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Last Updated: March 28, 2024

Claims for Patent: 8,709,443


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Summary for Patent: 8,709,443
Title:Reovirus for the treatment of cellular proliferative disorders
Abstract: Methods for treating proliferative disorders, by administering reovirus to a Ras-mediated proliferative disorder, are disclosed. The reovirus is administered so that it ultimately directly contacts ras-mediated proliferating cells. Proliferative disorders include but are not limited to neoplasms. Human reovirus, non-human mammalian reovirus, and/or avian reovirus can be used. If the reovirus is human reovirus, serotype 1 (e.g., strain Lang), serotype 2 (e.g., strain Jones), serotype 3 (e.g., strain Dearing or strain Abney), as well as other serotypes or strains of reovirus can be used. Combinations of more than one type and/or strain of reovirus can be used, as can reovirus from different species of animal. Either solid neoplasms or hematopoietic neoplasms can be treated.
Inventor(s): Lee; Patrick W. K. (Halifax, CA), Strong; James (Calgary, CA), Coffey; Matthew C. (Calgary, CA)
Assignee: Oncolytics Biotech Inc. (Calgary, Alberta, CA)
Application Number:13/287,399
Patent Claims:1. A pharmaceutical composition comprising a reovirus, a chemotherapeutic agent and a pharmaceutically acceptable excipient, wherein the chemotherapeutic agent is selected from the group consisting of 5-fluorouracil, mitomycin C, methotrexate, hydroxyurea, cyclophosphamide, dacarbazine, mitoxantrone, epirubicin, doxorubicin, herceptin, etoposide, pregnasome, carboplatin, cisplatin, taxol, taxotere, tamoxifen, anti-estrogens, interferons, aromatase inhibitors, progestational agents and LHRH analogs.

2. The pharmaceutical composition of claim 1, wherein the reovirus is formulated in a unit dosage form.

3. The pharmaceutical composition of claim 1, wherein the chemotherapeutic agent is formulated in a unit dosage form.

4. The pharmaceutical composition of claim 3, wherein the unit dose of reovirus comprises from about 10.sup.2 pfu to about 10.sup.13 pfu.

5. The pharmaceutical composition of claim 1, wherein the reovirus is a mammalian reovirus.

6. The pharmaceutical composition of claim 5, wherein the mammalian reovirus is a human reovirus.

7. The pharmaceutical composition of claim 6, wherein the reovirus is selected from the group consisting of serotype 1 reovirus, serotype 2 reovirus and serotype 3 reovirus.

8. The pharmaceutical composition of claim 1, wherein the chemotherapeutic agent is taxol.

9. The pharmaceutical composition of claim 1, wherein the chemotherapeutic agent is cisplatin.

10. The pharmaceutical composition of claim 1, wherein the chemotherapeutic agent is cyclophosphamide.

11. A pharmaceutical composition comprising a reovirus, a chemotherapeutic agent and a pharmaceutically acceptable excipient, wherein the chemotherapeutic agent is not BCNU, wherein the reovirus is formulated in a unit dosage form, and wherein the chemotherapeutic agent is formulated in a unit dosage form.

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