Claims for Patent: 8,586,533

Summary for Patent: 8,586,533

Title:	Treatment of early-stage osteoarthritis
Abstract:	A method for treating early-stage osteoarthritis in an animal is provided. The method comprises delivery of a therapeutically effective amount of a parathyroid hormone (PTH) or a PTH derived substance to an affected joint cavity of the patient. Methods for inhibiting articular chondrocytes apoptosis and for inhibiting a degenerative process of articular chondrocytes in an afflicted animal are also provided.
Inventor(s):	Ho; Mei-Ling (Kaohsiung, TW), Wang; Gwo-Jaw (Kaohsiung, TW), Chang; Je-Ken (Kaohsiung, TW), Fu; Yin-Chih (Kaohsiung, TW), Chen; Chung-Hwan (Kaohsiung, TW)
Assignee:	Kaohsiung Medical University (Kaohsiung, TW)
Application Number:	12/638,816
Patent Claims:	1. A method for treating early stage osteoarthritis in an animal comprising delivery of a therapeutically effective amount of an agent into a joint cavity of an affected joint of an animal in need of such treatment, wherein the agent comprises amino acids 1-34 of parathyroid hormone. 2. The method of claim 1, wherein said delivery is achieved by intra-articular injection. 3. The method of claim 1, wherein the therapeutically effective amount of agent is within the range of from about 0.1 pmole to about 5000 pmole. 4. The method of claim 1, wherein the therapeutically effective amount of agent is provided by delivery of from about 0.1 mL to about 10 mL of a solution in which the agent is present at a concentration of from about 1 nM to about 500 nM. 5. The method of claim 1, wherein the therapeutically effective amount of agent is provided by delivery of from about 1 mL to about 3 mL of a solution in which the agent is present at a concentration of from about 5 nM to about 100 nM. 6. The method of claim 1, wherein the agent consists of amino acids 1-34 of parathyroid hormone. 7. A method for inhibiting articular chondrocyte apoptosis in an animal, comprising delivery of a therapeutically effective amount of an agent into a joint cavity of an affected joint of an animal in need of such treatment, wherein the agent comprises amino acids 1-34 of parathyroid hormone. 8. The method of claim 7, wherein said delivery is achieved by intra-articular injection. 9. The method of claim 7, wherein the effective amount of agent is within the range of from about 0.1 pmole to about 5000 pmole. 10. The method of claim 7, wherein the effective amount of agent is provided by delivery of from about 0.1 mL to about 10 mL of a solution in which the agent is present at a concentration of from about 1 nM to about 500 nM. 11. The method of claim 7, wherein the effective amount of agent is provided by delivery of from about 1 mL to about 3 mL of a solution in which the agent is present at a concentration of from about 5 nM to about 100 nM. 12. The method of claim 7, wherein the agent consists of amino acids 1-34 of parathyroid hormone. 13. The method of claim 7, wherein the animal suffers from early stage osteoarthritis. 14. A method for inhibiting a degenerative process of an articular chondrocyte of an affected joint in an animal comprising delivery of a therapeutically effective amount of an agent into a joint cavity of an affected joint of an animal in need of such treatment, whereby the articular chondrocyte is contacted with the agent, wherein the agent comprises amino acids 1-34 of parathyroid hormone. 15. The method of claim 14, wherein said delivery is achieved by intra-articular injection. 16. The method of claim 14, wherein the effective amount of agent is within the range of from about 0.1 pmole to about 5000 pmole. 17. The method of claim 14, wherein the therapeutically effective amount of agent is provided by delivery of from about 0.1 mL to about 10 mL of a solution in which the agent is present at a concentration of from about 1 nM to about 500 nM. 18. The method of claim 14, wherein the therapeutically effective amount of agent is provided by delivery of from about 1 mL to about 3 mL of a solution in which the agent is present at a concentration of from about 5 nM to about 100 nM. 19. The method of claim 1, 7, or 14, wherein the animal is a human.

Details for Patent 8,586,533

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Nps Pharmaceuticals, Inc.	NATPARA	parathyroid hormone	For Injection	125511	01/23/2015		2028-12-16