Claims for Patent: 8,383,852
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Summary for Patent: 8,383,852
Title: | Compounds having a cyclic moiety and compositions for delivering active agents |
Abstract: | Compounds comprising cyclic moiety and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well. |
Inventor(s): | Tang; Pingwah (Elmsford, NY), Dinh; Steven (Briarcliff Manor, NY) |
Assignee: | Emisphere Technologies, Inc. (Cedar Knolls, NJ) |
Application Number: | 12/527,221 |
Patent Claims: | 1. A compound selected from the group consisting of: ##STR00027## ##STR00028## ##STR00029## ##STR00030## and pharmaceutically acceptable salts thereof.
2. A composition comprising: (A) a biologically active agent; and (B) at least one compound of claim 1. 3. The composition of claim 2, wherein the biologically active agent comprises at least one protein, polypeptide, peptide, hormone, polysaccharide, mucopolysaccharide, carbohydrate, or lipid. 4. The composition of claim 2, wherein the biologically active agent is selected from the group consisting of: BIBN-4096BS, growth hormones, human growth hormones recombinant human growth hormones (rhGH), bovine growth hormones, porcine growth hormones, growth hormone releasing hormones, growth hormone releasing factor, glucagon, interferons, .alpha.-interferon, .beta.-interferon, .gamma.-interferon, interleukin-1, interleukin-2, insulin, porcine insulin, bovine insulin, human insulin, human recombinant insulin, insulin-like growth factor (IGF), IGF-1, heparin, unfractionated heparin, heparinoids, dermatans, chondroitins, low molecular weight heparin, very low molecular weight heparin, ultra low molecular weight heparin, calcitonin, salmon calcitonin, eel calcitonin, human calcitonin; erythropoietin (EPO), atrial naturetic factor, antigens, monoclonal antibodies, somatostatin, protease inhibitors, adrenocorticotropin, gonadotropin releasing hormone, oxytocin, leutinizing-hormone-releasing-hormone, follicle stimulating hormone, glucocerebrosidase, thrombopoeitin, filgrastim, postaglandins, cyclosporin, vasopressin, cromolyn sodium, sodium chromoglycate, disodium chromoglycate, vancomycin, desferrioxamine (DFO), parathyroid hormone (PTH), fragments of PTH, glucagon-like peptide 1 (GLP-1), antimicrobials, anti-fungal agents, vitamins; analogs, fragments, mimetics and polyethylene glycol (PEG)-modified derivatives of these compounds; and any combination thereof. 5. The composition of claim 2, wherein the biologically active agent is selected from insulin, Leutenizing-hormone releasing hormone, GLP-1, heparin, recombinant human growth hormone, glucagon, argatraban, analogs, fragments, mimetics and polyethylene glycol (PEG)-modified derivatives of these compounds; and any combination thereof. 6. The composition of claim 2, wherein the biologically active agent is insulin. 7. A dosage unit form comprising: (A) at least one composition of claim 2; and (B) (a) an excipient, (b) a diluent, (c) a disintegrant, (d) a lubricant, (e) a plasticizer, (f) a colorant, (g) a dosing vehicle, or (h) any combination thereof. 8. A method for administering a biologically-active agent to an animal in need of the agent, the method comprising administering orally to the animal the composition of claim 2. 9. A method for preparing a composition comprising mixing: (A) at least one biologically active agent; (B) at least one compound of claim 1; and (C) optionally, a dosing vehicle. 10. A composition comprising a biologically active agent and a compound selected from: ##STR00031## ##STR00032## ##STR00033## ##STR00034## and pharmaceutically acceptable salts thereof. |
Details for Patent 8,383,852
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Eli Lilly And Company | HUMULIN R U-100 | insulin human | Injection | 018780 | 10/28/1982 | ⤷ Try a Trial | 2027-02-16 |
Eli Lilly And Company | HUMULIN R U-500 | insulin human | Injection | 018780 | 12/29/2015 | ⤷ Try a Trial | 2027-02-16 |
Eli Lilly And Company | HUMULIN R U-100 | insulin human | Injection | 018780 | 08/06/1998 | ⤷ Try a Trial | 2027-02-16 |
Eli Lilly And Company | HUMULIN R U-500 | insulin human | Injection | 018780 | 03/31/1994 | ⤷ Try a Trial | 2027-02-16 |
Eli Lilly And Company | HUMULIN R U-100 | insulin human | Injection | 018780 | 05/25/2018 | ⤷ Try a Trial | 2027-02-16 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
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