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Last Updated: March 29, 2024

Claims for Patent: 8,404,234


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Summary for Patent: 8,404,234
Title:Fixed dosing of HER antibodies
Abstract: The present invention concerns fixed dosing of HER antibodies, such as Pertuzumab.
Inventor(s): Allison; David E. (San Mateo, CA), Bruno; Rene (Marseilles, FR), Lu; Jian-Feng (Foster City, CA), Ng; Chee M. (San Mateo, CA)
Assignee: Genentech, Inc. (South San Francisco, CA)
Application Number:12/248,223
Patent Claims:1. An article of manufacture comprising a single dose vial containing a single fixed dose of pertuzumab, wherein the fixed dose is selected from the group consisting of 420 mg and 840 mg of pertuzumab.

2. The article of manufacture of claim 1 further comprising a package insert instructing the user to administer the fixed dose to a cancer patient.

3. The article of manufacture of claim 2 wherein the cancer is selected from the group consisting of ovarian cancer, peritoneal cancer, fallopian tube cancer, metastatic breast cancer (MBC), non-small cell lung cancer (NSCLC), prostate cancer, and colorectal cancer.

4. The article of manufacture of claim 1 comprising two vials, wherein a first vial contains a single fixed dose of 840 mg of pertuzumab, and a second vial contains a single fixed dose of 420 mg of pertuzumab.

5. An article of manufacture comprising a container holding a single fixed dose of a HER2 antibody comprising the variable light and variable heavy amino acid sequences in SEQ ID Nos. 3 and 4, respectively, wherein the fixed dose is selected from the group consisting of 420 mg and 840 mg of the HER2 antibody.

6. The article of manufacture of claim 5 wherein the fixed dose is 420 mg of the HER2 antibody.

7. The article of manufacture of claim 5 wherein the fixed dose is 840 mg of the HER2 antibody.

8. An article of manufacture comprising a 20 cc vial holding a single fixed dose of a HER2 antibody comprising the variable light and variable heavy amino acid sequences in SEQ ID Nos. 3 and 4, respectively, wherein the fixed dose is 420 mg of the HER2 antibody.

9. The article of manufacture of claim 1 wherein the vial is a 20 cc vial containing a 420 mg fixed dose of the HER2 antibody.

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