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Generated: September 18, 2019

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Claims for Patent: 8,323,643

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Summary for Patent: 8,323,643
Title:Methods for treating adhesive capsulitis
Abstract: The invention relates to the discovery that collagenase injections are effective in lyse the collagenous adhesions in the shoulder and treat the disorder, adhesive capsulitis. As such, the invention relates to methods of treating or preventing adhesive capsulitis, or frozen shoulder, in a patient in need of such treatment comprising injecting or otherwise delivering an effective amount of collagenase to the collagenous adhesions in the shoulder. The invention also relates to the use of collagenase in the manufacture of a medicament to treat adhesive capsulitis.
Inventor(s): Badalamente; Marie A. (Mt. Sinai, NY), Wang; Edward (Poluott, NY)
Assignee: The Research Foundation of State University of New York (Albany, NY)
Application Number:12/266,090
Patent Claims:1. A method of treating adhesive capsulitis in a subject in need of such treatment comprising delivering an effective amount of collagenase to collagenous adhesions in the shoulder, wherein the collagenase is obtained from Clostridium histolyticum, wherein the subject is a human patient and wherein the method comprises injecting collagenase to the patient in a dose of about 10,000 ABC units.

2. The method according to claim 1, wherein the collagenase is injected in a liquid pharmaceutically acceptable carrier wherein the volume of liquid injected is 0.5 ml or less.

3. The method according to claim 1, wherein the collagenase comprises collagenase I and collagenase II.

4. The method according to claim 2, wherein the injection is delivered in a single injection between the interval of the deltoid and pectoral muscles.

5. The method according to claim 1, wherein the patient is characterized by an active forward elevation of only 90 degrees and an active external rotation of less than 50 degrees.

6. The method according to claim 1, wherein after one month of receiving at least one administration of collagenase, the patient achieves an active external rotation of greater than 15.degree., as compared to baseline.

7. The method of claim 1, comprising administering one or two injections of about 10,000 ABC units of collagenase.

8. A method of treating adhesive capsulitis in a subject in need of such treatment comprising injecting collagenase in a dose of about 10,000 ABC units to collagenous adhesions in the shoulder of the subject, wherein the collagenase is injected in a liquid pharmaceutically acceptable carrier, wherein the volume of liquid injected is 0.5 ml or less, and wherein the collagenase is obtained from Clostridium histolyticum.

Details for Patent 8,323,643

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Advance Biofactures SANTYL collagenase VIAL 101995 001 1965-06-04   Try a Free Trial The Research Foundation of State University of New York (Albany, NY) 2025-01-21 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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