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Last Updated: April 25, 2024

Claims for Patent: 8,357,534

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Summary for Patent: 8,357,534

Title:	Isolation of human articular cartilage stem cells
Abstract:	The invention concerns a human stem cell isolated from the full depth of human cartilage tissue and/or isolated from aged human cartilage; and uses thereof.
Inventor(s):	Archer; Charles William (Aberdare, GB), Haven; Samantha Nichola (Cardiff, GB), Dowthwaite; Gary (Cardiff, GB)
Assignee:	University College Cardiff Consultants Limited (Cardiff, GB)
Application Number:	12/526,194
Patent Claims:	1. A method for isolating a human stem cell comprising: (a) obtaining human articular cartilage tissue from a full depth of the cartilage tissue; (b) digesting the tissue to release chondrocytes, by using enzymes; (c) exposing the isolated chondrocytes to fibronectin and/or a fragment thereof containing an RGD sequence; and (d) isolating those cells that bind fibronectin or said fragment. 2. A method according to claim 1 wherein said released chondrocytes are cultured on fibronectin, a RGD sequence, or a fragment of fibronectin containing a RGD sequence. 3. A method according to claim 1 wherein said articular cartilage is digested with a combination of pronase and collagenase. 4. A method according to claim 1 wherein said digested chondrocytes are either filtered or centrifuged in order to isolate chondrocyte tissue. 5. A method according to claim 1 wherein the articular cartilage tissue referred to is an aged tissue.

Details for Patent 8,357,534

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965	⤷ Try a Trial	2027-02-08
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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