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Last Updated: March 28, 2024

Claims for Patent: 8,158,360


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Summary for Patent: 8,158,360
Title:Effects of inhibitors of FGFR3 on gene transcription
Abstract: Methods of utilizing biomarkers to identify patients for treatment or to monitor response to treatment are taught herein. Alterations in levels of gene expression of the biomarkers, particularly in response to FGFR3 inhibition, are measured and identifications or adjustments may be made accordingly.
Inventor(s): Heise; Carla (Benicia, CA), Masih-Khan; Esther (Ontario, CA), Moler; Edward (Walnut Creek, CA), Rowe; Michael (Oakland, CA), Stewart; Keith (Scottsdale, AZ), Trudel; Suzanne (Ontario, CA)
Assignee: Novartis AG (Basel, CH)
Application Number:12/096,222
Patent Claims:1. A method of identifying a patient for treatment of a cell proliferative disorder with an inhibitor of FGFR3, the method comprising: testing a sample obtained from the patient after administration of the inhibitor to measure gene expression of at least one biomarker which is CCL3, wherein detection of an alteration in level of expression compared to a baseline gene expression measurement of the at least one biomarker is indicative of the candidacy of the patient for the treatment, and wherein the baseline gene expression measurement is the gene expression measured in the patient prior to administration of the inhibitor.

2. A method of identifying a patient for treatment of a cell proliferative disorder with an inhibitor of FGFR3, the method comprising: testing a sample obtained from a patient to measure gene expression of at least one biomarker which is CCL3, wherein detection of the presence of gene expression of the at least one biomarker is indicative of the candidacy of the patient for the treatment.

3. A method of monitoring response of a patient in need thereof to treatment for a cell proliferative disorder, the method comprising: administering an amount of an inhibitor of FGFR3 to the patient, testing a sample obtained from the patient after the administration of the inhibitor to measure gene expression of at least one biomarker which is CCL3, wherein detection of an alteration in level of expression of the at least one biomarker as compared to a baseline gene expression measurement is indicative of a response of the patient to the treatment, and wherein the baseline gene expression measurement is the gene expression measured in the patient prior to administration of the inhibitor.

4. A method of monitoring response of a patient to treatment by an inhibitor of FGFR3 for a cell proliferative disorder, the method comprising: testing a sample obtained from the patient after administration of the inhibitor of FGFR3 to measure gene expression of at least one biomarker which is CCL3, wherein detection of an alteration in level of expression of the at least one biomarker compared to a baseline gene expression measurement is indicative of a response of the patient to the treatment, and wherein the baseline gene expression measurement is the gene expression measured in the patient prior to administration of the inhibitor.

5. A method of utilizing a biomarker in treatment of a cell proliferative disorder in a patient, the method comprising testing a sample obtained from the patient after administration of an inhibitor of FGFR3 to measure gene expression of at least one biomarker which is CCL3, wherein the patient is subsequently administered the same or a different inhibitor of FGFR3 provided alteration of the level of expression of the at least one biomarker is detected upon administration of the initial inhibitor.

6. A method of adjusting a dosage amount of an inhibitor of FGFR3 for treatment of a cell proliferative disorder in a patient, the method comprising: monitoring gene expression of at least one biomarker which is CCL3 after the administration of an initial amount of the inhibitor, and adjusting the amount for subsequent administration of the inhibitor to the patient based upon the level of alteration of the expression of the biomarker or biomarkers that has occurred upon administration of the initial amount.

7. A method of utilizing a biomarker to identify an FGFR3 inhibitory compound for potential treatment of multiple myeloma or to guide a decision to progress an FGFR3 inhibitory compound to further development for treatment of multiple myeloma, the method comprising: contacting the compound with a KMS18 or KMS11 cell culture, and testing a portion of the cell culture to measure gene expression of at least one biomarker which is CCL3, wherein detection of an alteration in expression of the at least one biomarker compared to baseline gene expression measurement is indicative of an identification of the compound for treatment or a favorable decision to progress the compound for further development, and wherein the baseline gene expression measurement is gene expression measured in cell culture prior to the contacting.

8. A method of selecting an appropriate inhibitor of FGFR3 to administer to a patient in need of treatment with said inhibitor, the method comprising: testing a sample obtained from the patient after administration of an initial inhibitor of FGFR3 to measure gene expression of at least one biomarker which is CCL3, wherein the patient is subsequently administered the initial inhibitor of FGFR3 provided alteration of the level of expression of the at least one biomarker is detected upon administration of the initial inhibitor.

9. A method of utilizing CCL3 to identify an FGFR3 inhibitory compound for potential treatment of a cell proliferative disorder, the method comprising: contacting the compound with a cell line or tissue associated with the disorder, and testing a portion of the cell culture or tissue after the contacting to measure gene expression of at least one biomarker which is CCL3 that has been altered compared to a baseline gene expression measurement, wherein detection of an alteration in expression of the at least one biomarker is indicative of an identification of the compound for treatment, and wherein the baseline gene expression measurement is the gene expression measured from the cell or tissue prior to the contacting.

10. The method of claim 1, wherein the measurement of gene expression is made by detecting the quantity of RNA transcribed by the biomarker.

11. The method of claim 1, wherein the measurement of gene expression is made by detecting the quantity of DNA produced from reverse transcription of an RNA transcribed by the biomarker.

12. The method of claim 1, wherein the measurement of gene expression is made by detecting a polypeptide or protein encoded by the biomarker.

13. The method of claim 1, wherein the at least one biomarker is operably linked to a gene chip.

14. The method of claim 1, wherein the at least one biomarker is represented in computer readable format.

15. The method of claim 1, wherein the testing comprises contacting the sample with a gene chip comprising CCL3.

16. The method of claim 1, wherein the detecting step comprises comparing the gene expression level of the biomarker with a gene database.

17. The method of claim 1, wherein the treatment comprises administration of a therapeutically effective amount of the same or a different inhibitor of FGFR3 to the patient.

18. The method of claim 1, wherein the treatment is for a neoplastic disease.

19. The method of claim 1, wherein the treatment is for multiple myeloma.

20. The method of claim 1, wherein the treatment is for t(4; 14) multiple myeloma.

21. The method of claim 1, wherein the inhibitor is selected from the group consisting of CHIR-258, SU-5402, and PD-173074.

22. The method of claim 1, wherein the inhibitor is CHIR-258.

23. The method of claim 1, wherein the at least one biomarker further comprises a biomarker selected from the group consisting of LOC150271, CD48, DUSP4, and ITGB7.

24. The method of claim 1, further comprising establishing a baseline gene expression measurement level for the patient prior to administering the FGFR3 inhibitor.

25. The method of claim 1, wherein the biomarker is not any or all of CCL3, DUSP6, ANXA9, CR2, AL531683, ZNF589, AW274468, FRMD3, LTB, and WDR42A.

26. The method of claim 3, wherein the administration is repeated before the step of testing a sample obtained from the patient.

27. The method of claim 3, wherein the inhibitor of FGFR3 is administered in a therapeutically effective amount.

28. The method of claim 5, wherein the initial inhibitor and the subsequently administered inhibitor are each selected from the group consisting of CHIR-258, SU-5402, and PD-173074.

29. The method of claim 5, wherein the initial inhibitor is CHIR-258.

30. The method of claim 5, wherein the subsequently administered inhibitor is CHIR-258.

31. The method of claim 6, wherein the monitoring comprises contacting the sample with a gene chip comprising CCL3 and comparing the gene expression level of CCL3 with a gene database.

32. The method of any one of claims 1-5 or 6-9, wherein the at least one biomarker further comprises one or more biomarkers selected Table I. TABLE-US-00006 TABLE I ENTREZ GENE ID GENE SYMBOL GENE DESCRIPTION 200734 SPRED2 sprouty-related, EVH1 domain containing 2 117854 TRIM6 tripartite motif-containing 6 1846 DUSP4 dual specificity phosphatase 4 894 CCND2 cyclin D2 6241 RRM2 ribonucleotide reductase M2 polypeptide 4821 NKX2-2 NK2 transcription factor related, locus 2 (Drosophila) 3037 HAS2 hyaluronan synthase 2 990 CDC6 CDC6 cell division cycle 6 homolog (S. cerevisiae) 57405 SPBC25 spindle pole body component 25 homolog (S. cerevisiae) 934 CD24 CD24 antigen (small cell lung carcinoma cluster 4 antigen) 55165 C10orf3 chromosome 10 open reading frame 3 55388 MCM10 MCM10 minichromosome maintenance deficient 10 (S. cerevisiae) 79019 C22orf18 chromosome 22 open reading frame 18 9768 KIAA0101 KIAA0101 51659 Pfs2 DNA replication complex GINS protein PSF2 4605 MYBL2 v-myb myeloblastosis viral oncogene homolog (avian)-like 2 161742 SPRED1 sprouty-related, EVH1 domain containing 1 4175 MCM6 MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae) 11130 ZWINT ZW10 interactor 26298 EHF ets homologous factor 7117 TMSL3 thymosin-like 3 890 CCNA2 cyclin A2 79075 DCC1 defective in sister chromatid cohesion homolog 1 (S. cerevisiae) 83879 CDCA7 cell division cycle associated 7 22873 DZIP1 DAZ interacting protein 1 51514 DTL denticleless homolog (Drosophila) 55789 DEPDC1B DEP domain containing 1B 55355 DKFZp762E1312 hypothetical protein DKFZp762E1312 10052 GJA7 gap junction protein, alpha 7, 45kDa (connexin 45) 146909 LOC146909 hypothetical protein LOC146909 113130 CDCA5 cell division cycle associated 5 1017 CDK2 cyclin-dependent kinase 2 4176 MCM7 MCM7 minichromosome maintenance deficient 7 (S. cerevisiae) 81610 C20orf129 chromosome 20 open reading frame 129 9833 MELK maternal embryonic leucine zipper kinase 29128 UHRF1 ubiquitin-like, containing PHD and RING finger domains, 1 4171 MCM2 MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae) 79801 SHCBP1 SHC SH2-domain binding protein 1 28231 SLCO4A1 solute carrier organic anion transporter family, member 4A1 113115 FAM54A family with sequence similarity 54, member A 22974 TPX2 TPX2, microtubule-associated protein homolog (Xenopus laevis) 9232 PTTG1 pituitary tumor-transforming 1 137392 LOC137392 similar to CG6405 gene product 195828 ZNF367 zinc finger protein 367 4288 MKI67 antigen identified by monoclonal antibody Ki-67 701 BUB1B BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) 9928 KIF14 kinesin family member 14 3832 KIF11 kinesin family member 11 11065 UBE2C ubiquitin-conjugating enzyme E2C 9837 PSF1 DNA replication complex GINS protein PSF1 387103 C6orf173 chromosome 6 open reading frame 173 1870 E2F2 E2F transcription factor 2 79733 E2F8 E2F transcription factor 8 991 CDC20 CDC20 cell division cycle 20 homolog (S. cerevisiae) 3014 H2AFX H2A histone family, member X 10112 KIF20A kinesin family member 20A 993 CDC25A cell division cycle 25A 24137 KIF4A kinesin family member 4A 80144 FRAS1 Fraser syndrome 1 55010 FLJ20641 hypothetical protein FLJ20641 9319 TRIP13 thyroid hormone receptor interactor 13 9355 LHX2 LIM homeobox 2 7153 TOP2A topoisomerase (DNA) II alpha 170kDa 4174 MCM5 MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) 55215 FLJ10719 hypothetical protein FLJ10719 11013 TMSL8 thymosin-like 8 5983 RFC3 replication factor C (activator 1) 3, 38kDa 1063 CENPF centromere protein F, 350/400ka (mitosin) 3683 ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 2237 FEN1 flap structure-specific endonuclease 1 27338 UBE2S ubiquitin-conjugating enzyme E2S 4001 LMNB1 lamin B1 29089 UBE2T ubiquitin-conjugating enzyme E2T (putative) 55839 BM039 uncharacterized bone marrow protein BM039 2115 ETV1 ets variant gene 1 440279 UNC13C unc-13 homolog C (C. elegans) 962 CD48 CD48 antigen (B-cell membrane protein) 54910 SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C 1902 EDG2 endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2 64946 CENPH centromere protein H 157570 ESCO2 establishment of cohesion 1 homolog 2 (S. cerevisiae) 389835 FAM72A family with sequence similarity 72, member A 144455 E2F7 E2F transcription factor 7 51512 GTSE1 G-2 and S-phase expressed 1 7298 TYMS thymidylate synthetase 7374 UNG uracil-DNA glycosylase 5578 PRKCA protein kinase C, alpha 672 BRCA1 breast cancer 1, early onset 84952 CGNL1 cingulin-like 1 10252 SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 79682 MLF1IP MLF1 interacting protein 8851 CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) 10635 RAD51AP1 RAD51 associated protein 1 22998 KIAA1102 KIAA1102 protein 148203 LOC148203 hypothetical protein LOC148203 7465 WEE1 WEE1 homolog (S. pombe) 83540 CDCA1 cell division cycle associated 1 3070 HELLS helicase, lymphoid-specific 891 CCNB1 cyclin B1 6790 STK6 serine/threonine kinase 6 56992 KIF15 kinesin family member 15 7112 TMPO thymopoietin 63901 FLJ22794 FLJ22794 protein 9493 KIF23 kinesin family member 23 9133 CCNB2 cyclin B2 4173 MCM4 MCM4 minichromosome maintenance deficient 4 (S. cerevisiae) 7083 TK1 thymidine kinase 1, soluble 983 CDC2 cell division cycle 2, G1 to S and G2 to M 11339 OIP5 Opa interacting protein 5 51203 NUSAP1 nucleolar and spindle associated protein 1 5111 PCNA proliferating cell nuclear antigen 11004 KIF2C kinesin family member 2C 54443 ANLN anillin, actin binding protein (scraps homolog, Drosophila) 83461 CDCA3 cell division cycle associated 3 4085 MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 9201 DCAMKL1 doublecortin and CaM kinase-like 1 1111 CHEK1 CHK1 checkpoint homolog (S. pombe) 9055 PRC1 protein regulator of cytokinesis 1 7804 LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor 4915 NTRK2 neurotrophic tyrosine kinase, receptor, type 2 28951 TRIB2 tribbles homolog 2 (Drosophila) 4281 MID1 midline 1 (Opitz/BBB syndrome) 3148 HMGB2 high-mobility group box 2 3161 HMMR hyaluronan-mediated motility receptor (RHAMM) 10276 NET1 neuroepithelial cell transforming gene 1 29028 ATAD2 ATPase family, AAA domain containing 2 1062 CENPE centromere protein E, 312kDa 1491 CTH cystathionase (cystathionine gamma-lyase) 10615 SPAG5 sperm associated antigen 5 64581 CLEC7A C-type lectin domain family 7, member A 10592 SMC2L1 SMC2 structural maintenance of chromosomes 2-like 1 (yeast) 332 BIRC5 baculoviral IAP repeat-containing 5 (survivin) 4172 MCM3 MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) 64105 FKSG14 leucine zipper protein FKSG14 64151 HCAP-G chromosome condensation protein G 1163 CKS1B CDC28 protein kinase regulatory subunit 1B 122769 PPIL5 peptidylprolyl isomerase (cyclophilin)-like 5 3398 ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 22822 PHLDA1 pleckstrin homology-like domain, family A, member 1 1718 DHCR24 24-dehydrocholesterol reductase 145482 ZADH1 zinc binding alcohol dehydrogenase, domain containing 1 1847 DUSP5 dual specificity phosphatase 5 26271 FBXO5 F-box protein 5 9212 AURKB aurora kinase B 29968 PSAT1 phosphoserine aminotransferase 1 26147 PHF19 PHD finger protein 19 55635 DEPDC1 DEP domain containing 1 10403 KNTC2 kinetochore associated 2 64081 MAWBP MAWD binding protein 84858 ZNF503 zinc finger protein 503 55723 ASF1B ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 7272 TTK TTK protein kinase 9535 GMFG glia maturation factor, gamma 1058 CENPA centromere protein A, 17kDa 84515 MCM8 MCM8 minichromosome maintenance deficient 8 (S. cerevisiae) 54069 C21orf45 chromosome 21 open reading frame 45 5984 RFC4 replication factor C (activator 1) 4, 37kDa 389831 LOC389831 hypothetical gene supported by AL713796 157313 CDCA2 cell division cycle associated 2 29127 RACGAP1 Rac GTPase activating protein 1 55872 PBK PDZ binding kinase 4678 NASP nuclear autoantigenic sperm protein (histone-binding) 7171 TPM4 tropomyosin 4 7443 VRK1 vaccinia related kinase 1 699 BUB1 BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) 3925 STMN1 stathmin 1/oncoprotein 18 865 CBFB core-binding factor, beta subunit 399664 RKHD1 ring finger and KH domain containing 1 11168 PSIP1 PC4 and SFRS1 interacting protein 1 84057 GAJ GAJ protein 57082 CASC5 cancer susceptibility candidate 5 23286 KIBRA KIBRA protein 285513 LOC285513 hypothetical protein LOC285513 259266 ASPM asp (abnormal spindle)-like, microcephaly associated (Drosophila) 150468 FLJ40629 hypothetical protein FLJ40629 6659 SOX4 SRY (sex determining region Y)-box 4 51053 GMNN geminin, DNA replication inhibitor 3159 HMGA1 high mobility group AT-hook 1 81620 CDT1 DNA replication factor 11332 BACH brain acyl-CoA hydrolase 4751 NEK2 NIMA (never in mitosis gene a)-related kinase 2 1033 CDKN3 cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase) 8864 PER2 period homolog 2 (Drosophila) 3418 IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 63979 FIGNL1 fidgetin-like 1 55646 LYAR hypothetical protein FLJ20425 91614 LOC91614 novel 58.3 KDA protein 8630 HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6 1038 CDR1 cerebellar degeneration-related protein 1, 34kDa 6941 TCF19 transcription factor 19 (SC1) 256435S T6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosamini- de alpha-2,6-sialyltransferase 3 54892 LUZP5 leucine zipper protein 5 4603 MYBL1 v-myb myeloblastosis viral oncogene homolog (avian)-like 1 1719 DHFR dihydrofolate reductase 170954 KIAA1949 KIAA1949 7903 ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 9787 DLG7 discs, large homolog 7 (Drosophila) 56935 FN5 FN5 protein 3015 H2AFZ H2A histone family, member Z 10189 THOC4 THO complex 4 494143 LOC494143 similar to RIKEN cDNA 2510006C20 gene 6240 RRM1 ribonucleotide reductase M1 polypeptide 1894 ECT2 epithelial cell transforming sequence 2 oncogene 7913 DEK DEK oncogene (DNA binding) 2146 EZH2 enhancer of zeste homolog 2 (Drosophila) 55055 FLJ10036 Zwilch 11073 TOPBP1 topoisomerase (DNA) II binding protein 1 55502 HES6 hairy and enhancer of split 6 (Drosophila) 55247 NEIL3 nei endonuclease VIII-like 3 (E. coli) 54885 FLJ20298 FLJ20298 protein 83641 C10orf45 chromosome 10 open reading frame 45 64919 BCL11B B-cell CLL/lymphoma 11B (zinc finger protein) 26095 PTPN20 protein tyrosine phosphatase, non-receptor type 20 23590 TPRT trans-prenyltransferase 387882 LOC387882 hypothetical protein 51232 CRIM1 cysteine-rich motor neuron 1 801 CALM1 calmodulin 1 (phosphorylase kinase, delta) 55964 SEPT3 septin 3 493861 EID3 E1A-like inhibitor of differentiation 3 29980 DONSON downstream neighbor of SON 147138 EVER2 epidermodysplasia verruciformis 2 80150 ASRGL1 asparaginase like 1 5985 RFC5 replication factor C (activator 1) 5, 36.5kDa 51155 HN1 hematological and neurological expressed 1 7004 TEAD4 TEA domain family member 4 4325 MMP16 matrix metalloproteinase 16 (membrane-inserted)

203068 TUBB tubulin, beta polypeptide 4602 MYB v-myb myeloblastosis viral oncogene homolog (avian) 55706 TMEM48 transmembrane protein 48 348235 FAM33A family with sequence similarity 33, member A 8871 SYNJ2 synaptojanin 2 81563 C1orf21 chromosome 1 open reading frame 21 51192 CKLF chemokine-like factor 2326 FMO1 flavin containing monooxygenase 1 91057 NY-REN-41 NY-REN-41 antigen 10376 K-ALPHA-1 tubulin, alpha, ubiquitous 23234 DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 5982 RFC2 replication factor C (activator 1) 2, 40kDa 51063 FAM26B family with sequence similarity 26, member B 9953 HS3ST3B1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 79723 SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila) 79596 C13orf7 chromosome 13 open reading frame 7 23165 NUP205 nucleoporin 205kDa 9530 BAG4 BCL2-associated athanogene 4 3146 HMGB1 high-mobility group box 1 445815 PALM2-AKAP2 PALM2-AKAP2 protein 5557 PRIM1 primase, polypeptide 1, 49kDa 2983 GUCY1B3 guanylate cyclase 1, soluble, beta 3 51776 ZAK sterile alpha motif and leucine zipper containing kinase AZK 10926 ASK activator of S phase kinase 8833 GMPS guanine monphosphate synthetase 84930 MASTL microtubule associated serine/threonine kinase-like 90417 C15orf23 chromosome 15 open reading frame 23 8530 CST7 cystatin F (leukocystatin) 9532 BAG2 BCL2-associated athanogene 2 23310 hCAP-D3 KIAA0056 protein 283991 MGC29814 hypothetical protein MGC29814 91607 FLJ34922 hypothetical protein FLJ34922 7398 USP1 ubiquitin specific protease 1 2669 GEM GTP binding protein overexpressed in skeletal muscle 151246 SGOL2 shugoshin-like 2 (S. pombe) 23421 ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 84969 C20orf100 chromosome 20 open reading frame 100 201725 LOC201725 hypothetical protein LOC201725 5361 PLXNA1 plexin A1 3708 ITPR1 inositol 1,4,5-triphosphate receptor, type 1 55740 ENAH enabled homolog (Drosophila) 126731 C1orf96 chromosome 1 open reading frame 96 57037 ANKMY2 ankyrin repeat and MYND domain containing 2 23331 KIAA1043 KIAA1043 protein 3930 LBR lamin B receptor 3838 KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 1230 CCR1 chemokine (C-C motif) receptor 1 2200 FBN1 fibrillin 1 (Marfan syndrome) 6867 TACC1 transforming, acidic coiled-coil containing protein 1 27115 PDE7B phosphodiesterase 7B 11151 CORO1A coronin, actin binding protein, 1A 6385 SDC4 syndecan 4 (amphiglycan, ryudocan) 3182 HNRPAB heterogeneous nuclear ribonucleoprotein A/B 5757 PTMA prothymosin, alpha (gene sequence 28) 83990 BRIP1 BRCA1 interacting protein C-terminal helicase 1 9830 TRIM14 tripartite motif-containing 14 57761 TRIB3 tribbles homolog 3 (Drosophila) 2026 ENO2 enolase 2 (gamma, neuronal) 8727 CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 5880 RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 864 RUNX3 runt-related transcription factor 3 10950 BTG3 BTG family, member 3 81539 SLC38A1 solute carrier family 38, member 1 26051 PPP1R16B protein phosphatase 1, regulatory (inhibitor) subunit 16B 5793 PTPRG protein tyrosine phosphatase, receptor type, G 2767 GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 55013 FLJ20647 hypothetical protein FLJ20647 4885 NPTX2 neuronal pentraxin II 79710 MORC4 MORC family CW-type zinc finger 4 490 ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 2956 MSH6 mutS homolog 6 (E. coli) 6611 SMS spermine synthase 6627 SNRPA1 small nuclear ribonucleoprotein polypeptide A' 1434 CSE1L CSE1 chromosome segregation 1-like (yeast) 7371 UCK2 uridine-cytidine kinase 2 7277 TUBA1 tubulin, alpha 1 (testis specific) 1786 DNMT1 DNA (cytosine-5-)-methyltransferase 1 54801 FAM29A family with sequence similarity 29, member A 54908 FLJ20364 hypothetical protein FLJ20364 119467 MGC32871 hypothetical protein MGC32871 90390 THRAP6 thyroid hormone receptor associated protein 6 60468 BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 6510 SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 6628 SNRPB small nuclear ribonucleoprotein polypeptides B and B1 205 AK3L1 adenylate kinase 3-like 1 116832 RPL39L ribosomal protein L39-like 79902 PCNT1 pericentrin 1 54962 FLJ20516 timeless-interacting protein 23279 NUP160 nucleoporin 160kDa 23046 KIF21B kinesin family member 21B 2288 FKBP4 FK506 binding protein 4, 59kDa 5698 PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional protease 2) 10160 FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 8502 PKP4 plakophilin 4 10675 CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C) 29899 GPSM2 G-protein signalling modulator 2 (AGS3-like, C. elegans) 10602 CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 8243 SMC1L1 SMC1 structural maintenance of chromosomes 1-like 1 (yeast) 6347 CCL2 chemokine (C-C motif) ligand 2 5932 RBBP8 retinoblastoma binding protein 8 6877 TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa 10801 SEPT9 septin 9 55536 CDCA7L cell division cycle associated 7-like 11340 EXOSC8 exosome component 8 5873 RAB27A RAB27A, member RAS oncogene family 53354 PANK1 pantothenate kinase 1 2534 FYN FYN oncogene related to SRC, FGR, YES 55166 C6orf139 chromosome 6 open reading frame 139 27346 MAC30 hypothetical protein MAC30 79037 MGC2463 hypothetical protein MGC2463 116496 C1orf24 chromosome 1 open reading frame 24 84314 MGC10744 hypothetical protein MGC10744 23531 MMD monocyte to macrophage differentiation-associated 6558 SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporters), member 2 64282 PAPD5 PAP associated domain containing 5 55636 CHD7 chromodomain helicase DNA binding protein 7 55026 FLJ20716 hypothetical protein FLJ20716 22929 SEPHS1 selenophosphate synthetase 1 10541 ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 79621 FLJ11712 hypothetical protein FLJ11712 6432 SFRS7 splicing factor, arginine/serine-rich 7, 35kDa 5214 PFKP phosphofructokinase, platelet 26031 OSBPL3 oxysterol binding protein-like 3 1102 RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 6929 TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 6632 SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa 2047 EPHB1 EPH receptor B1 5168 ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin) 55257 C20orf20 chromosome 20 open reading frame 20 81611 ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 23246 BOP1 block of proliferation 1 23526 HA-1 minor histocompatibility antigen HA-1 84250 ANKRD32 ankyrin repeat domain 32 6999 TDO2 tryptophan 2,3-dioxygenase 8317 CDC7 CDC7 cell division cycle 7 (S. cerevisiae) 55752 SEPT11 septin 11 39 ACAT2 acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase) 54830 FLJ20130 hypothetical protein FLJ20130 83732 RIOK1 RIO kinase 1 (yeast) 10808 HSPH1 heat shock 105kDa/110kDa protein 1 489 ATP2A3 ATPase, Ca++ transporting, ubiquitous 3251 HPRT1 hypoxanthine phosphoribosyltransferase 1 (Lesch-Nyhan syndrome) 10051 SMC4L1 SMC4 structural maintenance of chromosomes 4-like 1 (yeast) 55816 DOK5 docking protein 5 3676 ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 8819 SAP30 sin3-associated polypeptide, 30kDa 4436 MSH2 mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) 10212 DDX39 DEAD (Asp-Glu-Ala-Asp) box polypeptide 39 5889 RAD51C RAD51 homolog C (S. cerevisiae) 134111 FLJ25076 similar to CG4502-PA 51377 UCHL5 ubiquitin carboxyl-terminal hydrolase L5 6657 SOX2 SRY (sex determining region Y)-box 2 241 ALOX5AP arachidonate 5-lipoxygenase-activating protein 79888 FLJ12443 hypothetical protein FLJ12443 1368 CPM carboxypeptidase M 397 ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 3336 HSPE1 heat shock 10kDa protein 1 (chaperonin 10) 2104 ESRRG estrogen-related receptor gamma 2171 FABP5 fatty acid binding protein 5 (psoriasis-associated) 6574 SLC20A1 solute carrier family 20 (phosphate transporter), member 1 2743 GLRB glycine receptor, beta 1019 CDK4 cyclin-dependent kinase 4 9295 SFRS11 splicing factor, arginine/serine-rich 11 56952 PRTFDC1 phosphoribosyl transferase domain containing 1 6472 SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 23512 SUZ12 suppressor of zeste 12 homolog (Drosophila) 586 BCAT1 branched chain aminotransferase 1, cytosolic 8836 GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) 10383 TUBB2 tubulin, beta, 2 54101 RIPK4 receptor-interacting serine-threonine kinase 4 130271 PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 129401 NUP35 nucleoporin 35kDa 10128 LRPPRC leucine-rich PPR-motif containing 51703 ACSL5 acyl-CoA synthetase long-chain family member 5 9448 MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 79017 C7orf24 chromosome 7 open reading frame 24 262 AMD1 adenosylmethionine decarboxylase 1 960 CD44 CD44 antigen (homing function and Indian blood group system) 81930 KIF18A kinesin family member 18A 64116 SLC39A8 solute carrier family 39 (zinc transporter), member 8 26586 CKAP2 cytoskeleton associated protein 2 51144 HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 51002 CGI-121 CGI-121 protein 9126 CSPG6 chondroitin sulfate proteoglycan 6 (bamacan) 79154 MGC4172 short-chain dehydrogenase/reductase 11096 ADAMTS5 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) 84803 MGC11324 hypothetical protein MGC11324 4082 MARCKS myristoylated alanine-rich protein kinase C substrate 4086 SMAD1 SMAD, mothers against DPP homolog 1 (Drosophila) 9446 GSTO1 glutathione S-transferase omega 1 23636 NUP62 nucleoporin 62kDa 81839 VANGL1 vang-like 1 (van gogh, Drosophila) 3149 HMGB3 high-mobility group box 3 79023 NUP37 nucleoporin 37kDa 10606 PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase 10492 SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 3320 HSPCA heat shock 90kDa protein 1, alpha 6119 RPA3 replication protein A3, 14kDa 55352 HSA272196 hypothetical protein, clone 2746033 9759 HDAC4 histone deacetylase 4 5725 PTBP1 polypyrimidine tract binding protein 1 2119 ETV5 ets variant gene 5 (ets-related molecule) 10019 LNK lymphocyte adaptor protein 9734 HDAC9 histone deacetylase 9 5885 RAD21 RAD21 homolog (S. pombe) 79930 DOK3 docking protein 3 22837 COBLL1 COBL-like 1 339448 LOC339448 hypothetical protein LOC339448 11051 NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21 9735 KNTC1 kinetochore associated 1 4148 MATN3 matrilin 3 4200 ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial 26084 SGEF Src homology 3 domain-containing guanine nucleotide exchange factor 27101 CACYBP calcyclin binding protein 23012 STK38L serine/threonine kinase 38 like 54566 EPB41L4B erythrocyte membrane protein band 4.1 like 4B 6566 SLC16A1 solute carrier family 16 (monocarboxylic acid transporters), member 1 54947 FLJ20481 hypothetical protein FLJ20481 255488 IBRDC2 IBR domain containing 2 2289 FKBP5 FK506 binding protein 5 5036 PA2G4 proliferation-associated 2G4, 38kDa 4869 NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 10384 BTN3A3 butyrophilin, subfamily 3, member A3 10785 WDR4 WD repeat domain 4 3099 HK2 hexokinase 2 56121 PCDHB15 protocadherin beta 15

10155 TRIM28 tripartite motif-containing 28 6340 SCNN1G sodium channel, nonvoltage-gated 1, gamma 25804 LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) 3939 LDHA lactate dehydrogenase A 57552 AADACL1 arylacetamide deacetylase-like 1 9184 BUB3 BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast) 657 BMPR1A bone morphogenetic protein receptor, type IA 5631 PRPS1 phosphoribosyl pyrophosphate synthetase 1 204 AK2 adenylate kinase 2 55270 NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15 10265 IRX5 iroquois homeobox protein 5 4640 MYO1A myosin IA 79180 EFHD2 EF hand domain family, member D2 4076 M11S1 membrane component, chromosome 11, surface marker 1 55276 PGM2 phosphoglucomutase 2 83857 ARG99 ARG99 protein 116448 OLIG1 oligodendrocyte transcription factor 1 5696 PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional protease 7) 1407 CRY1 cryptochrome 1 (photolyase-like) 11177 BAZ1A bromodomain adjacent to zinc finger domain, 1A 51015 ISOC1 isochorismatase domain containing 1 1789 DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 22948 CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 158563 LOC158563 hypothetical protein LOC158563 89891 WDR34 WD repeat domain 34 119 ADD2 adducin 2 (beta) 5358 PLS3 plastin 3 (T isoform) 7086 TKT transketolase (Wernicke-Korsakoff syndrome) 51174 TUBD1 tubulin, delta 1 23255 KIAA0802 KIAA0802 54149 C21orf91 chromosome 21 open reading frame 91 2271 FH fumarate hydratase 55076 TMEM45A transmembrane protein 45A 10436 C2F C2f protein 8553 BHLHB2 basic helix-loop-helix domain containing, class B, 2 10409 BASP1 brain abundant, membrane attached signal protein 1 22856 CHSY1 carbohydrate (chondroitin) synthase 1 84451 KIAA1804 mixed lineage kinase 4 3150 HMGN1 high-mobility group nucleosome binding domain 1 961 CD47 CD47 antigen (Rh-related antigen, integrin-associated signal transducer) 79038 ZFYVE21 zinc finger, FYVE domain containing 21 7291 TWIST1 twist homolog 1 (acrocephalosyndactyly 3; Saethre-Chotzen syndrome) (Drosophila) 9738 CP110 CP110 protein 10625 IVNS1ABP influenza virus NS1A binding protein 9368 SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1 3613 IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 8514 KCNAB2 potassium voltage-gated channel, shaker-related subfamily, beta member 2 4957 ODF2 outer dense fiber of sperm tails 2 4673 NAP1L1 nucleosome assembly protein 1-like 1 26018 LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 3033 HADHSC L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain 139886 LOC139886 hypothetical protein LOC139886 10360 NPM3 nucleophosmin/nucleoplasmin, 3 200894 ARL2L1 ADP-ribosylation factor-like 2-like 1 8364 HIST1H4C histone 1, H4c 378708 APITD1 apoptosis-inducing, TAF9-like domain 1 169270 ZNF596 zinc finger protein 596 6917 TCEA1 transcription elongation factor A (SII), 1 7091 TLE4 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) 3725 JUN v-jun sarcoma virus 17 oncogene homolog (avian) 1736 DKC1 dyskeratosis congenita 1, dyskerin 8566 PDXK pyridoxal (pyridoxine, vitamin B6) kinase 51176 LEF1 lymphoid enhancer-binding factor 1 87 ACTN1 actinin, alpha 1 10838 ZNF275 zinc finger protein 275 54517 FLJ20485 hypothetical protein FLJ20485 5150 PDE7A phosphodiesterase 7A 384 ARG2 arginase, type II 27316 RBMX RNA binding motif protein, X-linked 389206 CCDC4 coiled-coil domain containing 4 51312 SLC25A37 solute carrier family 25, member 37 9112 MTA1 metastasis associated 1 6711 SPTBN1 spectrin, beta, non-erythrocytic 1 10129 13CDNA73 hypothetical protein CG003 80014 BOMB BH3-only member B protein 27131 SNX5 sorting nexin 5 23089 PEG10 paternally expressed 10 5270 SERPINE2 serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 6764 ST5 suppression of tumorigenicity 5 7791 ZYX zyxin 22995 Cep152 KIAA0912 protein 4137 MAPT microtubule-associated protein tau 5411 PNN pinin, desmosome associated protein 3087 HHEX hematopoietically expressed homeobox 23171 GPD1L glycerol-3-phosphate dehydrogenase 1-like 56905 DKFZP434H132 DKFZP434H132 protein 3189 HNRPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 9099 USP2 ubiquitin specific protease 2 10098 TSPAN5 tetraspanin 5 401505 C9orf105 chromosome 9 open reading frame 105 51444 RNF138 ring finger protein 138 11118 BTN3A2 butyrophilin, subfamily 3, member A2 8089 YEATS4 YEATS domain containing 4 84108 PCGF6 polycomb group ring finger 6 7514 XPO1 exportin 1 (CRM1 homolog, yeast) 9818 NUPL1 nucleoporin like 1 10923 PC4 activated RNA polymerase II transcription cofactor 4 6526 SLC5A3 solute carrier family 5 (inositol transporters), member 3 26010 DNAPTP6 DNA polymerase-transactivated protein 6 5307 PITX1 paired-like homeodomain transcription factor 1 2643 GCH1 GTP cyclohydrolase 1 (dopa-responsive dystonia) 1503 CTPS CTP synthase 5777 PTPN6 protein tyrosine phosphatase, non-receptor type 6 23122 CLASP2 cytoplasmic linker associated protein 2 5588 PRKCQ protein kinase C, theta 64770 CCDC14 coiled-coil domain containing 14 6426 SFRS1 splicing factor, arginine/serine-rich 1 (splicing factor 2, alternate splicing factor) 81831 NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 56888 KCMF1 potassium channel modulatory factor 1 9221 NOLC1 nucleolar and coiled-body phosphoprotein 1 79366 NSBP1 nucleosomal binding protein 1 51729 WBP11 WW domain binding protein 11 84444 DOTI L DOT1-like, histone H3 methyltransferase (S. cerevisiae) 80218 MAK3 Mak3 homolog (S. cerevisiae) 84319 MGC4308 hypothetical protein MGC4308 112479 MGC16943 similar to RIKEN cDNA 4933424N09 gene 64396 GMCL1L germ cell-less homolog 1 (Drosophila)-like 5905 RANGAP1 Ran GTPase activating protein 1 2177 FANCD2 Fanconi anemia, complementation group D2 55632 KIAA1333 KIAA1333 3695 ITGB7 integrin, beta 7 9793 CKAP5 cytoskeleton associated protein 5 5318 PKP2 plakophilin 2 6652 SORD sorbitol dehydrogenase 80709 AKNA AT-hook transcription factor 55120 FANCL Fanconi anemia, complementation group L 92667 C20orf72 chromosome 20 open reading frame 72 3654 IRAK1 interleukin-1 receptor-associated kinase 1 55975 KLHL7 kelch-like 7 (Drosophila) 6397 SEC14L1 SEC14-like 1 (S. cerevisiae) 29117 BRD7 bromodomain containing 7 6732 SRPK1 SFRS protein kinase 1 401081 FLJ22763 hypothetical gene supported by AK026416 8520 HAT1 histone acetyltransferase 1 3119 HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 7283 TUBG1 tubulin, gamma 1 4809 NHP2L1 NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae) 2778 GNAS GNAS complex locus 5359 PLSCR1 phospholipid scramblase 1 196294 FLJ25059 hypothetical protein FLJ25059 3181 HNRPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 1794 DOCK2 dedicator of cytokinesis 2 55148 C14orf130 chromosome 14 open reading frame 130 25924 MYRIP myosin VIIA and Rab interacting protein 7533 YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 64968 MRPS6 mitochondrial ribosomal protein S6 4830 NME1 non-metastatic cells 1, protein (NM23A) expressed in 165055 FLJ32745 hypothetical protein FLJ32745 151827 LRRC34 leucine rich repeat containing 34 93081 LOC93081 hypothetical protein BC015148 196527 TMEM16F transmembrane protein 16F 1827 DSCR1 Down syndrome critical region gene 1 203562 TMEM31 transmembrane protein 31 11335 CBX3 chromobox homolog 3 (HP1 gamma homolog, Drosophila) 3662 IRF4 interferon regulatory factor 4 8624 DSCR2 Down syndrome critical region gene 2 4092 SMAD7 SMAD, mothers against DPP homolog 7 (Drosophila) 6934 TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 26112 DKFZP434C171 DKFZP434C171 protein 3329 HSPD1 heat shock 60kDa protein 1 (chaperonin) 5577 PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta 3202 HOXA5 homeo box AS 79442 LRRC2 leucine rich repeat containing 2 9631 NUP155 nucleoporin 155kDa 55366 LGR4 leucine-rich repeat-containing G protein-coupled receptor 4 23350 SR140 U2-associated SR140 protein 6434 SFRS10 splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila) 7975 MAFK v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian) 3187 HNRPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 94239 H2AFV H2A histone family, member V 54913 RPP25 ribonuclease P 25kDa subunit 9521 EEF1E1 eukaryotic translation elongation factor 1 epsilon 1 5471 PPAT phosphoribosyl pyrophosphate amidotransferase 340252 ZNF680 zinc finger protein 680 1021 CDK6 cyclin-dependent kinase 6 10560 SLC19A2 solute carrier family 19 (thiamine transporter), member 2 4201 MEA1 male-enhanced antigen 1 440145 LOC440145 similar to RIKEN cDNA 2410129H14 3843 RANBP5 RAN binding protein 5 3298 HSF2 heat shock transcription factor 2 387914 TMEM46 transmembrane protein 46 27347 STK39 serine threonine kinase 39 (STE20/SPS1 homolog, yeast) 6256 RXRA retinoid X receptor, alpha 6637 SNRPG small nuclear ribonucleoprotein polypeptide G 22800 RRAS2 related RAS viral (r-ras) oncogene homolog 2 91694 FLJ23749 hypothetical protein FLJ23749 22823 MTF2 metal response element binding transcription factor 2 51184 MGC14560 protein x 0004 10856 RUVBL2 RuvB-like 2 (E. coli) 7188 TRAF5 TNF receptor-associated factor 5 5272 SERPINB9 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 9 11169 WDHD1 WD repeat and HMG-box DNA binding protein 1 5606 MAP2K3 mitogen-activated protein kinase kinase 3 4783 NFIL3 nuclear factor, interleukin 3 regulated 51691 LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) 1528 CYB5 cytochrome b-5 79899 FLJ14213 hypothetical protein FLJ14213 7334 UBE2N ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) 2730 GCLM glutamate-cysteine ligase, modifier subunit 23157 SEPT6 septin 6 56155 TEX14 testis expressed sequence 14 23658 LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) 1400 CRMP1 collapsin response mediator protein 1 5684 PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 6713 SQLE squalene epoxidase 84955 NUDCD1 NudC domain containing 1 64318 C10or1117 chromosome 10 open reading frame 117 10196 HRMT1L3 HMT1 hnRNP methyltransferase-like 3 (S. cerevisiae) 29841 GRHL1 grainyhead-like 1 (Drosophila) 10055 SAE1 SUMO-1 activating enzyme subunit 1 9214 FAIM3 Fas apoptotic inhibitory molecule 3 57406 ABHD6 abhydrolase domain containing 6 25914 RTTN rotatin 23244 SCC-112 SCC-112 protein 3183 HNRPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 55117 SLC6A15 solute carrier family 6, member 15 6950 TCP1 t-complex 1 4660 PPP1R12B protein phosphatase 1, regulatory (inhibitor) subunit 12B 134429 STARD4 START domain containing 4, sterol regulated 157503 LOC157503 hypothetical protein LOC157503 253832 ZDHHC20 zinc finger, DHHC-type containing 20 375061 MGC15887 hypothetical gene supported by BC009447 84986 ARHGAP19 Rho GTPase activating protein 19 8407 TAGLN2 transgelin 2 285704 RGMB RGM domain family, member B 5050 PAFAH1B3 platelet-activating factor acetylhydrolase, isoform Ib, gamma subunit 29kDa 4208 MEF2C MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) 55614 C20orf23 chromosome 20 open reading frame 23 388796 LOC388796 hypothetical LOC388796 85463 ZC3H12C zinc finger CCCH-type containing 12C 51465 UBE2J1 ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast) 9994 CASP8AP2 CASP8 associated protein 2

26135 PAI-RBP1 PAI-1 mRNA binding protein 5634 PRPS2 phosphoribosyl pyrophosphate synthetase 2 286319 TUSC1 tumor suppressor candidate 1 6470 SHMT1 serine hydroxymethyltransferase 1 (soluble) 9397 NMT2 N-myristoyltransferase 2 10762 NUP50 nucleoporin 50kDa 201161 PRR6 proline rich 6 5019 OXCT1 3-oxoacid CoA transferase 1 159 ADSS adenylosuccinate synthase 23587 DERP6 S-phase 2 protein 10151 HNRPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1 8564 KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 1349 COX7B cytochrome c oxidase subunit VIIb 283824 LOC283824 hypothetical protein LOC283824 1123 CHN1 chimerin (chimaerin) 1 57522 SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 253782 LASS6 LAG1 longevity assurance homolog 6 (S. cerevisiae) 57685 KIAA1573 KIAA1573 protein 79695 GALNT12 UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyl- transferase 12 (GaINAc-T12) 90861 C16orf34 chromosome 16 open reading frame 34 26207 PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 1164 CKS2 CDC28 protein kinase regulatory subunit 2 396 ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 57530 CGN cingulin 1633 DCK deoxycytidine kinase 9208 LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 6453 ITSN1 intersectin 1 (SH3 domain protein) 24147 FJX1 four jointed box 1 (Drosophila) 9882 TBC1D4 TBC1 domain family, member 4 169200 DKFZp762C1112 hypothetical protein DKFZp762C1112 9331 B4GALT6 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6 55183 RIF1 RAP1 interacting factor homolog (yeast) 221362 LOC221362 hypothetical protein LOC221362 8458 TTF2 transcription termination factor, RNA polymerase II 1047 CLGN calmegin 56919 DHX33 DEAH (Asp-Glu-Ala-His) box polypeptide 33 93949 CXorf10 chromosome X open reading frame 10 5569 PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha 6891 TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 1960 EGR3 early growth response 3 11252 PACSIN2 protein kinase C and casein kinase substrate in neurons 2 51762 RAB8B RAB8B, member RAS oncogene family 81575 DKFZP434F0318 hypothetical protein DKFZp434F0318 56906 THAP10 THAP domain containing 10 55110 FLJ10292 mago-nashi homolog 5267 SERPINA4 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 1844 DUSP2 dual specificity phosphatase 2 9612 NCOR2 nuclear receptor co-repressor 2 3276 HRMT1L2 HMT1 hnRNP methyltransferase-like 2 (S. cerevisiae) 257415 MGC40405 hypothetical protein MGC40405 79720 FLJ12750 hypothetical protein FLJ12750 160897 ITR intimal thickness-related receptor 4522 MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetra- hydrofolate cyclohydrolase, formyltetrahydrofolate synthetase 4668 NAGA N-acetylgalactosaminidase, alpha- 84890 C10orf22 chromosome 10 open reading frame 22 5198 PFAS phosphoribosylformylglycinamidine synthase (FGAR amidotransferase) 55544 RNPC1 RNA-binding region (RNP1, RRM) containing 1 2618 GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 9261 MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 285761 DCBLD1 discoidin, CUB and LCCL domain containing 1 23225 NUP210 nucleoporin 210kDa 9792 SERTAD2 SERTA domain containing 2 56938 ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2 23254 KIAA1026 kazrin 4628 MYH10 myosin, heavy polypeptide 10, non-muscle 23176 SEPT8 septin 8 1432 MAPK14 mitogen-activated protein kinase 14 84549 RBM13 RNA binding motif protein 13 84133 ZNRF3 zinc and ring finger 3 6502 SKP2 S-phase kinase-associated protein 2 (p45) 59274 MESDC1 mesoderm development candidate 1 51496 HSPC129 hypothetical protein HSPC129 55151 TMEM38B transmembrane protein 38B 57609 KIAA1463 KIAA1463 protein 1039 CDR2 cerebellar degeneration-related protein 2, 62kDa 143098 MPP7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) 130589 GALM galactose mutarotase (aldose 1-epimerase) lymphocyte cytosolic 3937 LCP2 protein 2 (SH2 domain containing leukocyte protein of 76kDa) 5420 PODXL podocalyxin-like 6509 SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 64397 ZFP106 zinc finger protein 106 homolog (mouse) 4860 NP nucleoside phosphorylase 3535 IGL@ immunoglobulin lambda locus 1396 CRIP1 cysteine-rich protein 1 (intestinal) 1660 DHX9 DEAH (Asp-Glu-Ala-His) box polypeptide 9 4291 MLF1 myeloid leukemia factor 1 26973 CHORDC1 cysteine and histidine-rich domain (CHORD)-containing, zinc binding protein 1 81037 CRR9 cisplatin resistance related protein CRR9p 10574 CCT7 chaperonin containing TCP1, subunit 7 (eta) 79892 C10orf119 chromosome 10 open reading frame 119 9972 NUP153 nucleoporin 153kDa 10459 MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) 483 ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 7552 ZNF6 zinc finger protein 6 (CMPX1) 8165 AKAP1 A kinase (PRKA) anchor protein 1 29097 CNIH4 cornichon homolog 4 (Drosophila) 11198 SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 2184 FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 7037 TFRC transferrin receptor (p90, CD71) 6461 SHB Src homology 2 domain containing adaptor protein B 509 ATP5C1 ATP synthase, H+ transporting, mitochondrial F1complex, gamma polypeptide 1 5591 PRKDC protein kinase, DNA-activated, catalytic polypeptide 10682 EBP emopamil binding protein (sterol isomerase) 9188 DDX21 DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 3837 KPNB1 karyopherin (importin) beta 1 3191 HNRPL heterogeneous nuclear ribonucleoprotein L 10236 HNRPR heterogeneous nuclear ribonucleoprotein R 6907 TBL1X transducin (beta)-like 1X-linked 56172 ANKH ankylosis, progressive homolog (mouse) 23367 LARP1 La ribonucleoprotein domain family, member 1 5778 PTPN7 protein tyrosine phosphatase, non-receptor type 7 100 ADA adenosine deaminase 2821 GPI glucose phosphate isomerase 9697 TRAM2 translocation associated membrane protein 2 54927 CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 58478 MASA E-1 enzyme 6322 SCML1 sex comb on midleg-like 1 (Drosophila) 292 SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 10857 PGRMC1 progesterone receptor membrane component 1 55342 STRBP spermatid perinuclear RNA binding protein 7150 TOP1 topoisomerase (DNA) I 874 CBR3 carbonyl reductase 3 51096 WDR50 WD repeat domain 50 253558 LYCAT lysocardiolipin acyltransferase 79053 ALG8 asparagine-linked glycosylation 8 homolog (yeast, alpha-1,3-glucosyltransferase) 84300 C6orf125 chromosome 6 open reading frame 125 8975 USP13 ubiquitin specific protease 13 (isopeptidase T-3) 220988 HNRPA3 heterogeneous nuclear ribonucleoprotein A3 5315 PKM2 pyruvate kinase, muscle 7411 VBP1 von Hippel-Lindau binding protein 1 1665 DHX15 DEAH (Asp-Glu-Ala-His) box polypeptide 15 10963 STIP1 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein) 253461 ZBTB38 zinc finger and BTB domain containing 38 29080 HSPC128 HSPC128 protein 84275 MGC4399 mitochondrial carrier protein 1622 DBI diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein) 4953 ODC1 ornithine decarboxylase 1 2029 ENSA endosulfine alpha 6404 SELPLG selectin P ligand 81034 MFTC mitochondrial folate transporter/carrier 81542 TXNDC thioredoxin domain containing 25816 TNFAIP8 tumor necrosis factor, alpha-induced protein 8 51582 AZIN1 antizyme inhibitor 1 27436 EML4 echinoderm microtubule associated protein like 4 55720 FLJ10534 hypothetical protein FLJ10534 7295 TXN thioredoxin 10539 TXNL2 thioredoxin-like 2 86 ACTL6A actin-like 6A 6731 SRP72 signal recognition particle 72kDa 23314 SATB2 SATB family member 2 2273 FHL1 four and a half LIM domains 1 3422 IDI1 isopentenyl-diphosphate delta isomerase 10935 PRDX3 peroxiredoxin 3 2958 GTF2A2 general transcription factor IIA, 2, 12kDa 4144 MAT2A methionine adenosyltransferase II, alpha 1964 EIF1AX eukaryotic translation initiation factor 1A, X-linked 60 ACTB actin, beta 11191 PTENP1 phosphatase and tensin homolog (mutated in multiple advanced cancers 1), pseudogene 1 90843 TCEAL8 transcription elongation factor A (SII)-like 8 57181 SLC39A10 solute carrier family 39 (zinc transporter), member 10 11147 HHLA3 HERV-H LTR-associating 3 10553 HTATIP2 HIV-1 Tat interactive protein 2, 30kDa 3338 DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4 84888 SPPL2A signal peptide peptidase-like 2A 1955 EGFL5 EGF-like-domain, multiple 5 329 BIRC2 baculoviral IAP repeat-containing 2 29927 SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 9559 VPS26 vacuolar protein sorting 26 (yeast) 23270 TSPYL4 TSPY-like 4 6309 SC5DL sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, fungal)-like 10397 NDRG1 N-myc downstream regulated gene 1 27032 ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 11112 HIBADH 3-hydroxyisobutyrate dehydrogenase 1476 CSTB cystatin B (stefin B) 9620 CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila) 56650 C3orf4 chromosome 3 open reading frame 4 29922 NME7 non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase) 8887 TAXI BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 5445 PON2 paraoxonase 2 81889 FAHD1 fumarylacetoacetate hydrolase domain containing 1 694 BTG1 B-cell translocation gene 1, anti-proliferative 29058 C20orf30 chromosome 20 open reading frame 30 2752 GLUL glutamate-ammonia ligase (glutamine synthase) 79717 FLJ11838 hypothetical protein FLJ11838 170622 COMMD6 COMM domain containing 6 5792 PTPRF protein tyrosine phosphatase, receptor type, F 64393 WIG1 p53 target zinc finger protein 549 AUH AU RNA binding protein/enoyl-Coenzyme A hydratase 51282 SCAND1 SCAN domain containing 1 79027 ZNF655 zinc finger protein 655 6451 SH3BGRL SH3 domain binding glutamic acid-rich protein like 1347 COX7A2 cytochrome c oxidase subunit Vlla polypeptide 2 (liver) 550643 L00550643 hypothetical protein L00550643 6926 TBX3 T-box 3 (ulnar mammary syndrome) 51614 SDBCAG84 serologically defined breast cancer antigen 84 9520 NPEPPS aminopeptidase puromycin sensitive 51065 RPS27L ribosomal protein S27-like 10116 FEM1B fem-1 homolog b (C. elegans) 10521 DDX17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 81557 MAGED4 melanoma antigen family D, 4 10133 OPTN optineurin 54504 CPVL carboxypeptidase, vitellogenic-like 64062 C13orf10 chromosome 13 open reading frame 10 401115 LOC401115 hypothetical gene supported by BC038466; BC062790 6892 TAPBP TAP binding protein (tapasin) 8087 FXR1 fragile X mental retardation, autosomal homolog 1 7905 C5orf18 chromosome 5 open reading frame 18 3916 LAMP1 lysosomal-associated membrane protein 1 22982 KIAA0934 KIAA0934 55615 PRR5 proline rich protein 5 5651 PRSS7 protease, serine, 7 (enterokinase) 10449 ACAA2 acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase) 8934 RAB7L1 RAB7, member RAS oncogene family-like 1 10114 HIPK3 homeodomain interacting protein kinase 3 57560 WDR56 WD repeat domain 56 51205 ACP6 acid phosphatase 6, lysophosphatidic 6238 RRBP1 ribosome binding protein 1 homolog 180kDa (dog) 151011 SEPT10 septin 10 22920 KIFAP3 kinesin-associated protein 3 3958 LGALS3 lectin, galactoside-binding, soluble, 3 (galectin 3) 84186 ZCCHC7 zinc finger, CCHC domain containing 7 9452 ITM2A integral membrane protein 2A 10159 ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2

23641 LDOC1 leucine zipper, down-regulated in cancer 1 967 CD63 CD63 antigen (melanoma 1 antigen) 2517 FUCA1 fucosidase, alpha-L- 1, tissue 23219 FBXO28 F-box protein 28 79982 DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 7328 UBE2H ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast) 23355 KIAA0804 KIAA0804 257103 C21orf86 chromosome 21 open reading frame 86 6307 SC4MOL sterol-C4-methyl oxidase-like 23376 KIAA0776 KIAA0776 57700 KIAA1600 KIAA1600 85461 TANG TPR domain, ankyrin-repeat and coiled-coil-containing 4247 MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase 3383 ICAM1 intercellular adhesion molecule 1 (CD54), human rhinovirus receptor 493812 HCG11 HLA complex group 11 5921 RASA1 RAS p21 protein activator (GTPase activating protein) 1 23563 CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 51100 SH3GLB1 SH3-domain GRB2-like endophilin B1 339988 LOC339988 hypothetical protein LOC339988 79080 MGC2574 hypothetical protein MGC2574 55761 TTC17 tetratricopeptide repeat domain 17 144871 LOC144871 hypothetical protein LOC144871 4194 MDM4 Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse) 51030 FAM18B family with sequence similarity 18, member B 1650 DDOST dolichyl-diphosphooligosaccharide-protein glycosyltransferase 147463 ANKRD29 ankyrin repeat domain 29 3757 KCNH2 potassium voltage-gated channel, subfamily H (eag-related), member 2 116442 RAB39B RAB39B, member RAS oncogene family 10972 TMP21 transmembrane trafficking protein 57798 GATAD1 GATA zinc finger domain containing 1 1314 COPA coatomer protein complex, subunit alpha 2581 GALC galactosylceramidase (Krabbe disease) 91452 ACBD5 acyl-Coenzyme A binding domain containing 5 8879 SGPL1 sphingosine-1-phosphate lyase 1 4897 NRCAM neuronal cell adhesion molecule 23209 MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 440270 LOC440270 golgin-67 5034 P4HB procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide (protein disulfide isomerase-associated 1) 148646 FLJ32096 hypothetical protein FLJ32096 399917 LOC399917 similar to polymerase 7096 TLR1 toll-like receptor 1 80853 KIAA1718 KIAA1718 protein 378938 MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA) 1266 CNN3 calponin 3, acidic 58486 LOC58486 transposon-derived Buster1 transposase-like protein gene 1040 CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 9895 KIAA0329 KIAA0329 1509 CTSD cathepsin D (lysosomal aspartyl protease) 26115 DKFZP564D166 putative ankyrin-repeat containing protein 57162 PELI1 pellino homolog 1 (Drosophila) 57599 WDR48 WD repeat domain 48 285464 FLJ34443 hypothetical protein FLJ34443 55857 C20orf19 chromosome 20 open reading frame 19 339456 LOC339456 hypothetical protein LOC339456 51569 UFM1 ubiquitin-fold modifier 1 582 BBS1 Bardet-Biedl syndrome 1 4637 MYL6 myosin, light polypeptide 6, alkali, smooth muscle and non-muscle 1186 CLCN7 chloride channel 7 3490 IGFBP7 insulin-like growth factor binding protein 7 5095 PCCA propionyl Coenzyme A carboxylase, alpha polypeptide 10966 RAB40B RAB40B, member RAS oncogene family 285362 SUMF1 sulfatase modifying factor 1 56122 PCDHB14 protocadherin beta 14 57534 MIB1 mindbomb homolog 1 (Drosophila) 56951 C5orf15 chromosome 5 open reading frame 15 113177 C19orf36 chromosome 19 open reading frame 36 10379 ISGF3G interferon-stimulated transcription factor 3, gamma 48kDa 64224 FLJ22313 hypothetical protein FLJ22313 65084 FLJ22104 hypothetical protein FLJ22104 10537 UBD ubiquitin D 8548 BLZF1 basic leucine zipper nuclear factor 1 (JEM-1) 284214 LOC284214 hypothetical protein LOC284214 8334 HIST1H2AC histone 1, H2ac 80210 FLJ12584 melanoma/melanocyte specific protein KU-MEL-1 1182 CLCN3 chloride channel 3 26751 SH3YL1 SH3 domain containing, Ysc84-like 1 (S. cerevisiae) 114327 EFHC1 EF-hand domain (C-terminal) containing 1 7351 UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 10724 MGEA5 meningioma expressed antigen 5 (hyaluronidase) 9652 KIAA0372 KIAA0372 200958 MUC20 mucin 20 161527 LOC161527 hypothetical protein LOC161527 10314 LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) 2923 PDIA3 protein disulfide isomerase family A, member 3 84247 LDOC1L leucine zipper, down-regulated in cancer 1-like 3006 HIST1H1C histone 1, H1c 9562 MINPP1 multiple inositol polyphosphate histidine phosphatase, 1 115024 MGC20781 hypothetical protein MGC20781 65982 FLJ12895 hypothetical protein FLJ12895 5268 SERPINB5 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5 94240 EPSTI1 epithelial stromal interaction 1 (breast) 2621 GAS6 growth arrest-specific 6 401024 FLJ44048 FLJ44048 protein 57142 RTN4 reticulon 4 50854 C6orf48 chromosome 6 open reading frame 48 317649 EIF4E3 eukaryotic translation initiation factor 4E member 3 4179 MCP membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen) 54884 RetSat all-trans-13,14-dihydroretinol saturase 10154 PLXNC1 plexin C1 2630 GBAP glucosidase, beta; acid, pseudogene 7077 TIMP2 tissue inhibitor of metalloproteinase 2 23741 CRI1 CREBBP/EP300 inhibitor 1 949 SCARB1 scavenger receptor class B, member 1 1519 CTSO cathepsin O 51136 LOC51136 PTD016 protein 3428 IFI16 interferon, gamma-inducible protein 16 9516 LITAF lipopolysaccharide-induced TNF factor 3123 HLA-DRB1 major histocompatibility complex, class II, DR beta 1 1389 CREBL2 cAMP responsive element binding protein-like 2 5027 P2RX7 purinergic receptor P2X, ligand-gated ion channel, 7 6782 STCH stress 70 protein chaperone, microsome-associated, 60kDa 5645 PRSS2 protease, serine, 2 (trypsin 2) 84282 RNF135 ring finger protein 135 9852 EPM2AIP1 EPM2A (laforin) interacting protein 1 84333 PCGF5 polycomb group ring finger 5 23475 QPRT quinolinate phosphoribosyltransferase (nicotinate-nucleotide pyrophosphorylase (carboxylating)) 11142 PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 54832 VPS13C vacuolar protein sorting 13C (yeast) 1486 CTBS chitobiase, di-N-acetyl- 4601 MXI1 MAX interactor 1 1365 CLDN3 claudin 3 81622 UNC93B1 unc-93 homolog B1 (C. elegans) 54664 FLJ11273 hypothetical protein FLJ11273 9993 DGCR2 DiGeorge syndrome critical region gene 2 57179 KIAA1191 KIAA1191 protein 55958 KLHL9 kelch-like 9 (Drosophila) 81671 TMEM49 transmembrane protein 49 9666 DZIP3 zinc finger DAZ interacting protein 3 10509 SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 3782 KCNN3 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 4644 MYO5A myosin VA (heavy polypeptide 12, myoxin) 55179 FAIM Fas apoptotic inhibitory molecule 9687 GREB1 GREB1 protein 25861 DFNB31 deafness, autosomal recessive 31 9197 SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 10549 PRDX4 peroxiredoxin 4 27090 ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosamini- de alpha-2,6-sialyltransferase 4 3988 LIPA lipase A, lysosomal acid, cholesterol esterase (Wolman disease) 10577 NPC2 Niemann-Pick disease, type C2 441951 HSUP1 similar to RPE-spondin 26275 HIBCH 3-hydroxyisobutyryl-Coenzyme A hydrolase 401397 LOC401397 hypothetical LOC401397 81555 YIPF5 Yip1 domain family, member 5 19 ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 2896 GRN granulin 1312 COMT catechol-O-methyltransferase 127018 LYPLAL1 lysophospholipase-like 1 5911 RAP2A RAP2A, member of RAS oncogene family 3017 HIST1H2BD histone 1, H2bd 9139 CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 50848 F11R F11 receptor 3728 JUP junction plakoglobin 8615 VDP vesicle docking protein p115 79090 MGC2650 hypothetical protein MGC2650 51303 FKBP11 FK506 binding protein 11, 19kDa 64747 MFSD1 major facilitator superfamily domain containing 1 23471 TRAM1 translocation associated membrane protein 1 1832 DSP desmoplakin 125144 MGC40157 hypothetical protein MGC40157 10150 MBNL2 muscleblind-like 2 (Drosophila) 3082 HGF hepatocyte growth factor (hepapoietin A; scatter factor) 7750 ZNF198 zinc finger protein 198 2908 NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 25758 G2 G2 protein 10653 SPINT2 serine protease inhibitor, Kunitz type, 2 116151 C20orf108 chromosome 20 open reading frame 108 8933 CXX1 CAAX box 1 475 ATOX1 ATX1 antioxidant protein 1 homolog (yeast) 23406 COTL1 coactosin-like 1 (Dictyostelium) 57561 ARRDC3 arrestin domain containing 3 55205 ZNF532 zinc finger protein 532 25796 PGLS 6-phosphogluconolactonase 283846 DKFZp547E087 P1-3-kinase-related kinase SMG-1-like 57185 DJ462023.2 hypothetical protein dJ462O23.2 54431 DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 5800 PTPRO protein tyrosine phosphatase, receptor type, O 1465 CSRP1 cysteine and glycine-rich protein 1 950 SCARB2 scavenger receptor class B, member 2 51019 CGI-116 CGI-116 protein 5476 PPGB protective protein for beta-galactosidase (galactosialidosis) 54145 H2BFS H2B histone family, member S 65981 C1QDC1 C1q domain containing 1 81502 HM13 histocompatibility (minor) 13 3572 IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) 1299 COL9A3 collagen, type IX, alpha 3 1386 ATF2 activating transcription factor 2 4134 MAP4 microtubule-associated protein 4 3981 LIG4 ligase IV, DNA, ATP-dependent 57714 KIAA1618 KIAA1618 80315 CPEB4 cytoplasmic polyadenylation element binding protein 4 107 ADCY1 adenylate cyclase 1 (brain) 8804 CREG1 cellular repressor of E1A-stimulated genes 1 84181 CHD6 chromodomain helicase DNA binding protein 6 22871 NLGN1 neuroligin 1 659 BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 79158 MGC4170 MGC4170 protein 112399 EGLN3 egl nine homolog 3 (C. elegans) 10550 ARL6IP5 ADP-ribosylation-like factor 6 interacting protein 5 55573 H41 hypothetical protein H41 51706 NQO3A2 NAD(P)H:quinone oxidoreductase type 3, polypeptide A2 79738 FLJ23560 hypothetical protein FLJ23560 6672 SP100 nuclear antigen Sp100 145173 B3GTL beta 3-glycosyltransferase-like 3275 HRMT1L1 HMT1 hnRNP methyltransferase-like 1 (S. cerevisiae) 54059 C21orf57 chromosome 21 open reading frame 57 571 BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 6990 TCTE1L t-complex-associated-testis-expressed 1-like 9341 VAMP3 vesicle-associated membrane protein 3 (cellubrevin) 2180 ACSL1 acyl-CoA synthetase long-chain family member 1 2799 GNS glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID) 9236 CCPG1 cell cycle progression 1 51111 SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila) 598 BCL2L1 BCL2-like 1 57674 C17orf27 chromosome 17 open reading frame 27 1488 CTBP2 C-terminal binding protein 2 80267 C1orf22 chromosome 1 open reading frame 22 90701 SEC11L3 SEC11-like 3 (S. cerevisiae) 84218 TBC1D3 TBC1 domain family, member 3 7844 RNF103 ring finger protein 103 8440 NCK2 NCK adaptor protein 2 25934 NIPSNAP3A nipsnap homolog 3A (C. elegans) 3897 L1CAM L1 cell adhesion molecule 114915 TIGA1 TIGA1 754 PTTG1IP pituitary tumor-transforming 1 interacting protein 10525 HYOU1 hypoxia up-regulated 1 966 CD59 CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16,

EJ30, EL32 and G344) 25976 TIPARP TCDD-inducible poly(ADP-ribose) polymerase 3714 JAG2 jagged 2 8780 RIOK3 RIO kinase 3 (yeast) 55827 IQWD1 IQ motif and WD repeats 1 55830 GLT8D1 glycosyltransferase 8 domain containing 1 4779 NFE2L1 nuclear factor (erythroid-derived 2)-like 1 7286 TUFT1 tuftelin 1 1028 CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 60492 MDS025 hypothetical protein MDS025 27319 BHLHB5 basic helix-loop-helix domain containing, class B, 5 1958 EGR1 early growth response 1 89796 NAV1 neuron navigator 1 9240 PNMA1 paraneoplastic antigen MA1 6773 STAT2 signal transducer and activator of transcription 2, 113kDa 7494 XBP1 X-box binding protein 1 11057 ABHD2 abhydrolase domain containing 2 9451 EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 8878 SQSTM1 sequestosome 1 302 ANXA2 annexin A2 2590 GALNT2 UDP-N-acetyl-alpha-D-galactosamine: polypeptide N- acetylgalactosaminyltransferase 2 (GaINAc-T2) 1200 TPP1 tripeptidyl peptidase I 5973 RENBP renin binding protein 7259 TSPYL1 TSPY-like 1 112770 C1orf85 chromosome 1 open reading frame 85 93953 ACRC acidic repeat containing 90634 CG018 hypothetical gene CG018 1030 CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 158158 RASEF RAS and EF hand domain containing 2824 GPM6B glycoprotein M6B 9706 ULK2 unc-51-like kinase 2 (C. elegans) 92370 ACPL2 acid phosphatase-like 2 1203 CLN5 ceroid-lipofuscinosis, neuronal 5 8337 HIST2H2AA histone 2, H2aa 3998 LMAN1 lectin, mannose-binding, 1 56675 NRIP3 nuclear receptor interacting protein 3 4864 NPC1 Niemann-Pick disease, type Cl 3358 HTR2C 5-hydroxytryptamine (serotonin) receptor 2C 304 ANXA2P2 annexin A2 pseudogene 2 81790 RNF170 ring finger protein 170 2537 G1P3 interferon, alpha-inducible protein (clone IFI-6-16) 55251 C20orf36 chromosome 20 open reading frame 36 27344 PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor 10057 ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 81031 SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 467 ATF3 activating transcription factor 3 94103 ORMDL3 ORM1-like 3 (S. cerevisiae) 375593 TRIM50B tripartite motif-containing 50B 23015 GM88 88-kDa golgi protein 55818 JMJD1A jumonji domain containing 1A 5274 SERPINI1 serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1 23336 DMN desmuslin 255631 COL24A1 collagen, type XXIV, alpha 1 3995 FADS3 fatty acid desaturase 3 5797 PTPRM protein tyrosine phosphatase, receptor type, M 55876 GSDML gasdermin-like 999 CDH1 cadherin 1, type 1, E-cadherin (epithelial) 84897 TBRG1 transforming growth factor beta regulator 1 51363 GALNAC4S-6ST B cell RAG associated protein 9961 MVP major vault protein 2982 GUCY1A3 guanylate cyclase 1, soluble, alpha 3 706 BZRP benzodiazapine receptor (peripheral) 144203 OVOS2 ovostatin 2 8516 ITGA8 integrin, alpha 8 2037 EPB41L2 erythrocyte membrane protein band 4.1-like 2 1524 CX3CR1 chemokine (C-X3-C motif) receptor 1 222166 Ells1 hypothetical protein Ells1 339803 LOC339803 hypothetical protein LOC339803 5360 PLTP phospholipid transfer protein 1612 DAPK1 death-associated protein kinase 1 90161 HS6ST2 heparan sulfate 6-O-sulfotransferase 2 115701 ALPK2 alpha-kinase 2 50640 IPLA2(GAMMA) intracellular membrane-associated calcium-independent phospholipase A2 gamma 8473 OGT O-linked N-acetylglucosamine (GIcNAc) transferase (UDP-N-acetylglucosamine: polypeptide-N-acetylglucosaminyl transferase) 252839 TMEM9 transmembrane protein 9 150759 LOC150759 hypothetical protein LOC150759 401152 LOC401152 HCV F-transactivated protein 1 64065 PERP PERP, TP53 apoptosis effector 114793 FMNL2 formin-like 2 477 ATP1A2 ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide 59338 PLEKHAl pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 3727 JUND jun D proto-oncogene 85236 HIST1H2BK histone 1, H2bk 6513 SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 155038 GIMAP8 GTPase, IMAP family member 8 3055 HCK hemopoietic cell kinase 6542 SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 8996 NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 9728 KIAA0256 KIAA0256 gene product 51237 PACAP proapoptotic caspase adaptor protein 8987 GENX-3414 genethonin 1 132720 FLJ39370 hypothetical protein FLJ39370 1601 DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 54741 LEPROT leptin receptor overlapping transcript 81631 MAP1LC3B microtubule-associated protein 1 light chain 3 beta 9473 C1orf38 chromosome 1 open reading frame 38 94241 TP53INP1 tumor protein p53 inducible nuclear protein 1 5816 PVALB parvalbumin 115294 LOC115294 similar to hypothetical protein FLJ10883 23461 ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 10370 CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 9604 RNF14 ring finger protein 14 387263 C6orf120 chromosome 6 open reading frame 120 9120 SLC16A6 solute carrier family 16 (monocarboxylic acid transporters), member 6 3915 LAMC1 laminin, gamma 1 (formerly LAMB2) 23092 ARHGAP26 Rho GTPase activating protein 26 64778 FNDC3B fibronectin type III domain containing 3B 10140 TOB1 transducer of ERBB2, 1 23208 SYT11 synaptotag min XI 57730 KIAA1641 KIAA1641 120196 MGC34830 hypothetical protein MGC34830 7832 BTG2 BTG family, member 2 23259 DDHD2 DDHD domain containing 2 84981 MGC14376 hypothetical protein MGC14376 6448 SGSH N-sulfoglucosamine sulfohydrolase (sulfamidase) 9910 RABGAP1L RAB GTPase activating protein 1-like 1611 DAP death-associated protein 126823 KARCA1 kelch/ankyrin repeat containing cyclin Al interacting protein 388403 YPEL2 yippee-like 2 (Drosophila) 6720 SREBF1 sterol regulatory element binding transcription factor 1 58476 TP53INP2 tumor protein p53 inducible nuclear protein 2 8605 PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent) 3983 ABLIM1 actin binding LIM protein 1 4189 DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 1604 DAF decay accelerating factor for complement (CD55, Cromer blood group system) 29994 BAZ2B bromodomain adjacent to zinc finger domain, 2B 10156 RASA4 RAS p21 protein activator 4 9123 SLC16A3 solute carrier family 16 (monocarboxylic acid transporters), member 3 7846 TUBA3 tubulin, alpha 3 3956 LGALS1 lectin, galactoside-binding, soluble, 1 (galectin 1) 1647 GADD45A growth arrest and DNA-damage-inducible, alpha 6609 SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase) 56904 SH3GLB2 SH3-domain GRB2-like endophilin B2 440081 DDX12 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12 (CHL1-like helicase homolog, S. cerevisiae) 5163 PDK1 pyruvate dehydrogenase kinase, isoenzyme 1 25840 DKFZP586A0522 DKFZP586A0522 protein 51566 ARMCX3 armadillo repeat containing, X-linked 3 9388 LIPG lipase, endothelial 27250 PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 6302 SAS sarcoma amplified sequence 83937 RASSF4 Ras association (RaIGDS/AF-6) domain family 4 388677 NOTCH2NL Notch homolog 2 (Drosophila) N-terminal like 23646 PLD3 phospholipase D family, member 3 23643 LY96 lymphocyte antigen 96 9855 FARP2 FERM, RhoGEF and pleckstrin domain protein 2 65018 PINK1 PTEN induced putative kinase 1 57035 C1orf63 chromosome 1 open reading frame 63 85352 KIAA1644 KIAA1644 protein 283131 TncRNA trophoblast-derived noncoding RNA 143888 KDELC2 KDEL (Lys-Asp-Glu-Leu) containing 2 56204 FLJ10980 hypothetical protein FLJ10980 23446 CDW92 CDW92 antigen 23766 GABARAPL3 GABA(A) receptors associated protein like 3 1508 CTSB cathepsin B 4094 MAF v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) 22932 POMZP3 POM (POM121 homolog, rat) and ZP3 fusion 56243 KIAA1217 KIAA1217 1663 DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae) 1414 CRYBB1 crystallin, beta B1 154091 SLC2A12 solute carrier family 2 (facilitated glucose transporter), member 12 4121 MAN1A1 mannosidase, alpha, class 1A, member 1 11178 LZTS1 leucine zipper, putative tumor suppressor 1 10628 TXNIP thioredoxin interacting protein 83719 YPEL3 yippee-like 3 (Drosophila) 9863 MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 5660 PSAP prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy) 145788 FLJ27352 hypothetical LOC145788 84513 HTPAP HTPAP protein 57612 KIAA1466 KIAA1466 gene 57515 TDE2 tumor differentially expressed 2 29005 PRO1073 PRO1073 protein 51646 YPEL5 yippee-like 5 (Drosophila) 5269 SERPINB6 serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 6 30061 SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1 81030 ZBP1 Z-DNA binding protein 1 347733 RP11-506K6.1 tubulin, beta polypeptide paralog 390 RND3 Rho family GTPase 3 10765 JARID1B Jumonji, AT rich interactive domain 1B (RBP2-like) 9783 RIMS3 regulating synaptic membrane exocytosis 3 27122 DKK3 dickkopf homolog 3 (Xenopus laevis) 151556 GPR155 G protein-coupled receptor 155 8365 HIST1H4H histone 1, H4h 6480 ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 6591 SNAI2 snail homolog 2 (Drosophila) 54800 DRE1 DRE1 protein 3669 ISG20 interferon stimulated exonuclease gene 20kDa 23710 GABARAPL1 GABA(A) receptor-associated protein like 1 400172 LOC400172 similar to KIAA1641 protein; melanoma-associated antigen; CLL-associated antigen KW-1 153222 LOC153222 adult retina protein 54981 C9orf95 chromosome 9 open reading frame 95 5641 LGMN legumain 257019 FRMD3 FERM domain containing 3 8357 HIST1H3H histone 1, H3h 55281 FLJ11000 hypothetical protein FLJ11000 4050 LTB lymphotoxin beta (TNF superfamily, member 3) 203 AK1 adenylate kinase 1 5920 RARRES3 retinoic acid receptor responder (tazarotene induced) 3 284801 LOC284801 hypothetical protein LOC284801 150271 LOC150271 hypothetical protein LOC150271.

33. A method of identifying a patient for treatment of a cell proliferative disorder with an inhibitor of FGFR3, the method comprising: testing a sample obtained from the patient after administration of the inhibitor to measure gene expression of at least one biomarker selected from the group consisting of CCL3, DUSP6, ANXA9, CR2, AL531683, ZNF589, AW274468, FRMD3, LTB, and WDR42A, wherein at least one selected biomarker is CCL3, wherein detection of an alteration in level of expression compared to a baseline gene expression measurement of the at least one biomarker is indicative of the candidacy of the patient for treatment, wherein the baseline gene expression measurement is the gene expression measured in the patient prior to administration of the inhibitor.

34. A method of monitoring response of a patient to treatment by an inhibitor of FGFR3 for a cell proliferative disorder, the method comprising: testing a sample obtained from the patient after administration of the inhibitor of FGFR3 to measure gene expression of at least one biomarker selected from the group consisting of CCL3, DUSP6, ANXA9, CR2, AL531683, ZNF589, AW274468, FRMD3, LTB, and WDR42A, wherein at least one selected biomarker is CCL3, wherein detection of an alteration in level of expression of the at least one biomarker compared to a baseline gene expression measurement is indicative of a response of the patient to the treatment, and wherein the baseline gene expression measurement is the gene expression measured in the patient prior to administration of the inhibitor.

Details for Patent 8,158,360

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Bausch & Lomb Incorporated VITRASE hyaluronidase Injection 021640 05/05/2004 ⤷  Try a Trial 2025-12-08
Bausch & Lomb Incorporated VITRASE hyaluronidase Injection 021640 12/02/2004 ⤷  Try a Trial 2025-12-08
Amphastar Pharmaceuticals, Inc. AMPHADASE hyaluronidase Injection 021665 10/26/2004 ⤷  Try a Trial 2025-12-08
Akorn, Inc. HYDASE hyaluronidase Injection 021716 10/25/2005 ⤷  Try a Trial 2025-12-08
Recordati Rare Diseases, Inc. ELSPAR asparaginase For Injection 101063 01/10/1978 ⤷  Try a Trial 2025-12-08
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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