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Last Updated: March 28, 2024

Claims for Patent: 8,206,757


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Summary for Patent: 8,206,757
Title:Composition of ashwagandha and indian gooseberry
Abstract: A therapeutic composition comprising extracts of the plant species ashwagandha (Withania somnifera) and Indian gooseberry (Phyllanthus emblica). A composition of ashwagandha and Indian gooseberry may: (1) lower cortisol and increase DHEA, (2) prevents free radical-induced photoaging, (3) inhibit collagenase activity in vitro, (4) inhibit hyaluronidase activity in vitro, (5) display superior cascading antioxidant activity, (6) reduce C-reactive protein, (7) enhance mood.
Inventor(s): McNeary; Peter (Brattleboro, VT)
Assignee: Nutragenesis, LLC (Brattleboro, VT) Natreon, Inc. (New Brunswick, NJ)
Application Number:12/604,092
Patent Claims:1. A therapeutic composition for internal use by a human subject in the reduction of premature skin aging consisting essentially of a skin age reducing synergistically effective combination of an extract of Phyllanthus emblica and an extract of Withania somnifera wherein said Phyllanthus emblica and said Withania somnifera are present in the composition in a weight ratio of about 1:7 Phyllanthus emblica to Withania somnifera to a weight ratio of about 7:1 Phyllanthus emblica to Withania somnifera.

2. The therapeutic composition according to claim 1, wherein said Phyllanthus emblica and said Withania somnifera are present in the composition in a weight ratio of about 6:2 Phyllanthus emblica to Withania somnifera to a weight ratio of about 2:6 Phyllanthus emblica to Withania somnifera.

3. The therapeutic composition according to claim 1, wherein the Phyllanthus emblica and Withania somnifera are present in the composition in a weight ratio of about 6:2 Phyllanthus emblica to Withania somnifera to a weight ratio of about 3:5 Phyllanthus emblica to Withania somnifera.

4. The therapeutic composition according to claim 1, wherein the Phyllanthus emblica and Withania somnifera are present in the composition in a weight ratio of about 6:2 Phyllanthus emblica to Withania somnifera to a weight ratio of about 2:2 Phyllanthus emblica to Withania somnifera.

5. The therapeutic composition according to claim 1, wherein the Phyllanthus emblica and Withania somnifera are present in the composition in a weight ratio of about 5:3.

6. The therapeutic composition according to claim 1, comprising about 60 wt. % Withania somnifera to about 65 wt. % Withania somnifera and about 35 wt. % Phyllanthus emblica to about 40 wt. % Phyllanthus emblica.

7. The therapeutic composition according to claim 1, wherein said synergistically effective combination includes Phyllanthus emblica to Withania somnifera in a weight to weight ratio that is effective to synergistically inhibit collagenase.

8. The therapeutic composition according to claim 7, wherein said synergistically effective combination includes Phyllanthus emblica to Withania somnifera in a weight to weight ratio that is effective to provide at least a 50% activity inhibition of collagenases Type I and Type IV.

9. The therapeutic composition according to claim 1, wherein said synergistically effective combination includes Phyllanthus emblica to Withania somnifera in a weight to weight ratio that is effective to synergistically inhibit hyaluronidase.

10. The therapeutic composition according to claim 9, wherein said synergistically effective combination includes Phyllanthus emblica to Withania somnifera in a weight to weight ratio that is effective to provide at least 86% inhibition of hyaluronidase activity at 1:1000.

11. The therapeutic composition according to claim 1, wherein said synergistically effective combination includes Phyllanthus emblica to Withania somnifera in a weight to weight ratio that is effective to provide an ORAC (Oxygen Radical Absorbance Capacity) value of at least 967 .mu.mole Trolox equivalents/g.

12. The therapeutic composition according to claim 1, wherein said synergistically effective combination includes Phyllanthus emblica to Withania somnifera in a weight to weight ratio that is effective to provide an HORAC (Hydroxyl Radical Antioxidant Capacity) value of 154 .mu.mole caffeic acid equivalents/g.

Details for Patent 8,206,757

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Bausch & Lomb Incorporated VITRASE hyaluronidase Injection 021640 05/05/2004 ⤷  Try a Trial 2028-10-22
Bausch & Lomb Incorporated VITRASE hyaluronidase Injection 021640 12/02/2004 ⤷  Try a Trial 2028-10-22
Amphastar Pharmaceuticals, Inc. AMPHADASE hyaluronidase Injection 021665 10/26/2004 ⤷  Try a Trial 2028-10-22
Akorn, Inc. HYDASE hyaluronidase Injection 021716 10/25/2005 ⤷  Try a Trial 2028-10-22
Smith & Nephew, Inc. SANTYL collagenase Ointment 101995 06/04/1965 ⤷  Try a Trial 2028-10-22
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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