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Last Updated: March 28, 2024

Claims for Patent: 8,420,780


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Summary for Patent: 8,420,780
Title:Mutated netrin 4, fragments thereof and uses thereof as drugs
Abstract: Proteins having the amino acid sequence of SEQ ID NO: 2 or SEQ ID NO: 4, or fragments of said sequences are provided. The protein fragments are represented by the sequences of SEQ ID NO: 2q, q varying from 3 to 36, and the sequences of SEQ ID NO: 185 to SEQ ID NO: 209. Nucleotide sequences coding for said proteins are also provided.
Inventor(s): Plouet; Jean (Paris, FR), Leconte; Laurence (Antony, FR), Lejmi; Esma (Issy les Moulineaux, FR)
Assignee: INSERM (Institut National de la Sante et de la Recherche Medicale) (Paris, FR) Centre National de la Recherche Scientifique (Paris, FR) IVS Institut des Vaisseaux et du Sang (Paris, FR)
Application Number:12/523,074
Patent Claims:1. An isolated fragment of a Netrin 4 protein, said fragment consisting of the amino acid sequence selected from the group consisting of: SEQ ID NO: 8, SEQ ID NO: 10, SEQ ID NO: 56, SEQ ID NO: 74, SEQ ID NO: 116, SEQ ID NO: 193, SEQ ID NO: 197, SEQ ID NO: 199, SEQ ID NO: 201, SEQ ID NO: 204, SEQ ID NO: 206, SEQ ID NO: 207 and SEQ ID NO: 208.

2. A pharmaceutical composition comprising: the isolated fragment of a Netrin 4 protein according to claim 1; and a pharmaceutically acceptable vehicle.

3. A combination product comprising: the isolated fragment of a Netrin 4 protein according to claim 1; and an anti-angiogenic agent selected from the group consisting of: an anti-VEGF agent, bevacizumab, pegaptanib, ranibizumab, sunitinib, sorafenib, humanized antibodies against neuropiline-1, humanized antibodies against DLL4, AM 386, and agents interfering with an angiopoietin pathway.

4. A pharmaceutical composition comprising pericytes or vascular smooth muscle cells, in association with the isolated fragment of a Netrin 4 protein according to claim 1.

Details for Patent 8,420,780

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. AVASTIN bevacizumab Injection 125085 02/26/2004 ⤷  Try a Trial 2027-01-19
Genentech, Inc. LUCENTIS ranibizumab Injection 125156 06/30/2006 ⤷  Try a Trial 2027-01-19
Genentech, Inc. LUCENTIS ranibizumab Injection 125156 08/10/2012 ⤷  Try a Trial 2027-01-19
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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