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Last Updated: March 29, 2024

Claims for Patent: 8,377,902


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Summary for Patent: 8,377,902
Title:RNAi compound targeted to thrombospondin-1 and applications thereof
Abstract: The present invention relates to an RNAi compound and an expression plasmid for inhibiting expression of Thrombospondin-1, which comprises a target sequence selected from Thrombospondin-1 gene. The present invention also related to a pharmaceutical composition comprising the RNAi compound and applications thereof. The RNAi compound can reduce the expression of Thrombospondin-1 to activate immune responses. In addition, the present invention also disclosed that an RNAi compound targeted to Thrombospondin-1 gene can delay tumor progression.
Inventor(s): Lai; Ming-Derg (Tainan, TW), Huang; Shih-Shien (Tainan, TW), Yen; Meng-Chi (Tainan, TW), Lin; Chi-Chen (Taichung, TW), Weng; Tzu-Yang (Tainan, TW)
Assignee: National Cheng Kung University (TW)
Application Number:12/985,684
Patent Claims:1. An expression plasmid for RNAi inhibition of Thrombospondin-1 expression, comprising: a target sequence; and a reverse complement of the target sequence, wherein: the target sequence is selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3; the expression plasmid directs the synthesis of an siRNA or shRNA that targets the human Thrombospondin-1 gene in human cells; and the expression plasmid further comprises the Her2/neu gene.

2. The expression plasmid of claim 1, wherein the Her2/neu gene comprises SEQ ID NO: 10.

3. A pharmaceutical composition, comprising: the expression plasmid of claim 1; and a pharmaceutically acceptable carrier.

4. The pharmaceutical composition of claim 3, wherein the pharmaceutically acceptable carrier is selected from the group consisting of saline, phosphate buffered saline (PBS), and sterile water.

5. The expression plasmid of claim 1, further comprising a hairpin sequence.

6. The expression plasmid of claim 5, wherein the hairpin sequence is SEQ ID NO: 9.

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