Claims for Patent: 8,536,146
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Summary for Patent: 8,536,146
Title: | Cytoplasmic BK.sub.Ca channel intron-containing mRNAs contribute to the intrinsic excitability of hippocampal neurons |
Abstract: | The invention relates to a method of modulating neuronal function by modulating the cytoplasmic level in a neuron of an intron-containing mRNA. The methods are useful in diagnostic, research and therapeutic applications. |
Inventor(s): | Eberwine; James (Philadelphia, PA), Sul; Jai-Yoon (Bensalem, PA), Bell; Thomas J. (Turnersville, NJ), Miyashiro; Kevin (Philadelphia, PA) |
Assignee: | The Trustees of the University of Pennsylvania (Philadelphia, PA) |
Application Number: | 12/597,460 |
Patent Claims: | 1. A method of decreasing the excitability of a neuron, said method comprising administering to the neuron an siRNA molecule specific for intron-containing KCNMA1 mRNA,
wherein the administration of the siRNA molecule specific for intron-containing KNCMA1 mRNA decreases the cytoplasmic level of intron-containing KCNMA1 mRNA in the neuron, wherein the decrease in the cytoplasmic level of intron-containing KCNMA1 mRNA
causes a decrease in the excitability of the neuron.
2. The method of claim 1, wherein said intron-containing KCNMA1 mRNA comprises intron 16. 3. The method of claim 2, wherein said intron 16-containing KCNMA1 mRNA further comprises exon 17 spliced directly to exon 18. 4. The method of claim 1, wherein decreasing the cytoplasmic level of intron-containing KCNMA1 mRNA causes a change in distribution of BK.sub.Ca channels in the neuron. 5. A method of modulating the function of a neuron, said method comprising administering to the neuron an siRNA molecule specific for intron-containing KCNMA1 mRNA, wherein the administration of the siRNA molecule specific for intron-containing KNCMA1 mRNA decreases the cytoplasmic level of intron-containing KCNMA1 mRNA in the neuron, wherein the decrease in the cytoplasmic level of intron-containing KCNMA1 mRNA modulates the function of the neuron. 6. The method of claim 5, wherein the intron-containing KCNMA1 mRNA is dendritically targeted. 7. The method of claim 1, wherein the siRNA molecule specific for intron-containing KCNMA1 mRNA comprises a nucleotide sequence selected from the group consisting of SEQ ID NO:31, SEQ ID NO:32, SEQ ID NO:33 and SEQ ID NO:34. 8. The method of claim 5 wherein the siRNA molecule specific for intron-containing KCNMA1 mRNA comprises a nucleotide sequence selected from the group consisting of SEQ ID NO:31, SEQ ID NO:32, SEQ ID NO:33 and SEQ ID NO:34. |
Details for Patent 8,536,146
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Merck Sharp & Dohme Corp. | INTRON A | interferon alfa-2b | For Injection | 103132 | 06/04/1986 | ⤷ Try a Trial | 2039-02-26 |
Merck Sharp & Dohme Corp. | INTRON A | interferon alfa-2b | For Injection | 103132 | ⤷ Try a Trial | 2039-02-26 | |
Merck Sharp & Dohme Corp. | INTRON A | interferon alfa-2b | Injection | 103132 | ⤷ Try a Trial | 2039-02-26 | |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
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