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Last Updated: April 25, 2024

Claims for Patent: 8,187,881

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Summary for Patent: 8,187,881

Title:	Methods related to wound healing
Abstract:	The invention is directed to methods for the treatment of wounds. Such methods utilize novel compositions, including but not limited to amnion-derived multipotent cells (herein referred to as AMP cells), conditioned media derived therefrom (herein referred to as amnion-derived cellular cytokine suspension or ACCS), cell lysates derived therefrom, cell products derived therefrom, each alone or in combination.
Inventor(s):	Smith; Charlotte A. (Pittsburgh, PA), Trumpower; Catherine J. (Pittsburgh, PA), Marshall; Vivienne S. (Glenshaw, PA)
Assignee:	Stemnion, Inc. (Pittsburgh, PA)
Application Number:	12/592,658
Patent Claims:	1. A method for accelerating wound healing of a treated burn wound as compared to the healing rate of a non-treated burn wound in a patient in need thereof comprising treating the burn wound by topically administering to the patient's burn wound 0.50 .mu.L-2000 .mu.L conditioned medium per cm.sup.2 of burn wound, wherein the conditioned medium is made by a) obtaining a placenta and isolating an amnion from the placenta; b) enzymatically releasing amnion-derived epithelial cells from the amnion; c) collecting the released amnion-derived epithelial cells; d) culturing the collected amnion-derived epithelial cells of step (c) in basal culture medium that is supplemented with human serum albumin and human recombinant EGF; and e) collecting the conditioned medium. 2. The method of claim 1 wherein the treatment increases tensile strength and breaking strength of the healing treated burn wound as compared to the tensile strength and breaking strength in a healing non-treated burn wound. 3. The method of claim 1 wherein the treatment reduces fibrosis and collagen contraction in a healing treated burn wound as compared to the fibrosis and collagen contraction in a healing non-treated burn wound. 4. The method of claim 1 wherein the conditioned medium is pooled conditioned medium.

Details for Patent 8,187,881

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Grifols Therapeutics Llc	ALBUKED, PLASBUMIN-20, PLASBUMIN-25, PLASBUMIN-5	albumin (human)	For Injection	101138	10/21/1942	⤷ Try a Trial	2025-03-31
Baxalta Us Inc.	BUMINATE, FLEXBUMIN	albumin (human)	Injection	101452	03/03/1954	⤷ Try a Trial	2025-03-31
Csl Behring Ag	ALBURX	albumin (human)	Injection	102366	07/23/1976	⤷ Try a Trial	2025-03-31
Grifols Biologicals Llc	ALBUTEIN	albumin (human)	Injection	102478	08/15/1978	⤷ Try a Trial	2025-03-31
Instituto Grifols, S.a.	HUMAN ALBUMIN GRIFOLS	albumin (human)	Injection	103352	02/17/1995	⤷ Try a Trial	2025-03-31
Instituto Grifols, S.a.	HUMAN ALBUMIN GRIFOLS	albumin (human)	Injection	103352	06/11/2003	⤷ Try a Trial	2025-03-31
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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