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Last Updated: April 18, 2024

Claims for Patent: 8,536,146

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Summary for Patent: 8,536,146

Title:	Cytoplasmic BK.sub.Ca channel intron-containing mRNAs contribute to the intrinsic excitability of hippocampal neurons
Abstract:	The invention relates to a method of modulating neuronal function by modulating the cytoplasmic level in a neuron of an intron-containing mRNA. The methods are useful in diagnostic, research and therapeutic applications.
Inventor(s):	Eberwine; James (Philadelphia, PA), Sul; Jai-Yoon (Bensalem, PA), Bell; Thomas J. (Turnersville, NJ), Miyashiro; Kevin (Philadelphia, PA)
Assignee:	The Trustees of the University of Pennsylvania (Philadelphia, PA)
Application Number:	12/597,460
Patent Claims:	1. A method of decreasing the excitability of a neuron, said method comprising administering to the neuron an siRNA molecule specific for intron-containing KCNMA1 mRNA, wherein the administration of the siRNA molecule specific for intron-containing KNCMA1 mRNA decreases the cytoplasmic level of intron-containing KCNMA1 mRNA in the neuron, wherein the decrease in the cytoplasmic level of intron-containing KCNMA1 mRNA causes a decrease in the excitability of the neuron. 2. The method of claim 1, wherein said intron-containing KCNMA1 mRNA comprises intron 16. 3. The method of claim 2, wherein said intron 16-containing KCNMA1 mRNA further comprises exon 17 spliced directly to exon 18. 4. The method of claim 1, wherein decreasing the cytoplasmic level of intron-containing KCNMA1 mRNA causes a change in distribution of BK.sub.Ca channels in the neuron. 5. A method of modulating the function of a neuron, said method comprising administering to the neuron an siRNA molecule specific for intron-containing KCNMA1 mRNA, wherein the administration of the siRNA molecule specific for intron-containing KNCMA1 mRNA decreases the cytoplasmic level of intron-containing KCNMA1 mRNA in the neuron, wherein the decrease in the cytoplasmic level of intron-containing KCNMA1 mRNA modulates the function of the neuron. 6. The method of claim 5, wherein the intron-containing KCNMA1 mRNA is dendritically targeted. 7. The method of claim 1, wherein the siRNA molecule specific for intron-containing KCNMA1 mRNA comprises a nucleotide sequence selected from the group consisting of SEQ ID NO:31, SEQ ID NO:32, SEQ ID NO:33 and SEQ ID NO:34. 8. The method of claim 5 wherein the siRNA molecule specific for intron-containing KCNMA1 mRNA comprises a nucleotide sequence selected from the group consisting of SEQ ID NO:31, SEQ ID NO:32, SEQ ID NO:33 and SEQ ID NO:34.

Details for Patent 8,536,146

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132	06/04/1986	⤷ Try a Trial	2039-02-26
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132		⤷ Try a Trial	2039-02-26
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	Injection	103132		⤷ Try a Trial	2039-02-26
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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