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Last Updated: March 29, 2024

Claims for Patent: 8,299,106


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Summary for Patent: 8,299,106
Title:Compositions of kinase inhibitors and their use for treatment of cancer and other diseases related to kinases
Abstract: The present invention relates to novel thiazole-substituted indolin-2-ones as inhibitors of CSCPK and related kinases; to methods of inhibiting cancer stem cells by using a kinase inhibitor; to pharmaceutical compositions containing such compounds; and to methods of using such compounds in the treatment of a protein kinase related disorder in a mammal; and to processes of making such compounds and intermediates thereof.
Inventor(s): Li; Chiang Jia (Cambridge, MA), Liu; Ji-Feng (Winchester, MA), Li; Youzhi (Westwood, MA), Li; Wei (Wayland, MA), Rogoff; Harry (Wrentham, MA)
Assignee: Boston Biomedical, Inc. (Norwood, MA)
Application Number:12/676,869
Patent Claims:1. A compound selected from the group consisting of: ##STR00024## ##STR00025## and an enantiomer, diastereomer, tautomer, or pharmaceutically acceptable salt or solvate thereof.

2. A pharmaceutical composition comprising a compound or a pharmaceutically-acceptable salt thereof as claimed in claim 1 and a pharmaceutically-acceptable excipient, carrier, or diluent.

3. The pharmaceutical composition of claim 2, wherein the pharmaceutically-acceptable excipient, carrier, or diluent is a solution mixture or a suspension mixture comprising, by weight, about 12.5% of dimethylacetamide, about 52.5% of PEG400, and about 35% of 20% Vitamin E.

4. The pharmaceutical composition of claim 2, further comprising at least one other anti-cancer therapy agent.

5. The pharmaceutical composition of claim 4, wherein said anti-cancer therapy agent is at least one agent selected from the group consisting of radiotherapy (XRT) agents, cytotoxic agents, targeted agents, and adjunctive agents.

6. The pharmaceutical composition of claim 4 or 5, wherein said anti-cancer therapy agent is selected from the group consisting of gemcitabine, erlotinib, paclitaxel, docetaxel, carboplatin, cisplatin, 5-fluorouracil, doxorubicin, sorafenib, imatinib, bevacizumab, cetuximab, and trastuzumab.

Details for Patent 8,299,106

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 09/25/1998 ⤷  Try a Trial 2027-09-06
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 02/10/2017 ⤷  Try a Trial 2027-09-06
Eli Lilly And Company ERBITUX cetuximab Injection 125084 02/12/2004 ⤷  Try a Trial 2027-09-06
Eli Lilly And Company ERBITUX cetuximab Injection 125084 03/28/2007 ⤷  Try a Trial 2027-09-06
Genentech, Inc. AVASTIN bevacizumab Injection 125085 02/26/2004 ⤷  Try a Trial 2027-09-06
Genentech, Inc. HERCEPTIN HYLECTA trastuzumab and hyaluronidase-oysk Injection 761106 02/28/2019 ⤷  Try a Trial 2027-09-06
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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