Claims for Patent: 8,574,259

Summary for Patent: 8,574,259

Title:	Intravascular filter with drug reservoir
Abstract:	An intravascular filter can capture and eliminate emboli. In particular, an intravascular filter may include a plurality of filter legs extending from an apical head. The filter legs may be configured to capture emboli. A drug reservoir that includes or contains a therapeutic drug can be disposed near the apical head. The therapeutic drug, such as a thrombolytic or anti-coagulatory drug, may be eluted in response to a captured emboli.
Inventor(s):	Welch; Eric D. (Miramar, FL), Girton; Timothy S. (Edina, MN), WasDyke; Joel M. (Eden Prairie, MN)
Assignee:	Lifescreen Sciences LLC (Frisco, TX)
Application Number:	11/125,531
Patent Claims:	1. An intravascular filter, comprising: a plurality of filter legs, each of the filter legs having a free end and an opposite joined end; an apical head, the joined end of each of the filter legs secured to the apical head, each of the filter legs radiating outwardly from the apical head; and a drug reservoir disposed near the apical head, the drug reservoir comprising a drug dispersed only within poly(styrene-b-isobutylene-b-styrene), wherein the drug reservoir comprises a cup having a hollow volume positioned inside the plurality of filter legs, the cup having an open end and a closed end, where the closed end is positioned closest to the apical head while the open end extends away from the apical head. 2. The intravascular filter of claim 1, wherein the therapeutic drug comprises a thrombolytic agent. 3. The intravascular filter of claim 2, wherein the thrombolytic agent comprises a drug selected from the group consisting of reteplase, alteplase, urokinase, prourokinase, anisoylated streptokinase activator complex, and streptokinase. 4. The intravascular filter of claim 1, wherein the therapeutic drug comprises an anti-coagulant. 5. The intravascular filter of claim 4, wherein the anti-coagulant comprises one of heparin or coumadin. 6. The intravascular filter of claim 1, wherein the poly(styrene-b-isobutylene-b-styrene) is configured to permit the therapeutic drug to elute from the poly(styrene-b-isobutylene-b-styrene). 7. The intravascular filter of claim 1, wherein the plurality of filter legs comprise stainless steel. 8. The intravascular filter of claim 1, wherein the apical head comprises stainless steel. 9. The intravascular filter of claim 1, wherein the plurality of filter legs comprise nitinol. 10. The intravascular filter of claim 1, wherein the apical head comprises nitinol. 11. A method of dissolving embolic debris within a vasculature, comprising steps of: providing an intravascular filter having an apical head and a drug reservoir positioned at or near the apical head, the drug reservoir comprising a thrombolytic drug dispersed only within poly(styrene-b-isobutylene-b-styrene), wherein the drug reservoir comprises a cup having a hollow volume positioned inside the plurality of filter legs, the cup having an open end and a closed end, where the closed end is positioned closest to the apical head while the open end extends away from the apical head; deploying the intravascular filter within the vasculature; and eluting a thrombolytic drug from the drug reservoir in response to an emboli contacting the drug reservoir, thereby dissolving the embolic debris.

Details for Patent 8,574,259

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Microbix Biosystems Inc.	KINLYTIC	urokinase	For Injection	021846	01/16/1978		2039-03-29
Genentech, Inc.	ACTIVASE	alteplase	For Injection	103172	11/13/1987		2039-03-29
Genentech, Inc.	CATHFLO ACTIVASE	alteplase	For Injection	103172	09/04/2001		2039-03-29
Chiesi Usa, Inc.	RETAVASE	reteplase	For Injection	103786	10/30/1996		2039-03-29