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Last Updated: January 26, 2021

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Claims for Patent: 8,399,517

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Summary for Patent: 8,399,517
Title:Calcilytic compounds
Abstract: Novel calcilytic compounds and methods of using them are provided.
Inventor(s): Marquis; Robert W. (Collegeville, PA), Casillas; Linda N. (Collegeville, PA), Ramanjulu; Joshi M. (Collegeville, PA), Callahan; James Francis (King of Prussia, PA)
Assignee: GlaxoSmithKline, LLC (Philadelphia, PA)
Application Number:12/894,644
Patent Claims:1. A method of increasing serum parathyroid hormone levels in mammals, which comprises the administration to a subject in need of treatment thereof an effective amount of 3-{3,4-Difluoro-5-[(R)-2-hydroxy-3-(2-indan-2-yl-1,1-dimethyl-ethylamino)- -propoxy]-phenyl}-propionic acid ethyl ester.

2. A method of increasing serum parathyroid hormone levels in mammals, which comprises the administration to a subject in need of treatment thereof an effective amount of a pharmaceutically acceptable salt of 3-{3,4-Difluoro-5-[(R)-2-hydroxy-3-(2-indan-2-yl-1,1-dimethyl-ethylamino)- -propoxy]-phenyl}-propionic acid ethyl ester.

3. A method of increasing serum parathyroid hormone levels in mammals, which comprises the administration to a subject in need of treatment thereof an effective amount of 3-{3,4-Difluoro-5-[(R)-2-hydroxy-3-(2-indan-2-yl-1,1-dimethyl-ethylamino)- -propoxy]-phenyl}-propionic acid ethyl ester hydrochloride.

Details for Patent 8,399,517

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23   Start Trial GlaxoSmithKline, LLC (Philadelphia, PA) 2029-02-26 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23   Start Trial GlaxoSmithKline, LLC (Philadelphia, PA) 2029-02-26 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 003 2015-01-23   Start Trial GlaxoSmithKline, LLC (Philadelphia, PA) 2029-02-26 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 004 2015-01-23   Start Trial GlaxoSmithKline, LLC (Philadelphia, PA) 2029-02-26 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

International Patent Family for US Patent 8,399,517

Country Patent Number Estimated Expiration
South Africa 200504104   Start Trial
World Intellectual Property Organization (WIPO) 2004047751   Start Trial
Uruguay 28089   Start Trial
United States of America 2006058391   Start Trial
United States of America 2009163589   Start Trial
United States of America 2011054021   Start Trial
United States of America 2013158114   Start Trial
>Country >Patent Number >Estimated Expiration

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