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Last Updated: March 28, 2024

Claims for Patent: 8,574,611


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Summary for Patent: 8,574,611
Title:Composite bone repair material
Abstract: The present invention relates to a sliceable composite bone repair material comprising a porous block-shaped ceramic scaffold and a stabilizing polymer disposed therein. Said ceramic scaffold is a synthetic ceramic material or a naturally-derived material. Additionally said scaffold comprises interconnected macropores.
Inventor(s): Seibl; Reinhart (Zurich, CH), Molenberg; Aaldert Rens (Binningen, CH), Neidhardt; Astrid Sylvia (Thalwil, CH), Beuling; Nienke (Delft, NL)
Assignee: Straumann Holding AG (Basel, CH)
Application Number:12/667,496
Patent Claims:1. A sliceable composite bone repair material comprising: a porous block-shaped scaffold comprising a bone substitute material comprising a synthetic ceramic material, and wherein said scaffold comprises interconnected macropores; and a stabilizing polymer disposed therein, wherein the stabilizing polymer is a degradable polyethylene glycol hydrogel formed by a cross-linking Michael-type addition reaction of at least two precursor molecules, wherein said cross-linking reaction forms an ester linkage between the at least two precursor molecules, and wherein said hydrogel is degradable in water.

2. Composite bone repair material of claim 1 wherein the scaffold is a synthetic ceramic material comprising a calcium phosphate.

3. Composite bone repair material of claim 2 wherein the calcium phosphate is selected from the group consisting of hydroxyapatite and tricalcium phosphate or a mixture thereof.

4. Composite bone repair material according to claim 1 wherein the ceramic scaffold has a total porosity between 75% and 95%.

5. Composite bone repair material according to claim 1 wherein the ceramic scaffold has at least a second portion with enhanced mechanical strength similar to cortical bone.

6. Composite bone repair material according to claim 1 further comprising a bioactive agent.

7. Composite bone repair material of claim 6, wherein the bioactive agent is released from the stabilizing polymer.

8. Composite bone repair material of claim 6, wherein the bioactive agent is selected from the group of parathyroid hormone, bone morphogenic protein and enamel matrix derivatives.

9. A device for the treatment of oral bone defects including the composite bone repair material of claim 1.

10. A kit for preparing a composite bone repair material according to claim 1 comprising the porous block-shaped synthetic ceramic scaffold and the stabilizing polymer.

11. A kit according to claim 10 comprising: a) the porous block-shaped synthetic ceramic scaffold; b) a multi-arm PEG-thiol; c) a multi-arm PEG-acrylate, wherein the total number of arms is equal or larger than five; and d) buffers for the multi-arm PEG-thiol and multi-arm PEG-acrylate.

12. A kit according to claim 10 additionally comprising a bioactive agent.

13. A kit according to claim 11 additionally comprising a bioactive agent premixed either with the multi-arm PEG-thiol or with the multi-arm PEG-acrylate.

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