Claims for Patent: 8,343,955

Summary for Patent: 8,343,955

Title:	Benzoxazepin PI3K inhibitor compounds and methods of use
Abstract:	Benzoxazepin compounds of Formula I, including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, wherein: Z.sup.1 is CR.sup.1 or N; Z.sup.2 is CR.sup.2 or N; Z.sup.3 is CR.sup.3 or N; Z.sup.4 is CR.sup.4 or N; and B is a pyrazolyl, imidazolyl, or triazolyl ring fused to the benzoxepin ring, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed. ##STR00001##
Inventor(s):	Blaquiere; Nicole (South San Francisco, CA), Do; Steven (South San Francisco, CA), Dudley; Danette (South San Francisco, CA), Folkes; Adrian (Basel, CH), Heald; Robert (Harlow, GB), Heffron; Timothy (South San Francisco, CA), Jones; Mark (Harlow, GB), Kolesnikov; Aleksandr (South San Francisco, CA), Ndubaku; Chudi (South San Francisco, CA), Olivero; Alan G. (South San Francisco, CA), Price; Stephen (Harlow, GB), Staben; Steven (South San Francisco, CA), Wang; Lan (South San Francisco, CA)
Assignee:	Genentech, Inc. (South San Francisco, CA)
Application Number:	13/477,587
Patent Claims:	1. A method of treating cancer in a patient having cancer comprised of administering to said patient a therapeutically effective amount of a compound selected from Formula Id: ##STR00868## stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, wherein: Z.sup.1 is CR.sup.1 or N; Z.sup.2 is CR.sup.2 or N; Z.sup.3 is CR.sup.3 or N; Z.sup.4 is CR.sup.4 or N; R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are independently selected from H, F, Cl, Br, I, --CN, --COR.sup.10, --CO.sub.2R.sup.10, --C(.dbd.O)N(R.sup.10)OR.sup.11, --C(.dbd.NR.sup.10)NR.sup.10R.sup.11, --C(.dbd.O)NR.sup.10R.sup.11, --NO.sub.2, --NR.sup.10R.sup.11, --NR.sup.12C(.dbd.O)R.sup.10, --NR.sup.12C(.dbd.O)OR.sup.11, --NR.sup.12C(.dbd.O)NR.sup.10R.sup.11, --NR.sup.12C(.dbd.O)(C.sub.1-C.sub.12 alkylene)NR.sup.10R.sup.11, NR.sup.12(C.sub.1-C.sub.12 alkylene)NR.sup.10R.sup.11, NR.sup.12(C.sub.1-C.sub.12 alkylene)OR.sup.10, --NR.sup.12(C.sub.1-C.sub.12 alkylene)C(.dbd.O)NR.sup.10R.sup.11, --OR.sup.10, --SR.sup.10, --S(O).sub.2R.sup.10, --C(.dbd.O)NR.sup.10(C.sub.1-C.sub.12 alkylene)NR.sup.10R.sup.11, --C(.dbd.O)NR.sup.10(C.sub.1-C.sub.12 alkylene)NR.sup.10C(.dbd.O)OR.sup.11, --C(.dbd.O)NR.sup.10(C.sub.1-C.sub.12 alkylene)NR.sup.10C(.dbd.O)R.sup.11, --C(.dbd.O)NR.sup.10(C.sub.1-C.sub.12 alkylene)R.sup.10, C.sub.1-C.sub.12 alkyl, C.sub.2-C.sub.8 alkenyl, C.sub.2-C.sub.8 alkynyl, C.sub.3-C.sub.12 carbocyclyl, C.sub.2-C.sub.20 heterocyclyl, C.sub.6-C.sub.20 aryl, C.sub.1-C.sub.20 heteroaryl, --(C.sub.3-C.sub.12 carbocyclyl)-(C.sub.1-C.sub.12 alkyl), --(C.sub.2-C.sub.20 heterocyclyl)-(C.sub.1-C.sub.12 alkyl), --(C.sub.6-C.sub.20 aryl)-(C.sub.1-C.sub.12 alkyl), --(C.sub.1-C.sub.20 heteroaryl)-(C.sub.1-C.sub.12 alkyl), --(C.sub.1-C.sub.12 alkylene)-(C.sub.3-C.sub.12 carbocyclyl), --(C.sub.1-C.sub.12 alkylene)-(C.sub.2-C.sub.20 heterocyclyl), --(C.sub.1-C.sub.12 alkylene)-(C.sub.2-C.sub.20 heterocyclyl)-(C.sub.2-C.sub.20 heterocyclyl), --(C.sub.1-C.sub.12 alkylene)-(C.sub.2-C.sub.20 heterocyclyl)-(C.sub.3-C.sub.12 carbocyclyl), --(C.sub.1-C.sub.12 alkylene)-(C.sub.2-C.sub.20 heterocyclyl)-C(.dbd.O)--(C.sub.2-C.sub.20 heterocyclyl), --(C.sub.1-C.sub.12 alkylene)-(C.sub.1-C.sub.20 heteroaryl), --(C.sub.1-C.sub.12 alkylene)-(C.sub.2-C.sub.20 heterocyclyl)-(C.sub.1-C.sub.12 alkyl), --(C.sub.1-C.sub.12 alkylene)-(C.sub.6-C.sub.20 aryl)-(C.sub.1-C.sub.12 alkyl), --(C.sub.1-C.sub.12 alkylene)-(C.sub.1-C.sub.20 heteroaryl)-(C.sub.1-C.sub.12 alkyl), --(C.sub.1-C.sub.12 alkylene)-C(.dbd.O)--(C.sub.2-C.sub.20 heterocyclyl), --(C.sub.1-C.sub.12 alkylene)C(.dbd.O)OR.sup.10, --(C.sub.1-C.sub.12 alkylene)C(.dbd.O)NR.sup.10R.sup.11, --(C.sub.1-C.sub.12 alkylene)-NR.sup.10R.sup.11, --(C.sub.1-C.sub.12 alkylene)NR.sup.12C(.dbd.O)R.sup.10, --(C.sub.1-C.sub.12 alkylene)OR.sup.10, --(C.sub.1-C.sub.12 alkylene)-NR.sup.10--(C.sub.1-C.sub.12 alkylene)-(C.sub.1-C.sub.20 heteroaryl), --(C.sub.1-C.sub.12 alkylene)-NR.sup.10--(C.sub.1-C.sub.12 alkylene)-(C.sub.1-C.sub.20 heterocyclyl), --(C.sub.1-C.sub.12 alkylene)-NR.sup.10--(C.sub.1-C.sub.12 alkylene)-NHC(.dbd.O)--(C.sub.1-C.sub.20 heteroaryl), --(C.sub.1-C.sub.12 alkylene)-(C.sub.2-C.sub.20 heterocyclyl)-NR.sup.10R.sup.11, and --(C.sub.1-C.sub.12 alkylene)-(C.sub.2-C.sub.20 heterocyclyl)-(C.sub.1-C.sub.12 alkyl)-NR.sup.10R.sup.11, where alkyl, alkenyl, alkynyl, alkylene, carbocyclyl, heterocyclyl, aryl, and heteroaryl are optionally substituted with one or more groups independently selected from F, Cl, Br, I, R.sup.10, --SR.sup.10, --S(O).sub.2R.sup.10, --S(O).sub.2NR.sup.10R.sup.11, NR.sup.10R.sup.11, --NR.sup.12C(O)R.sup.10, CO.sub.2R.sup.10, --C(O)R.sup.10, --CONR.sup.10R.sup.11, oxo, and --OR.sup.10; A is selected from --C(.dbd.O)NR.sup.5R.sup.6, --NR.sup.5R.sup.6, C.sub.6-C.sub.20 aryl, C.sub.2-C.sub.20 heterocyclyl and C.sub.1-C.sub.20 heteroaryl wherein aryl, heterocyclyl and heteroaryl are optionally substituted with one or more groups independently selected from F, Cl, Br, I, --CN, --COR.sup.10, --CO.sub.2R.sup.10, --C(.dbd.O)N(R.sup.10)OR.sup.11, --C(.dbd.NR.sup.10)NR.sup.10R.sup.11, --C(.dbd.O)NR.sup.10R.sup.11, --NO.sub.2, --NR.sup.10R.sup.11, --NR.sup.12C(.dbd.O)R.sup.10, --NR.sup.12C(.dbd.O)OR.sup.11, --NR.sup.12C(.dbd.O)NR.sup.10R.sup.11, --NR.sup.12C(.dbd.O)(C.sub.1-C.sub.12 alkylene)NR.sup.10R.sup.11, --NR.sup.12(C.sub.1-C.sub.12 alkylene)NR.sup.10R.sup.11, --NR.sup.12(C.sub.1-C.sub.12 alkylene)OR.sup.10, --NR.sup.12(C.sub.1-C.sub.12 alkylene)C(.dbd.O)NR.sup.10R.sup.11, --OR.sup.10, --S(O).sub.2R.sup.10, --C(.dbd.O)NR.sup.10(C.sub.1-C.sub.12 alkylene)NR.sup.10R.sup.11, --C(.dbd.O)NR.sup.10(C.sub.1-C.sub.12 alkylene)NR.sup.10C(.dbd.O)OR.sup.11, --C(.dbd.O)NR.sup.10(C.sub.1-C.sub.12 alkylene)NR.sup.10C(.dbd.O)R.sup.11, --C(.dbd.O)NR.sup.10(C.sub.1-C.sub.12 alkylene)R.sup.10, C.sub.1-C.sub.12 alkyl, C.sub.2-C.sub.8 alkenyl, C.sub.2-C.sub.8 alkynyl, C.sub.3-C.sub.12 carbocyclyl, C.sub.2-C.sub.20 heterocyclyl, C.sub.6-C.sub.20 aryl, C.sub.1-C.sub.20 heteroaryl, --(C.sub.3-C.sub.12 carbocyclyl)-(C.sub.1-C.sub.12 alkyl), --(C.sub.2-C.sub.20 heterocyclyl)-(C.sub.1-C.sub.12 alkyl), --(C.sub.6-C.sub.20 aryl)-(C.sub.1-C.sub.12 alkyl), --(C.sub.1-C.sub.20 heteroaryl)-(C.sub.1-C.sub.12 alkyl), --(C.sub.1-C.sub.12 alkylene)-(C.sub.3-C.sub.12 carbocyclyl), --(C.sub.1-C.sub.12 alkylene)-(C.sub.2-C.sub.20 heterocyclyl), --(C.sub.1-C.sub.12 alkylene)-(C.sub.2-C.sub.20 heterocyclyl)-(C.sub.2-C.sub.20 heterocyclyl), --(C.sub.1-C.sub.12 alkylene)-(C.sub.2-C.sub.20 heterocyclyl)-(C.sub.3-C.sub.12 carbocyclyl), --(C.sub.1-C.sub.12 alkylene)-(C.sub.2-C.sub.20 heterocyclyl)-C(.dbd.O)--(C.sub.2-C.sub.20 heterocyclyl), --(C.sub.1-C.sub.12 alkylene)-(C.sub.1-C.sub.20 heteroaryl), --(C.sub.1-C.sub.12 alkylene)-(C.sub.2-C.sub.20 heterocyclyl)-(C.sub.1-C.sub.12 alkyl), --(C.sub.1-C.sub.12 alkylene)-(C.sub.6-C.sub.20 aryl)-(C.sub.1-C.sub.12 alkyl), --(C.sub.1-C.sub.12 alkylene)-(C.sub.1-C.sub.20 heteroaryl)-(C.sub.1-C.sub.12 alkyl), --(C.sub.1-C.sub.12 alkylene)-C(.dbd.O)--(C.sub.2-C.sub.20 heterocyclyl), --(C.sub.1-C.sub.12 alkylene)C(.dbd.O)OR.sup.10, --(C.sub.1-C.sub.12 alkylene)-NR.sup.10R.sup.11, --(C.sub.1-C.sub.12 alkylene)NR.sup.12C(.dbd.O)R.sup.10, --(C.sub.1-C.sub.12 alkylene)OR.sup.10, --(C.sub.1-C.sub.12 alkylene)-NR.sup.10--(C.sub.1-C.sub.12 alkylene)-(C.sub.1-C.sub.20 heteroaryl), --(C.sub.1-C.sub.12 alkylene)-NR.sup.10--(C.sub.1-C.sub.12 alkylene)-(C.sub.1-C.sub.20 heterocyclyl), --(C.sub.1-C.sub.12 alkylene)-NR.sup.10--(C.sub.1-C.sub.12 alkylene)-NHC(.dbd.O)--(C.sub.1-C.sub.20 heteroaryl), --(C.sub.1-C.sub.12 alkylene)-(C.sub.2-C.sub.20 heterocyclyl)-NR.sup.10R.sup.11, and --(C.sub.1-C.sub.12 alkylene)-(C.sub.2-C.sub.20 heterocyclyl)-(C.sub.1-C.sub.12 alkyl)-NR.sup.10R.sup.11, where alkyl, alkenyl, alkynyl, alkylene, carbocyclyl, heterocyclyl, aryl, and heteroaryl are optionally substituted with one or more groups independently selected from F, Cl, Br, I, R.sup.10, --SR.sup.10, --S(O).sub.2R.sup.10, NR.sup.10R.sup.11, --NR.sup.12C(O)R.sup.10, --CO.sub.2R.sup.10, --CONR.sup.10R.sup.11, and --OR.sup.10; R.sup.5 is selected from H, and C.sub.1-C.sub.12 alkyl, optionally substituted with one or more groups independently selected from F, Cl, Br, I, --CN, --CO.sub.2H, --CONH.sub.2, --CONHCH.sub.3, --NH.sub.2, --NO.sub.2, --N(CH.sub.3).sub.2, --NHCOCH.sub.3, --NHS(O).sub.2CH.sub.3, --OH, --OCH.sub.3, --OCH.sub.2CH.sub.3, --S(O).sub.2NH.sub.2, and --S(O).sub.2CH.sub.3; R.sup.6 is selected from C.sub.1-C.sub.12 alkyl, C.sub.3-C.sub.12 carbocyclyl, C.sub.2-C.sub.20 heterocyclyl, C.sub.1-C.sub.20 heteroaryl, and C.sub.6-C.sub.20 aryl, each optionally substituted with one or more groups independently selected from F, Cl, Br, I, --CH.sub.3, --CH.sub.2OH, --CH.sub.2C.sub.6H.sub.5, --CN, --CF.sub.3, --CO.sub.2H, --C(O)CH.sub.3, --NH.sub.2, --NO.sub.2, --N(CH.sub.3).sub.2, --NHCOCH.sub.3, --NHS(O).sub.2CH.sub.3, --OH, oxo, --OCH.sub.3, --OCH.sub.2CH.sub.3, --S(O).sub.2NH.sub.2, --S(O).sub.2CH.sub.3, --C(.dbd.O)NR.sup.10(C.sub.1-C.sub.12 alkylene)NR.sup.10R.sup.11, phenyl, pyridinyl, tetrahydro-furan-2-yl, 2,3-dihydro-benzofuran-2-yl, 1-isopropyl-pyrrolidin-3-ylmethyl, morpholin-4-yl, piperidin-1-yl, piperazinyl, piperazin-4-yl-2-one, piperazin-4-yl-3-one, pyrrolidin-1-yl, thiomorpholin-4-yl, S-dioxothiomorpholin-4-yl, --C.ident.CR.sup.13, --CH.dbd.CHR.sup.13, and --C(.dbd.O)NR.sup.10R.sup.11; or R.sup.5 and R.sup.6 together with the nitrogen atom to which they are attached form C.sub.2-C.sub.20 heterocyclyl or C.sub.1-C.sub.20 heteroaryl, optionally substituted with one or more groups selected from F, Cl, Br, I, CH.sub.3, C(CH.sub.3).sub.3, --CH.sub.2OH, --CH.sub.2CH.sub.2OH, --CH.sub.2C.sub.6H.sub.5, pyridin-2-yl, 6-methyl-pyridin-2-yl, pyridin-4-yl, pyridin-3-yl, pyrimidin-2-yl, pyrazin-2-yl, tetrahydro-furan-carbonyl, 2-methoxy-phenyl, benzoyl, cyclopropylmethyl, (tetrahydrofuran-2-yl)methyl, 2,6-dimethyl-morpholin-4-yl, 4-methyl-piperazine-carbonyl, pyrrolidine-1-carbonyl, cyclopropanecarbonyl, 2,4-difluoro-phenyl, pyridin-2-ylmethyl, morpholin-4-yl, --CN, --CF.sub.3, --CO.sub.2H, --CONH.sub.2, --CONHCH.sub.3, --CON(CH.sub.3).sub.2, --COCF.sub.3, --COCH.sub.3, --COCH(CH.sub.3).sub.2, --NO.sub.2, NHCH.sub.3, --N(CH.sub.3).sub.2, --N(CH.sub.2CH.sub.3).sub.2, --NHCOCH.sub.3, --NCH.sub.3COCH.sub.3, --NHS(O).sub.2CH.sub.3, --OH, --OCH.sub.3, --OCH.sub.2CH.sub.3, --CH.sub.2OCH.sub.3, --CH.sub.2CH.sub.2OCH.sub.3, --CH.sub.2S(O).sub.2NHCH.sub.3, --CH.sub.2S(O).sub.2CH.sub.2CH.sub.3, --S(O).sub.2NHCH.sub.3, --S(O).sub.2CH.sub.2CH.sub.3, --S(O).sub.2NH.sub.2, --S(O).sub.2N(CH.sub.3).sub.2 and --S(O).sub.2CH.sub.3; R.sup.10, R.sup.11 and R.sup.12 are independently selected from H, C.sub.1-C.sub.12 alkyl, --(C.sub.1-C.sub.12 alkylene)-(C.sub.2-C.sub.20 heterocyclyl), --(C.sub.1-C.sub.12 alkylene)-(C.sub.6-C.sub.20 aryl), --(C.sub.1-C.sub.12 alkylene)-(C.sub.3-C.sub.12 carbocyclyl), C.sub.2-C.sub.8 alkenyl, C.sub.2-C.sub.8 alkynyl, C.sub.3-C.sub.12 carbocyclyl, C.sub.2-C.sub.20 heterocyclyl, C.sub.6-C.sub.20 aryl, and C.sub.1-C.sub.20 heteroaryl, each of which are optionally substituted with one or more groups independently selected from F, Cl, Br, I, --CH.sub.3, --CH.sub.2CH.sub.3, --CH(CH.sub.3).sub.2, --CH.sub.2OH, --CH.sub.2OCH.sub.3, --CH.sub.2CH.sub.2OH, --C(CH.sub.3).sub.2OH, --CH.sub.2C(CH.sub.3).sub.2OH, --CH.sub.2CH(CH.sub.3)OH, --CH.sub.2CO.sub.2H, --CH.sub.2CO.sub.2CH.sub.3, --CH.sub.2NH.sub.2, --(CH.sub.2).sub.2N(CH.sub.3).sub.2, --CH.sub.2C.sub.6H.sub.5, --CN, --CF.sub.3, --CO.sub.2H, --C(O)CH.sub.3, --C(O)CH(OH)CH.sub.3, --CO.sub.2CH.sub.3, --CONH.sub.2, --CONHCH.sub.3, --CON(CH.sub.3).sub.2, --C(CH.sub.3).sub.2CONH.sub.2, --NH.sub.2, --NO.sub.2, --N(CH.sub.3).sub.2, --N(CH.sub.3)C(CH.sub.3).sub.2CONH.sub.2, --N(CH.sub.3)CH.sub.2CH.sub.2S(O).sub.2CH.sub.3, --NHCOCH.sub.3, --NHS(O).sub.2CH.sub.3, .dbd.O (oxo), --OH, --OCH.sub.3, --OCH.sub.2CH.sub.3, --OCH.sub.2CH.sub.2OH, --OP(O)(OH).sub.2, --SCH.sub.3, --S(O).sub.2CH.sub.3, --S(O).sub.2NH.sub.2, --S(O).sub.2N(CH.sub.3).sub.2, --CH.sub.2S(O).sub.2NHCH.sub.3, --CH.sub.2S(O).sub.2CH.sub.2CH.sub.3, --S(O).sub.2NHCH.sub.3, --S(O).sub.2CH.sub.2CH.sub.3, pyrrolidin-1-yl, 2-oxopyrrolidin-1-yl, cyclopropyl, cyclopentyl, oxetanyl, 4-methylpiperazin-1-yl, and 4-morpholinyl; or R.sup.10 and R.sup.11 together with the nitrogen atom to which they are attached form a C.sub.2-C.sub.20 heterocyclyl ring or C.sub.1-C.sub.20 heteroaryl each of which are optionally substituted with one or more groups independently selected from F, Cl, Br, I, --CH.sub.3, --CH.sub.2OH, --CH.sub.2C.sub.6H.sub.5, --CN, --CF.sub.3, --CO.sub.2H, --CONH.sub.2, --CONHCH.sub.3, --NO.sub.2, --N(CH.sub.3).sub.2, --NHCOCH.sub.3, --NHS(O).sub.2CH.sub.3, --OH, oxo, --OCH.sub.3, --OCH.sub.2CH.sub.3, --S(O).sub.2NH.sub.2, --S(O).sub.2CH.sub.3, --CH(CH.sub.3).sub.2, --CH.sub.2CF.sub.3, --CH.sub.2CH.sub.2OH and --C(CH.sub.3).sub.2OH; and R.sup.13 is selected from H, F, Cl, Br, I, --CH.sub.3, --CH.sub.2CH.sub.3, --CN, --CF.sub.3, --CH.sub.2N(CH.sub.3).sub.2, --CH.sub.2OH, --CO.sub.2H, --CONH.sub.2, --CON(CH.sub.3).sub.2, --NO.sub.2, and --S(O).sub.2CH.sub.3; wherein the cancer is selected from breast, colon, glioma, lung, melanoma, ovarian and prostate. 2. The method of claim 1 wherein Z.sup.1 is CR.sup.1; Z.sup.2 is CR.sup.2; Z.sup.3 is CR.sup.3; and Z.sup.4 is CR.sup.4. 3. The method of claim 1 wherein Z.sup.1 is N; Z.sup.2 is CR.sup.2; Z.sup.3 is CR.sup.3; and Z.sup.4 is CR.sup.4. 4. The method of claim 1 wherein Z.sup.1 is CR.sup.1; Z.sup.2 is N; Z.sup.3 is CR.sup.3; and Z.sup.4 is CR.sup.4. 5. The method of claim 1 wherein Z.sup.1 is CR.sup.1; Z.sup.2 is CR.sup.2; Z.sup.3 is N; and Z.sup.4 is CR.sup.4. 6. The method of claim 1 wherein Z.sup.1 is CR.sup.1; Z.sup.2 is CR.sup.2; Z.sup.3 is CR.sup.3; and Z.sup.4 is N. 7. The method of claim 1 wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are independently selected from H, F, Cl, Br, I, CN, NO.sub.2, and C.sub.1-C.sub.6 alkyl. 8. The method of claim 1 wherein R.sup.2 and R.sup.3 are independently selected from --NR.sup.10R.sup.11, C(.dbd.O)NR.sup.10R.sup.11 and a --(C.sub.1-C.sub.12 alkylene)C(.dbd.O)NR.sup.10R.sup.11. 9. The method of claim 1 wherein R.sup.2 and R.sup.3 are independently selected from optionally substituted C.sub.3-C.sub.12 carbocyclyl, C.sub.2-C.sub.20 heterocyclyl, C.sub.6-C.sub.20 aryl, and C.sub.1-C.sub.20 heteroaryl. 10. The method of claim 9 wherein R.sup.2 and R.sup.3 are independently selected from optionally substituted azabicyclo[3.2.1]octanyl, azetidinyl, cyclopropyl, 3,8-diazabicyclo[3.2.1]octanyl, dihydropyrrolidinyl, imidazolyl, morpholinyl, oxetanyl, phenyl, piperazinone, piperazinyl, piperidyl, pyrazinyl, pyrazolyl, pyridinyl, pyridinone, pyrimidinyl, pyrrolidinyl, tetrahydropyranyl, and tetrahydropyridinyl. 11. The method of claim 1 wherein R.sup.2 and R.sup.3 are independently --OR.sup.10. 12. The method of claim 11 wherein R.sup.2 is --OR.sup.10 and Z.sup.3 is N. 13. The method of claim 1 wherein A is --C(.dbd.O)NR.sup.5R.sup.6. 14. The method of claim 13 wherein R.sup.5 is CH.sub.3. 15. The method of claim 13 wherein R.sup.6 is phenyl substituted with one or more groups independently selected from F, Cl, Br, I, --CH.sub.2OH, --CH.sub.2C.sub.6H.sub.5, --CN, --CF.sub.3, --CO.sub.2H, --CONH.sub.2, --CONHCH.sub.3, --NO.sub.2, --N(CH.sub.3).sub.2, --NHCOCH.sub.3, --NHS(O).sub.2CH.sub.3, --OH, --OCH.sub.3, --OCH.sub.2CH.sub.3, --S(O).sub.2NH.sub.2, --S(O).sub.2CH.sub.3, morpholin-4-yl, piperidin-1-yl, piperazinyl, piperazin-4-yl-2-one, piperazin-4-yl-3-one, pyrrolidin-1-yl, thiomorpholin-4-yl, S-dioxothiomorpholin-4-yl, --C.ident.CR.sup.13, and --CH.dbd.CHR.sup.13. 16. The method of claim 1 wherein R.sup.5 and R.sup.6 together with the nitrogen atom to which they are attached form morpholin-4-yl, piperidin-1-yl, piperazinyl, piperazin-4-yl-2-one, piperazin-4-yl-3-one, pyrrolidin-1-yl, thiomorpholin-4-yl, S-dioxothiomorpholin-4-yl, azocan-1-yl, azetidin-1-yl, octahydropyrido[1,2-a]pyrazin-2-yl, [1,4]diazepan-1-yl, or indolinyl. 17. The method of claim 1 wherein A is C.sub.2-C.sub.20 heterocyclyl or C.sub.1-C.sub.20 heteroaryl substituted with --CH.sub.2OH, --CH.sub.2CO.sub.2H, --CH(CH.sub.3)CH.sub.2OCH.sub.3, --CH.sub.3, --CH(CH.sub.3).sub.2, --CH.sub.2CH(CH.sub.3).sub.2, --CH.sub.2CF.sub.3, --C(.dbd.O)CH.sub.3, --C(.dbd.O)NHCH.sub.3, --C(.dbd.O)N(CH.sub.3).sub.2, --CO.sub.2H, --CO.sub.2CH.sub.3, --CH.sub.2CO.sub.2CH.sub.3, --NH.sub.2, --NHC(.dbd.O)CH.sub.3, --OH, --OCH.sub.3, --S(O).sub.2CH.sub.3, 1-methylpiperid-4-yl, 4-methylpiperazin-1-yl, 4-morpholinyl, (4-methylpiperazin-1yl)carboxamide, --CH.sub.2(1H-1,2,4-triazol-5-yl), cyclopropyl, cyclopropylmethyl, or cyclobutyl. 18. The method of claim 1 wherein A is a C.sub.1-C.sub.20 heteroaryl selected from pyridyl, isoxazolyl, imidazolyl, pyrazolyl, pyrrolyl, thiazolyl, pyridazinyl, pyrimidinyl, pyrazinyl, oxazolyl, oxadiazolyl, 1,3,4-oxadiazol-2(3H)-one, furanyl, thienyl, 1,2,3-triazolyl, 1,2,4-triazolyl, 1,2,4-triazol-5(4H)-one, 4,5-dihydro-1,2,4-triazin-6(1H)-one, tetrazolyl, pyrrolo[2,3-b]pyridinyl, indazolyl, 3,4-dihydroquinolinyl, and benzo[d]thiazole. 19. The method of claim 1 wherein A is selected from the structures: ##STR00869## where R.sup.9 is independently selected from H, F, Cl, Br, I, --CH.sub.3, --CH.sub.2CH.sub.3, --CH(CH.sub.3).sub.2, --C(CH.sub.3).sub.3, --CH.sub.2CH(CH.sub.3).sub.2, --CH.sub.2OH, --CH.sub.2CO.sub.2H, --CH(CH.sub.3)CH.sub.2OCH.sub.3, --CN, --CF.sub.3, --CH.sub.2CF.sub.3, --CH.sub.2NH.sub.2, --CH.sub.2CH.sub.2NH.sub.2, --C(.dbd.O)CH.sub.3, --CH.sub.2C(.dbd.O)NHCH.sub.3, --C(.dbd.O)NHCH.sub.3, --CO.sub.2H, --CH.sub.2CO.sub.2CH.sub.3, --NH.sub.2, --OH, --OCH.sub.3, --SCH.sub.3, --S(O).sub.2CH.sub.3, cyclopropyl, cyclopropylmethyl, 1-methylpiperid-4-yl, 4-methylpiperazin-1-yl, 4-morpholinyl, morpholin-4-yl-ethyl, benzyl, and phenyl, where benzyl and phenyl are optionally substituted with one or more groups selected from F, Cl, Br, I, --CH.sub.2OH, --CH.sub.2CO.sub.2H, --CN, --CH.sub.2NH.sub.2, --CH.sub.3, --C(.dbd.O)CH.sub.3, --C(.dbd.O)NHCH.sub.3, --CO.sub.2H, --CH.sub.2CO.sub.2CH.sub.3, --NH.sub.2, --OCH.sub.3, --S(O).sub.2CH.sub.3, 1-methylpiperid-4-yl, 4-methylpiperazin-1-yl, and 4-morpholinyl; and where the wavy line indicates the site of attachment. 20. The method of claim 19 wherein R.sup.9 is --CH(CH.sub.3).sub.2. 21. The method of claim 19 wherein A is substituted 1H-1,2,4-triazol-5-yl. 22. The method of claim 19 wherein A is selected from the structures: ##STR00870## ##STR00871## ##STR00872## where the wavy line indicates the site of attachment. 23. The method of claim 1 wherein the compound is selected from: 2-(1-(2-chlorophenyl)-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1- ,2-d][1,4]oxazepine-10-carboxamide; 2-(1-(2-chlorophenyl)-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1- ,2-d][1,4]oxazepine-9-carboxamide; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1- ,4]oxazepine-10-carboxamide; (2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][- 1,4]oxazepin-10-yl)(S-dioxothiomorpholino)methanone; (4-(2-hydroxypropan-2-yl)piperidin-1-yl)(2-(1-isopropyl-1H-1,2,4-triazol-- 5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-10-yl)methanone; 2-(1-isopropyl-1H-pyrazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxa- zepine-10-carboxamide; N-(2-(methylsulfonyl)ethyl)-2-(1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-- 5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-10-carboxamide; (4-isopropylpiperazin-1-yl)(2-(1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-- 5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-10-yl)methanone; N-(1-hydroxy-2-methylpropan-2-yl)-2-(1-(2,2,2-trifluoroethyl)-1H-1,2,4-tr- iazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-10-carboxamide- ; (4-(2-hydroxyethyl)piperazin-1-yl)(2-(1-(2,2,2-trifluoroethyl)-1H-1,2,4-- triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-10-yl)methano- ne; morpholino(2-(1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-yl)-5,6-dihy- drobenzo[f]imidazo[1,2-d][1,4]oxazepin-10-yl)methanone; (4-hydroxypiperidin-1-yl)(2-(1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-- yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-10-yl)methanone; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-N-(2-(methylsulfonyl)ethyl)-5,6-dih- ydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-9-carboxamide; 2-(1-(2-chlorophenyl)-1H-1,2,4-triazol-5-yl)-N-(2-(methylsulfonyl)ethyl)-- 5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-9-carboxamide; 2-(1-(2-chlorophenyl)-1H-1,2,4-triazol-5-yl)-N-(1-hydroxy-2-methylpropan-- 2-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-10-carboxamide; (2-(1-(2-chlorophenyl)-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[- 1,2-d][1,4]oxazepin-10-yl)(4-isopropylpiperazin-1-yl)methanone; 2-(1-(2,4-difluorophenyl)-1H-1,2,4-triazol-5-yl)-N-(1-hydroxy-2-methylpro- pan-2-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-10-carboxamide; 2-(4-cyano-1-isopropyl-1H-pyrazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d]- [1,4]oxazepine-9-carboxamide; 2-(1-(2-chlorophenyl)-1H-1,2,4-triazol-5-yl)-N-methyl-5,6-dihydrobenzo[f]- imidazo[1,2-d][1,4]oxazepine-9-carboxamide; ((3S,5R)-3,5-dimethylpiperazin-1-yl)(2-(1-(2,2,2-trifluoroethyl)-1H-1,2,4- -triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-10-yl)methan- one; N-methyl-2-(1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-yl)-5,6-dihyd- robenzo[f]imidazo[1,2-d][1,4]oxazepine-9-carboxamide; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-N-methyl-5,6-dihydrobenzo[f]imidazo- [1,2-d][1,4]oxazepine-9-carboxamide; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-10-(1H-pyrazol-4-yl)-5,6-dihydroben- zo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-(2-chlorophenyl)-1H-imidazol-2-yl)-N-(1-hydroxy-2-methylpropan-2-yl)- -5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-10-carboxamide; (2-(1-(2,4-difluorophenyl)-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imid- azo[1,2-d][1,4]oxazepin-10-yl)(4-(2-hydroxyethyl)piperazin-1-yl)methanone; N-(1-hydroxy-2-methylpropan-2-yl)-2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5- ,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-9-carboxamide; N-(1-hydroxy-2-methylpropan-2-yl)-2-(1-(S-dioxo-tetrahydrothiophen-3-yl)-- 1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-10-- carboxamide; 2-(1-(2-chlorophenyl)-1H-1,2,4-triazol-5-yl)-N-(1-hydroxy-2-methylpropan-- 2-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-9-carboxamide; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-N-methoxy-5,6-dihydrobenzo[f]imidaz- o[1,2-d][1,4]oxazepine-9-carboxamide; N-hydroxy-2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidaz- o[1,2-d][1,4]oxazepine-9-carboxamide; 2-(1-(2,4-difluorophenyl)-1H-1,2,4-triazol-5-yl)-N-methyl-5,6-dihydrobenz- o[f]imidazo[1,2-d][1,4]oxazepine-9-carboxamide; 1-(4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,- 2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropan-2-ol; 2-(4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,- 2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)ethanol; methyl 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1- ,4]oxazepine-9-carboxylate; methyl 2-(1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imi- dazo[1,2-d][1,4]oxazepine-9-carboxylate; 2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]i- midazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)ethanol; 10-bromo-2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo- [1,2-d][1,4]oxazepine; 1-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]i- midazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropan-2-ol; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-9-(1-(2-(methylsulfonyl)ethyl)azeti- din-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(3-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,- 2-d][1,4]oxazepin-9-yl)azetidin-1-yl)acetamide; (1-aminocyclopropyl)(3-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydro- benzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)azetidin-1-yl)methanone; 9-bromo-2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[- 1,2-d][1,4]oxazepine; 1-(4-(2-(1-isopropyl-4-methyl-1H-imidazol-2-yl)-5,6-dihydrobenzo[f]imidaz- o[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropan-2-ol; 2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]i- midazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide; 2-(3-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,- 2-d][1,4]oxazepin-9-yl)azetidin-1-yl)-N,N-dimethylethanesulfonamide; 2-(3-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,- 2-d][1,4]oxazepin-9-yl)azetidin-1-yl)-N,N-dimethylacetamide; 9-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)-2-(1-isopropyl-1H-1,2,4-triazol-5- -yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; N-isopropyl-2-(3-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[- f]imidazo[1,2-d][1,4]oxazepin-9-yl)azetidin-1-yl)acetamide; 2-(3-{2-[2-(2,4-Difluoro-phenyl)-2H-[1,2,4]triazol-3-yl]-4,5-dihydro-2H-6- -oxa-1,2-diaza-benzo[e]azulen-8-yl}-azetidin-1-yl)-ethanol; 1-(4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,- 2-d][1,4]oxazepin-9-yl)-1H-imidazol-1-yl)-2-methylpropan-2-ol; 3-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d- ][1,4]oxazepin-10-yl)pyridin-2(1H)-one; 9-(1-(2-(3-fluoroazetidin-1-yl)ethylsulfonyl)azetidin-3-yl)-2-(1-isopropy- l-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(3-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,- 2-d][1,4]oxazepin-9-yl)azetidin-1-yl)-2-methylpropanamide; 2-(4-(2-(1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo- [f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)ethanol; 2-(4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,- 2-d][1,4]oxazepin-9-yl)-1H-imidazol-1-yl)ethanol; 2-(5-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,- 2-d][1,4]oxazepin-9-yl)-1H-imidazol-1-yl)ethanol; 2-(1-(2-morpholinoethyl)-1H-imidazol-2-yl)-10-(1H-pyrazol-4-yl)-5,6-dihyd- robenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-9-(1-(2-morpholinoethyl)-1- H-pyrazol-4-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(4-(2-(3-amino-1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]im- idazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)ethanol; 2-(3-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,- 2-d][1,4]oxazepin-9-yl)azetidin-1-yl)-N-methylacetamide; 1-(4-(2-(3-amino-1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]im- idazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropan-2-ol; 1-(4-(2-(1-isopropyl-1H-imidazol-2-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][- 1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropan-2-ol; 2-(4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,- 2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide; 2-(4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,- 2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanoic acid; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-9-(1H-pyrazol-4-yl)-5,6-dihydrobenz- o[f]imidazo[1,2-d][1,4]oxazepine; 3-(2-(1-(2,2,2-trifluoro ethyl)-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxaze- pin-10-yl)pyridin-2(1H)-one; 5-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d- ][1,4]oxazepin-9-yl)pyridin-2-amine; 2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]i- midazo[1,2-d][1,4]oxazepin-9-yl)-1H-imidazol-1-yl)ethanol; 2-(2-(9-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl)-5,6-dihydrobenzo[f- ]imidazo[1,2-d][1,4]oxazepin-2-yl)-1H-imidazol-1-yl)-N-methylacetamide; N,N-diethyl-2-(4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[- f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)ethanamine; 5-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d- ][1,4]oxazepin-9-yl)pyrimidin-2-amine; 9-(1H-imidazol-5-yl)-2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroben- zo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-9-(1-(2-(methylsulfonyl)ethyl)piper- idin-4-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,- 2-d][1,4]oxazepin-9-yl)piperidin-1-yl)acetamide; 2-hydroxy-1-(4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]- imidazo[1,2-d][1,4]oxazepin-9-yl)piperidin-1-yl)-2-methylpropan-1-one; (2S)-2-hydroxy-1-(3-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,- 6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)azetidi- n-1-yl)propan-1-one; 2-(4-(2-(3-amino-1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]im- idazo[1,2-d][1,4]oxazepin-9-yl)-1H-imidazol-1-yl)ethanol; 2-(3-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[- f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)azetidin-1-yl)ethanol; 5-(5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-2-yl)-1-isopropyl-1H-1,- 2,4-triazol-3-amine; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo- [1,2-d][1,4]oxazepine; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]pyrido[4,3- -f][1,4]oxazepine; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-10-(4-methylpiperazin-1-yl)-5,6-dih- ydroimidazo[1,2-d]pyrido[4,3-f][1,4]oxazepine; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-9-(pyrimidin-5-yl)-5,6-dih- ydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 9-(5-fluoropyridin-3-yl)-2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5- ,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(3-amino-1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[- 1,2-d][1,4]oxazepine-9-carbonitrile; N-(5-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]i- midazo[1,2-d][1,4]oxazepin-9-yl)pyridin-2-yl)acetamide; 9-bromo-2-(1-isopropyl-3-(methylthio)-1H-1,2,4-triazol-5-yl)-5,6-dihydrob- enzo[f]imidazo[1,2-d][1,4]oxazepine; 5-(9-(5-fluoropyridin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepi- n-2-yl)-1-isopropyl-1H-1,2,4-triazol-3-amine; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-9-(1-(tetrahydro-2H-pyran-2-yl)-1H-- imidazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 3-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]i- midazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-9-(pyridin-3-yl)-5,6-dihyd- robenzo[f]imidazo[1,2-d][1,4]oxazepine; 5-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imid- azo[1,2-d][1,4]oxazepin-9-yl)-N,N-dimethylpyrimidin-2-amine; 5-(5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-2-yl)-1-isopropyl-N-met- hyl-1H-1,2,4-triazol-3-amine; N-isopropyl-2-(4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[- f]imidazo[1,2-d][1,4]oxazepin-9-yl)piperidin-1-yl)acetamide; 2-(4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,- 2-d][1,4]oxazepin-9-yl)piperidin-1-yl)-N,2-dimethylpropanamide; 2-(4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,- 2-d][1,4]oxazepin-9-yl)piperidin-1-yl)-N,N-dimethylethanesulfonamide; 2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]i- midazo[1,2-d][1,4]oxazepin-9-yl)piperidin-1-yl)acetamide; 2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]i- midazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanoic acid; 1-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]i- midazo[1,2-d][1,4]oxazepin-9-yl)-1H-imidazol-1-yl)-2-methylpropan-2-ol; 5-(9-fluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-2-yl)-1-isopro- pyl-1H-1,2,4-triazol-3-amine; 2-(4-(2-(3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d- ][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)ethanol; 2-(4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,- 2-d][1,4]oxazepin-9-yl)-2-methyl-1H-imidazol-1-yl)ethanol; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-9-(2-methyl-1-(2-(tetrahydro-2H-pyr- an-2-yloxy)ethyl)-1H-imidazol-4-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]- oxazepine; 5-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobe- nzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)pyrimidin-2-amine; 5-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imid- azo[1,2-d][1,4]oxazepin-10-yl)pyridin-2(1H)-one; 5-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imid- azo[1,2-d][1,4]oxazepin-10-yl)pyridin-2(1H)-one; 1-(4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,- 2-d][1,4]oxazepin-9-yl)-2-methyl-1H-imidazol-1-yl)-2-methylpropan-2-ol; N-(azetidin-3-yl)-2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidaz- o[1,2-d]pyrido[4,3-f][1,4]oxazepin-10-amine; 3-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]pyrido[- 4,3-f][1,4]oxazepin-10-ylamino)propane-1,2-diol; 3-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imid- azo[1,2-d][1,4]oxazepin-10-yl)pyridine-2(1H)-one; 9-chloro-2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]p- yrido[3,4-f][1,4]oxazepine; 1-(4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,- 2-d][1,4]oxazepin-9-yl)-2-methyl-1H-imidazol-1-yl)-2-methylpropan-2-ol; N-(azetidin-3-yl)-2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidaz- o[1,2-d]pyrido[4,3-f][1,4]oxazepin-10-amine; 3-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]pyrido[- 4,3-f][1,4]oxazepin-10-ylamino)propane-1,2-diol; 3-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imid- azo[1,2-d][1,4]oxazepin-10-yl)pyridin-2(1H)-one; 3-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]pyrido[- 4,3-f][1,4]oxazepin-10-yl)pyridin-2(1H)-one; 2-(5-(9-cyclopropyl-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-2-yl)-- 3-methyl-1H-1,2,4-triazol-1-yl)propan-1-ol; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-9-(2-methyl-1H-imidazol-5-yl)-5,6-d- ihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 1-(4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,- 2-d][1,4]oxazepin-9-yl)-1-methyl-1H-imidazol-2-yl)-2-methylpropan-2-ol; 1-(4-(2-(3-(hydroxymethyl)-1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydro- benzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropan-- 2-ol; N-tert-butyl-2-(4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydro- benzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)piperidin-1-yl)acetamide; 2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]i- midazo[1,2-d][1,4]oxazepin-9-yl)piperidin-1-yl)-N-methylacetamide; N-ethyl-2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrob- enzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)piperidin-1-yl)acetamide; N-isopropyl-2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihy- drobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)piperidin-1-yl)acetamide; 2-(4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,- 2-d][1,4]oxazepin-9-yl)piperidin-1-yl)-N,N-dimethylacetamide; 2-(4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,- 2-d][1,4]oxazepin-9-yl)piperidin-1-yl)-N-methylacetamide; 10-fluoro-2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo- [f]imidazo[1,2-d][1,4]oxazepine; 9-(1,2-dimethyl-1H-imidazol-4-yl)-2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5- ,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 5-(10-fluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-2-yl)-1-isopr- opyl-1H-1,2,4-triazol-3-amine; 9,10-difluoro-2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrob- enzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(4-(2-(1,3-dimethyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1- ,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)ethanol; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-9-(1-(2-methoxyethyl)piperidin-4-yl- )-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,- 2-d][1,4]oxazepin-9-yl)piperidin-1-yl)-2-methylpropanamide; 2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]i- midazo[1,2-d][1,4]oxazepin-9-yl)piperidin-1-yl)ethanol; 2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]i- midazo[1,2-d][1,4]oxazepin-9-yl)piperidin-1-yl)-2-methylpropanamide; 1-(5-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,- 2-d][1,4]oxazepin-9-yl)-1H-imidazol-2-yl)-2-methylpropan-2-ol; 9-(1,2-dimethyl-1H-imidazol-5-yl)-2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5- ,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 1-(4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,- 2-d][1,4]oxazepin-9-yl)piperidin-1-yl)-2-methylpropan-2-ol; 2-(4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,- 2-d][1,4]oxazepin-9-yl)piperidin-1-yl)ethanol; and 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-9-(tetrahydro-2H-pyran-4-yl)-5,6-di- hydrobenzo[f]imidazo[1,2-d][1,4]oxazepine. 24. The method of claim 1 wherein the compound is selected from: methyl 2-(2-ethoxyphenyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-9-carb- oxylate; methyl 2-(3-isopropylphenyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-9-c- arboxylate; methyl 2-(2-ethylphenyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-9-carbo- xylate; methyl 2-(2-isopropylphenyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-9-c- arboxylate; methyl 2-(3-(trifluoromethyl)phenyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxaze- pine-9-carboxylate; 2-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imid- azo[1,2-d][1,4]oxazepin-9-yl)acetamide; 2-(5-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,- 2-d][1,4]oxazepin-9-yl)-2-methyl-1H-imidazol-1-yl)ethanol; 1-(4-(2-(1-isopropyl-3-(methoxymethyl)-1H-1,2,4-triazol-5-yl)-5,6-dihydro- benzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropan-- 2-ol; (3R,4R)-4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]- imidazo[1,2-d][1,4]oxazepin-9-yl)piperidin-3-ol; racemic-cis/trans-2-(3-hydroxy-4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5- ,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)piperidin-1-yl)-N,N-dim- ethylacetamide; 2-(5-(9-bromo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-2-yl)-1-isop- ropyl-1H-1,2,4-triazol-3-yl)acetamide; 5-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]pyrido[- 4,3-f][1,4]oxazepin-10-yl)pyridin-2(1H)-one; 4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]pyrido[- 4,3-f][1,4]oxazepin-10-yl)piperazin-2-one; 2-(4-(2-(1-isopropyl-3-(methoxymethyl)-1H-1,2,4-triazol-5-yl)-5,6-dihydro- benzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)piperidin-1-yl)acetamide; 2-(1-isopropyl-3-(methoxymethyl)-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[- f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-9-methoxy-5,6-dihydroimidazo[1,2-d]- pyrido[3,4-f][1,4]oxazepine; 9-fluoro-2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[- f]imidazo[1,2-d][1,4]oxazepine; 5-(9,10-difluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-2-yl)-1-i- sopropyl-1H-1,2,4-triazol-3-amine; 9-bromo-2-(3-cyclopropyl-1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobe- nzo[f]imidazo[1,2-d][1,4]oxazepine; 9-(1-ethylpiperidin-4-yl)-2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihyd- robenzo[f]imidazo[1,2-d][1,4]oxazepine; (5-(5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-2-yl)-1-isopropyl-1H-1- ,2,4-triazol-3-yl)methanol; 3-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imid- azo[1,2-d][1,4]oxazepin-9-yl)propanamide; 9-chloro-2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]p- yrido[3,4-f][1,4]oxazepine; 1-(5-(5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-2-yl)-1-isopropyl-1H- -1,2,4-triazol-3-yl)-N,N-dimethylmethanamine; racemic-cis-2-(3-hydroxy-4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dih- ydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)piperidin-1-yl)-N,N-dimethyla- cetamide; racemic-trans-2-(3-hydroxy-4-(2-(1-isopropyl-1H-1,2,4-triazol-5-- yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)piperidin-1-yl)-N,- N-dimethylacetamide; 2-((1R,3r,5S)-3-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f- ]imidazo[1,2-d][1,4]oxazepin-9-yl)-8-azabicyclo[3.2.1]octan-8-yl)acetamide 2-((1R,3s, 5S)-3-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1- ,2-d][1,4]oxazepin-9-yl)-8-azabicyclo[3.2.1]octan-8-yl)acetamide; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-9-(4-methylpiperazin-1-yl)-5,6-dihy- droimidazo[1,2-d]pyrido[3,2-f][1,4]oxazepine; 4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]pyrido[- 3,2-f][1,4]oxazepin-9-yl)piperazin-2-one; 4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]pyrido[- 3,4-f][1,4]oxazepin-9-yl)piperazin-2-one; 4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imid- azo[1,2-d][1,4]oxazepin-10-yl)pyridin-2(1H)-one; (3R,4S)-4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenz- o[f]imidazo[1,2-d][1,4]oxazepin-9-yl)piperidin-3-ol; 2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]i- midazo[1,2-d][1,4]oxazepin-9-yl)piperidin-1-yl)-N,N-dimethylacetamide; 2-(3-hydroxy-4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]- imidazo[1,2-d][1,4]oxazepin-9-yl)piperidin-1-yl)-N,2-dimethylpropanamide; 2-(4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]pyri- do[3,4-f][1,4]oxazepin-9-yl)piperazin-1-yl)-N,N-dimethylacetamide; 2-(4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]pyri- do[3,4-f][1,4]oxazepin-9-yl)piperazin-1-yl)acetamide; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]pyrido[3,2- -f][1,4]oxazepin-9(8H)-one; 2-(4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]pyri- do[3,2-f][1,4]oxazepin-9-yl)piperazin-1-yl)-N-methylacetamide; 2-(4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]pyri- do[3,2-f][1,4]oxazepin-9-yl)piperazin-1-yl)-N,N-dimethylacetamide; 2-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d- ][1,4]oxazepin-9-yl)acetic acid; 1-((2-(1-isopropyl-1H-pyrazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4- ]oxazepin-9-yl)methyl)urea; (2S)-1-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]py- rido[3,4-f][1,4]oxazepin-9-yl)pyrrolidine-2-carboxamide; 1-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]pyrido[- 3,4-f][1,4]oxazepin-9-yl)piperidine-4-carboxamide; 1-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]pyrido[- 3,4-f][1,4]oxazepin-9-yl)piperidin-4-ol; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-9-morpholino-5,6-dihydroimidazo[1,2- -d]pyrido[3,4-f][1,4]oxazepine; N-isopropyl-2-(4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidaz- o[1,2-d]pyrido[3,4-f][1,4]oxazepin-9-yl)piperazin-1-yl)acetamide; 1-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]pyrido[- 3,2-f][1,4]oxazepin-9-yl)azetidine-3-carboxamide; (2S)-2-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[- 1,2-d][1,4]oxazepin-9-yl)propanamide; (2R)-2-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[- 1,2-d][1,4]oxazepin-9-yl)propanamide; 2-(1-isopropyl-1H-pyrazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxa- zepine-9-carboxamide; (2-(1-isopropyl-1H-pyrazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]ox- azepin-9-yl)methanamine; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-9-(oxetan-3-yl)-5,6-dihydr- obenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(3-hydroxy-4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]- imidazo[1,2-d][1,4]oxazepin-9-yl)piperidin-1-yl)-N,2-dimethylpropanamide; 2-(3-hydroxy-4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]- imidazo[1,2-d][1,4]oxazepin-9-yl)piperidin-1-yl)-N,2-dimethylpropanamide; 2-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d- ][1,4]oxazepin-9-yl)acetamide; N-hydroxy-2-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imi- dazo[1,2-d][1,4]oxazepin-9-yl)acetamide; (9-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl)-5,6-dihydrobenzo[f]imid- azo[1,2-d][1,4]oxazepin-2-yl)(S-dioxothiomorpholino)methanone; 1-((2-(1-(2,4-difluorophenyl)-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydro- benzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)methyl)urea; (2-(1-(2,4-difluorophenyl)-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroben- zo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)methanamine; 9-(1-(2-(dimethylamino)-2-oxoethyl)piperidin-4-yl)-N-(2-hydroxyethyl)-N-i- sopropyl-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-9-(1-isopropylpiperidin-4-yl)-5,6-d- ihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]i- midazo[1,2-d][1,4]oxazepin-9-yl)piperidin-1-yl)-2-methylpropan-1-ol; 2-(4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,- 2-d][1,4]oxazepin-9-yl)piperidin-1-yl)-2-methylpropan-1-ol; 4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d- ][1,4]oxazepin-9-yl)pyrazolidine-3,5-dione; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-9-(1-(2,2,2-trifluoroethyl)piperidi- n-4-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(3-hydroxy-4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]- imidazo[1,2-d][1,4]oxazepin-9-yl)piperidin-1-yl)-N,N-dimethylacetamide; 1-((2-(1-(2,4-difluorophenyl)-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydro- benzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)methylamino)-2-methylpropan-2-ol; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]pyrido[3,4- -f][1,4]oxazepine; (2R)-1-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]py- rido[3,4-f][1,4]oxazepin-9-yl)pyrrolidine-2-carboxamide; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-9-(pyrrolidin-1-yl)-5,6-dihydroimid- azo[1,2-d]pyrido[3,4-f][1,4]oxazepine; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-N-methyl-5,6-dihydroimidazo[1,2-d]p- yrido[3,2-f][1,4]oxazepin-9-amine; (2S,4R)-4-hydroxy-1-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-d- ihydroimidazo[1,2-d]pyrido[3,4-f][1,4]oxazepin-9-yl)pyrrolidine-2-carboxam- ide; (2S)-1-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimi- dazo[1,2-d]pyrido[3,4-f][1,4]oxazepin-9-yl)pyrrolidine-2-carboxamide; 1-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]pyrido[- 3,4-f][1,4]oxazepin-9-yl)azetidin-3-ol; (3R)-1-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]py- rido[3,4-f][1,4]oxazepin-9-yl)pyrrolidin-3-ol; (1-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]pyrido- [3,4-f][1,4]oxazepin-9-yl)piperidin-4-yl)methanol; (2S,4S)-4-fluoro-1-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimid- azo[1,2-d]pyrido[3,4-f][1,4]oxazepin-9-yl)pyrrolidine-2-carboxamide; (2S,4R)-4-hydroxy-1-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimi- dazo[1,2-d]pyrido[3,4-f][1,4]oxazepin-9-yl)pyrrolidine-2-carboxamide; (2S)-1-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[- 1,2-d][1,4]oxazepin-9-yl)pyrrolidine-2-carboxamide; (2R)-1-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[- 1,2-d][1,4]oxazepin-9-yl)pyrrolidine-2-carboxamide; (2S)-1-(2-(1-isopropyl-1H-imidazol-2-yl)-5,6-dihydroimidazo[1,2-d]pyrido[- 3,4-f][1,4]oxazepin-9-yl)pyrrolidine-2-carboxamide; (2S)-1-(2-(1-(2,4-difluorophenyl)-1H-1,2,4-triazol-5-yl)-5,6-dihydroimida- zo[1,2-d]pyrido[3,4-f][1,4]oxazepin-9-yl)pyrrolidine-2-carboxamide; (2R)-2-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f- ]imidazo[1,2-d][1,4]oxazepin-9-yl)pyrrolidine-1-carboxamide; (2S)-2-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f- ]imidazo[1,2-d][1,4]oxazepin-9-yl)pyrrolidine-1-carboxamide; (2S)-4,4-difluoro-1-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimi- dazo[1,2-d]pyrido[3,4-f][1,4]oxazepin-9-yl)pyrrolidine-2-carboxamide; (2S,4S)-4-fluoro-1-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-di- hydroimidazo[1,2-d]pyrido[3,4-f][1,4]oxazepin-9-yl)pyrrolidine-2-carboxami- de; (2S)-4,4-difluoro-1-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,- 6-dihydroimidazo[1,2-d]pyrido[3,4-f][1,4]oxazepin-9-yl)pyrrolidine-2-carbo- xamide; (2S,4S)-4-hydroxy-1-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dih- ydroimidazo[1,2-d]pyrido[3,4-f][1,4]oxazepin-9-yl)pyrrolidine-2-carboxamid- e; (2S,4S)-4-hydroxy-1-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6- -dihydroimidazo[1,2-d]pyrido[3,4-f][1,4]oxazepin-9-yl)pyrrolidine-2-carbox- amide; 2-(1-isopropyl-1H-imidazol-2-yl)-5,6-dihydroimidazo[1,2-d]pyrido[3,- 4-f][1,4]oxazepine; (5-(9-chloro-5,6-dihydroimidazo[1,2-d]pyrido[3,4-f][1,4]oxazepin-2-yl)-1-- (2,2,2-trifluoroethyl)-1H-1,2,4-triazol-3-yl)methanol; (2R)-1-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]py- rido[3,4-f][1,4]oxazepin-9-yl)-2,5-dihydro-1H-pyrrole-2-carboxamide; (2S)-1-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]py- rido[3,4-f][1,4]oxazepin-9-yl)-2,5-dihydro-1H-pyrrole-2-carboxamide; (5-(9-(pyrrolidin-1-yl)-5,6-dihydroimidazo[1,2-d]pyrido[3,4-f][1,4]oxazep- in-2-yl)-1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-3-yl)methanol; (2S)-1-(2-(1-(3,5-difluorophenyl)-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dih- ydroimidazo[1,2-d]pyrido[3,4-f][1,4]oxazepin-9-yl)pyrrolidine-2-carboxamid- e; (2S)-2-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]- pyrido[3,4-f][1,4]oxazepin-9-ylamino)propanamide; (2S)-1-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]py- rido[3,4-f][1,4]oxazepin-9-yl)-3,3-dimethylpyrrolidine-2-carboxamide; (5-(9-(dimethylamino)-5,6-dihydroimidazo[1,2-d]pyrido[3,4-f][1,4]oxazepin- -2-yl)-1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-3-yl)methanol; (2S,3S)-3-hydroxy-1-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-d- ihydroimidazo[1,2-d]pyrido[3,4-f][1,4]oxazepin-9-yl)pyrrolidine-2-carboxam- ide; (2S,3R)-3-hydroxy-1-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5- ,6-dihydroimidazo[1,2-d]pyrido[3,4-f][1,4]oxazepin-9-yl)pyrrolidine-2-carb- oxamide; (2S,3R)-3-hydroxy-1-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-di- hydroimidazo[1,2-d]pyrido[3,4-f][1,4]oxazepin-9-yl)pyrrolidine-2-carboxami- de; (2S,3S)-3-hydroxy-1-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydro- imidazo[1,2-d]pyrido[3,4-f][1,4]oxazepin-9-yl)pyrrolidine-2-carboxamide; (2S)-1-(2-(3-methyl-1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-yl)-5,6-d- ihydroimidazo[1,2-d]pyrido[3,4-f][1,4]oxazepin-9-yl)pyrrolidine-2-carboxam- ide; (2S,4R)-4-fluoro-1-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,- 6-dihydroimidazo[1,2-d]pyrido[3,4-f][1,4]oxazepin-9-yl)pyrrolidine-2-carbo- xamide; (2S,4R)-4-fluoro-1-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihy- droimidazo[1,2-d]pyrido[3,4-f][1,4]oxazepin-9-yl)pyrrolidine-2-carboxamide- ; (2R)-1-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]p- yrido[3,4-f][1,4]oxazepin-9-yl)-2-methylpyrrolidine-2-carboxamide; 1-isopropyl-4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]i- midazo[1,2-d][1,4]oxazepin-9-yl)piperidine-3-carboxamide; 2-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]pyrido[- 3,4-f][1,4]oxazepin-9-ylamino)acetamide; (2S)-1-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]py- rido[3,4-f][1,4]oxazepin-9-yl)-N-methylpyrrolidine-2-carboxamide; (2S,3S)-1-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d- ]pyrido[3,4-f][1,4]oxazepin-9-yl)-3-methylpyrrolidine-2-carboxamide; (2S,4R)-1-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d- ]pyrido[3,4-f][1,4]oxazepin-9-yl)-4-methoxypyrrolidine-2-carboxamide; (2S,3S)-1-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d- ]pyrido[3,4-f][1,4]oxazepin-9-yl)-3-methoxypyrrolidine-2-carboxamide; (2S)-1-(2-(1-cyclohexyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]p- yrido[3,4-f][1,4]oxazepin-9-yl)pyrrolidine-2-carboxamide; (2S)-1-(2-(1-(2-chlorophenyl)-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1- ,2-d]pyrido[3,4-f][1,4]oxazepin-9-yl)pyrrolidine-2-carboxamide; 9-bromo-2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f- ]imidazo[1,2-d][1,4]oxazepine; ethyl 2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]i- midazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanoate; (5-(9-(dimethylamino)-5,6-dihydroimidazo[1,2-d]pyrido[3,4-f][1,4]oxazepin- -2-yl)-1-isopropyl-1H-1,2,4-triazol-3-yl)methanol; 4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d- ][1,4]oxazepin-9-yl)-1-methyl-1,2,5,6-tetrahydropyridine-3-carboxamide; 4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d- ][1,4]oxazepin-9-yl)-1-methyl-1,2,3,6-tetrahydropyridine-3-carboxamide; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-N-methyl-5,6-dihydroimidazo[1,2-d]p- yrido[3,4-f][1,4]oxazepin-9-amine; (5-(9-(3,3-difluoroazetidin-1-yl)-5,6-dihydroimidazo[1,2-d]pyrido[3,4-f][- 1,4]oxazepin-2-yl)-1-isopropyl-1H-1,2,4-triazol-3-yl)methanol; 9-chloro-2-(1-isopropyl-1H-pyrazol-5-yl)-5,6-dihydroimidazo[1,2-d]pyrido[- 3,4-f][1,4]oxazepine; 2-(3-methyl-1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-yl)-9-(2-(1-methy- lpiperidin-2-yl)pyrrolidin-1-yl)-5,6-dihydroimidazo[1,2-d]pyrido[3,4-f][1,- 4]oxazepine; 2-(3-methyl-1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-yl)-9-(2-(2-methy- lbenzyl)pyrrolidin-1-yl)-5,6-dihydroimidazo[1,2-d]pyrido[3,4-f][1,4]oxazep- ine; 2-(3-methyl-1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-yl)-9-(2-(pip- eridin-1-ylmethyl)pyrrolidin-1-yl)-5,6-dihydroimidazo[1,2-d]pyrido[3,4-f][- 1,4]oxazepine; 2-(1-(2-chlorophenyl)-1H-1,2,4-triazol-5-yl)-N,N-dimethyl-5,6-dihydroimid- azo[1,2-d]pyrido[3,4-f][1,4]oxazepin-9-amine; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-9-(1-methyl-1H-pyrazol-4-y- l)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(3-amino-1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-yl)-5,6-dihydroben- zo[f]imidazo[1,2-d][1,4]oxazepine-10-carbonitrile; 2-(3-amino-1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-yl)-5,6-dihydroben- zo[f]imidazo[1,2-d][1,4]oxazepine-9-carbonitrile; (2S)-2-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]py- rido[3,4-f][1,4]oxazepin-9-yloxy)propanamide; 2-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]pyrido[- 3,4-f][1,4]oxazepin-9-yloxy)acetamide; 2-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d- ][1,4]oxazepin-9-yloxy)acetamide; 2-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]pyrido[- 3,4-f][1,4]oxazepin-9-yloxy)-2-methylpropanamide; (2S,4R)-4-cyano-1-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimida- zo[1,2-d]pyrido[3,4-f][1,4]oxazepin-9-yl)pyrrolidine-2-carboxamide; 5-(9-cyclopropyl-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-2-yl)-1-i- sopropyl-1H-1,2,4-triazol-3-amine; 5-(10-fluoro-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-2-yl)-1-(2,2,- 2-trifluoroethyl)-1H-1,2,4-triazol-3-amine; (2S)-1-(2-(1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-yl)-5,6-dihydroimi- dazo[1,2-d]pyrido[3,4-f][1,4]oxazepin-9-yl)pyrrolidine-2-carboxamide; (2S)-1-(2-(1-isopropyl-1H-pyrazol-5-yl)-5,6-dihydroimidazo[1,2-d]pyrido[3- ,4-f][1,4]oxazepin-9-yl)pyrrolidine-2-carboxamide; 3-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d- ][1,4]oxazepin-9-yl)-2-methylpropanamide; (2S)-2-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[- 1,2-d][1,4]oxazepin-9-yloxy)propanamide; (3S)-1-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]py- rido[3,4-f][1,4]oxazepin-9-yl)pyrrolidine-3-carbonitrile; N-((1H-pyrazol-5-yl)methyl)-2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dih- ydroimidazo[1,2-d]pyrido[3,4-f][1,4]oxazepin-9-amine; 2-(2-(1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[- 1,2-d]pyrido[3,4-f][1,4]oxazepin-9-ylamino)propan-1-ol; 2-(1-isopropyl-3-(methoxymethyl)-1H-1,2,4-triazol-5-yl)-9-methyl-5,6-dihy- drobenzo[f]imidazo[1,2-d][1,4]oxazepine; N-(3,4-dimethoxybenzyl)-2-(1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-yl- )-5,6-dihydroimidazo[1,2-d]pyrido[3,4-f][1,4]oxazepin-9-amine; 5-(10-cyclopropyl-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-2-yl)-1-- (2,2,2-trifluoroethyl)-1H-1,2,4-triazol-3-amine; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo- [1,2-d][1,4]oxazepine-9-carbonitrile; 2-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d- ][1,4]oxazepin-9-ylamino)acetamide; 2-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d- ][1,4]oxazepin-9-yl)ethanesulfonamide; 2-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]pyrido[- 3,4-f][1,4]oxazepin-9-yloxy)propanamide; 9-(difluoromethyl)-2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dih- ydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d- ][1,4]oxazepin-9-yl)-1-methyl-1,2,3,6-tetrahydropyridine-3-carboxamide; 4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d- ][1,4]oxazepin-9-yl)-1-methyl-1,2,3,6-tetrahydropyridine-3-carboxamide; 2-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]pyrido[- 3,4-f][1,4]oxazepin-9-ylamino)-1-(1-methyl-1H-imidazol-2-yl)ethanol; 2-(1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2- -d]pyrido[3,4-f][1,4]oxazepin-9-amine; 2-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]pyrido[- 3,4-f][1,4]oxazepin-9-yloxy)-3-methylbutanamide; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]pyrido[3,4- -f][1,4]oxazepin-9-amine; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-10-(1-methyl-1H-pyrazol-4-- yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo- [1,2-d][1,4]oxazepine-10-carbonitrile; 2-(1-(2,4-difluorophenyl)-1H-1,2,4-triazol-5-yl)-N-(2-(methylsulfonyl)ben- zyl)-5,6-dihydroimidazo[1,2-d]pyrido[3,4-f][1,4]oxazepin-9-amine; 1-(2-(2-(1-(2,4-difluorophenyl)-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo- [1,2-d]pyrido[3,4-f][1,4]oxazepin-9-ylamino)ethyl)pyrrolidin-2-one; 2-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-- d]pyrido[3,4-f][1,4]oxazepin-9-ylamino)acetamide; 1-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d- ][1,4]oxazepin-9-yl)piperidine-2-carboxamide; 2-((2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]pyrido- [3,4-f][1,4]oxazepin-9-yl)(methyl)amino)acetamide; N-(3-(1H-imidazol-1-yl)propyl)-2-(1-(2,4-difluorophenyl)-1H-1,2,4-triazol- -5-yl)-5,6-dihydroimidazo[1,2-d]pyrido[3,4-f][1,4]oxazepin-9-amine; N-((1H-imidazol-2-yl)methyl)-2-(1-(2,4-difluorophenyl)-1H-1,2,4-triazol-5- -yl)-5,6-dihydroimidazo[1,2-d]pyrido[3,4-f][1,4]oxazepin-9-amine; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]p- yrido[3,4-f][1,4]oxazepin-9-amine; 1-(2,2,2-trifluoroethyl)-5-(10-(trifluoromethyl)-5,6-dihydrobenzo[f]imida- zo[1,2-d][1,4]oxazepin-2-yl)-1H-1,2,4-triazol-3-amine; 2-(2-(1-(2,4-difluorophenyl)-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,- 2-d]pyrido[3,4-f][1,4]oxazepin-9-ylamino)-1-(1-methyl-1H-imidazol-2-yl)eth- anol; 8-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]py- rido[3,4-f][1,4]oxazepin-9-yl)-3,8-diazabicyclo[3.2.1]octan-2-one; 3-methyl-2-(2-(1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-yl)-5,6-dihydr- obenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yloxy)butanamide; 2-(1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imi- dazo[1,2-d][1,4]oxazepin-9-ol; (2S)-1-(2-(1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-yl)-5,6-dihydroben- zo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)pyrrolidine-2-carboxamide; (2S)-1-(2-(1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-yl)-5,6-dihydroben- zo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)piperidine-2-carboxamide; (3S)-4-(2-(1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-yl)-5,6-dihydroben- zo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)morpholine-3-carboxamide; 2-methyl-2-(2-(1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-yl)-5,6-dihydr- obenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yloxy)propanamide; (2R)-2-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]py- rido[3,4-f][1,4]oxazepin-9-ylamino)propanamide; 2-(2-(3-methyl-1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-yl)-5,6-dihydr- oimidazo[1,2-d]pyrido[3,4-f][1,4]oxazepin-9-ylamino)acetamide; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-9-(2-(methylsulfonyl)phenyl)-5,6-di- hydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d- ][1,4]oxazepin-9-yl)benzamide; 9-(2-ethylphenyl)-2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[- f]imidazo[1,2-d][1,4]oxazepine; (2-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-- d][1,4]oxazepin-9-yl)phenyl)methanol; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo- [1,2-d][1,4]oxazepin-9-amine; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1- ,4]oxazepin-9-amine; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-10-methyl-5,6-dihydrobenzo- [f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-9-methyl-5,6-dihydrobenzo[- f]imidazo[1,2-d][1,4]oxazepine; 10-(difluoromethyl)-2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimid- azo[1,2-d]pyrido[4,3-f][1,4]oxazepine; 1-isopropyl-5-(10-(trifluoromethyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4- ]oxazepin-2-yl)-1H-1,2,4-triazol-3-amine; (2R)-2-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[- 1,2-d][1,4]oxazepin-9-yloxy)propanamide; (2S)-2-(2-(1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-yl)-5,6-dihydroben- zo[f]imidazo[1,2-d][1,4]oxazepin-9-yloxy)propanamide; (2R)-2-(2-(1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-yl)-5,6-dihydroben- zo[f]imidazo[1,2-d][1,4]oxazepin-9-yloxy)propanamide; N-(3,4-dimethoxybenzyl)-2-(3-methyl-1-(2,2,2-trifluoroethyl)-1H-1,2,4-tri- azol-5-yl)-5,6-dihydroimidazo[1,2-d]pyrido[3,4-f][1,4]oxazepin-9-amine; 2-(3-methyl-1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-yl)-5,6-dihydroim- idazo[1,2-d]pyrido[3,4-f][1,4]oxazepin-9-amine; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1- ,4]oxazepin-9-ol; 2-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-- d]pyrido[3,4-f][1,4]oxazepin-9-ylamino)acetic acid; 9-(difluoromethoxy)-2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenz- o[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imi- dazo[1,2-d][1,4]oxazepin-9-amine; (2S)-2-(2-(1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-yl)-5,6-dihydroben- zo[f]imidazo[1,2-d][1,4]oxazepin-9-yloxy)butanamide; (2R)-2-(2-(1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-yl)-5,6-dihydroben- zo[f]imidazo[1,2-d][1,4]oxazepin-9-yloxy)butanamide; 2-(2-(1-(2,2,2-trifluoro ethyl)-1H-1,2,4-triazol-5-yl)-5,6-dihydroimidazo[1,2-d]pyrido[3,4-f][1,4]- oxazepin-9-ylamino)acetamide; 3-((2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-- d][1,4]oxazepin-9-yloxy)methyl)oxetan-3-amine; 1-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d- ][1,4]oxazepin-9-yl)piperidine-2-carboxamide; 9-ethyl-2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f- ]imidazo[1,2-d][1,4]oxazepine; 1-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d- ][1,4]oxazepin-9-yl)piperidine-2-carboxamide; (2S)-3-methyl-2-(2-(1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-yl)-5,6-d- ihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yloxy)butanamide; (2R)-3-methyl-2-(2-(1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-yl)-5,6-d- ihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yloxy)butanamide; ethyl 3-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]i- midazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanoate; methyl 3-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobe- nzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanoat- e; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-9-(1H-pyrazol-4-yl)-5,6-- dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 3-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]i- midazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanoic acid; 9-isopropoxy-2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imi- dazo[1,2-d][1,4]oxazepine; methyl 2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]i- midazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanoate; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-9-(oxetan-3-yloxy)-5,6-dihydrobenzo- [f]imidazo[1,2-d][1,4]oxazepine; 9-ethoxy-2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo- [1,2-d][1,4]oxazepine; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-9-(2,2,2-trifluoroethoxy)-5,6-dihyd- robenzo[f]imidazo[1,2-d][1,4]oxazepine; (2S)-2-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[- 1,2-d][1,4]oxazepin-9-yloxy)propanoic acid; (2S)-3-hydroxy-2-(2-(1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-yl)-5,6-- dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yloxy)propanamide; (2S)-2-(2-(1-isopropyl-1H-11580493,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]i- midazo[1,2-d][1,4]oxazepin-9-yloxy)butanamide; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-9-methoxy-5,6-dihydrobenzo- [f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-9-methoxy-5,6-dihydrobenzo[f]imidaz- o[1,2-d][1,4]oxazepine; 9-ethoxy-2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[- f]imidazo[1,2-d][1,4]oxazepine; 9-isopropoxy-2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobe- nzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-9-(2,2,2-trifluoroethoxy)-- 5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-9-(oxetan-3-yloxy)-5,6-dih- ydrobenzo[f]imidazo[1,2-d][1,4]oxazepine; 9-cyclopropoxy-2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]i- midazo[1,2-d][1,4]oxazepine; 9-cyclobutoxy-2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]im- idazo[1,2-d][1,4]oxazepine; 9-cyclobutoxy-2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrob- enzo[f]imidazo[1,2-d][1,4]oxazepine; N-((3-aminooxetan-3-yl)methyl)-2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-- dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-amine; (3-amino-1-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imid- azo[1,2-d][1,4]oxazepin-9-yl)azetidin-3-yl)methanol; 2-(2-(1-(2,2,2-trifluoro ethyl)-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxaze- pin-9-ylamino)acetamide; 1-(2-(1-(2,2,2-trifluoro ethyl)-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxaze- pin-9-yloxy)cyclopropanecarboxamide; 2-(2-(1-(2,2,2-trifluoro ethyl)-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxaze- pin-9-yl)cyclopropanecarboxamide; (2S)-2-(2-(1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-yl)-5,6-dihydroben- zo[f]imidazo[1,2-d][1,4]oxazepin-9-ylamino)propanamide; 2-(2-(1-(2,2,2-trifluoro ethyl)-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxaze- pin-9-yl)cyclopropanecarboxamide; (2S)-3-hydroxy-2-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[- f]imidazo[1,2-d][1,4]oxazepin-9-yloxy)propanamide; 2-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d- ][1,4]oxazepin-9-yloxy)pentanamide; and 2-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d- ][1,4]oxazepin-9-yloxy)-4-methylpentanamide. 25. The method of claim 1 wherein the compound is selected from: 9-cyclopropoxy-2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydro- benzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d- ][1,4]oxazepin-9-yloxy)-3-methylbutanamide; 2-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d- ][1,4]oxazepin-9-ylthio)propanamide; 2-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d- ][1,4]oxazepin-9-ylthio)propanamide; (2S)-1-(2-(1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-yl)-5,6-dihydroben- zo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)azetidine-2-carboxamide; (2S)-2-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[- 1,2-d][1,4]oxazepin-9-ylamino)propanamide; (2S)-2-(2-(1-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2- -d][1,4]oxazepin-9-yloxy)propanamide; (2S)-4-hydroxy-2-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[- f]imidazo[1,2-d][1,4]oxazepin-9-yloxy)butanamide; (2S)-3-methoxy-2-(2-(1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-yl)-5,6-- dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-ylamino)propanamide; (2S)-1-(2-(1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-yl)-5,6-dihydroben- zo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)piperazine-2-carboxamide; (2S)-2-(2-(1-ethyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-- d][1,4]oxazepin-9-yloxy)propanamide; (2S)-2-(2-(1-tert-butyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo- [1,2-d][1,4]oxazepin-9-yloxy)propanamide; (2S)-2-(2-(1-(2,4-difluorophenyl)-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo- [f]imidazo[1,2-d][1,4]oxazepin-9-yloxy)propanamide; (2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][- 1,4]oxazepin-9-yl)methyl carbamate; (2S)-1-(2-(3-methyl-1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-yl)-5,6-d- ihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)pyrrolidine-2-carboxamide; 2-cyclopropyl-2-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f- ]imidazo[1,2-d][1,4]oxazepin-9-yloxy)acetamide; (2S)-2-((2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo- [1,2-d][1,4]oxazepin-9-yl)(methyl)amino)propanamide; (2S)-1-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[- 1,2-d][1,4]oxazepin-9-yl)azetidine-2-carboxamide; 1-((2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-- d][1,4]oxazepin-9-yl)methyl)-1-methylurea; (2S)-1-(2-(3-methyl-1-(2,2,2-trifluoroethyl)-1H-1,2,4-triazol-5-yl)-5,6-d- ihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)azetidine-2-carboxamide; (2S)-2-(2-(1-cyclopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidaz- o[1,2-d][1,4]oxazepin-9-yloxy)propanamide; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-10-phenyl-5,6-dihydrobenzo[f]imidaz- o[1,2-d][1,4]oxazepine; 1-isopropyl-5-(10-phenyl-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-2- -yl)-1H-1,2,4-triazol-3-amine; 2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-10-(pyrimidin-5-yl)-5,6-dihydrobenz- o[f]imidazo[1,2-d][1,4]oxazepine; 1-isopropyl-5-(10-(pyrimidin-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]- oxazepin-2-yl)-1H-1,2,4-triazol-3-amine; 1-(2-chlorophenyl)-5-(10-(pyrimidin-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-- d][1,4]oxazepin-2-yl)-1H-1,2,4-triazol-3-amine; 10-(4-chlorophenyl)-2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenz- o[f]imidazo[1,2-d][1,4]oxazepine; 5-(10-(4-chlorophenyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-2-y- l)-1-isopropyl-1H-1,2,4-triazol-3-amine; 10-(4-chlorophenyl)-2-(1-(2-chlorophenyl)-1H-1,2,4-triazol-5-yl)-5,6-dihy- drobenzo[f]imidazo[1,2-d][1,4]oxazepine; 2-(1-(2-chlorophenyl)-1H-1,2,4-triazol-5-yl)-10-phenyl-5,6-dihydrobenzo[f- ]imidazo[1,2-d][1,4]oxazepine; 1-(2-chlorophenyl)-5-(10-phenyl-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxa- zepin-2-yl)-1H-1,2,4-triazol-3-amine; 2-(1-(2-chlorophenyl)-1H-1,2,4-triazol-5-yl)-10-(pyrimidin-5-yl)-5,6-dihy- drobenzo[f]imidazo[1,2-d][1,4]oxazepine; 1-(2-chlorophenyl)-5-(10-(4-chlorophenyl)-5,6-dihydrobenzo[f]imidazo[1,2-- d][1,4]oxazepin-2-yl)-1H-1,2,4-triazol-3-amine; 9-(4-chlorophenyl)-2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo- [f]imidazo[1,2-d][1,4]oxazepine; 9-(4-chlorophenyl)-2-(1-(2-chlorophenyl)-1H-1,2,4-triazol-5-yl)-5,6-dihyd- robenzo[f]imidazo[1,2-d][1,4]oxazepine; 5-(9-(4-chlorophenyl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-2-yl- )-1-isopropyl-1H-1,2,4-triazol-3-amine; and 1-(2-chlorophenyl)-5-(9-(4-chlorophenyl)-5,6-dihydrobenzo[f]imidazo[1,2-d- ][1,4]oxazepin-2-yl)-1H-1,2,4-triazol-3-amine. 26. The method of claim 1 wherein the compound is 2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]i- midazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)ethanol. 27. The method of claim 1 wherein the compound is 2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]i- midazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide. 28. The method of claim 1 wherein the compound is 2-(4-(2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,- 2-d][1,4]oxazepin-9-yl)-1H-imidazol-1-yl)ethanol. 29. The method of claim 1 further comprising administering to the patient an additional therapeutic agent selected from a chemotherapeutic agent, an anti-inflammatory agent, an immunomodulatory agent, a neurotropic factor, an agent for treating cardiovascular disease, an agent for treating liver disease, an anti-viral agent, an agent for treating blood disorders, an agent for treating diabetes, and an agent for treating immunodeficiency disorders. 30. The method of claim 29 wherein the additional therapeutic agent is selected from trastuzumab, pertuzumab, letrozole, fulvestrant, paclitaxel, and docetaxel. 31. The method of claim 1 wherein the cancer is breast cancer.

Details for Patent 8,343,955

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Genentech, Inc.	HERCEPTIN	trastuzumab	For Injection	103792	09/25/1998		2039-02-26
Genentech, Inc.	HERCEPTIN	trastuzumab	For Injection	103792	02/10/2017		2039-02-26
Genentech, Inc.	PERJETA	pertuzumab	Injection	125409	06/08/2012		2039-02-26
Genentech, Inc.	HERCEPTIN HYLECTA	trastuzumab and hyaluronidase-oysk	Injection	761106	02/28/2019		2039-02-26