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Summary for Patent: 8,323,643
|Title:||Methods for treating adhesive capsulitis|
|Abstract:||The invention relates to the discovery that collagenase injections are effective in lyse the collagenous adhesions in the shoulder and treat the disorder, adhesive capsulitis. As such, the invention relates to methods of treating or preventing adhesive capsulitis, or frozen shoulder, in a patient in need of such treatment comprising injecting or otherwise delivering an effective amount of collagenase to the collagenous adhesions in the shoulder. The invention also relates to the use of collagenase in the manufacture of a medicament to treat adhesive capsulitis.|
|Inventor(s):||Badalamente; Marie A. (Mt. Sinai, NY), Wang; Edward (Poluott, NY)|
|Assignee:||The Research Foundation of State University of New York (Albany, NY)|
|Patent Claims:||1. A method of treating adhesive capsulitis in a subject in need of such treatment comprising delivering an effective amount of collagenase to collagenous adhesions in the
shoulder, wherein the collagenase is obtained from Clostridium histolyticum, wherein the subject is a human patient and wherein the method comprises injecting collagenase to the patient in a dose of about 10,000 ABC units.
2. The method according to claim 1, wherein the collagenase is injected in a liquid pharmaceutically acceptable carrier wherein the volume of liquid injected is 0.5 ml or less.
3. The method according to claim 1, wherein the collagenase comprises collagenase I and collagenase II.
4. The method according to claim 2, wherein the injection is delivered in a single injection between the interval of the deltoid and pectoral muscles.
5. The method according to claim 1, wherein the patient is characterized by an active forward elevation of only 90 degrees and an active external rotation of less than 50 degrees.
6. The method according to claim 1, wherein after one month of receiving at least one administration of collagenase, the patient achieves an active external rotation of greater than 15.degree., as compared to baseline.
7. The method of claim 1, comprising administering one or two injections of about 10,000 ABC units of collagenase.
8. A method of treating adhesive capsulitis in a subject in need of such treatment comprising injecting collagenase in a dose of about 10,000 ABC units to collagenous adhesions in the shoulder of the subject, wherein the collagenase is injected in a liquid pharmaceutically acceptable carrier, wherein the volume of liquid injected is 0.5 ml or less, and wherein the collagenase is obtained from Clostridium histolyticum.
|Applicant||Tradename||Biologic Ingredient||Dosage Form||BLA||Number||Approval Date||Patent No.||Assignee||Estimated Patent Expiration||Status||Orphan||Source|
|Smith And Nephew||SANTYL||collagenase||OINTMENT;TOPICAL||101995||001||1965-06-04||Start Trial||The Research Foundation of State University of New York (Albany, NY)||2025-01-21||RX||search|
|>Applicant||>Tradename||>Biologic Ingredient||>Dosage Form||>BLA||>Number||>Approval Date||>Patent No.||>Assignee||>Estimated Patent Expiration||>Status||>Orphan||>Source|
|Country||Patent Number||Estimated Expiration|
|South Africa||200705931||Start Trial|
|South Africa||200807221||Start Trial|
|World Intellectual Property Organization (WIPO)||2006078870||Start Trial|
|World Intellectual Property Organization (WIPO)||2007100590||Start Trial|
|World Intellectual Property Organization (WIPO)||2007100675||Start Trial|
|United States of America||10071143||Start Trial|
|>Country||>Patent Number||>Estimated Expiration|
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