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Last Updated: April 19, 2024

Claims for Patent: 8,273,794

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Summary for Patent: 8,273,794

Title:	Compounds and compositions for delivering active agents
Abstract:	Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
Inventor(s):	Gomez-Orellana; Maria Isabel (New Rochelle, NY), Gschneidner; David (Thornwood, NY), Leone-Bay; Andrea (Ridgefield, CT), Moye-Sherman; Destardi (Newburgh, NY), Pusztay; Stephen V. (Sleepy Hollow, NY), Rath; Parshuram (Yorktown Heights, NY), Tang; Pingwah (Elmsford, NY), Weidner; John J. (Wappingers Falls, NY), Song; Jianfeng (West Windsor, NJ)
Assignee:	Emisphere Technologies, Inc. (Cedar Knolls, NJ)
Application Number:	11/569,004
Patent Claims:	1. A compound selected from: ##STR00039## ##STR00040## ##STR00041## and salts thereof. 2. A pharmaceutical composition comprising: (A) at least one biologically active agent; and (B) a compound of claim 1. 3. The pharmaceutical composition of claim 2, wherein said biologically active agent is selected from the group consisting of Amylin, Amylin Agonists, Adrenocorticotropin, Antigens, Antimicrobials, Antibiotics, Anti-Bacteria's, Anti-Fungal Agents, Anti-Migraine Agents, Calcitonin Gene-Related Protein Antagonists, Sumatriptan Succinate, Antivirals, Atrial Naturetic Factor, Bisphosphonates, Salmon Calcitonin, Eel Calcitonin, Porcine Calcitonin, Human Calcitonin, Cholecystokinin (CCK), CCK Agonists; Cromolyn Sodium, Cyclosporine, Desferrioxamine (DFO), Erythropoietin, Exedin, Exedin Agonists, Filgrastim, Follicle Stimulating Hormone, Glucagon-Like Peptide 1 (GLP-1), Glucagon, Glucagon-Like Peptide 2 (GLP-2); Glucocerebrosidase, Gonadotropin Releasing Hormone, Growth Hormone Releasing Factor; Growth Hormone Releasing Hormones, Growth Hormones, Human Growth Hormones (hGH), Recombinant Human Growth Hormones (rhGH), Bovine Growth Hormones, Porcine Growth Hormones; Heparin, Unfractionated Heparin, Heparinoids, Dermatans, Chondroitins, Low Molecular Weight Heparin, Very Low Molecular Weight Heparin, Ultra Low Molecular Weight Heparin, synthetic heparins, Porcine Insulin, Bovine Insulin, Human Insulin, Human Recombinant Insulin; Insulin-Like Growth Factor, IGF-1; Interferons, .alpha. Interferons, .beta. Interferons, .theta. Interferons, .gamma. Interferons; Interleukin-1; Interleukin-2; Interleukin-11; Interleukin-21; Leutinizing Hormone, Leutinizing Hormone Releasing Hormone, Leptin, Monoclonal Antibodies, TNF-alpha soluble receptors, Oxytocin, Parathyroid Hormone (PTH), PTH fragments, PTH 1-34, PTH 1-38, Peptide YY (PYY), PYY Agonists, Prostaglandins; Protease Inhibitors, Somatostatin, Thrombopoietin, Vancomycin, Vasopressin, Vitamins, Vaccines, and combinations thereof. 4. A compound selected from: ##STR00042## ##STR00043## ##STR00044## ##STR00045## ##STR00046## ##STR00047## ##STR00048## ##STR00049## ##STR00050## ##STR00051## and salts thereof. 5. A pharmaceutical composition comprising: (A) at least one biologically active agent; and (B) a compound of claim 4. 6. A pharmaceutical composition comprising: (A) at least one biologically active agent; and (B) a compound selected from: ##STR00052## ##STR00053## ##STR00054## ##STR00055## ##STR00056## ##STR00057## ##STR00058## ##STR00059## ##STR00060## ##STR00061## and salts thereof, wherein said biologically active agent is selected from the group consisting of Amylin, Amylin Agonists, Adrenocorticotropin, Antigens, Antimicrobials, Antibiotics, Anti-Bacterials, Anti-Fungal Agents, Anti-Migraine Agents, Calcitonin Gene-Related Protein Antagonists, Sumatriptan Succinate, Antivirals, Atrial Naturetic Factor, Bisphosphonates, Salmon Calcitonin, Eel Calcitonin, Porcine Calcitonin, Human Calcitonin, Cholecystokinin (CCK), CCK Agonists; Cromolyn Sodium, Cyclosporine, Desferrioxamine (DFO), Erythropoietin, Exedin, Exedin Agonists, Filgrastim, Follicle Stimulating Hormone, Glucagon-Like Peptide 1 (GLP-1), Glucagon, Glucagon-Like Peptide 2 (GLP-2); Glucocerebrosidase, Gonadotropin Releasing Hormone, Growth Hormone Releasing Factor; Growth Hormone Releasing Hormones, Growth Hormones, Human Growth Hormones (hGH), Recombinant Human Growth Hormones (rhGH), Bovine Growth Hormones, Porcine Growth Hormones; Heparin, Unfractionated Heparin, Heparinoids, Dermatans, Chondroitins, Low Molecular Weight Heparin, Very Low Molecular Weight Heparin, Ultra Low Molecular Weight Heparin, synthetic heparins, Porcine Insulin, Bovine Insulin, Human Insulin, Human Recombinant Insulin; Insulin-Like Growth Factor, IGF-1; Interferons, .alpha. Interferons, .beta. Interferons, .theta. Interferons, .gamma. Interferons; Interleukin-1; Interleukin-2; Interleukin-11; Interleukin-21; Leutinizing Hormone, Leutinizing Hormone Releasing Hormone, Leptin, Monoclonal Antibodies, TNF-alpha soluble receptors, Oxytocin, Parathyroid Hormone (PTH), PTH fragments, PTH 1-34, PTH 1-38, Peptide YY (PYY), PYY Agonists, Prostaglandins; Protease Inhibitors, Somatostatin, Thrombopoietin, Vancomycin, Vasopressin, Vitamins, Vaccines, and combinations thereof. 7. A compound selected from: ##STR00062## ##STR00063## ##STR00064## and salts thereof. 8. A pharmaceutical composition comprising: (A) at least one biologically active agent; and (B) a compound of claim 7. 9. A pharmaceutical composition comprising: (A) at least one biologically active agent; and (B) a compound selected from ##STR00065## and salts thereof. 10. A compound selected from: ##STR00066## ##STR00067## ##STR00068## and salts thereof. 11. A pharmaceutical composition comprising: (A) at least one biologically active agent; and (B) a compound of claim 10. 12. A compound selected from: ##STR00069## and salts thereof. 13. A pharmaceutical composition comprising: (A) at least one biologically active agent; and (B) a compound of claim 12. 14. The pharmaceutical composition of claim 2, wherein the biologically active agent is recombinant human growth hormone. 15. The pharmaceutical composition of claim 2, wherein the biologically active agent is insulin. 16. The pharmaceutical composition of claim 2, wherein the biologically active agent is heparin. 17. The pharmaceutical composition of claim 2, wherein the biologically active agent is calcitonin. 18. The pharmaceutical composition of claim 2, wherein the biologically active agent is interferon. 19. The pharmaceutical composition of claim 2, wherein the biologically active agent is cromolyn sodium. 20. A compound according to claim 1, selected from Compounds 3, 4, 6, 8, 11, 13, 14, 16, 18, 19, 20, 21, and salts thereof. 21. A pharmaceutical composition comprising (A) at least one biologically active agent and (B) a compound of claim 20. 22. A compound according to claim 4, selected from Compounds 23-27, 30-35, 38, 39, 41-49, 51-55, 57-59, 61-65, 68, 69, 71-78, 80-85, 87, 88, 90-96, 98-104, 106-108, 110, and salts thereof. 23. A pharmaceutical composition comprising (A) at least one biologically active agent and (B) a compound of claim 22. 24. A compound selected from ##STR00070## ##STR00071## and salts thereof. 25. A pharmaceutical composition comprising (A) at least one biologically active agent and (B) a compound of claim 24.

Details for Patent 8,273,794

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Eli Lilly And Company	HUMULIN R U-100	insulin human	Injection	018780	10/28/1982	⤷ Try a Trial	2024-05-14
Eli Lilly And Company	HUMULIN R U-500	insulin human	Injection	018780	12/29/2015	⤷ Try a Trial	2024-05-14
Eli Lilly And Company	HUMULIN R U-100	insulin human	Injection	018780	08/06/1998	⤷ Try a Trial	2024-05-14
Eli Lilly And Company	HUMULIN R U-500	insulin human	Injection	018780	03/31/1994	⤷ Try a Trial	2024-05-14
Eli Lilly And Company	HUMULIN R U-100	insulin human	Injection	018780	05/25/2018	⤷ Try a Trial	2024-05-14
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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