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Last Updated: March 29, 2024

Claims for Patent: 8,663,599


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Summary for Patent: 8,663,599
Title:Pharmaceutical composition of nanoparticles
Abstract: The invention discloses a pharmaceutical composition of pH-sensitive liposome nanoparticles for lodging in a target tissue cell in situ of an animal subject, the nanoparticles comprising a proton-releasing photosensitive compound that releases protons upon photolysis, wherein the compound is in vesicles of the liposomes. A light or UV light is provided to induce the photosensitive compound to release the protons, thus the released protons causing the pH-sensitive liposome to decompose.
Inventor(s): Sung; Hsing-Wen (Hsinchu, TW), Liao; Zi-Xian (Hsinchu, TW), Chung; Min-Fan (Hsinchu, TW), Chen; Ko-Jie (Hsinchu, TW), Cheng; Po-Yuan (Hsinchu, TW), Tu; Hosheng (Newport Beach, CA)
Assignee: GP Medical, Inc. (Newport Beach, CA) National Tsing Hua University (Hsinchu, TW)
Application Number:13/682,929
Patent Claims:1. A composition of liposomes, comprising a proton-releasing photosensitive compound that releases protons upon photolysis, wherein said compound is loaded in vesicles of said liposomes that are pH-sensitive.

2. The composition according to claim 1, wherein the liposomes comprises HSPC (L-.alpha.-phosphatidylcholine, hydrogenated), DOTMA (N-[1-(2,3-dioleyloxy)propyl]-N,N,N-trimethylammonium chloride), cholesterol, and bicarbonates.

3. The composition according to claim 2, wherein said bicarbonates are sodium bicarbonates, ammonium bicarbonates, potassium bicarbonates, or calcium bicarbonates.

4. The composition according to claim 1, wherein said liposomes are adapted for delivery to a blood vessel or a lymphoid system of an animal subject.

5. The composition according to claim 4, wherein said liposomes enter cells of the animal subject via an endocytosis pathway.

6. The composition according to claim 1, wherein said liposomes further comprise at least one bioactive agent.

7. The composition according to claim 1, wherein said liposomes further comprise a cancer targeting moiety.

8. The composition according to claim 1, wherein said liposomes further comprise a deoxyribonucleic acid.

9. The composition according to claim 1, wherein said liposomes further comprise a small interfering ribonucleic acid.

10. The composition according to claim 1, wherein said liposomes further comprise an anticancer drug.

11. The composition according to claim 1, wherein said liposomes further comprise a chemodrug.

12. The composition according to claim 1, wherein said liposomes further comprise an adjuvant.

13. The composition according to claim 12, wherein said adjuvant is Bacille Calmette-Guerin (BCG), an interferon, or a colony-stimulating factor GM-CSF.

14. The composition according to claim 12, wherein said adjuvant is cyclophosphamide, azathioprine, cyclosporine, mycophenolate mofetil, intravenous immunoglobulin, or rituximab.

15. The composition according to claim 1, wherein said liposomes further comprise a coagulant.

16. The composition according to claim 1, wherein said liposomes further comprise doxorubicin, camptothecin, paclitaxel, or daunorubicin.

17. The composition according to claim 1, wherein said proton-releasing photosensitive compound is ester o-nitrobenzyl acetate.

18. The composition according to claim 1, wherein the liposomes have a size less than about 300 nanometers.

19. The composition according to claim 1, wherein said liposomes comprise a chemoimmunotherapeutic bioactive agent consisting of an immunologic adjuvant, chemodrugs, and an oxidant.

20. The composition according to claim 1, wherein said liposomes are adapted for delivery to a tumor site directly.

Details for Patent 8,663,599

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. RITUXAN rituximab Injection 103705 11/26/1997 ⤷  Try a Trial 2024-10-05
Idec Pharmaceuticals Corp. RITUXAN rituximab Injection 103737 02/19/2002 ⤷  Try a Trial 2024-10-05
Genentech, Inc. RITUXAN HYCELA rituximab and hyaluronidase human Injection 761064 06/22/2017 ⤷  Try a Trial 2024-10-05
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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