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Last Updated: March 29, 2024

Claims for Patent: 8,388,907


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Summary for Patent: 8,388,907
Title:Devices and methods for the collection and detection of substances
Abstract: The present invention provides a single self-contained device for collecting, extracting, on-site testing, and transferring for forensic confirmatory analysis, a wide variety of substances including, but not limited to, drugs of abuse, explosives, weapons of mass destruction, food toxins and industrial wastes. Samples can be obtained from a surface by swabbing a suspect area or the testing of solid materials (pills, capsules, powders), air samples and biological and non-biological fluids by placing the substance in the device. The device includes a swab, a retention well including a wash, and analysis technologies that can be, for example, a lateral flow testing system. The swab is rinsed with a wash prior to testing thereby not compromising the chemistry of the detection technologies and allowing for a wide variety of applications under a number of field conditions. Also, the device is a single self-contained unit instead of having a separate reagent droppers or sprays, making it compact and easy to use. Moreover, the device is designed to not only collect and test samples but to seal the originally target analyte, not affected by testing procedures, in a specially designed cap for shipping under chain of custody documentation to a forensic laboratory for confirmatory testing.
Inventor(s): Gold; Mark S. (Alachua, FL), Martin; David M. (Lansdale, PA), Gold; Steven T. (Rydal, PA), Goldberger; Bruce A. (Newberry, FL)
Assignee: University of Florida Research Foundation, Inc. (Gainesville, FL)
Application Number:12/614,422
Patent Claims:1. A method for detecting an analyte by utilizing a device having a main body comprising a hollow interior; at least one swab affixed to a first end of the main body for obtaining a sample; at least one sealed receptacle disposed within the main body and having therein a wash for dissolving an analyte; a release mechanism within the housing capable of being engaged with the sealed receptacle to release the wash; a cap removably attached to the first end of the main body and having a hollow depression therein for receiving released wash, such that any analyte on the swab is dissolved into the wash; at least one analysis strip disposed within the main body having thereon at least one conjugate zone and at least one reaction zone, whereby the presence or absence of an analyte within the wash triggers the reaction zone to exhibit a noticeable signal; and a button operably engaged with the main body, such that, when aligned in a first position and activated by depressing, the button engages the sealed recepticle with the release mechanism, such that the swab is exposed to the wash so as to dissolve any analyte thereon and, when the button is aligned in a second position and activated by depressing, at least a portion of the at least one analysis strip is exposed to the dissolved analyte in the wash, a) removing the cap on the main body of the device; b) bringing the swab on the device into contact with the surface or medium to be sampled; c) replacing the cap on the device so that it covers the swab and seals the end of the main body; d) aligning the button to the first position; e) activating, by depressing, the button so that the wash is released and washes over the swab to dissolve any analyte thereon into the cap; f) aligning the button to the second position; g) activating the button to expose at least a portion of the analysis strip to the dissolved analyte in the cap, so as to cause the reaction zone to exhibit a noticeable signal; and h) determining whether the analyte is present by observing the signal.

2. The method, according to claim 1, further comprising: removing the cap with the dissolved analyte therein; sealing the cap with a lid; and transporting the cap to a facility for further testing of the analyte.

3. The method, according to claim 1, wherein the device further comprises a results area on the main body for observing the signal.

4. The method, according to claim 1, wherein the sample is obtained from a surface, powder, liquid, or air.

5. The method, according to claim 1, wherein more than one analyte is dissolved in the wash, such that more than one signal is exhibited by the reaction zone on the analysis strip.

6. The method, according to claim 1, wherein the analysis strip of the device is a lateral flow analysis strip.

7. The method, according to claim 6, further comprising a control zone on the analysis strip.

8. The method, according to claim 1, wherein the swab of the device comprises polyester treated with 0.1 molar sodium tetraborate in a 1% non-ionic surfactant having pH 8.6.

9. The method, according to claim 1, wherein the wash comprises distilled sterile water or a buffer solution.

10. The method, according to claim 1, wherein the analyte is selected from the group consisting of: amphetamines, methamphetamine, 3,4-methylenedioxy-N-methylamphetamine (a.k.a., MDMA, Ecstasy), barbiturates, benzodiazepines, cannabinoids, cocaine, fentanyl, lysergic acid diethylamide (a.k.a., LSD), methaqualone, opiates, phencyclidine, propoxyphene, and their metabolites.

11. The method, according to claim 1, wherein the analyte is the parent compound of THC (.DELTA..sup.9-tetrahydrocannabinol), cocaine or heroin.

12. The method according to claim 1, wherein the analyte is one or more explosives selected from the group consisting of cyclotetramethylene-tetranitramine (a.k.a., HMX), cyclotrimethylenetrinitramine (a.k.a., RDX), nitroglycerine (a.k.a., NG), triaminotrinitrobenzene (a.k.a., TATB), 2,4,6-TrinitrophenylmethyInitramine (a.k.a., Tetryl), pentaerythritol tetranitrate (a.k.a., PETN), trinitrotoluene (a.k.a., TNT), 2,4-Dinitrotoluene (a.k.a., DNT), 1,3,5-Trinitrobenzene (a.k.a., TNB), dinitrobenzene (a.k.a., DNB), and nitrocellulose (a.k.a., NC).

13. The method, according to claim 1, wherein the analyte is a pain killer or erectile dysfunction drug.

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