Claims for Patent: 8,440,830

Summary for Patent: 8,440,830

Title:	Tetrahydro-fused pyridines as histone deacetylase inhibitors
Abstract:	The compounds of formula (I), wherein ring D and ring E together form a fused ring system selected from formula (II), (III), (IV), (V), (VI), (VII), and the salts of these compounds are novel, effective inhibitors of histone deacetylases. ##STR00001##
Inventor(s):	Maier; Thomas (Stockach, DE), Beckers; Thomas (Constance, DE), Baer; Thomas (Reichenau, DE), Vennemann; Matthias (Constance, DE), Gekeler; Volker (Constance, DE), Zimmermann; Astrid (Muehltal, DE), Gimmnich; Petra (Constance, DE), Padiya; Kamlesh (Virar, IN), Joshi; Hemant (Navi Mumbai, IN), Joshi; Uday (Thane, IN), Makhija; Mahindra (Ghatkopar, IN), Harel; Dipak (Maharashtra, IN)
Assignee:	4SC AG (Planegg-Martinsried, DE)
Application Number:	12/678,806
Patent Claims:	1. A compound of formula I ##STR00187## wherein ring D and ring E together form a fused ring system, which is one of the following groups ##STR00188## A is (C.sub.1-C.sub.4)alkyl, (C.sub.1-C.sub.4)alkoxy(C.sub.1-C.sub.2)alkyl, (C.sub.1-C.sub.4)alkylthio(C.sub.1-C.sub.2)alkyl, mono- or -di(C.sub.1-C.sub.4)alkylamino(C.sub.1-C.sub.2)alkyl, (C.sub.3-C.sub.7)cycloalkyl optionally substituted by R1 and/or R2, (C.sub.3-C.sub.7)cycloalkyl substituted by R3, azetidinyl optionally substituted by R1 and/or R2, pyrrolidinyl optionally substituted by R1 and/or R2, piperidinyl optionally substituted by R1 and/or R2, phenyl optionally substituted by R1 and/or R2, phenyl substituted by R4, naphthyl optionally substituted by R1 and/or R2, pyridyl optionally substituted by R1 and/or R2, pyridyl substituted by R5, pyrimidinyl optionally substituted by R1 and/or R2, pyrimidinyl substituted by R8, triazinyl optionally substituted by R1 and/or R2, triazinyl substituted by R9; quinolinyl optionally substituted by R1 and/or R2, isoquinolinyl optionally substituted by R1 and/or R2, thienyl optionally substituted by R1 and/or R2, thiazolyl optionally substituted by R1 and/or R2 or indazolyl optionally substituted by R1 and/or R2; R1 is halogen, hydroxyl, cyano, nitro, amino, carboxyl, (C.sub.1-C.sub.4)alkyl, (C.sub.1-C.sub.4)alkoxy, (C.sub.1-C.sub.4)alkyl which is partially or completely substituted by fluorine, (C.sub.1-C.sub.4)alkoxy which is predominantly or completely substituted by fluorine, (C.sub.1-C.sub.4)alkoxy(C.sub.1-C.sub.2)alkyl, (C.sub.1-C.sub.4)alkoxycarbonyl, mono- or -di(C.sub.1-C.sub.4)alkylamino, or (C.sub.1-C.sub.4)alkylcarbonylamino; R2 is halogen, hydroxyl, amino, (C.sub.1-C.sub.4)alkyl, or (C.sub.1-C.sub.4)alkoxy or R1 and R2 when ortho to each other form a methylenedioxy or ethylenedioxy group; R3 is 3-pyridyl, or 4-pyridyl; R4 is phenyl, phenoxy, 4-methylpiperazinyl, benzylNHC(.dbd.O)NH--, or (C.sub.1-C.sub.4)alkylphenyl-sulfonylamino; R5 is (C.sub.1-C.sub.4)alkylphenylsulfonylamino or N(R6)R7, wherein R6 and R7 together and with inclusion of the nitrogen atom to which they are bonded form an azetidinyl-, pyrrolidinyl-, piperidinyl-, piperazinyl-, 4-methylpiperazinyl-, morpholinyl- or thiomorpholinyl-ring; R8 is pyridyl or (C.sub.1-C.sub.4)alkylphenylsulfonylamino; R9 is piperidinyl; L is bond, --(CH.sub.2).sub.nS(O).sub.2--, --C(.dbd.O)--, --C(.dbd.S)--, --(CH.sub.2).sub.nOC(.dbd.O)--, --(CH.sub.2).sub.nN(R10)C(.dbd.O)--, --(CH.sub.2).sub.nN(R10)C(.dbd.NR11)-, --(CH.sub.2).sub.nN(R10)C(.dbd.S)--, --C.dbd.C--C(.dbd.O)--, --N.dbd.C(R11)-, --(CH.sub.2).sub.nN(R10)C(.dbd.O)C(.dbd.O)--, --OCH.sub.2C(.dbd.O)--, --N(R10)C(.dbd.CR11)-, --N(R10)CH.sub.2C(.dbd.O)-- or --N.dbd.C(NR11)-; R10 is hydrogen, (C.sub.1-C.sub.4)alkyl or (C.sub.1-C.sub.4) alkoxy(C.sub.1-C.sub.2)alkyl; R11 is hydrogen, hydroxyl, cyano, nitro, or (C.sub.1-C.sub.4)alkyl; B is hydrogen, halogen, (C.sub.1-C.sub.4)alkyl, (C.sub.1-C.sub.4)alkoxy, thienyl, or N(R12)R13 wherein R12 and R13 independently of one another are hydrogen, (C.sub.1-C.sub.4)alkyl, (C.sub.1-C.sub.4)alkylcarbonyl, or R12 and R13 together and with inclusion of the nitrogen atom to which they are bonded form an azetidinyl-, pyrrolidinyl-, piperidinyl-, piperazinyl-, 4-methylpiperazinyl-, morpholinyl- or thiomorpholinyl-ring; R14 is hydrogen or (C.sub.1-C.sub.4)alkyl; and n is an integer selected from 0 to 2; or a salt thereof. 2. A compound of formula I according to claim 1 wherein A is (C.sub.1-C.sub.4)alkyl, (C.sub.1-C.sub.4)alkoxy(C.sub.1-C.sub.2)alkyl, (C.sub.1-C.sub.4)alkylthio(C.sub.1-C.sub.2)alkyl, mono- or -di(C.sub.1-C.sub.4)alkylamino(C.sub.1-C.sub.2)alkyl, cyclohexyl optionally substituted by R1 and/or R2, cyclohexyl substituted by R3, azetidinyl optionally substituted by R1 and/or R2, piperidinyl optionally substituted by R1 and/or R2, phenyl optionally substituted by R1 and/or R2, phenyl substituted by R4, naphthyl optionally substituted by R1 and/or R2, pyridyl optionally substituted by R1 and/or R2, pyridyl substituted by R5, pyrimidinyl optionally substituted by R1 and/or R2, pyrimidinyl substituted by R8, triazinyl optionally substituted by R1 and/or R2, triazinyl substituted by R9, quinolinyl optionally substituted by R1 and/or R2, isoquinolinyl optionally substituted by R1 and/or R2, thienyl optionally substituted by R1 and/or R2, thiazolyl optionally substituted by R1 and/or R2 or indazolyl optionally substituted by R1 and/or R2; R1 is fluorine, hydroxyl, cyano, nitro, amino, carboxyl, (C.sub.1-C.sub.4)alkyl, (C.sub.1-C.sub.4)alkoxy, (C.sub.1-C.sub.4)alkyl which is partially or completely substituted by fluorine, (C.sub.1-C.sub.4)alkoxy which is predominantly or completely substituted by fluorine, (C.sub.1-C.sub.4)alkoxy(C.sub.1-C.sub.2)alkyl, (C.sub.1-C.sub.4)alkoxycarbonyl, mono- or -di(C.sub.1-C.sub.4)alkylamino, or (C.sub.1-C.sub.4)alkylcarbonylamino; R2 is fluorine, hydroxyl, amino, (C.sub.1-C.sub.4)alkyl, or (C.sub.1-C.sub.4)alkoxy or R1 and R2 when ortho to each other form a methylenedioxy or ethylenedioxy group; R4 is phenyl, phenoxy, 4-methylpiperazinyl, benzylNHC(.dbd.O)NH--, or methylphenylsulfonylamino; R5 is methylphenylsulfonylamino, or N(R6)R7, wherein R6 and R7 together and with inclusion of the nitrogen atom to which they are bonded form an azetidinyl-, piperidinyl-, piperazinyl-, 4-methylpiperazinyl-, or morpholinyl-ring; R8 is pyridyl or methylphenylsulfonylamino; L is bond, --(CH.sub.2).sub.nS(O).sub.2--, --C(.dbd.O)--, --C(.dbd.S)--, --(CH.sub.2).sub.nOC(.dbd.O)--, --(CH.sub.2).sub.nN(R10)C(.dbd.O)--, --(CH.sub.2).sub.nN(R10)C(.dbd.NR11)-, --(CH.sub.2).sub.nN(R10)C(.dbd.S)--, --C.dbd.C--C(.dbd.O)--, --N.dbd.C(R11)-, --(CH.sub.2).sub.nN(R10)C(.dbd.O)C(.dbd.O)--, --OCH.sub.2C(.dbd.O)--, --N(R10)C(.dbd.CR11)-, --N(R10)CH.sub.2C(.dbd.O)-- or --N.dbd.C(NR11)-; R11 is hydrogen, hydroxyl, cyano, nitro, methyl, or ethyl; B is hydrogen, halogen, (C.sub.1-C.sub.4)alkyl, (C.sub.1-C.sub.4)alkoxy, thienyl, or N(R12)R13 wherein R12 and R13 independently of one another are hydrogen, (C.sub.1-C.sub.4)alkyl, or R12 and R13 together and with inclusion of the nitrogen atom to which they are bonded form a pyrrolidinyl-ring; R14 is hydrogen or methyl; n is an integer selected from 0 and 1; or a salt thereof. 3. A compound of formula I according to claim 1 wherein A is (C.sub.1-C.sub.4)alkyl, (C.sub.1-C.sub.4)alkoxy(C.sub.1-C.sub.2)alkyl, cyclohexyl optionally substituted by R1 and/or R2, cyclohexyl substituted by R3, piperidinyl optionally substituted by R1 and/or R2, phenyl optionally substituted by R1 and/or R2, phenyl substituted by R4, naphthyl optionally substituted by R1 and/or R2, pyridyl optionally substituted by R1 and/or R2, pyridyl substituted by R5, pyrimidinyl optionally substituted by R1 and/or R2, pyrimidyl substituted by R8, triazinyl optionally substituted by R1 and/or R2, triazinyl substituted by R9, quinolinyl optionally substituted by R1 and/or R2, isoquinolinyl optionally substituted by R1 and/or R2, thienyl optionally substituted by R1 and/or R2, thiazolyl optionally substituted by R1 and/or R2 or indazolyl optionally substituted by R1 and/or R2; R1 is fluorine, hydroxyl, nitro, cyano, amino, carboxyl, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, methoxy, ethoxy, propoxy, isopropoxy, trifluoromethyl, difluoromethyl, difluoromethoxy, trifluoromethoxy, methoxyethyl, ethoxyethyl, methoxymethyl, ethoxymethyl, Methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, methylamino, dimethylamino, ethylamino, diethylamino, methylcarbonylamino, or ethylcarbonylamino; R2 is fluorine, hydroxyl, methyl, ethyl, propyl, isopropyl, methoxy, ethoxy, propoxy, or isopropoxy or R1 and R2 when ortho to each other form a methylenedioxy group; R4 is phenyl, phenoxy, 4-methylpiperazinyl, benzylNHC(.dbd.O)NH--, or methylphenylsulfonylamino, R5 is methylphenylsulfonylamino, N(R6)R7, wherein R6 and R7 together and with inclusion of the nitrogen atom to which they are bonded form an azetidinyl-, piperidinyl-, piperazinyl-, 4-methylpiperazinyl-, morpholinyl-ring; R8 is pyridyl or methylphenylsulfonylamino; L is bond, --(CH.sub.2).sub.nS(O).sub.2--, --C(.dbd.O)--, --C(.dbd.S)--, --(CH.sub.2).sub.nOC(.dbd.O)--, --(CH.sub.2).sub.nN(R10)C(.dbd.O)--, --(CH.sub.2).sub.nN(R10)C(.dbd.NR11)-, --(CH.sub.2).sub.nN(R10)C(.dbd.S)--, --C.dbd.C--C(.dbd.O)--, --N.dbd.C(R11)-, --(CH.sub.2).sub.nN(R10)C(.dbd.O)C(.dbd.O)--, --OCH.sub.2C(.dbd.O)--, --N(R10)C(.dbd.CR11)-, --N(R10)CH.sub.2C(.dbd.O)-- or --N.dbd.C(NR11)-; R10 is hydrogen, methyl, ethyl, propyl, methoxyethyl, ethoxyethyl, methoxymethyl, or ethoxymethyl; R11 is hydrogen, hydroxyl, cyano, nitro, methyl, or ethyl; B is hydrogen, fluorine, chlorine, methyl, ethyl, propyl, isopropyl, methoxy, ethoxy, thienyl, N(R12)R13 wherein R12 and R13 independently of one another are hydrogen, methyl, ethyl, or R12 and R13 together and with inclusion of the nitrogen atom to which they are bonded form a pyrrolidinyl-ring; R14 is hydrogen or methyl; n is an integer selected from 0 and 1; or a salt thereof. 4. A compound of formula I according to claim 1 wherein L is --(CH.sub.2).sub.nN(R10)C(.dbd.O)C(.dbd.O); A is (C.sub.1-C.sub.4)alkyl, (C.sub.1-C.sub.4)alkoxy(C.sub.1-C.sub.2)alkyl, mono- or -di(C.sub.1-C.sub.4)alkylamino(C.sub.1-C.sub.2)alkyl, cyclohexyl optionally substituted by R1 and/or R2, cyclohexyl substituted by R3, phenyl optionally substituted by R1 and/or R2, phenyl substituted by R4, naphthyl optionally substituted by R1 and/or R2, pyridyl optionally substituted by R1 and/or R2, pyridyl substituted by R5, quinolinyl optionally substituted by R1 and/or R2, or isoquinolinyl optionally substituted by R1 and/or R2; R1 is fluorine, hydroxyl, nitro, amino, carboxyl, (C.sub.1-C.sub.4)alkyl, (C.sub.1-C.sub.4)alkoxy, (C.sub.1-C.sub.4)alkyl which is partially or completely substituted by fluorine, (C.sub.1-C.sub.4)alkoxy which is predominantly or completely substituted by fluorine, (C.sub.1-C.sub.4)alkoxy(C.sub.1-C.sub.2)alkyl, (C.sub.1-C.sub.4)alkoxycarbonyl, mono- or -di(C.sub.1-C.sub.4)alkylamino or (C.sub.1-C.sub.4)alkylcarbonylamino; R2 is hydroxyl, (C.sub.1-C.sub.4)alkyl or (C.sub.1-C.sub.4)alkoxy or R1 and R2 when ortho to each other form a methylenedioxy group; R4 is phenyl, phenoxy, or 4-methylpiperazinyl; R5 is N(R6)R7, wherein R6 and R7 together and with inclusion of the nitrogen atom to which they are bonded form an azetidinyl-, piperidinyl-, piperazinyl-, 4-methylpiperazinyl-, morpholinyl-ring; R10 is hydrogen or (C.sub.1-C.sub.4)alkyl; B is hydrogen, fluorine, chlorine, (C.sub.1-C.sub.4)alkyl, (C.sub.1-C.sub.4)alkoxy, or thienyl; R14 is hydrogen, or methyl; n is an integer selected from 0 and 1; or a salt thereof. 5. A compound of formula I according to claim 1 wherein L is --(CH.sub.2).sub.nN(R10)C(.dbd.O)--; A is (C.sub.1-C.sub.4)alkyl, (C.sub.1-C.sub.4)alkoxy(C.sub.1-C.sub.2)alkyl, (C.sub.1-C.sub.4)alkylthio(C.sub.1-C.sub.2)alkyl, mono- or -di(C.sub.1-C.sub.4)alkylamino(C.sub.1-C.sub.2)alkyl, cyclohexyl optionally substituted by R1 and/or R2, cyclohexyl substituted by R3, azetidinyl optionally substituted by R1 and/or R2, piperidinyl optionally substituted by R1 and/or R2, phenyl optionally substituted by R1 and/or R2, phenyl substituted by R4, naphthyl optionally substituted by R1 and/or R2, pyridyl optionally substituted by R1 and/or R2, pyridyl substituted by R5, quinolinyl optionally substituted by R1 and/or R2, isoquinolinyl optionally substituted by R1 and/or R2, or indazolyl optionally substituted by R1 and/or R2; R1 is fluorine, hydroxyl, nitro, amino, carboxyl, (C.sub.1-C.sub.4)alkyl, (C.sub.1-C.sub.4)alkoxy, (C.sub.1-C.sub.4)alkyl which is partially or completely substituted by fluorine, (C.sub.1-C.sub.4)alkoxy which is predominantly or completely substituted by fluorine, (C.sub.1-C.sub.4)alkoxy(C.sub.1-C.sub.2)alkyl, (C.sub.1-C.sub.4)alkoxycarbonyl, mono- or -di(C.sub.1-C.sub.4)alkylamino or (C.sub.1-C.sub.4)alkylcarbonylamino; R2 is hydroxyl, (C.sub.1-C.sub.4)alkyl, or (C.sub.1-C.sub.4)alkoxy or R1 and R2 when ortho to each other form a methylenedioxy group; R3 is 3-pyridyl or 4-pyridyl; R4 is phenyl, phenoxy, or 4-methylpiperazinyl; R5 is N(R6)R7, wherein R6 and R7 together and with inclusion of the nitrogen atom to which they are bonded form an azetidinyl-, piperidinyl-, piperazinyl-, 4-methylpiperazinyl-, or morpholinyl-ring; R10 is hydrogen, (C.sub.1-C.sub.4)alkyl, methoxyethyl, ethoxyethyl, methoxymethyl, or ethoxymethyl; B is hydrogen, fluorine, chlorine, (C.sub.1-C.sub.4)alkyl, (C.sub.1-C.sub.4)alkoxy, thienyl, or N(R12)R13 wherein R12 and R13 independently of one another are hydrogen, (C.sub.1-C.sub.4)alkyl, or R12 and R13 together and with inclusion of the nitrogen atom to which they are bonded form a pyrrolidinyl-ring; R14 is hydrogen or methyl; n is an integer selected from 0 and 1; or a salt thereof. 6. A compound of formula I according to claim 1 wherein L is --C(.dbd.O)--; A is (C.sub.1-C.sub.4)alkyl, (C.sub.1-C.sub.4)alkoxy(C.sub.1-C.sub.2)alkyl, (C.sub.1-C.sub.4)alkylthio(C.sub.1-C.sub.2)alkyl, mono- or -di(C.sub.1-C.sub.4)alkylamino(C.sub.1-C.sub.2)alkyl, phenyl optionally substituted by R1 and/or R2, phenyl substituted by R4, naphthyl optionally substituted by R1 and/or R2, pyridyl optionally substituted by R1 and/or R2, quinolinyl optionally substituted by R1 and/or R2, or isoquinolinyl optionally substituted by R1 and/or R2; R1 is (C.sub.1-C.sub.4)alkyl, (C.sub.1-C.sub.4)alkoxy, (C.sub.1-C.sub.4)alkyl which is partially or completely substituted by fluorine, (C.sub.1-C.sub.4)alkoxy which is predominantly or completely substituted by fluorine, (C.sub.1-C.sub.4)alkoxy(C.sub.1-C.sub.2)alkyl, (C.sub.1-C.sub.4)alkoxycarbonyl, or mono- or -di(C.sub.1-C.sub.4)alkylamino; R2 is (C.sub.1-C.sub.4)alkyl or (C.sub.1-C.sub.4)alkoxy; R4 is phenyl or phenoxy; B is hydrogen, fluorine, chlorine, (C.sub.1-C.sub.4)alkyl, or thienyl; R14 is hydrogen or methyl; or a salt thereof. 7. A compound of formula I according to claim 1 wherein L is --(CH.sub.2).sub.nN(R10)C(.dbd.N(R11)-; A is (C.sub.1-C.sub.4)alkyl, (C.sub.1-C.sub.4)alkoxy(C.sub.1-C.sub.2)alkyl, (C.sub.1-C.sub.4)alkylthio(C.sub.1-C.sub.2)alkyl, mono- or -di(C.sub.1-C.sub.4)alkylamino(C.sub.1-C.sub.2)alkyl, phenyl optionally substituted by R1 and/or R2, phenyl substituted by R4, or naphthyl optionally substituted by R1 and/or R2; R1 is (C.sub.1-C.sub.4)alkyl, (C.sub.1-C.sub.4)alkoxy, (C.sub.1-C.sub.4)alkyl which is partially or completely substituted by fluorine, (C.sub.1-C.sub.4)alkoxy which is predominantly or completely substituted by fluorine, (C.sub.1-C.sub.4)alkoxy(C.sub.1-C.sub.2)alkyl, (C.sub.1-C.sub.4)alkoxycarbonyl, or mono- or -di(C.sub.1-C.sub.4)alkylamino; R2 is (C.sub.1-C.sub.4)alkoxy, or R1 and R2 when ortho to each other form a methylenedioxy group; R4 is phenyl, or phenoxy; R10 is hydrogen, or (C.sub.1-C.sub.4)alkyl; R11 is hydrogen, cyano, or methyl; B is hydrogen, fluorine, chlorine, (C.sub.1-C.sub.4)alkyl, (C.sub.1-C.sub.4)alkoxy, or thienyl; R14 is hydrogen, or methyl; n is an integer selected from 0 and 1; or a salt thereof. 8. A compound of formula I according to claim 1 wherein L is --N.dbd.C(R11)-; A is (C.sub.1-C.sub.4)alkyl, phenyl optionally substituted by R1 and/or R2, phenyl substituted by R4, or naphthyl optionally substituted by R1 and/or R2; R1 is (C.sub.1-C.sub.4)alkyl, (C.sub.1-C.sub.4)alkoxy, (C.sub.1-C.sub.4)alkyl which is partially or completely substituted by fluorine, (C.sub.1-C.sub.4)alkoxy which is predominantly or completely substituted by fluorine, (C.sub.1-C.sub.4)alkoxy(C.sub.1-C.sub.2)alkyl, (C.sub.1-C.sub.4)alkoxycarbonyl, or mono- or -di(C.sub.1-C.sub.4)alkylamino; R2 is (C.sub.1-C.sub.4)alkoxy, or R1 and R2 when ortho to each other form a methylenedioxy group; R4 is phenyl; R11 is hydrogen, or methyl; B is hydrogen, fluorine, chlorine, (C.sub.1-C.sub.4)alkyl, (C.sub.1-C.sub.4)alkoxy, or thienyl; R14 is hydrogen, or methyl; or a salt thereof. 9. A compound of formula I according to claim 1 wherein L is --N(R10)C(.dbd.C(R11))-; A is (C.sub.1-C.sub.4)alkyl, phenyl optionally substituted by R1 and/or R2, phenyl substituted by R4, or naphthyl optionally substituted by R1 and/or R2; R1 is fluorine, (C.sub.1-C.sub.4)alkyl, (C.sub.1-C.sub.4)alkoxy, (C.sub.1-C.sub.4)alkyl which is partially or completely substituted by fluorine, (C.sub.1-C.sub.4)alkoxy which is predominantly or completely substituted by fluorine, (C.sub.1-C.sub.4)alkoxy(C.sub.1-C.sub.2)alkyl, (C.sub.1-C.sub.4)alkoxycarbonyl, or mono- or -di(C.sub.1-C.sub.4)alkylamino; R2 is (C.sub.1-C.sub.4)alkoxy, or R1 and R2 when ortho to each other form a methylenedioxy group; R4 is phenyl; R10 is hydrogen, or (C.sub.1-C.sub.4)alkyl; R11 is hydrogen, nitro, or methyl; B is hydrogen, fluorine, chlorine, (C.sub.1-C.sub.4)alkyl, (C.sub.1-C.sub.4)alkoxy, or thienyl; R14 is hydrogen, or methyl; or a salt thereof. 10. A compound of formula I according to claim 1 wherein L is --(CH.sub.2).sub.nS(O).sub.2--; A is (C.sub.1-C.sub.4)alkyl, phenyl optionally substituted by R1 and/or R2, phenyl substituted by R4, naphthyl optionally substituted by R1 and/or R2, thienyl optionally substituted by R1 and/or R2, thiazolyl optionally substituted by R1 and/or R2; R1 is fluorine, (C.sub.1-C.sub.4)alkyl, (C.sub.1-C.sub.4)alkoxy, (C.sub.1-C.sub.4)alkyl which is partially or completely substituted by fluorine, (C.sub.1-C.sub.4)alkoxy which is predominantly or completely substituted by fluorine, (C.sub.1-C.sub.4)alkoxy(C.sub.1-C.sub.2)alkyl, (C.sub.1-C.sub.4)alkoxycarbonyl, mono- or -di(C.sub.1-C.sub.4)alkylamino, or (C.sub.1-C.sub.4)alkylcarbonylamino; R2 is (C.sub.1-C.sub.4)alkyl, or (C.sub.1-C.sub.4)alkoxy, or R1 and R2 when ortho to each other form a methylenedioxy group; R4 is phenyl; B is hydrogen, fluorine, chlorine, (C.sub.1-C.sub.4)alkyl, (C.sub.1-C.sub.4)alkoxy or thienyl; R14 is hydrogen or methyl; or a salt thereof. 11. A compound of formula I according to claim 1 wherein L is --N(R10)C(.dbd.S)--; A is (C.sub.1-C.sub.4)alkyl, cyclohexyl optionally substituted by R1 and/or R2, cyclohexyl substituted by R3, piperidinyl optionally substituted by R1 and/or R2, phenyl optionally substituted by R1 and/or R2, phenyl substituted by R4, naphthyl optionally substituted by R1 and/or R2, pyridyl optionally substituted by R1 and/or R2, quinolinyl optionally substituted by R1 and/or R2, or isoquinolinyl optionally substituted by R1 and/or R2; R1 is fluorine, (C.sub.1-C.sub.4)alkyl, (C.sub.1-C.sub.4)alkoxy, (C.sub.1-C.sub.4)alkyl which is partially or completely substituted by fluorine, (C.sub.1-C.sub.4)alkoxy which is predominantly or completely substituted by fluorine, (C.sub.1-C.sub.4)alkoxy(C.sub.1-C.sub.2)alkyl, (C.sub.1-C.sub.4)alkoxycarbonyl, or mono- or -di(C.sub.1-C.sub.4)alkylamino; R2 is (C.sub.1-C.sub.4)alkyl or (C.sub.1-C.sub.4)alkoxy, or R1 and R2 when ortho to each other form a methylenedioxy group; R4 is phenyl; R10 is hydrogen or (C.sub.1-C.sub.4)alkyl; B is hydrogen, fluorine, chlorine, (C.sub.1-C.sub.4)alkyl, (C.sub.1-C.sub.4)alkoxy, or thienyl; R14 is hydrogen or methyl; or a salt thereof. 12. A compound of formula I according to claim 1 wherein L is --OCH.sub.2C(.dbd.O)--; A is (C.sub.1-C.sub.4)alkyl, phenyl optionally substituted by R1 and/or R2, phenyl substituted by R4, naphthyl optionally substituted by R1 and/or R2; R1 is fluorine, (C.sub.1-C.sub.4)alkyl, (C.sub.1-C.sub.4)alkoxy, (C.sub.1-C.sub.4)alkyl which is partially or completely substituted by fluorine, (C.sub.1-C.sub.4)alkoxy which is predominantly or completely substituted by fluorine, (C.sub.1-C.sub.4)alkoxy(C.sub.1-C.sub.2)alkyl, (C.sub.1-C.sub.4)alkoxycarbonyl, or mono- or -di(C.sub.1-C.sub.4)alkylamino; R2 is (C.sub.1-C.sub.4)alkyl or (C.sub.1-C.sub.4)alkoxy, or R1 and R2 when ortho to each other form a methylenedioxy group; R4 is phenyl; B is hydrogen, fluorine, chlorine, (C.sub.1-C.sub.4)alkyl, (C.sub.1-C.sub.4)alkoxy, or thienyl; R14 is hydrogen or methyl; or a salt thereof. 13. A compound of formula I according to claim 1 wherein L is --(CH.sub.2).sub.nOC(.dbd.O); A is (C.sub.1-C.sub.4)alkyl, phenyl optionally substituted by R1 and/or R2, phenyl substituted by R4, naphthyl optionally substituted by R1 and/or R2, pyridyl optionally substituted by R1 and/or R2, pyridyl substituted by R5; R1 is fluorine, hydroxyl, nitro, amino, carboxyl, (C.sub.1-C.sub.4)alkyl, (C.sub.1-C.sub.4)alkoxy, (C.sub.1-C.sub.4)alkyl which is partially or completely substituted by fluorine, (C.sub.1-C.sub.4)alkoxy which is predominantly or completely substituted by fluorine, (C.sub.1-C.sub.4)alkoxy(C.sub.1-C.sub.2)alkyl, (C.sub.1-C.sub.4)alkoxycarbonyl, or mono- or -di(C.sub.1-C.sub.4)alkylamino; R2 is hydroxyl, (C.sub.1-C.sub.4)alkyl, or (C.sub.1-C.sub.4)alkoxy or R1 and R2 when ortho to each other form a methylenedioxy group; R4 is phenyl, phenoxy, or 4-methylpiperazinyl; R5 is N(R6)R7, wherein R6 and R7 together and with inclusion of the nitrogen atom to which they are bonded form an azetidinyl-, piperidinyl-, piperazinyl-, 4-methylpiperazinyl-, or morpholinyl-ring; B is hydrogen, fluorine, chlorine, (C.sub.1-C.sub.4)alkyl, (C.sub.1-C.sub.4)alkoxy, or thienyl; R14 is hydrogen or methyl; n is an integer selected from 0 and 1; or a salt thereof. 14. A compound of formula I according to claim 1 wherein L is --C.dbd.C--C(.dbd.O)--; A is (C.sub.1-C.sub.4)alkyl, phenyl optionally substituted by R1 and/or R2, or naphthyl optionally substituted by R1 and/or R2; R1 is fluorine, hydroxyl, (C.sub.1-C.sub.4)alkyl, (C.sub.1-C.sub.4)alkoxy, (C.sub.1-C.sub.4)alkyl which is partially or completely substituted by fluorine, (C.sub.1-C.sub.4)alkoxy which is predominantly or completely substituted by fluorine, (C.sub.1-C.sub.4)alkoxy(C.sub.1-C.sub.2)alkyl, (C.sub.1-C.sub.4)alkoxycarbonyl, or mono- or -di(C.sub.1-C.sub.4)alkylamino; R2 is hydroxyl, (C.sub.1-C.sub.4)alkyl, or (C.sub.1-C.sub.4)alkoxy or R1 and R2 when ortho to each other form a methylenedioxy group; B is hydrogen, fluorine, chlorine, (C.sub.1-C.sub.4)alkyl, (C.sub.1-C.sub.4)alkoxy, or thienyl; R14 is hydrogen or methyl; or a salt thereof. 15. A compound of formula I according to claim 1 wherein L is --N(R10)CH.sub.2C(.dbd.O)--; A is (C.sub.1-C.sub.4)alkyl, (C.sub.1-C.sub.4)alkoxy(C.sub.1-C.sub.2)alkyl, (C.sub.1-C.sub.4)alkylthio(C.sub.1-C.sub.2)alkyl, mono- or di(C.sub.1-C.sub.4)alkylamino(C.sub.1-C.sub.2)alkyl, cyclohexyl optionally substituted by R1 and/or R2, cyclohexyl substituted by R3, azetidinyl optionally substituted by R1 and/or R2, piperidinyl optionally substituted by R1 and/or R2, phenyl optionally substituted by R1 and/or R2, phenyl substituted by R4, naphthyl optionally substituted by R1 and/or R2, pyridyl optionally substituted by R1 and/or R2, pyridyl substituted by R5, quinolinyl optionally substituted by R1 and/or R2, isoquinolinyl optionally substituted by R1 and/or R2, or indazolyl quinolinyl optionally substituted by R1 and/or R2; R1 is fluorine, hydroxyl, nitro, amino, carboxyl, (C.sub.1-C.sub.4)alkyl, (C.sub.1-C.sub.4)alkoxy, (C.sub.1-C.sub.4)alkyl which is partially or completely substituted by fluorine, (C.sub.1-C.sub.4)alkoxy which is predominantly or completely substituted by fluorine, (C.sub.1-C.sub.4)alkoxy(C.sub.1-C.sub.2)alkyl, (C.sub.1-C.sub.4)alkoxycarbonyl, or mono- or -di(C.sub.1-C.sub.4)alkylamino or (C.sub.1-C.sub.4)alkylcarbonylamino; R2 is hydroxyl, (C.sub.1-C.sub.4)alkyl, or (C.sub.1-C.sub.4)alkoxy or R1 and R2 when ortho to each other form a methylenedioxy group; R4 is phenyl, phenoxy, or 4-methylpiperazinyl; R5 is N(R6)R7, wherein R6 and R7 together and with inclusion of the nitrogen atom to which they are bonded form an azetidinyl-, piperidinyl-, piperazinyl-, 4-methylpiperazinyl-, or morpholinyl-ring; R10 is hydrogen, (C.sub.1-C.sub.4)alkyl, methoxyethyl, ethoxyethyl, methoxymethyl or ethoxymethyl; B is hydrogen, fluorine, chlorine, (C.sub.1-C.sub.4)alkyl, (C.sub.1-C.sub.4)alkoxy, thienyl or N(R12)R13 wherein R12 and R13 independently of one another are hydrogen, (C.sub.1-C.sub.4)alkyl, or R12 and R13 together and with inclusion of the nitrogen atom to which they are bonded form a pyrrolidinyl-ring; R14 is hydrogen or methyl; or a salt thereof. 16. A compound of formula I according to claim 1 wherein L is bond; A is (C.sub.1-C.sub.4)alkyl, phenyl optionally substituted by R1 and/or R2, phenyl substituted by R4, naphthyl optionally substituted by R1 and/or R2, pyridyl optionally substituted by R1 and/or R2, pyridyl substituted by R5, pyrimidinyl optionally substituted by R1 and/or R2, pyrimidinyl substituted by R8; R1 is fluorine, hydroxyl, nitro, amino, (C.sub.1-C.sub.4)alkyl, (C.sub.1-C.sub.4)alkoxy, (C.sub.1-C.sub.4)alkyl which is partially or completely substituted by fluorine, (C.sub.1-C.sub.4)alkoxy which is predominantly or completely substituted by fluorine, (C.sub.1-C.sub.4)alkoxy(C.sub.1-C.sub.2)alkyl, (C.sub.1-C.sub.4)alkoxycarbonyl, or mono- or -di(C.sub.1-C.sub.4)alkylamino; R2 is hydroxyl, (C.sub.1-C.sub.4)alkyl, or (C.sub.1-C.sub.4)alkoxy or R1 and R2 when ortho to each other form a methylenedioxy group; R4 is phenyl, phenoxy, benzylNHC(.dbd.O)NH--, or methylphenylsulfonylamino; R5 is methylphenylsulfonylamino, or N(R6)R7, wherein R6 and R7 together and with inclusion of the nitrogen atom to which they are bonded form an azetidinyl-, piperidinyl-, piperazinyl-, 4-methylpiperazinyl-, or morpholinyl-ring; R8 is hydrogen, fluorine, chlorine, (C.sub.1-C.sub.4)alkyl, (C.sub.1-C.sub.4)alkoxy, or thienyl; R14 is hydrogen or methyl; or a salt thereof. 17. A compound of formula I, which is one of the following compounds N.sup.2-(2-aminophenyl)-N.sup.5-biphenyl-4-yl-6,7-dihydro[1,3]thiazolo[5,- 4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-[4-(dimethylamino)phenyl]-6,7-dihydro[1,3- ]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-(4-methoxyphenyl)-6,7-dihydro[1,3]thiazol- o[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-benzyl-6,7-dihydro[1,3]thiazolo[5,4-c]pyr- idine-2,5(4H)-dicarboxamide, Methyl 4-[({2-[(2-aminophenyl)carbamoyl]-6,7-dihydro[1,3]thiazolo[5,4-c]pyridine- -5(4H)-yl}carbonyl)amino]benzoate, N.sup.2-(2-aminophenyl)-N.sup.5-(4-phenoxyphenyl)-6,7-dihydro[1,3]thiazol- o[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-1,3-benzodioxol-5-yl-6,7-dihydro[1,3]thia- zolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-[2-(trifluoromethoxy)phenyl]-6,7-dihydro[- 1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-[4-(trifluoromethoxy)phenyl]-6,7-dihydro[- 1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-[2-(difluoromethoxy)phenyl]-6,7-dihydro[1- ,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-[4-(difluoromethoxy)phenyl]-6,7-dihydro[1- ,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-quinolin-3-yl-6,7-dihydro[1,3]thiazolo[5,- 4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-(4-methylphenyl)-6,7-dihydro[1,3]thiazolo- [5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-(pyridin-3-ylmethyl)-6,7-dihydro[1,3]thia- zolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-pyridin-4-yl-6,7-dihydro[1,3]thiazolo[5,4- -c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-(2-methoxyethyl)-6,7-dihydro[1,3]thiazolo- [5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-methyl-6,7-dihydro[1,3]thiazolo[5,4-c]pyr- idine-2,5(4H)-dicarboxamide N.sup.2-(2-aminophenyl)-N.sup.5-[3-(dimethylamino)phenyl]-6,7-dihydro[1,3- ]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-(3,4-dimethoxyphenyl)-6,7-dihydro[1,3]thi- azolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-(2-methoxyethyl)-N.sup.5-methyl-6,7-dihyd- ro[1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-ethyl-N.sup.5-isopropyl-6,7-dihydro[1,3]t- hiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-[4-(dimethylamino)phenyl]-N.sup.5-methyl-- 6,7-dihydro[1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-[3-(dimethylamino)phenyl]-N.sup.5-methyl-- 6,7-dihydro[1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-(3,4-dimethoxyphenyl)-N.sup.5-methyl-6,7-- dihydro[1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-(3,4-dimethoxyphenyl)-N-5-ethyl-6,7-dihyd- ro[1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-(3,4-dimethoxyphenyl)-N.sup.5-(2-methoxye- thyl)-6,7-dihydro[1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-methyl-N.sup.5-pyridin-3-yl-6,7-dihydro[1- ,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-ethyl-N.sup.5-pyridin-3-yl-6,7-dihydro[1,- 3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-1,3-benzodioxol-5-yl-N.sup.5-ethyl-6,7-di- hydro[1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-1,3-benzodioxol-5-yl-N.sup.5-(2-methoxyet- hyl)-6,7-dihydro[1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-1,3-benzodioxol-5-yl-N.sup.5-methyl-6,7-d- ihydro[1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-[3-(4-methylpiperazin-1-yl)phenyl]-6,7-di- hydro[1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-(2-methoxyethyl)-N.sup.5-pyridin-3-yl-6,7- -dihydro[1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-(6-morpholin-4-ylpyridin-3-yl)-6,7-dihydr- o[1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-(6-azetidin-1-ylpyridin-3-yl)-6,7-dihydro- [1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-[6-(dimethylamino)pyridin-3-yl]-6,7-dihyd- ro[1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]-- 6,7-dihydro[1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-(6-methoxypyridin-3-yl)-6,7-dihydro[1,3]t- hiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-pyridin-3-yl-6,7-dihydro[1,3]thiazolo[5,4- -c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-butyl-6,7-dihydro[1,3]thiazolo[5,4-c]pyri- dine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-(4-pyridin-3-ylcyclohexyl)-6,7-dihydro[1,- 3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-piperidin-4-yl-6,7-dihydro[1,3]thiazolo[5- ,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-amino-5-methoxyphenyl)-N.sup.5-(4-methoxyphenyl)-6,7-dihydro[1- ,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-(4-pyridin-4-ylcyclohexyl)-6,7-dihydro[1,- 3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-amino-5-isopropylphenyl)-N.sup.5-(4-methoxyphenyl)-6,7-dihydro- [1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-amino-5-methoxyphenyl)-N.sup.5-isoquinolin-5-yl-6,7-dihydro[1,- 3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-amino-5-methoxyphenyl)-N.sup.5-[4-(dimethylamino)phenyl]-6,7-d- ihydro[1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-amino-5-isopropylphenyl)-N.sup.5-(3,4-dimethoxyphenyl)-6,7-dih- ydro[1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-amino-5-isopropylphenyl)-N.sup.5-isoquinolin-5-yl-6,7-dihydro[- 1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-amino-5-isopropylphenyl)-N.sup.5-[4-(dimethylamino)phenyl]-6,7- -dihydro[1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-amino-5-methoxyphenyl)-N.sup.5-(4-fluorophenyl)-6,7-dihydro[1,- 3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-amino-5-isopropylphenyl)-N.sup.5-(4-fluorophenyl)-6,7-dihydro[- 1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-[2-amino-5-(dimethylamino)phenyl]-N.sup.5-(4-methoxyphenyl)-6,7-d- ihydro[1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-[2-amino-5-(2-thienyl)phenyl]-N.sup.5-(4-methoxyphenyl)-6,7-dihyd- ro[1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-[2-amino-5-(2-thienyl)phenyl]-N.sup.5-[4-(dimethylamino)phenyl]-6- ,7-dihydro[1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-[2-amino-5-(3-thienyl)phenyl]-N.sup.5-(4-methoxyphenyl)-6,7-dihyd- ro[1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-[2-amino-5-(dimethylamino)phenyl]-N.sup.5-[4-(dimethylamino)pheny- l]-6,7-dihydro[1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-amino-5-pyrrolidin-1-ylphenyl)-N.sup.5-(4-methoxyphenyl)-6,7-d- ihydro[1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-[2-amino-5-(3-thienyl)phenyl]-N.sup.5-[4-(dimethylamino)phenyl]-6- ,7-dihydro[1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-amino-5-isopropylphenyl)-N.sup.5-pyridin-3-yl-6,7-dihydro[1,3]- thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-[2-amino-5-(dimethylamino)phenyl]-N.sup.5-(3,4-dimethoxyphenyl)-6- ,7-dihydro[1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-isoquinolin-5-yl-6,7-dihydro[1,3]thiazolo- [5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-[3-(dimethylamino)phenyl]-6,7-dihydro[1,3- ]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide dihydrochloride, N-(2-aminophenyl)-5-[{[4-(dimethylamino)phenyl]amino}(oxo)acetyl]-4,5,6,7- -tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-{[(4-methoxyphenyl)amino](oxo)acetyl}-4,5,6,7-tetrahy- dro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-{[(3,4-dimethoxyphenyl)amino](oxo)acetyl}-4,5,6,7-tet- rahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-{oxo[(4-pyridin-4-ylcyclohexyl)amino]acetyl}-4,5,6,7-- tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[(isoquinolin-5-ylamino)(oxo)acetyl]-4,5,6,7-tetrahyd- ro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-{oxo[(4-pyridin-3-ylcyclohexyl)amino]acetyl}-4,5,6,7-- tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-{[(6-methoxypyridin-3-yl)amino](oxo)acetyl}-4,5,6,7-t- etrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[{[(6-(dimethylamino)pyridin-3-yl]amino}(oxo)acetyl]-- 4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-(oxo {[4-(trifluoromethoxy)phenyl]amino}acetyl)-4,5,6,7-tetrahydro[1,3]thiazol- o[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-{[(6-morpholin-4-ylpyridin-3-yl)amino](oxo)acetyl}-4,- 5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[(1,3-benzodioxol-5-ylamino)(oxo)acetyl]-4,5,6,7-tetr- ahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-{[(4-methylphenyl)amino](oxo)acetyl}-4,5,6,7-tetrahyd- ro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-{[(5-methylpyridin-2-yl)amino](oxo)acetyl}-4,5,6,7-te- trahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[oxo(quinolin-3-ylamino)acetyl]-4,5,6,7-tetrahydro[1,- 3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-amino-5-methoxyphenyl)-5-{[(4-methoxyphenyl)amino](oxo)acetyl}-4,5,6- ,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[(butylamino)(oxo)acetyl]-4,5,6,7-tetrahydro[1,3]thia- zolo[5,4-c]pyridine-2-carboxamide, N-(2-amino-5-isopropylphenyl)-5-{[(3,4-dimethoxyphenyl)amino](oxo)acetyl}- -4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-amino-5-isopropylphenyl)-5-{[(4-methoxyphenyl)amino](oxo)acetyl}-4,5- ,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-amino-5-methoxyphenyl)-5-{[(3,4-dimethoxyphenyl)amino](oxo)acetyl}-4- ,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-amino-5-methoxyphenyl)-5-[(butylamino)(oxo)acetyl]-4,5,6,7-tetrahydr- o[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-amino-5-isopropylphenyl)-5-[(butylamino)(oxo)acetyl]-4,5,6,7-tetrahy- dro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[(benzylamino)(oxo)acetyl]-4,5,6,7-tetrahydro[1,3]thi- azolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[{[6-(4-methylpiperazin-1-yl)pyridin-3-yl]amino}(oxo)- acetyl]-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-{oxo[(pyridin-3-ylmethyl)amino]acetyl}-4,5,6,7-tetrah- ydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-(biphenyl-4-ylcarbonyl)-4,5,6,7-tetrahydro[1,3]thiazo- lo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-(4-methylbenzoyl)-4,5,6,7-tetrahydro[1,3]thiazolo[5,4- -c]pyridine-2-carboxamide, Methyl 4-({2-[(2-aminophenyl)carbamoyl]-6,7-dihydro[1,3]thiazolo[5,4-c]pyridin-5- (4H)-yl}carbonyl)benzoate, N-(2-aminophenyl)-5-[4-(dimethylamino)benzoyl]-4,5,6,7-tetrahydro[1,3]thi- azolo[5,4-c]pyridine-2-carboxamide, 5-Acetyl-N-(2-aminophenyl)-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine- -2-carboxamide, N-(2-aminophenyl)-5-(4-methoxybenzoyl)-4,5,6,7-tetrahydro[1,3]thiazolo[5,- 4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-(quinolin-3-ylcarbonyl)-4,5,6,7-tetrahydro[1,3]thiazo- lo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-(2-naphthoyl)-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]p- yridine-2-carboxamide, N-(2-aminophenyl)-5-[(6-methylpyridin-3-yl)carbonyl]-4,5,6,7-tetrahydro[1- ,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[3-(dimethylamino)benzoyl]-4,5,6,7-tetrahydro[1,3]thi- azolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-(anilinocarbonothioyl)-4,5,6,7-tetrahydro[1,3]thiazol- o[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-({[4-(dimethylamino)phenyl]amino}carbonothioyl)-4,5,6- ,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[(piperidin-4-ylamino)carbonothioyl]-4,5,6,7-tetrahyd- ro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-{[(4-pyridin-3-ylcyclohexyl)amino]carbonothioyl}-4,5,- 6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-amino-5-methoxyphenyl)-5-(anilinocarbonothioyl)-4,5,6,7-tetrahydro[1- ,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[(pyridin-3-ylamino)carbonothioyl]-4,5,6,7-tetrahydro- [1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[(isoquinolin-5-ylamino)carbonothioyl]-4,5,6,7-tetrah- ydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[(butylamino)carbonothioyl]-4,5,6,7-tetrahydro[1,3]th- iazolo[5,4-c]pyridine-2-carboxamide, N-(2-amino-5-methoxyphenyl)-5-{[(4-methoxyphenyl)amino]carbonothioyl}-4,5- ,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-amino-5-methoxyphenyl)-5-[(pyridin-3-ylamino)carbonothioyl]-4,5,6,7-- tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-amino-5-isopropylphenyl)-5-[(pyridin-3-ylamino)carbonothioyl]-4,5,6,- 7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-amino-5-isopropylphenyl)-5-(anilinocarbonothioyl)-4,5,6,7-tetrahydro- [1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-amino-5-isopropylphenyl)-5-{[(4-methoxyphenyl)amino]carbonothioyl}-4- ,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-isopropylphenyl)-5-{imino[(4-methoxyphenyl)amino]meth- yl}-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-amino-5-isopropylphenyl)-5-{imino[(4-methoxyphenyl)amino]methyl}-4,5- ,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[(benzylamino)(imino)methyl]-4,5,6,7-tetrahydro[1,3]t- hiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[anilino(methylimino)methyl]-4,5,6,7-tetrahydro[1,3]t- hiazolo[5,4-c]pyridine-2-carboxamide, N-(2-amino-5-methoxyphenyl)-5-[[(4-methoxyphenyl)amino](methylimino)methy- l]-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[anilino(cyanoimino)methyl]-4,5,6,7-tetrahydro[1,3]th- iazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-{(cyanoimino)[(4-methoxyphenyl)amino]methyl}-4,5,6,7-- tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-{(cyanoimino)[(3,4-dimethoxyphenyl)amino]methyl}-4,5,- 6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-{(cyanoimino)[(2-methylphenyl)amino]methyl}-4,5,6,7-t- etrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[(cyanoimino){[4-(dimethylamino)phenyl]amino}methyl]-- 4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[(cyanoimino)(pentylamino)methyl]-4,5,6,7-tetrahydro[- 1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[(benzylamino)(cyanoimino)methyl]-4,5,6,7-tetrahydro[- 1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-amino-5-methoxyphenyl)-5-[(cyanoamino)(phenylimino)methyl]-4,5,6,7-t- etrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-amino-5-methoxyphenyl)-5-{(cyanoamino)[(4-methoxyphenyl)imino]methyl- }-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-amino-5-isopropylphenyl)-5-{(cyanoamino)[(4-methoxyphenyl)imino]meth- yl}-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[N-phenylethanimidoyl]-4,5,6,7-tetrahydro[1,3]thiazol- o[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[N-(3,4-dimethoxyphenyl)ethanimidoyl]-4,5,6,7 tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[N-(4-methoxyphenyl)ethanimidoyl]-4,5,6,7-tetrahydro[- 1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-amino-5-methoxyphenyl)-5-[N-phenylethanimidoyl]-4,5,6,7-tetrahydro[1- ,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-amino-5-methoxyphenyl)-5-[N-(4-methoxyphenyl)ethanimidoyl]-4,5,6,7-t- etrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-amino-5-methoxyphenyl)-5-[N-(3,4-dimethoxyphenyl)ethanimidoyl]-4,5,6- ,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-amino-5-isopropylphenyl)-5-[N-(4-methoxyphenyl)ethanimidoyl]-4,5,6,7- -tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-amino-5-isopropylphenyl)-5-[N-(3,4-dimethoxyphenyl)ethanimidoyl]-4,5- ,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-{N-[4-(dimethylamino)phenyl]ethanimidoyl}-4,5,6,7-tet- rahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-amino-5-isopropylphenyl)-5-[N-phenylethanimidoyl]-4,5,6,7-tetrahydro- [1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[1-anilino-2-nitrovinyl]-4,5,6,7-tetrahydro[1,3]thiaz- olo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-{1-[(4-methoxyphenyl)amino]-2-nitrovinyl}-4,5,6,7-tet- rahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[1-(butylamino)-2-nitrovinyl]-4,5,6,7-tetrahydro[1,3]- thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-{1-[(4-isopropylphenyl)amino]-2-nitrovinyl}-4,5,6,7-t- etrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[1-{[4-(dimethylamino)phenyl]amino}-2-nitrovinyl]-4,5- ,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-{1-[(3,4-dimethoxyphenyl)amino]-2-nitrovinyl}-4,5,6,7- -tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-amino-5-methoxyphenyl)-5-{1-[(4-methoxyphenyl)amino]-2-nitrovinyl}-4- ,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-amino-5-methoxyphenyl)-5-{1-[(4-isopropylphenyl)amino]-2-nitrovinyl}- -4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-amino-5-methoxyphenyl)-5-[1-{[4-(dimethylamino)phenyl]amino}-2-nitro- vinyl]-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-amino-5-isopropylphenyl)-5-[1-anilino-2-nitrovinyl]-4,5,6,7-tetrahyd- ro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-[2-amino-5-(1-methylethyl)phenyl]-5-{1-[(4-methoxyphenyl)amino]-2-nitro- ethenyl}-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-amino-5-isopropylphenyl)-5-[1-{[4-(dimethylamino)phenyl]amino}-2-nit- rovinyl]-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-amino-5-isopropylphenyl)-5-{1-[(4-isopropylphenyl)amino]-2-nitroviny- l}-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-amino-5-methoxyphenyl)-5-{1-[(4-fluorophenyl)amino]-2-nitrovinyl}-4,- 5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[(4-methylphenyl)sulfonyl]-4,5,6,7-tetrahydro[1,3]thi- azolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-(benzylsulfonyl)-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-- c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-(biphenyl-4-ylsulfonyl)-4,5,6,7-tetrahydro[1,3]thiazo- lo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[(4-methoxyphenyl)sulfonyl]-4,5,6,7-tetrahydro[1,3]th- iazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-(methylsulfonyl)-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-- c]pyridine-2-carboxamide, 5-[(4-acetamidophenyl)sulfonyl]-N-(2-aminophenyl)-4,5,6,7-tetrahydro[1,3]- thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-(2-naphthylsulfonyl)-4,5,6,7-tetrahydro[1,3]thiazolo[- 5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-(2-thienylsulfonyl)-4,5,6,7-tetrahydro[1,3]thiazolo[5- ,4-c]pyridine-2-carboxamide, Methyl 3-({2-[(2-aminophenyl)carbamoyl]-6,7-dihydro[1,3]thiazolo[5,4-c]pyridine-- 5(4H)-yl}sulfonyl)thiophene-2-carboxylate, 5-[(2-acetamido-4-methyl-1,3-thiazol-5-yl)sulfonyl]-N-(2-aminophenyl)-4,5- ,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[(3-methoxyphenyl)sulfonyl]-4,5,6,7-tetrahydro[1,3]th- iazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-{[4-(trifluoromethyl)phenyl]sulfonyl}-4,5,6,7-tetrahy- dro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-{[3-(trifluoromethyl)phenyl]sulfonyl}-4,5,6,7-tetrahy- dro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[(3-fluorophenyl)sulfonyl]-4,5,6,7-tetrahydro[1,3]thi- azolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-(isopropylsulfonyl)-4,5,6,7-tetrahydro[1,3]thiazolo[5- ,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-{[3-(difluoromethoxy)phenyl]sulfonyl}-4,5,6,7-tetrahy- dro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-{[4-(difluoromethoxy)phenyl]sulfonyl}-4,5,6,7-tetrahy- dro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-{[3-(trifluoromethoxy)phenyl]sulfonyl}-4,5,6,7-tetrah- ydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-{[4-(trifluoromethoxy)phenyl]sulfonyl}-4,5,6,7-tetrah- ydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-amino-5-methoxyphenyl)-5-[(4-methylphenyl)sulfonyl]-4,5,6,7-tetrahyd- ro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide N-(2-amino-5-isopropylphenyl)-5-[(4-methylphenyl)sulfonyl]-4,5,6,7-tetrah- ydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-amino-5-methoxyphenyl)-5-[(4-methoxyphenyl)sulfonyl]-4,5,6,7-tetrahy- dro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-(phenoxyacetyl)-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c- ]pyridine-2-carboxamide N-(2-aminophenyl)-5-[(4-methylphenoxy)acetyl]-4,5,6,7-tetrahydro[1,3]thia- zolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[(4-methoxyphenoxy)acetyl]-4,5,6,7-tetrahydro[1,3]thi- azolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[(2-naphthyloxy)acetyl]-4,5,6,7-tetrahydro[1,3]thiazo- lo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[(biphenyl-4-yloxy)acetyl]-4,5,6,7-tetrahydro[1,3]thi- azolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-(methoxyacetyl)-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c- ]pyridine-2-carboxamide, N-(2-amino-5-isopropylphenyl)-5-[(4-methoxyphenoxy)acetyl]-4,5,6,7-tetrah- ydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[(3-methoxyphenoxy)acetyl]-4,5,6,7-tetrahydro[1,3]thi- azolo[5,4-c]pyridine-2-carboxamide, Methyl 2-[(2-aminophenyl)carbamoyl]-6,7-dihydro[1,3]thiazolo[5,4-c]pyridine-5(4H- )-carboxylate, Biphenyl-4-yl 2-[(2-aminophenyl)carbamoyl]-6,7-dihydro[1,3]thiazolo[5,4-c]pyridine-5(4H- )-carboxylate, 4-Methylphenyl 2-[(2-aminophenyl)carbamoyl]-6,7-dihydro[1,3]thiazolo[5,4-c]pyridine-5(4H- )-carboxylate, 4-Methoxyphenyl 2-[(2-aminophenyl)carbamoyl]-6,7-dihydro[1,3]thiazolo[5,4-c]pyridine-5(4H- )-carboxylate, 4-(Propoxycarbonyl)phenyl 2-[(2-aminophenyl)carbamoyl]-6,7-dihydro[1,3]thiazolo[5,4-c]pyridine-5(4H- )-carboxylate, 2-Naphthyl 2-[(2-aminophenyl)carbamoyl]-6,7-dihydro[1,3]thiazolo[5,4-c]pyridine-5(4H- )-carboxylate, 3,4-Dimethoxyphenyl 2-[(2-aminophenyl)carbamoyl]-6,7-dihydro[1,3]thiazolo[5,4-c]pyridine-5(4H- )-carboxylate, Butyl 2-[(2-aminophenyl)carbamoyl]-6,7-dihydro[1,3]thiazolo[5,4-c]pyridine-5(4H- )-carboxylate, Benzyl 2-[(2-aminophenyl)carbamoyl]-6,7-dihydro[1,3]thiazolo[5,4-c]pyridine-5(4H- )-carboxylate, Pyridin-3-ylmethyl 2-[(2-aminophenyl)carbamoyl]-6,7-dihydro[1,3]thiazolo[5,4-c]pyridine-5(4H- )-carboxylate, N-(2-aminophenyl)-5-[3-(1,3-benzodioxol-5-yl)prop-2-enoyl]-4,5,6,7-tetrah- ydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[3-(3,4-dihydroxyphenyl)prop-2-enoyl]-4,5,6,7-tetrahy- dro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-pyrimidin-2-yl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]- pyridine-2-carboxamide, N-(2-aminophenyl)-5-(4-pyridin-3-ylpyrimidin-2-yl)-4,5,6,7-tetrahydro[1,3- ]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-(5-nitropyridin-2-yl)-4,5,6,7-tetrahydro[1,3]thiazolo- [5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[5-(trifluoromethyl)pyridin-2-yl]-4,5,6,7-tetrahydro[- 1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-(5-{[(4-methylphenyl)sulfonyl]amino}pyrimidin-2-yl)-4- ,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-(5-{[(4-methylphenyl)sulfonyl]amino}pyridine-2-yl)-4,- 5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-{4-[(benzylcarbamoyl)amino]phenyl}-4,5,6,7-tetrahydro- [1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-(4-{[(4-methylphenyl)sulfonyl]amino}phenyl)-4,5,6,7-t- etrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[(4-methylphenyl)sulfonyl]-4,5,6,7-tetrahydrothieno[3- ,2-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[(4-methylphenyl)sulfonyl]-4,5,6,7-tetrahydrofuro[3,2- -c]pyridine-2-carboxamide, N-(2-aminophenyl)-1-methyl-5-[(4-methylphenyl)sulfonyl]-4,5,6,7-tetrahydr- o-1H-pyrrolo[3,2-c]pyridine-2-carboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-pyridine-3-yl-6,7-dihydrothieno[3,2-c]pyr- idine-2,5(4H)-dicarboxamide, 6,7-Dihydro-4H-thieno[3,2-c]pyridine-2,5-dicarboxylic acid 2-[(2-amino-phenyl)-amide]5-[(2-difluoromethoxy-phenyl)-amide], N.sup.2-(2-aminophenyl)-N.sup.5-(3,4-dimethoxyphenyl)-6,7-dihydrothieno[3- ,2-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-[2-amino-5-(2-thienyl)phenyl]-N.sup.5-butyl-6,7-dihydrothieno[3,2- -c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-[2-amino-5-(2-thienyl)phenyl]-N.sup.5-pyridine-3-yl-6,7-dihydroth- ieno[3,2-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-amino-5-thiophene-2-ylphenyl)-N.sup.5-(4-methoxyphenyl)-6,7-di- hydrothieno[3,2-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-(2-methoxyethyl)-6,7-dihydrothieno[3,2-c]- pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-pyridine-3-yl-6,7-dihydrothieno[3,2-c]pyr- idine-2,5-(4H)dicarboxamide, 3,4-dimethoxyphenyl 2-[(2-aminophenyl)carbamoyl]-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carbo- xylate, N.sup.2-(2-aminophenyl)-1-methyl-N.sup.5-pyridine-3-yl-1,4,6,7-tet- rahydro-5H-pyrrolo[3,2-c]pyridine-2,5-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-(3,4-dimethoxyphenyl)-1-methyl-1,4,6,7-te- trahydro-5H-pyrrolo[3,2-c]pyridine-2,5-dicarboxamide, 2-(difluoromethoxy)phenyl 2-[(2-aminophenyl)carbamoyl]-1-methyl-1,4,6,7-tetrahydro-5H-pyrrolo[3,2-c- ]pyridine-5-carboxylate, 3,4-dimethoxyphenyl 2-[(2-aminophenyl)carbamoyl)-1-methyl-1,4,6,7-tetrahydro-5H-pyrrolo[3,2-c- ]pyridine-5-carboxylate, N.sup.2-(2-aminophenyl)-N.sup.6-pyridine-3-yl-4,7-dihydrothieno[2,3-c]pyr- idine-2,6(5H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.6-(3,4-dimethoxyphenyl)-4,7-dihydrothieno[2- ,3-c]pyridine-2,6(5H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.6-(2-methoxyethyl)-4,7-dihydrothieno[2,3-c]- pyridine-2,6(5H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.6-[2-(difluoromethoxy)phenyl]-4,7-dihydroth- ieno[2,3-c]pyridine-2,6(5H)-dicarboxamide, N.sup.2-(2-amino-5-isopropylphenyl)-N.sup.6-pyridine-3-yl-4,7-dihydrothie- no[2,3-c]pyridine-2,6(5H)-dicarboxamide, N.sup.2-(2-amino-5-isopropylphenyl)-N.sup.6-[3,4 difluoromethoxy)phenyl]-4,7-dihydrothieno[2,3-c]pyridine-2,6(5H)-dicarbox- amide, N.sup.2-(2-amino-5-isopropylphenyl)-N.sup.6-(4-fluorophenyl)-4,7-di- hydrothieno[2,3-c]pyridine-2,6(5H)-dicarboxamide, N.sup.2-(2-amino-5-isopropylphenyl)-N.sup.6-(3,4-dimethoxyphenyl)-4,7-dih- ydrothieno[2,3-c]pyridine-2,6(5H)-dicarboxamide, 3,4-dimethoxyphenyl 2-[(2-aminophenyl)carbamoyl]-4,7-dihydrothieno[2,3-c]pyridine-6(5H)-carbo- xylate, 3,4-dimethoxyphenyl 2-[(2-amino-5-isopropylphenyl)carbamoyl]-4,7-dihydrothieno[2,3-c]pyridine- -6(5H)-carboxylate, N-(2-aminophenyl)-6-[(3-methoxyphenoxy)acetyl]-4,5,6,7-tetrahydrothieno[2- ,3-c]pyridine-2-carboxamide, N-(2-amino-5-isopropylphenyl)-6-[(3-methoxyphenoxy)acetyl]-4,5,6,7-tetrah- ydrothieno[2,3-c]pyridine-2-carboxamide, N.sup.2-(2-aminophenyl)-1-methyl-N.sup.6-pyridine-3-yl-1,4,5,7-tetrahydro- -6H-pyrrolo[2,3-c]pyridine-2,6-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.6-(3,4-dimethoxyphenyl)-1-methyl-1,4,5,7-te- trahydro-6H-pyrrolo[2,3-c]pyridine-2,6-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.6-(2-methoxyethyl)-1-methyl-1,4,5,7-tetrahy- dro-6H-pyrrolo[2,3-c]pyridine-2,6-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.6-pyridine-3-yl-1,4,5,7-tetrahydro-6H-pyrro- lo[2,3-c]pyridine-2,6-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.6-(3,4-dimethoxyphenyl)-1,4,5,7-tetrahydro-- 6H-pyrrolo[2,3-c]pyridine-2,6-dicarboxamide, 3,4-dimethoxyphenyl 2-[(2-aminophenyl)carbamoyl]-1-methyl-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c- ]pyridine-6-carboxylate, 3,4-dimethoxyphenyl 2-[(2-aminophenyl)carbamoyl]-1,4,5,7-tetrahydro-6H-pyrrolo[2,3-c]pyridine- -6-carboxylate, N-(2-aminophenyl)-5-(N-1,3-benzodioxol-5-ylglycyl)-4,5,6,7-tetrahydro[1,3- ]hiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[N-(3-methoxyphenyl)glycyl]-4,5,6,7-tetrahydro[1,3]th- iazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[N-(6-methoxypyridine-3-yl)glycyl]-4,5,6,7-tetrahydro- [1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-[3-(trifluoromethoxy)phenyl]-6,7-dihydro[- 1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-(3-morpholin-4-ylphenyl)-6,7-dihydro[1,3]- thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-[4-(methylthio)phenyl]-6,7-dihydro[1,3]th- iazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-[3-(methylthio)phenyl]-6,7-dihydro[1,3]th- iazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-(3-methoxyphenyl)-6,7-dihydro[1,3]thiazol- o[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-1H-indazol-5-yl-6,7-dihydro[1,3]thiazolo[- 5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5, N.sup.5-diethyl-6,7-dihydro[1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxa- mide, N.sup.2-(2-amino-5-chlorophenyl)-N.sup.5-(4-methoxyphenyl)-6,7-dihyd- ro[1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-amino-5-chlorophenyl)-N.sup.5-(3,4-dimethoxyphenyl)-6,7-dihydr- o[1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-amino-5-chlorophenyl)-N.sup.5-pyridine-3-yl-6,7-dihydro[1,3]th- iazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-[3-(difluoromethoxy)phenyl]-6,7-dihydro[1- ,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-[4-(methylsulfonyl)phenyl]-6,7-dihydro[1,- 3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-[3-(methylsulfonyl)phenyl]-6,7-dihydro[1,- 3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-amino-5-fluorophenyl)-N.sup.5-1,3-benzodioxol-5-yl-6,7-dihydro- [1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-amino-5-fluorophenyl)-N.sup.5-(3,4-dimethoxyphenyl)-6,7-dihydr- o[1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-[2-amino-5-(2-thienyl)phenyl]-N.sup.5-pyridine-3-yl-6,7-dihydro[1- ,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-[2-amino-5-(3-thienyl)phenyl]-N.sup.5-[2-(difluoromethoxy)phenyl]- -6,7-dihydro[1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-[2-amino-5-(3-thienyl)phenyl]-N.sup.5-(3,4-dimethoxyphenyl)-6,7-d- ihydro[1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-[2-amino-5-(3-thienyl)phenyl]-N.sup.5-(2-methoxyethyl)-6,7-dihydr- o[1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-[2-amino-5-(2-thienyl)phenyl]-N.sup.5-(3,4-dimethoxyphenyl)-6,7-d- ihydro[1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-[2-amino-5-(2-thienyl)phenyl]-N.sup.5-(2-methoxyethyl)-6,7-dihydr- o[1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-[2-amino-5-(2-thienyl)phenyl]-N.sup.5-pyridine-3-yl-6,7-dihydro[1- ,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-[2-amino-5-(2-thienyl)phenyl]-N.sup.5-[2-(difluoromethoxy)phenyl]- -6,7-dihydro[1,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-(4-cyanophenyl)-6,7-dihydro[1,3]thiazolo[- 5,4-c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N-5-(3-cyanophenyl)-6,7-dihydro[1,3]thiazolo[5,4-- c]pyridine-2,5(4H)-dicarboxamide, N.sup.2-[2-amino-5-(3-thienyl)phenyl]-N.sup.5-pyridine-3-yl-6,7-dihydro[1- ,3]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, N-(2-aminophenyl)-5-[4-(trifluoromethoxy)benzoyl]-4,5,6,7-tetrahydro[1,3]- thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[4-(difluoromethoxy)benzoyl]-4,5,6,7-tetrahydro[1,3]t- hiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[3-(trifluoromethoxy)benzoyl]-4,5,6,7-tetrahydro[1,3]- thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[3-pyridine-3-ylprop-2-enoyl)-4,5,6,7 tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, 3-methoxyphenyl 2-[(2-aminophenyl)carbamoyl]-6,7-dihydro[1,3]thiazolo[5,4-c]pyridine-5(4H- )-carboxylate, 3,4-dimethoxypheny 2-{[2-amino-5-(3-thienyl)phenyl]carbamoyl}-6,7-dihydro[1,3]thiazolo[5,4-c- ]pyridine-5(4H)-carboxylate, 3,4-dimethoxyphenyl 2-{[2-amino-5-(2-thienyl)phenyl]carbamoyl}-6,7-dihydro[1,3]thiazolo[5,4-c- ]pyridine-5(4H)-carboxylate, benzyl 2-[(2-aminophenyl)carbamoyl]-6,7-dihydro[1,3]thiazolo[5,4-c]pyridine-5(4H- )-carboxylate, N-(2-aminophenyl)-5-[{[3-(difluoromethoxy)phenyl]amino}(oxo)acetyl]-4,5,6- ,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-(oxo {[3-(trifluoromethoxy)phenyl]amino}acetyl)-4,5,6,7-tetrahydro[1,3]thiazol- o[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-(oxo {[2-(trifluoromethoxy)phenyl]amino}acetyl)-4,5,6,7-tetrahydro[1,3]thiazol- o[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[{[2-(difluoromethoxy)phenyl]amino}(oxo)acetyl]-4,5,6- ,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-(oxo{[2-(trifluoromethoxy)phenyl]amino}acetyl)-4,5,6,- 7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-[2-amino-5-(2-thienyl)phenyl]-5-[(3-methoxyphenoxy)acetyl]-4,5,6,7-tetr- ahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-[2-amino-5-(3-thienyl)phenyl]-5-[(3-methoxyphenoxy)acetyl]-4,5,6,7-tetr- ahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-amino-5-fluorophenyl)-5-[(3-methoxyphenoxy)acetyl]-4,5,6,7-tetrahydr- o[1,3]thiazolo[5,4-c]pyridine-2-carboxamide, N-(2-aminophenyl)-5-[(4-methoxyphenyl)sulfonyl]-4,5,6,7-tetrahydro[1,3]th- iazolo[5,4-c]pyridine-2-carboxamide, N.sup.2-(2-aminophenyl)-N.sup.5-(6-methoxypyridine-3-yl)-6,7-dihydro[1,3]- thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide dihydrochloride, N.sup.2-(2-aminophenyl)-N.sup.5-pyridine-3-yl-6,7-dihydro[1,3]thiazolo[5,- 4-c]pyridine-2,5(4H)-dicarboxamide dihydrochloride, N.sup.2-(2-aminophenyl)-N.sup.5-(6-methoxypyridine-3-yl)-6,7-dihydro[1,3]- thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide-4-methylaniline (1:2), N.sup.2-(2-aminophenyl)-N.sup.5-pyridine-3-yl-6,7-dihydro[1,3]thiazolo[5,- 4-c]pyridine-2,5(4H)-dicarboxamide-4-methylaniline (1:2), N-(2-aminophenyl)-5-[(3-methoxyphenoxy)acetyl]-4,5,6,7-tetrahydro[1,3]thi- azolo[5,4-c]pyridine-2-carboxamide-4-methylaniline (1:1), benzyl 2-[(2-aminophenyl)carbamoyl]-6,7-dihydro[1,3]thiazolo[5,4-c]pyridine-5(4H- )-carboxylate-4-methylaniline (1:1), N-(2-aminophenyl)-5-[(3-methoxyphenoxy)acetyl]-4,5,6,7-tetrahydro[1,3]thi- azolo[5,4-c]pyridine-2-carboxamide methanesulfonate, benzyl 2-[(2-aminophenyl)carbamoyl]-6,7-dihydro[1,3]thiazolo[5,4-c]pyridine-5(4H- )-carboxylate methanesulfonate, benzyl 2-[(2-aminophenyl)carbamoyl]-6,7-dihydro[1,3]thiazolo[5,4-c]pyridine-5(4H- ) carboxylate sulfate, N-(2-aminophenyl)-5-[(4-methoxyphenyl)sulfonyl]-4,5,6,7-tetrahydro[1,3]th- iazolo[5,4-c]pyridine-2-carboxamide sulphate, N.sup.2-(2-aminophenyl)-N.sup.5-pyridine-3-yl-1,4,6,7-tetrahydro-5H-pyrro- lo[3,2-c]pyridine-2,5-dicarboxamide, N.sup.2-(2-amino-5-fluorophenyl)-N.sup.6-pyridine-3-yl-4,7-dihydrothieno[- 2,3-c]pyridine-2,6(5H)-dicarboxamide, N.sup.2-(2-amino-5-fluorophenyl)-N.sup.6-(pyridine-3-ylmethyl)-4,7-dihydr- othieno[2,3-c]pyridine-2,6(5H)-dicarboxamide, N.sup.2-(2-amino-5-fluorophenyl)-N.sup.6-pyridine-4-yl-4,7-dihydrothieno[- 2,3-c]pyridine-2,6(5H)-dicarboxamide, N.sup.2-(2-amino-5-fluorophenyl)-N.sup.6-quinoline-3-yl-4,7-dihydrothieno- [2,3-c]pyridine-2,6(5H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.6-(pyridine-3-ylmethyl)-4,7-dihydrothieno[2- ,3-c]pyridine-2,6(5H)-dicarboxamide, N.sup.2-(2-aminophenyl)-N.sup.6-pyridine-4-yl-4,7-dihydrothieno[2,3-c]pyr- idine-2,6(5H)-dicarboxamide, or N.sup.2-(2-aminophenyl)-N.sup.6-quinoline-3-yl -4,7-dihydrothieno[2,3-c]pyridine-2,6(5H)-dicarboxamide or a salt thereof. 18. A pharmaceutical composition comprising one or more compounds of formula I as claimed in claim 1 and one or more pharmaceutically acceptable excipients, diluents and/or carriers. 19. A pharmaceutical combination comprising a compound of claim 1 and a chemotherapeutic anticancer agent, which is one of the following compounds Cyclophosphamid, Ifosfamid, Temozolomide, Thiotepa, Melphalan, chloroethylnitrosourea, cisplatin, oxaliplatin, carboplatin, vincristine, vinblastine, vinorelbine, Paclitaxel, Docetaxel, paclitaxel bound to albumin, Epothilone B, Azaepothilone, ZK-EPO, Doxorubicin, Etoposide camptothecin, Irinotecan, Topotecan, 5-fluorouracil, Capecitabine, Arabinosylcytosine, Gemcitabine, 6-mercaptopurine, 6-thioguanine, fludarabine, methotrexate or premetrexed. 20. A pharmaceutical combination comprising a compound of claim 1 and a target-specific anticancer agent, which is one of the following compounds Imatinib, Gefitinib, Sorafenib, Sunitinib, Erlotinib, Dasatinib, Lapatinib, Vatalanib, Vandetanib, Pazopanib, Bortezumib, 17-allylaminogeldanamycin, 17-dimethylaminogeldanamycin, combretastatin A4 phosphate, AVE8062, Bevacizumab, Vandetanib, Pazopanib, Trastuzumab, Rituximab, Alemtuzumab, Tositumomab, Cetuximab, Avastin, Panitumumab, Gemtuzumab ozogamicin, Ibritumomab tiuxetan, Oblimersen, MG98, CPG-7909, Imiquimod, Isatoribine, Resiquimod, Tamoxifen, Raloxifen, Flutamide, Casodex, Leuprolide, Goserelin, Triptorelin, Anastozol, or Letrozole. 21. A pharmaceutical combination comprising a compound of claim 1 and an anti-cancer agent, which is one of the following compounds 5 FU, actinomycin D, ABARELIX, ABCIXIMAB, ACLARUBICIN, ADAPALENE, ALEMTUZUMAB, ALTRETAMINE, AMINOGLUTETHIMIDE, AMIPRILOSE, AMRUBICIN, ANASTROZOLE, ANCITABINE, ARTEMISININ, AZATHIOPRINE, BASILIXIMAB, BENDAMUSTINE, BEVACIZUMAB, BEXXAR, BICALUTAMIDE, BLEOMYCIN, BORTEZOMIB, BROXURIDINE, BUSULFAN, CAMPATH, CAPECITABINE, CARBOPLATIN, CARBOQUONE, CARMUSTINE, CETRORELIX, CHLORAMBUCIL, CHLORMETHINE, CISPLATIN, CLADRIBINE, CLOMIFENE, CYCLOPHOSPHAMIDE, DACARBAZINE, DACLIZUMAB, DACTINOMYCIN, DASATINIB, DAUNORUBICIN, DECITABINE, DESLORELIN, DEXRAZOXANE, DOCETAXEL, DOXIFLURIDINE, DOXORUBICIN, DROLOXIFENE, DROSTANOLONE, EDELFOSINE, EFLORNITHINE, EMITEFUR, EPIRUBICIN, EPITIOSTANOL, EPTAPLATIN, ERBITUX, ERLOTINIB, ESTRAMUSTINE, ETOPOSIDE, EXEMESTANE, FADROZOLE, FINASTERIDE, FLOXURIDINE, FLUCYTOSINE, FLUDARABINE, FLUOROURACIL, FLUTAMIDE, FORMESTANE, FOSCARNET, FOSFESTROL, FOTEMUSTINE, FULVESTRANT, GEFITINIB, GENASENSE, GEMCITABINE, GLIVEC, GOSERELIN, GUSPERIMUS, HERCEPTIN, IDARUBICIN, IDOXURIDINE, IFOSFAMIDE, IMATINIB, IMPROSULFAN, INFLIXIMAB, IRINOTECAN, IXABEPILONE, LANREOTIDE, LAPATINIB, LETROZOLE, LEUPRORELIN, LOBAPLATIN, LOMUSTINE, LUPROLIDE, MELPHALAN, MERCAPTOPURINE, METHOTREXATE, METUREDEPA, MIBOPLATIN, MIFEPRISTONE, MILTEFOSINE, MIRIMOSTIM, MITOGUAZONE, MITOLACTOL, MITOMYCIN, MITOXANTRONE, MIZORIBINE, MOTEXAFIN, MYLOTARG, NARTOGRASTIM, NEBAZUMAB, NEDAPLATIN, NILUTAMIDE, NIMUSTINE, OCTREOTIDE, ORMELOXIFENE, OXALIPLATIN, PACLITAXEL, PALIVIZUMAB, PANITUMUMAB, PATUPILONE, PAZOPANIB, PEGASPARGASE, PEGFILGRASTIM, PEMETREXED, PENTETREOTIDE, PENTOSTATIN, PERFOSFAMIDE, PIPOSULFAN, PIRARUBICIN, PLICAMYCIN, PREDNIMUSTINE, PROCARBAZINE, PROPAGERMANIUM, PROSPIDIUM CHLORIDE, RALOXIFEN, RALTITREXED, RANIMUSTINE, RANPIRNASE, RASBURICASE, RAZOXANE, RITUXIMAB, RIFAMPICIN, RITROSULFAN, ROMURTIDE, RUBOXISTAURIN, SARGRAMOSTIM, SATRAPLATIN, SIROLIMUS, SOBUZOXANE, SORAFENIB, SPIROMUSTINE, STREPTOZOCIN, SUNITINIB, TAMOXIFEN, TASONERMIN, TEGAFUR, TEMOPORFIN, TEMOZOLOMIDE, TENIPOSIDE, TESTOLACTONE, THIOTEPA, THYMALFASIN, TIAMIPRINE, TOPOTECAN, TOREMIFENE, TRAIL, TRASTUZUMAB, TREOSULFAN, TRIAZIQUONE, TRIMETREXATE, TRIPTORELIN, TROFOSFAMIDE, UREDEPA, VALRUBICIN, VATALANIB, VANDETANIB, VERTEPORFIN, VINBLASTINE, VINCRISTINE, VINDESINE, VINORELBINE, VOROZOLE or ZEVALIN. 22. A pharmaceutical composition comprising one or more compounds of claim 17 and one or more pharmaceutically acceptable excipients, diluents and/or carriers. 23. A compound of formula I according to claim 1 which is N.sup.2-(2-aminophenyl)-N.sup.5-pyridin-3-yl-6,7-dihydro[1,3]thiazolo[5,4- -c]pyridine-2,5(4H)-dicarboxamide or a pharmaceutically acceptable salt thereof. 24. A pharmaceutical composition comprising the compound of claim 23 or a pharmaceutically acceptable salt thereof and one or more pharmaceutically acceptable excipients, diluents and/or carriers. 25. A compound of formula I according to claim 1 which is N.sup.2-(2-aminophenyl)-N.sup.5-biphenyl-4-yl-6,7-dihydro[1,3]thiazolo[5,- 4-c]pyridine-2,5(4H)-dicarboxamide, or a pharmaceutically acceptable salt thereof. 26. A compound of formula I according to claim 1 which is N.sup.2-(2-aminophenyl)-N.sup.5-[4-(dimethylamino)phenyl]-6,7-dihydro[1,3- ]thiazolo[5,4-c]pyridine-2,5(4H)-dicarboxamide, or a pharmaceutically acceptable salt thereof. 27. A compound of formula I according to claim 1 which is N.sup.2-(2-aminophenyl)-N.sup.5-(4-methoxyphenyl)-6,7-dihydro[1,3]thiazol- o[5,4-c]pyridine-2,5(4H)-dicarboxamide, or a pharmaceutically acceptable salt thereof. 28. A compound of formula I according to claim 1 which is N.sup.2-(2-aminophenyl)-N.sup.5-quinolin-3-yl-6,7-dihydro[1,3]thiazolo[5,- 4-c]py-ridine-2,5(4H)-dicarboxamide, or a pharmaceutically acceptable salt thereof. 29. A compound of formula I according to claim 1 which is N-(2-aminophenyl)-5-[(4-methylphenyl)sulfonyl]-4,5,6,7-tetrahydro[1,3]-th- i-azolo[5,4-c]pyridine-2-carboxamide, or a pharmaceutically acceptable salt thereof. 30. A compound of formula I according to claim 1 which is N-(2-aminophenyl)-5-[(4-methoxyphenyl)sulfonyl]-4,5,6,7-tetrahydro[1,3]th- i-azolo[5,4-c]pyridine-2-carboxamide, 4-methylphenyl-2-[(2-aminophenyl)carbamoyl]-6,7-dihydro[1,3]thiazolo[5,4-- c]pyridine-5(4H-)-carboxylate, or Pyridin-3-ylmethyl-2-[(2-aminophenyl)carbamoyl]-6,7-dihydro[1,3]thiazolo[- 5,4-c]pyridine-5(4H-)-carboxylate, or a pharmaceutically acceptable salt thereof.

Details for Patent 8,440,830

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Partner Therapeutics, Inc.	LEUKINE	sargramostim	For Injection	103362	03/05/1991		2027-09-19
Partner Therapeutics, Inc.	LEUKINE	sargramostim	Injection	103362	03/05/1991		2027-09-19
Servier Pharmaceuticals Llc	ONCASPAR	pegaspargase	Injection	103411	02/01/1994		2027-09-19
Janssen Biotech, Inc.	REOPRO	abciximab	Injection	103575	12/22/1994		2027-09-19
Genentech, Inc.	RITUXAN	rituximab	Injection	103705	11/26/1997		2027-09-19