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Last Updated: April 24, 2024

Claims for Patent: 8,663,617

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Summary for Patent: 8,663,617

Title:	Wound healing peptides and methods of use thereof
Abstract:	The current invention relates to methods and compositions for the treatment of wounds in a mammalian subject. Particularly, the invention relates to novel polypeptides and encoding nucleic acids that stimulate keratinocyte and endothelial cell motility and/or proliferation.
Inventor(s):	Herman; Ira M (Newton, MA)
Assignee:	Tufts University (Medford, MA)
Application Number:	13/652,889
Patent Claims:	1. A method to promote wound healing in a subject in need thereof, comprising administering to the subject a peptide consisting essentially of an amino acid sequence selected from the group consisting of SEQ ID Nos: 4-10 and 13. 2. The method of claim 1, wherein the peptide is administered in an amount effective to enhance the rate of migration of keratinocytes or endothelial cells, or a combination of keratinocytes and endothelial cells, towards a wound edge. 3. The method of claim 1, wherein the administration of the peptide results in an increase in the re-epithelialization of the wound. 4. The method of claim 1, wherein the administration of the peptide results in an increase in angiogenesis in or near the wound. 5. The method of claim 1, wherein the peptide is administered at a wound site. 6. The method of claim 1, wherein the wound is a thermal, chronic, acute or surgical wound. 7. The method of claim 1, further comprising administering to the subject a second agent. 8. The method of claim 7, wherein the second agent is a polypeptide. 9. The method of claim 7, wherein the second agent is a growth factor, cytokine, or enzyme. 10. The method of claim 7, wherein the second agent is a non-human collagenase. 11. The method of claim 10, wherein the non-human collagenase is bacterial collagenase. 12. The method of claim 1, wherein the subject is a mammalian subject. 13. The method of claim 12, wherein the mammalian subject is a human.

Details for Patent 8,663,617

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965	⤷ Try a Trial	2039-03-29
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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