You’re using a public version of DrugPatentWatch with 5 free searches available | Register to unlock more free searches. CREATE FREE ACCOUNT

Last Updated: March 28, 2024

Claims for Patent: 8,414,876


✉ Email this page to a colleague

« Back to Dashboard


Summary for Patent: 8,414,876
Title:Methods of using IL-1 antagonists to treat autoinflammatory disease
Abstract: Methods of treating, inhibiting, or ameliorating an autoinflammatory disorder, disease, or condition in a subject in need thereof, comprising administering to a subject in need a therapeutic amount of an interleukin 1 (IL-1) antagonist, wherein the autoinflammatory disorder, disease, or condition is treated, inhibited, or ameliorated. The IL-1 antagonist is a molecule capable of binding and inhibiting IL-1. The therapeutic methods are useful for treating a human adult or child suffering from Neonatal Onset Multisystem Inflammatory Disorder (NOMID/CINCA), Muckle-Wells Syndrome (MWS), Familial Cold Autoinflammatory Syndrome (FCAS), familial mediterranean fever (FMF), tumor necrosis factor receptor-associated periodic fever syndrome (TRAPS), or systemic onset juvenile idiopathic arthritis (Still\'s Disease).
Inventor(s): Mellis; Scott (New Rochelle, NY), Karow; Margaret (Santa Rosa Valley, NY), Yancopoulos; George D. (Yorktown Heights, NY), Papadopoulos; Joanne (LaGrangeville, NY)
Assignee: Regeneron Pharmaceuticals, Inc. (Tarrytown, NY)
Application Number:13/224,372
Patent Claims:1. A method of treating, inhibiting, or ameliorating an autoinflammatory disorder, disease, or condition selected from the group consisting of Neonatal Onset Multisystem Inflammatory Disorder (NOMID/CINCA), Muckle-Wells Syndrome (MWS), Familial Cold Autoinflammatory syndrome (FCAS), familial Mediterranean fever (FMF), tumor necrosis factor receptor-associated periodic fever syndrome (TRAPS), and Still's Disease, the method comprising administering to a subject in need thereof an IL-1 fusion protein antagonist comprising the amino acid sequence of SEQ ID NO:10, as a first therapeutic agent, in a dose range of 100-320 mg on a weekly basis.

2. The method of claim 1, wherein the IL-1 fusion protein antagonist is administered subcutaneously, intramuscularly, intravenously, topically, transdermally or orally.

3. The method of claim 1 further comprising administering one or more additional therapeutic agents selected from the group consisting of a NSAID, an IL-1 fusion protein antagonist that is different from the first therapeutic agent, etanercept (Enbrel.RTM., Amgen), infliximab (Remicade.RTM., Centocor), Humira.RTM. (Abbott), thalidomide, a steroid, anakinra (Kineret.RTM., Amgen), colchicine, IL-18BP or a derivative, an IL-18-binding fusion protein, anti-IL-18, anti-IL-18R1, anti-IL-18Racp, aspirin, prednisolone, methotrexate, cyclosporine A, caspase-1, p38, IKK1/2, CTLA-41g, anti-IL-6and anti-IL6Ra.

4. The method of claim 3, wherein the first therapeutic agent and the additional therapeutic agent or agents are administered simultaneously.

5. The method of claim 3, wherein the first therapeutic agent and the additional therapeutic agent or agents are administered sequentially.

6. The method of claim 1, the method comprising administering to the subject in need thereof the IL-1 fusion protein antagonist at a dose of 100 mg, 160 mg, or 320 mg, on a weekly basis.

7. The method of claim 6, wherein the IL-1 fusion protein antagonist is administered subcutaneously, intramuscularly, intravenously, topically, transdermally or orally.

8. The method of claim 6 further comprising administering one or more additional therapeutic agents selected from the group consisting of a NSAID, an IL-1 fusion protein antagonist that is different from the first therapeutic agent, etanercept (Enbrel.RTM., Amgen), infliximab (Remicade.RTM., Centocor), Humira.RTM. (Abbott), thalidomide, a steroid, anakinra (Kineret.RTM., Amgen), colchicine, IL-18BP or a derivative, an IL-18-binding fusion protein, anti-IL-18, anti-IL-18R1, anti-IL-18Racp, aspirin, prednisolone, methotrexate, cyclosporine A, caspase-1, p38, IKK1/2, CTLA-41g, anti-IL-6 and anti-IL6Ra.

9. The method of claim 8, wherein the first therapeutic agent and the additional therapeutic agent or agents are administered simultaneously.

10. The method of claim 8, wherein the first therapeutic agent and the additional therapeutic agent or agents are administered sequentially.

11. The method of claim 1, wherein the autoinflammatory disorder, disease, condition is Still's Disease, and the Still's disease is juvenile onset Still's Disease or adult onset Still's Disease.

Details for Patent 8,414,876

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Janssen Biotech, Inc. REMICADE infliximab For Injection 103772 08/24/1998 ⤷  Try a Trial 2039-03-29
Immunex Corporation ENBREL etanercept For Injection 103795 11/02/1998 ⤷  Try a Trial 2039-03-29
Immunex Corporation ENBREL etanercept For Injection 103795 05/27/1999 ⤷  Try a Trial 2039-03-29
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.