Claims for Patent: 8,445,532
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Summary for Patent: 8,445,532
Title: | Use of phthalide derivatives |
Abstract: | Phthalide derivatives and the use of which to manufacture the sensitizer or reverser of the antineoplastic agent are described. The phthalide derivatives can enhance the sensitivity of drug-resistance tumor cells against chemotherapy and decrease the drug-resistance of tumor cells 5-30 folder and enhance notably several chemotherapy agents-induced apoptosis of tumor cells. |
Inventor(s): | Chen; Fei (Shanghai, CN), Wang; Tao (Shanghai, CN) |
Assignee: | |
Application Number: | 12/088,778 |
Patent Claims: | 1. A method of treating a tumor having resistance to an anti-cancer drug in a subject, wherein the tumor exhibits either (1) overexpression of at least one selected
from the group consisting of P-gp and Bcl-2, or (2) over-activity of glyoxalase I, the method comprising: administering to the subject, the anti-cancer drug and a therapeutically effective amount of at least one phthalide compound selected from the group
consisting of ##STR00016## ##STR00017## ##STR00018## wherein the amount is an amount effective for inhibiting either (1) overexpression of at least one selected from the group consisting of P-gp and Bcl-2, or (2) over-activity of glyoxalase I in the
subject.
2. The method of claim 1, further comprising administering at least one anti-tumor drug selected from the group consisting of: doxorubicin; Vincristine; paclitaxel; Cisplatin; Actinomycin; Bleomycin; Busulfan; Capecitabine; Carboplatin; Carmustine; Chlorambucil; Cyclophosphamide; Cytarabine; Daunorubicin; Epirubicin; Etop1; Vepeside; Etoposide; Fludarabine; Fluorouracil; Gemcitabine; Trastuzumab; Hydroxycarbamide; Idarubicin; Ifosfamide; Irinotecan; Lomustine; Melphalan; Mercaptopurine; Methotrexate; Mitomycin; Mitoxantrone; Dihydroxyanthraquinone; Oxaliplatin; Procarbazine; Methylhydrazine; rituximab; Steroid; Streptozocin; Docetaxel; Thioguanine; Thiotepa; Ledertepa; Tespamin; Raltitrexed; Topotecan; Treosulfan; Uracil; Vinblastine; Vinca alkaloid; Vindesine; Vinorelbine; Hydroxycamptothecin; and mixtures thereof. 3. The method of claim 2, wherein said at least one anti-tumor drug is used to treat tumors selected from the group consisting of: non-small cell lung cancer, prostate cancer, intestinal cancer, hepatocarcinoma, leukaemia, myeloma, lymphoma, mammary cancer, ovary cancer, gastric cancer, esophagus cancer, colonic cancer, or sarcoma. 4. The method of claim 1, wherein the anti-cancer drug is selected from the group consisting of: doxorubicin; Vincristine; paclitaxel; Cisplatin; Actinomycin; Bleomycin; Busulfan; Capecitabine; Carboplatin; Carmustine; Chlorambucil; Cyclophosphamide; Cytarabine; Daunorubicin; Epirubicin; Etop1; Vepeside; Etoposide; Fludarabine; Fluorouracil; Gemcitabine; Trastuzumab; Hydroxycarbamide; Idarubicin; Ifosfamide; Irinotecan; Lomustine; Melphalan; Mercaptopurine; Methotrexate; Mitomycin; Mitoxantrone; Dihydroxyanthraquinone; Oxaliplatin; Procarbazine; Methylhydrazine; rituximab; Steroid; Streptozocin; Docetaxel; Thioguanine; Thiotepa; Ledertepa; Tespamin; Raltitrexed; Topotecan; Treosulfan; Uracil; Vinblastine; Vinca alkaloid; Vindesine; Vinorelbine; and Hydroxycamptothecin. 5. The method of claim 1, wherein the at least one phthalide compound is ##STR00019## |
Details for Patent 8,445,532
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Genentech, Inc. | RITUXAN | rituximab | Injection | 103705 | 11/26/1997 | ⤷ Try a Trial | 2039-02-26 |
Idec Pharmaceuticals Corp. | RITUXAN | rituximab | Injection | 103737 | 02/19/2002 | ⤷ Try a Trial | 2039-02-26 |
Genentech, Inc. | HERCEPTIN | trastuzumab | For Injection | 103792 | 09/25/1998 | ⤷ Try a Trial | 2039-02-26 |
Genentech, Inc. | HERCEPTIN | trastuzumab | For Injection | 103792 | 02/10/2017 | ⤷ Try a Trial | 2039-02-26 |
Genentech, Inc. | RITUXAN HYCELA | rituximab and hyaluronidase human | Injection | 761064 | 06/22/2017 | ⤷ Try a Trial | 2039-02-26 |
Genentech, Inc. | HERCEPTIN HYLECTA | trastuzumab and hyaluronidase-oysk | Injection | 761106 | 02/28/2019 | ⤷ Try a Trial | 2039-02-26 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
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