Claims for Patent: 8,414,772

Summary for Patent: 8,414,772

Title:	Method for differentiation of substances
Abstract:	A method and a device for differentiation of substances in a body fluid, such as blood, plasma or used peritoneal dialysis fluid, for example for hemodialysis. The device has a compartment having several inlets for entering a body fluid, a transition fluid and a diffusion fluid for flowing parallel with each other in laminar flow layers with substantially equal flow velocities. The transition fluid layer is interposed between the body fluid layer and the diffusion fluid layer. The compartment further has a first outlet for removing the body fluid and the transition fluid and a second outlet for removing the diffusion fluid. Pumps are arranged for controlling the flow velocities so that a marker substance, such as albumin, will not diffuse from the body fluid layer across the transition layer, during the passage of the body fluid from the inlet to the outlet of the compartment.
Inventor(s):	Tyren; Carl (Monaco, MC), Ahlmen; Jarl (Billdal, SE)
Assignee:	Pacar Holding AB (SE)
Application Number:	12/743,497
Patent Claims:	1. A method for differentiation of substances in a body fluid, comprising entering the body fluid, a transition fluid and a diffusion fluid via inlets into a compartment for flowing parallel with each other in laminar flow layers with substantially equal flow velocities, whereby the transition fluid layer is interposed between the body fluid layer and the diffusion fluid layer; removing the body fluid and at least a portion of the transition fluid via a first outlet and removing at least the diffusion fluid via a second outlet from the compartment; adjusting the flow velocities so that a marker substance will not diffuse across the transition layer, during the passage from an inlet to an outlet of the compartment; whereby the transition fluid is sterile. 2. The method according to claim 1, whereby the marker substance is albumin. 3. The method according to claim 1, whereby substances in the body fluid having a larger diffusion velocity than the marker substance diffuse into the diffusion fluid. 4. The method according to claim 1, whereby the transition fluid and the diffusion fluid are the same fluid, which is dialysis liquid for hemodialysis. 5. The method according to claim 1, wherein the diffusion fluid is non-sterile. 6. The method according to claim 1, wherein the sterile transition fluid is sterile water.

Details for Patent 8,414,772

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	ZOSTAVAX	zoster vaccine live	For Injection	125123	05/25/2006		2027-11-19