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Last Updated: March 19, 2024

Claims for Patent: 8,581,043


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Summary for Patent: 8,581,043
Title:Nicotiana nucleic acid molecules and uses thereof
Abstract: The present invention features Nicotiana nucleic acid sequences such as sequences encoding constitutive, or ethylene or senescence induced polypeptides, in particular cytochrome p450 enzymes, in Nicotiana plants and methods for using these nucleic acid sequences and plants to alter desirable traits, for example by using breeding protocols.
Inventor(s): Xui; Dongmei (Glen Allen, VA), Nielsen; Mark T. (Nicholas, KY)
Assignee: U.S. Smokeless Tobacco Company LLC (Richmond, VA)
Application Number:12/755,733
Patent Claims:1. A method for reducing the expression of nicotine demethylase in a tobacco plant, said method comprising expressing a transgene encoding an antisense RNA molecule that inhibits expression of said nicotine demethylase in said plant, said antisense RNA molecule comprising at least 25 consecutive nucleotides that have 100% sequence identity to an intron of SEQ ID NO: 4, wherein expression of said nicotine demethylase is inhibited in said plant relative to a tobacco plant lacking said transgene.

2. The method of claim 1, wherein said tobacco plant is from a species selected from the group consisting of Nicotiana tabacum, Nicotiana sylvestris, Nicotiana tomentosiformis, and Nicotiana glauca.

3. The method of claim 1, wherein said transgene comprises a constitutive promoter.

4. The method of claim 1, wherein said transgene comprises an inducible promoter.

5. The method of claim 1, wherein said antisense RNA molecule comprises at least 100 nucleotides that have 100% sequence identity to an intron of SEQ ID NO: 4.

6. The method of claim 1, wherein said antisense RNA molecule comprises at least 250 nucleotides that have 100% sequence identity to an intron of SEQ ID NO: 4.

7. The method of claim 1, wherein said antisense RNA molecule comprises at least 500 nucleotides that have 100% or greater sequence identity to an intron of SEQ ID NO: 4.

8. The method of claim 1, wherein said tobacco plant is Nicotiana tabacum.

Details for Patent 8,581,043

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 06/04/1986 ⤷  Try a Trial 2021-11-13
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 ⤷  Try a Trial 2021-11-13
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b Injection 103132 ⤷  Try a Trial 2021-11-13
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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