxel, tezacitabine, cyclophosphamide, vinca alkaloids, anthracyclines, rituximab, and trastuzumab. 9. The compound of claim 1, wherein A is selected from 4-t-butylphenyl, 2-chlorophenyl, 3-chlorophenyl, 4-chlorophenyl, 3,4-dichlorophenyl, 2,4-difluorophenyl, 2-methoxyphenyl, 4-methoxyphenyl, 4-methylphenyl, 2-pyrrolidin-3-ylphenyl, 4-(trifluoromethyl)phenyl. 10. The compound of claim 1, wherein R.sup.4 is selected --(CH.sub.2).sub.2--NH.sub.2, --CH.sub.2-azetidin-3-yl, --CH.sub.2-(2,5-dihydropyrrol-3-yl), --CH.sub.2-morpholin-2-yl, --CH.sub.2-pyrrolidin-3-yl, --CH.sub.2-(3-fluoropyrrolidin-3-yl), --CH.sub.2-(3-hydroxypyrrolidin-3-yl), --CH.sub.2-(4-fluoropyrrolidin-3-yl), --CH.sub.2-(4-hydroxypyrrolidin-3-yl), --CH.sub.2-(2-hydroxymethylpyrrolidin-3-yl), --CH.sub.2-piperidin-3-yl, --CH.sub.2CH(NH.sub.2)CH.sub.2OH, --(CH.sub.2).sub.3--NH.sub.2, --(CH.sub.2).sub.3--NHCH.sub.3, --(CH.sub.2).sub.3--N(CH.sub.3).sub.2, --(CH.sub.2).sub.3NH-cyclopropyl, --(CH.sub.2).sub.3NH-cyclobutyl, --(CH.sub.2).sub.3NHCH.sub.2-cyclopropyl, --CH.sub.2CHOHCH.sub.2NH.sub.2, --CH.sub.2CH(CH.sub.2OH)CH.sub.2NH.sub.2, --CH.sub.2C(CH.sub.3).sub.2CH.sub.2--N(CH.sub.3).sub.2, --CH.sub.2C(CH.sub.3).sub.2CH.sub.2-(4-methylpiperazin-1-yl), --(CH.sub.2).sub.2CH(NH.sub.2)CH.sub.3, --CH.sub.2CHFCH.sub.2NH.sub.2, --(CH.sub.2).sub.2C(CH.sub.3).sub.2NH.sub.2, --(CH.sub.2).sub.2CH(NH.sub.2)CH.sub.2OCH.sub.3, --(CH.sub.2).sub.2CH(NH.sub.2)CH.sub.2F, and --CH.sub.2CHFCH(NH.sub.2)CH.sub.2OH. 11. The compound of claim 1, wherein A.sup.1 is selected from the group consisting of phenyl, 3-chlorophenyl, 3-cyanophenyl, 2-fluorophenyl, 3-fluorophenyl, 4-fluorophenyl, 3-hydroxyphenyl, 3-methoxyphenyl, 2-methylphenyl, and 3-methylphenyl. |
Details for Patent 8,735,599
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Genentech, Inc. | RITUXAN | rituximab | Injection | 103705 | 11/26/1997 | ⤷ Try a Trial | 2024-06-18 |
Idec Pharmaceuticals Corp. | RITUXAN | rituximab | Injection | 103737 | 02/19/2002 | ⤷ Try a Trial | 2024-06-18 |
Genentech, Inc. | HERCEPTIN | trastuzumab | For Injection | 103792 | 09/25/1998 | ⤷ Try a Trial | 2024-06-18 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
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